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Robin A. Pixley, PhD

Professor, Sol Sherry Thrombosis Research Center

Telephone:  215-707-4440

Fax:  215-707-7863

Email: robin.pixley@temple.edu

Sol Sherry Thrombosis Research Center

New York University, New York, NY

1975, B.A., Biology

 

New York Medical College, Valhalla, NY

1980, M.S., Biochemistry

 

New York Medical College, Valhalla, NY

The Graduate School

1982, Ph.D. Biochemistry

 

Temple University School of Medicine, Philadelphia,  PA

Thrombosis Research Center

1982-1985, Postdoctoral Fellow

 

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The main focus of my research is examining the interactions of the plasma kallikrein kinin system (KKS) proteins.   We are currently examining the role of these proteins in in-vivo animal models and in-vitro systems.   The KKS proteins have been demonstrated in our laboratory to play a role in inflammation and angiogenesis through the plasma enzyme and inhibitor reactions and interaction with cellular receptors.  Specifically, I am examining the interaction of high molecular mass kininogen, factor XII and prekallikrein with endothelial cell receptors which include the urokinase plasminogen activator receptor (uPAR), the complement C1 receptor protein, gC1qR and with other structural features the endothelial cell membrane such as the cytokeratins and dextrans.

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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

19483730. Liu Y, Pixley R, Fusaro M, Godoy G, Kim E, Bromberg ME, Colman RW, Cleaved high-molecular-weight kininogen and its domain 5 inhibit migration and invasion of human prostate cancer cells through the epidermal growth factor receptor pathway. Oncogene 28:30(2756-65)2009 Jul 30

18394675. Hung SH, Liu AH, Pixley RA, Francis P, Williams LD, Matsko CM, Barnes KD, Sivendran S, Colman RF, Colman RW, A new nonhydrolyzable reactive cGMP analogue, (Rp)-guanosine-3',5'-cyclic-S-(4-bromo-2,3-dioxobutyl)monophosphorothioate, which targets the cGMP binding site of human platelet PDE3A. Bioorg Chem 36:3(141-7)2008 Jun

18062965. Liu Y, Sainz IM, Wu Y, Pixley R, Espinola RG, Hassan S, Khan MM, Colman RW, The inhibition of tube formation in a collagen-fibrinogen, three-dimensional gel by cleaved kininogen (HKa) and HK domain 5 (D5) is dependent on Src family kinases. Exp Cell Res 314:4(774-88)2008 Feb 15

17597995. Sainz IM, Pixley RA, Colman RW, Fifty years of research on the plasma kallikrein-kinin system: from protein structure and function to cell biology and in-vivo pathophysiology. Thromb Haemost 98:1(77-83)2007 Jul

17155949. Bior AD, Pixley RA, Colman RW, Domain 5 of kininogen inhibits proliferation of human colon cancer cell line (HCT-116) by interfering with G1/S in the cell cycle. J Thromb Haemost 5:2(403-11)2007 Feb

16873361. Hung SH, Zhang W, Pixley RA, Jameson BA, Huang YC, Colman RF, Colman RW, New insights from the structure-function analysis of the catalytic region of human platelet phosphodiesterase 3A: a role for the unique 44-amino acid insert. J Biol Chem 281:39(29236-44)2006 Sep 29

16708906. Isordia-Salas I, Sainz IM, Pixley RA, Martínez-Murillo C, Colman RW, [High molecular weight kininogen in inflammation and angiogenesis: a review of its properties and therapeutic applications] Rev Invest Clin 57:6(802-13)2005 Nov-Dec

16187087. Sainz IM, Isordia-Salas I, Espinola RG, Long WK, Pixley RA, Colman RW, Multiple myeloma in a murine syngeneic model:modulation of growth and angiogenesis by a monoclonal antibody to kininogen. Cancer Immunol Immunother 55:7(797-807)2006 Jul

16059911. Sainz IM, Isordia-Salas I, Castaneda JL, Agelan A, Liu B, DeLa Cadena RA, Pixley RA, Adam A, Sartor RB, Colman RW, Modulation of inflammation by kininogen deficiency in a rat model of inflammatory arthritis. Arthritis Rheum 52:8(2549-52)2005 Aug

15900628. Isordia-Salas I, Pixley RA, Sáinz IM, Martínez-Murillo C, Colman RW, The role of plasma high molecular weight kininogen in experimental intestinal and systemic inflammation. Arch Med Res 36:1(87-95)2005 Jan-Feb

15610905. Isordia-Salas I, Pixley RA, Sáinz IM, Martínez-Murillo C, Colman RW, The role of plasma high molecular weight kininogen in experimental intestinal and systemic inflammation. Arch Med Res 35:5(369-77)2004 Sep-Oct

15331420. Espinola RG, Uknis A, Sainz IM, Isordia-Salas I, Pixley R, DeLa Cadena R, Long W, Agelan A, Gaughan J, Adam A, Colman RW, A monoclonal antibody to high-molecular weight kininogen is therapeutic in a rodent model of reactive arthritis. Am J Pathol 165:3(969-76)2004 Sep

15161672. Song JS, Sainz IM, Cosenza SC, Isordia-Salas I, Bior A, Bradford HN, Guo YL, Pixley RA, Reddy EP, Colman RW, Inhibition of tumor angiogenesis in vivo by a monoclonal antibody targeted to domain 5 of high molecular weight kininogen. Blood 104:7(2065-72)2004 Oct 1

15001555. Sainz IM, Uknis AB, Isordia-Salas I, Dela Cadena RA, Pixley RA, Colman RW, Interactions between bradykinin (BK) and cell adhesion molecule (CAM) expression in peptidoglycan-polysaccharide (PG-PS)-induced arthritis. FASEB J 18:7(887-9)2004 May

12911595. Pixley RA, Lin Y, Isordia-Salas I, Colman RW, Fine mapping of the sequences in domain 5 of high molecular weight kininogen (HK) interacting with heparin and zinc. J Thromb Haemost 1:8(1791-8)2003 Aug

12871554. Colman RW, Pixley RA, Sainz IM, Song JS, Isordia-Salas I, Muhamed SN, Powell JA Jr, Mousa SA, Inhibition of angiogenesis by antibody blocking the action of proangiogenic high-molecular-weight kininogen. J Thromb Haemost 1:1(164-70)2003 Jan

12842992. Isordia-Salas I, Pixley RA, Parekh H, Kunapuli SP, Li F, Stadnicki A, Lin Y, Sartor RB, Colman RW, The mutation Ser511Asn leads to N-glycosylation and increases the cleavage of high molecular weight kininogen in rats genetically susceptible to inflammation. Blood 102:8(2835-42)2003 Oct 15

12489803. Isordia-Salas I, Pixley RA, Li F, Sainz I, Balfour Sartor R, Adam A, Colman RW, Chronic intestinal inflammation and angiogenesis in genetically susceptible rats is modulated by kininogen deficiency. Int Immunopharmacol 2:13-14(1895-905)2002 Dec

12065305. Isordia-Salas I, Pixley RA, Li F, Sainz I, Sartor RB, Adam A, Colman RW, Kininogen deficiency modulates chronic intestinal inflammation in genetically susceptible rats. Am J Physiol Gastrointest Liver Physiol 283:1(G180-6)2002 Jul

10819977. Lin Y, Pixley RA, Colman RW, Kinetic analysis of the role of zinc in the interaction of domain 5 of high-molecular weight kininogen (HK) with heparin. Biochemistry 39:17(5104-10)2000 May 2

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