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Hemant Parekh, PhD

Hemant Parekh, PhD



Professor, Pathology and Laboratory Medicine

Telephone:  215-707-8024

Fax:  215-707-4160

Email: hparek00@temple.edu



Department of Pathology and Laboratory Medicine


Educational Background:


Seth G.S. Medical College

Bombay University


MSc, Biochemistry, 1986


Cancer Research Institute

Bombay University


PhD, Biochemistry, 1990

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Research Interests:


Atypical taxol resistance-associated genes

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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

20338228. Pallai R, Simpkins H, Chen J, Parekh HK, The CCAAT box binding transcription factor, nuclear factor-Y (NF-Y) regulates transcription of human aldo-keto reductase 1C1 (AKR1C1) gene. Gene 459:1-2(11-23)2010 Jul 1

17661040. Chen J, Adikari M, Pallai R, Parekh HK, Simpkins H, Dihydrodiol dehydrogenases regulate the generation of reactive oxygen species and the development of cisplatin resistance in human ovarian carcinoma cells. Cancer Chemother Pharmacol 61:6(979-87)2008 May

17224078. Parekh HK, Adikari M, Vennapusa B, Differential partitioning of Galphai1 with the cellular microtubules: a possible mechanism of development of Taxol resistance in human ovarian carcinoma cells. J Mol Signal 1:(3)2006 Nov 10

16181989. Isordia-Salas I, Manns JM, Sainz I, Parekh H, DeLa Cadena RA, Thromsbospondin-1 binds to the heavy chain of elastase activated coagulation factor V (FVaHNE) and enhances thrombin generation on the surface of a promyelocytic cell line. Thromb Res 116:6(533-43)2005

15508192. Khurana JS, Ogino S, Shen T, Parekh H, Scherbel U, DeLong W, Feldman MD, Zhang PJ, Wolfe HJ, Alman BA, Bone morphogenetic proteins are expressed by both bone-forming and non-bone-forming lesions. Arch Pathol Lab Med 128:11(1267-69)2004 Nov

15506826. Khurana JS, Ogino S, Shen T, Parekh H, Scherbel U, Delong W, Feldman MD, Zhang PJ, Wolfe HJ, Alman BA, Bone Morphogenetic Proteins Are Expressed by Both Bone-Forming and Non-Bone-Forming Lesions. Arch Pathol Lab Med 128:11(1267-1269)2004 Nov

15138708. Deng HB, Adikari M, Parekh HK, Simpkins H, Ubiquitous induction of resistance to platinum drugs in human ovarian, cervical, germ-cell and lung carcinoma tumor cells overexpressing isoforms 1 and 2 of dihydrodiol dehydrogenase. Cancer Chemother Pharmacol 54:4(301-7)2004 Oct

12842992. Isordia-Salas I, Pixley RA, Parekh H, Kunapuli SP, Li F, Stadnicki A, Lin Y, Sartor RB, Colman RW, The mutation Ser511Asn leads to N-glycosylation and increases the cleavage of high molecular weight kininogen in rats genetically susceptible to inflammation. Blood 102:8(2835-42)2003 Oct 15

11931848. Parekh HK, Deng HB, Choudhary K, Houser SR, Simpkins H, Overexpression of sorcin, a calcium-binding protein, induces a low level of paclitaxel resistance in human ovarian and breast cancer cells. Biochem Pharmacol 63:6(1149-58)2002 Mar 15

11842089. Deng HB, Parekh HK, Chow KC, Simpkins H, Increased expression of dihydrodiol dehydrogenase induces resistance to cisplatin in human ovarian carcinoma cells. J Biol Chem 277:17(15035-43)2002 Apr 26

11606393. Kumar A, Soprano DR, Parekh HK, Cross-resistance to the synthetic retinoid CD437 in a paclitaxel-resistant human ovarian carcinoma cell line is independent of the overexpression of retinoic acid receptor-gamma. Cancer Res 61:20(7552-5)2001 Oct 15

9251895. Parekh H, Simpkins H, The transport and binding of taxol. Gen Pharmacol 29:2(167-72)1997 Aug

9330642. Parekh H, Pillarisetti K, Kunapuli S, Simpkins H, Isolation of a hamster cDNA homologous to the mouse and human cyclin kinase inhibitory protein p27Kip1. Somat Cell Mol Genet 23:2(147-51)1997 Mar

9105396. Parekh H, Wiesen K, Simpkins H, Acquisition of taxol resistance via P-glycoprotein- and non-P-glycoprotein-mediated mechanisms in human ovarian carcinoma cells. Biochem Pharmacol 53:4(461-70)1997 Feb 21

8625294. Mirakhur B, Parekh HK, Simpkins H, Expression of the cisplatin resistance phenotype in a human ovarian carcinoma cell line segregates with chromosomes 11 and 16. Cancer Res 56:10(2256-62)1996 May 15

8573197. Parekh H, Simpkins H, Species-specific differences in taxol transport and cytotoxicity against human and rodent tumor cells. Evidence for an alternate transport system. Biochem Pharmacol 51:3(301-11)1996 Feb 9

8599869. Parekh H, Simpkins H, Cross-resistance and collateral sensitivity to natural product drugs in cisplatin-sensitive and -resistant rat lymphoma and human ovarian carcinoma cells. Cancer Chemother Pharmacol 37:5(457-62)1996

7585575. Parekh HK, Simpkins H, The differential expression of cytokeratin 18 in cisplatin-sensitive and -resistant human ovarian adenocarcinoma cells and its association with drug sensitivity. Cancer Res 55:22(5203-6)1995 Nov 15

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