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Ruma Mukerjee, PhD

 

Ruma Mukerjee, PhD

 

Assistant Professor, Fels Institute for Cancer Research and Molecular Biology

Assistant Professor, Neurology

Telephone:  215-707-8417

Fax:  215-707-5963

Email: rmukerje@temple.edu

 

Fels Institute for Cancer Research and Molecular Biology

Department of Neurology

 

Educational Background:

 

Undergraduate degree, Lucknow University, India

 

PhD, Lucknow University, India

 

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Research Interests:

 

The Dengue virus (DV) pathogenesis remains a problem especially since there are no molecular markers to predict the early signs of the disease. The virus is known to promote vascular permeability, cerebral edema leading to Dengue hemorrhagic fever or Dengue shock syndrome. Among the viral proteins, Dengue virus NS1- glycoprotein secreted and accumulated in patients sera capture the attention of researchers due to its ability to be detected and measured. The DV-NS1 has capability to alter the expression of various cytokine, chemokine and inflammatory protein in endothelial cells. The mechanism used by DV-NS1 to cause vascular damage remains unclear. Our gene array analysis followed by functional assay led to the conclusion that DV-NS1 contributes significantly towards the severity of disease. My research involves identifying new biomarkers for DV pathogenesis as well as mechanism involve in severity of the disease. This could serve towards development of more effective therapeutic approach against DV.

 

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PUBMED PUBLICATIONS :


Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

25102850. Stanifer JW, Jing B, Tolan S, Helmke N, Mukerjee R, Naicker S, Patel U, The epidemiology of chronic kidney disease in sub-Saharan Africa: a systematic review and meta-analysis. Lancet Glob Health 2:3(e174-81)2014 Mar

24872081. Bagashev A, Mukerjee R, Santerre M, Del Carpio-Cano FE, Shrestha J, Wang Y, He JJ, Sawaya BE, Involvement of miR-196a in HIV-associated neurocognitive disorders. Apoptosis 19:8(1202-14)2014 Aug

23813301. Zhang R, Mukerjee R, Highly efficient factorial designs for cDNA microarray experiments: use of approximate theory together with a step-up step-down procedure. Stat Appl Genet Mol Biol 12:4(489-503)2013 Aug

23603988. Bagashev A, Fan S, Mukerjee R, Claudio PP, Chabrashvili T, Leng RP, Benchimol S, Sawaya BE, Cdk9 phosphorylates Pirh2 protein and prevents degradation of p53 protein. Cell Cycle 12:10(1569-77)2013 May 15

22042001. Chang JR, Ghafouri M, Mukerjee R, Bagashev A, Chabrashvili T, Sawaya BE, Role of p53 in neurodegenerative diseases. Neurodegener Dis 9:2(68-80)2012

21956116. Chang JR, Mukerjee R, Bagashev A, Del Valle L, Chabrashvili T, Hawkins BJ, He JJ, Sawaya BE, HIV-1 Tat protein promotes neuronal dysfunction through disruption of microRNAs. J Biol Chem 286:47(41125-34)2011 Nov 25

21816823. Mukerjee R, Chang JR, Del Valle L, Bagashev A, Gayed MM, Lyde RB, Hawkins BJ, Brailoiu E, Cohen E, Power C, Azizi SA, Gelman BB, Sawaya BE, Deregulation of microRNAs by HIV-1 Vpr protein leads to the development of neurocognitive disorders. J Biol Chem 286:40(34976-85)2011 Oct 7

21249135. Deshmane SL, Mukerjee R, Fan S, Sawaya BE, High-performance capillary electrophoresis for determining HIV-1 Tat protein in neurons. PLoS One 6:1(e16148)2011 Jan 7

21088492. Mukerjee R, Claudio PP, Chang JR, Del Valle L, Sawaya BE, Transcriptional regulation of HIV-1 gene expression by p53. Cell Cycle 9:22(4569-78)2010 Nov 15

19747512. Romagnoli L, Wollebo HS, Deshmane SL, Mukerjee R, Del Valle L, Safak M, Khalili K, White MK, Modulation of JC virus transcription by C/EBPbeta. Virus Res 146:1-2(97-106)2009 Dec

19581932. Cherrier T, Suzanne S, Redel L, Calao M, Marban C, Samah B, Mukerjee R, Schwartz C, Gras G, Sawaya BE, Zeichner SL, Aunis D, Van Lint C, Rohr O, p21(WAF1) gene promoter is epigenetically silenced by CTIP2 and SUV39H1. Oncogene 28:38(3380-9)2009 Sep 24

19328187. Rom I, Deshmane SL, Mukerjee R, Khalili K, Amini S, Sawaya BE, HIV-1 Vpr deregulates calcium secretion in neural cells. Brain Res 1275:(81-6)2009 Jun 12

19275580. Pandey RC, Datta D, Mukerjee R, Srinivasan A, Mahalingam S, Sawaya BE, HIV-1 Vpr: a closer look at the multifunctional protein from the structural perspective. Curr HIV Res 7:2(114-28)2009 Mar

19204000. Deshmane SL, Mukerjee R, Fan S, Del Valle L, Michiels C, Sweet T, Rom I, Khalili K, Rappaport J, Amini S, Sawaya BE, Activation of the oxidative stress pathway by HIV-1 Vpr leads to induction of hypoxia-inducible factor 1alpha expression. J Biol Chem 284:17(11364-73)2009 Apr 24

19023660. Sawaya BE, Deshmane SL, Mukerjee R, Fan S, Khalili K, TNF alpha production in morphine-treated human neural cells is NF-kappaB-dependent. J Neuroimmune Pharmacol 4:1(140-9)2009 Mar

