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Duraiswamy Navaneetham, PhDDuraiswamy Navaneetham, PhD

 

Assistant Professor, Sol Sherry Thrombosis Research Center

Telephone:  215-707-9288

Fax:  215-707-3005

Email: dnavanee@temple.edu

 

Sol Sherry Thrombosis Research Center

 

Educational Background:

 

All India Institute of Medical Sciences, New Delhi, India
1994, Ph.D .

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Research Interests:

 

Serine Protease Factor XIa and its regulation by platelet secreted Protease Nexin 2 (PN2) in human.   Structural and functional relationship between the protease and its high affinity Kunitz type inhibitor PN2.

 

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PUBMED PUBLICATIONS :


Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

19920152. Salameh MA, Robinson JL, Navaneetham D, Sinha D, Madden BJ, Walsh PN, Radisky ES, The amyloid precursor protein/protease nexin 2 Kunitz inhibitor domain is a highly specific substrate of mesotrypsin. J Biol Chem :()2009 Nov 17

17676929. Sinha D, Marcinkiewicz M, Navaneetham D, Walsh PN, Macromolecular substrate-binding exosites on both the heavy and light chains of factor XIa mediate the formation of the Michaelis complex required for factor IX-activation. Biochemistry 46:34(9830-9)2007 Aug 28

16085935. Navaneetham D, Jin L, Pandey P, Strickler JE, Babine RE, Abdel-Meguid SS, Walsh PN, Structural and mutational analyses of the molecular interactions between the catalytic domain of factor XIa and the Kunitz protease inhibitor domain of protease nexin 2. J Biol Chem 280:43(36165-75)2005 Oct 28

12968031. Yun TH, Baglia FA, Myles T, Navaneetham D, López JA, Walsh PN, Leung LL, Thrombin activation of factor XI on activated platelets requires the interaction of factor XI and platelet glycoprotein Ib alpha with thrombin anion-binding exosites I and II, respectively. J Biol Chem 278:48(48112-9)2003 Nov 28

11723227. Wang Y, Pereira EF, Maus AD, Ostlie NS, Navaneetham D, Lei S, Albuquerque EX, Conti-Fine BM, Human bronchial epithelial and endothelial cells express alpha7 nicotinic acetylcholine receptors. Mol Pharmacol 60:6(1201-9)2001 Dec

11180203. Navaneetham D, Penn AS, Howard JF Jr, Conti-Fine BM, Human thymuses express incomplete sets of muscle acetylcholine receptor subunit transcripts that seldom include the delta subunit. Muscle Nerve 24:2(203-10)2001 Feb

10771024. Conti-Fine BM, Navaneetham D, Lei S, Maus AD, Neuronal nicotinic receptors in non-neuronal cells: new mediators of tobacco toxicity? Eur J Pharmacol 393:1-3(279-94)2000 Mar 30

9878084. Navaneetham D, Penn AS, Howard JF Jr, Conti-Fine BM, TCR-Vbeta usage in the thymus and blood of myasthenia gravis patients. J Autoimmun 11:6(621-33)1998 Dec

9804613. Maus AD, Pereira EF, Karachunski PI, Horton RM, Navaneetham D, Macklin K, Cortes WS, Albuquerque EX, Conti-Fine BM, Human and rodent bronchial epithelial cells express functional nicotinic acetylcholine receptors. Mol Pharmacol 54:5(779-88)1998 Nov

9668251. Raju R, Navaneetham D, Protti MP, Horton RM, Hoppe BL, Howard J Jr, Conti-Fine BM, Acetylcholine receptor-specific CD4+ T cells in myasthenia gravis patients have individual, but restricted TCR V beta usage. Ann N Y Acad Sci 841:(324-8)1998 May 13

9668248. Conti-Fine BM, Navaneetham D, Karachunski PI, Raju R, Diethelm-Okita B, Okita D, Howard J Jr, Wang ZY, T cell recognition of the acetylcholine receptor in myasthenia gravis. Ann N Y Acad Sci 841:(283-308)1998 May 13

9376076. Raju R, Navaneetham D, Kellermann SA, Freeman SL, Morris JC, McCormick DJ, Conti-Fine BM, TCR vbeta usage of TSH receptor-specific CD4+ T cells in Graves' disease patients and healthy humans. J Autoimmun 10:5(479-89)1997 Oct

9193799. Navaneetham D, Penn A, Howard J Jr, Conti-Fine BM, Expression of the alpha 7 subunit of the nicotinic acetylcholine receptor in normal and myasthenic human thymuses. Cell Mol Biol (Noisy-le-grand) 43:3(433-42)1997 May

9185882. Raju R, Navaneetham D, Protti MP, Horton RM, Hoppe BL, Howard J Jr, Conti-Fine BM, TCR V beta usage by acetylcholine receptor-specific CD4+ T cells in myasthenia gravis. J Autoimmun 10:2(203-17)1997 Apr

8800408. Navaneetham D, Sivashanmugam P, Rajalakshmi M, Changes in binding of lectins to epididymal, ejaculated, and capacitated spermatozoa of the rhesus monkey. Anat Rec 245:3(500-8)1996 Jul

8566002. Raju R, Navaneetham D, Okita D, Diethelm-Okita B, McCormick D, Conti-Fine BM, Epitopes for human CD4+ cells on diphtheria toxin: structural features of sequence segments forming epitopes recognized by most subjects. Eur J Immunol 25:12(3207-14)1995 Dec

7702848. Raju R, Hoppe BL, Navaneetham D, Conti-Fine BM, Rapid method for the elution and analysis of PCR products separated on high resolution acrylamide gels. Biotechniques 18:1(32, 34, 36)1995 Jan

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