18719392. Mukerjee R, Deshmane SL, Fan S, Del Valle L, White MK, Khalili K, Amini S, Sawaya BE, Involvement of the p53 and p73 transcription factors in neuroAIDS. Cell Cycle 7:17(2682-90)2008 Sep 1

18649942. Mukerjee R, Deshmane SL, Darbinian N, Czernik M, Khalili K, Amini S, Sawaya BE, St. John's Wort protein, p27SJ, regulates the MCP-1 promoter. Mol Immunol 45:15(4028-35)2008 Sep

17653096. Siddiqui K, Del Valle L, Morellet N, Cui J, Ghafouri M, Mukerjee R, Urbanska K, Fan S, Pattillo CB, Deshmane SL, Kiani MF, Ansari R, Khalili K, Roques BP, Reiss K, Bouaziz S, Amini S, Srinivasan A, Sawaya BE, Molecular mimicry in inducing DNA damage between HIV-1 Vpr and the anticancer agent, cisplatin. Oncogene 27:1(32-43)2008 Jan 3

17251582. Mameli G, Deshmane SL, Ghafouri M, Cui J, Simbiri K, Khalili K, Mukerjee R, Dolei A, Amini S, Sawaya BE, C/EBPbeta regulates human immunodeficiency virus 1 gene expression through its association with cdk9. J Gen Virol 88:Pt 2(631-40)2007 Feb

17031851. Mukerjee R, Sawaya BE, Khalili K, Amini S, Association of p65 and C/EBPbeta with HIV-1 LTR modulates transcription of the viral promoter. J Cell Biochem 100:5(1210-6)2007 Apr 1

16938324. Kang W, Mukerjee R, Gartner JJ, Hatzigeorgiou AG, Sandri-Goldin RM, Fraser NW, Characterization of a spliced exon product of herpes simplex type-1 latency-associated transcript in productively infected cells. Virology 356:1-2(106-14)2006 Dec 5-20

16690926. Rossi A, Mukerjee R, Ferrante P, Khalili K, Amini S, Sawaya BE, Human immunodeficiency virus type 1 Tat prevents dephosphorylation of Sp1 by TCF-4 in astrocytes. J Gen Virol 87:Pt 6(1613-23)2006 Jun

16690919. Gorrill T, Feliciano M, Mukerjee R, Sawaya BE, Khalili K, White MK, Activation of early gene transcription in polyomavirus BK by human immunodeficiency virus type 1 Tat. J Gen Virol 87:Pt 6(1557-66)2006 Jun

15681060. Naito J, Mukerjee R, Mott KR, Kang W, Osorio N, Fraser NW, Perng GC, Identification of a protein encoded in the herpes simplex virus type 1 latency associated transcript promoter region. Virus Res 108:1-2(101-10)2005 Mar

15207620. Mukerjee R, Kang W, Suri V, Fraser NW, A non-consensus branch point plays an important role in determining the stability of the 2-kb LAT intron during acute and latent infections of herpes simplex virus type-1. Virology 324:2(340-9)2004 Jul 1

12890636. Kang W, Mukerjee R, Fraser NW, Establishment and maintenance of HSV latent infection is mediated through correct splicing of the LAT primary transcript. Virology 312:1(233-44)2003 Jul 20

9649218. Agarwal R, Chaturvedi UC, Misra A, Mukerjee R, Kapoor S, Nagar R, Tandon R, Mathur A, Production of cytotoxic factor by peripheral blood mononuclear cells (PBMC) in patients with dengue haemorrhagic fever. Clin Exp Immunol 112:3(477-81)1998 Jun

9332166. Mukerjee R, Chaturvedi UC, ELISA for detection of dengue virus-induced cytokine and its antibody. Indian J Exp Biol 35:3(225-31)1997 Mar

8977376. Misra A, Mukerjee R, Chaturvedi UC, Release of reactive oxygen intermediates by dengue virus-induced macrophage cytotoxin. Int J Exp Pathol 77:5(237-42)1996 Oct

9099923. Misra A, Mukerjee R, Chaturvedi UC, Production of nitrite by dengue virus-induced cytotoxic factor. Clin Exp Immunol 104:3(406-11)1996 Jun

8762862. Mukerjee R, Misra A, Chaturvedi UC, Dengue virus-induced cytotoxin releases nitrite by spleen cells. Int J Exp Pathol 77:2(45-51)1996 Apr

8536363. Mukerjee R, Chaturvedi UC, Effect of adjuvants on immunization with dengue virus-induced cytotoxic factor. Clin Exp Immunol 102:3(496-500)1995 Dec

8786153. Dhawan R, Mukerjee R, Chaturvedi UC, Khare SD, Flow cytometric analysis of T4:T8 splenic cell during dengue virus infection of mice. Indian J Exp Biol 33:11(816-23)1995 Nov

7586676. Mukerjee R, Chaturvedi UC, Dhawan R, Dengue virus-induced human cytotoxic factor: production by peripheral blood leucocytes in vitro. Clin Exp Immunol 102:2(262-7)1995 Nov

7966570. Deka N, Sharma MD, Mukerjee R, Isolation of the novel agent from human stool samples that is associated with sporadic non-A, non-B hepatitis. J Virol 68:12(7810-5)1994 Dec

8187327. Chaturvedi UC, Mukerjee R, Dhawan R, Active immunization by a dengue virus-induced cytokine. Clin Exp Immunol 96:2(202-7)1994 May

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