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Stephen Arnoff


Tracy L. McGaha, PhD


Assistant Professor, Medicine

Telephone:  215-707-0740

FAX: 215-707-4148

Email: tmcgaha@temple.edu


Department of Medicine, Section of Rheumatology


Educational Background:


BS, Microbiology, University of Oklahoma, Norman, OK, 1996


MS, Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 1998


PhD, Biomedical Sciences, New York University, New York City, NY, 2002


Postdoctoral Fellowships, Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York City, NY, 2002-2006; Department of Pathology and Immunology, The University of Geneva, Geneva, Switzerland, 2006

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professional affiliations:

  • American Association for the Advancement of Science
  • American Association of Immunologists

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research interests:

  • Mechanisms of pathology progression in auto-immune inflammatory disease
  • Epigenetic modifications of mesenchymal cells in fibrotic lesions
  • The role of marginal zone macrophages in the maintenance of peripheral tolerance
  • B cell maturation in the germinal center

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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

26601142. Sharma MD, Shinde R, McGaha TL, Huang L, Holmgaard RB, Wolchok JD, Mautino MR, Celis E, Sharpe AH, Francisco LM, Powell JD, Yagita H, Mellor AL, Blazar BR, Munn DH, The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment. Sci Adv 1:10(e1500845)2015 Nov

26317232. McGaha TL, IDO-GCN2 and autophagy in inflammation. Oncotarget 6:26(21771-2)2015 Sep 8

26261340. Ravishankar B, Liu H, Shinde R, Chaudhary K, Xiao W, Bradley J, Koritzinsky M, Madaio MP, McGaha TL, The amino acid sensor GCN2 inhibits inflammatory responses to apoptotic cells promoting tolerance and suppressing systemic autoimmunity. Proc Natl Acad Sci U S A 112:34(10774-9)2015 Aug 25

26216892. Shinde R, Shimoda M, Chaudhary K, Liu H, Mohamed E, Bradley J, Kandala S, Li X, Liu K, McGaha TL, B Cell-Intrinsic IDO1 Regulates Humoral Immunity to T Cell-Independent Antigens. J Immunol 195:5(2374-82)2015 Sep 1

25980011. Chaudhary K, Shinde R, Liu H, Gnana-Prakasam JP, Veeranan-Karmegam R, Huang L, Ravishankar B, Bradley J, Kvirkvelia N, McMenamin M, Xiao W, Kleven D, Mellor AL, Madaio MP, McGaha TL, Amino acid metabolism inhibits antibody-driven kidney injury by inducing autophagy. J Immunol 194:12(5713-24)2015 Jun 15

25786206. McGaha TW Jr, Young RM, Burkett-Cadena ND, Iburg JP, Beau JM, Hassan S, Katholi CR, Cupp EW, Baker BJ, Unnasch TR, Noblet R, Identification of communal oviposition pheromones from the black fly Simulium vittatum. PLoS One 10:3(e0118904)2015

25722732. McGaha TL, Madaio MP, Lupus Nephritis: Animal Modeling of a Complex Disease Syndrome Pathology. Drug Discov Today Dis Models 11:(13-18)2014 Spring

25646302. Paschall AV, Zhang R, Qi CF, Bardhan K, Peng L, Lu G, Yang J, Merad M, McGaha T, Zhou G, Mellor A, Abrams SI, Morse HC 3rd, Ozato K, Xiong H, Liu K, IFN regulatory factor 8 represses GM-CSF expression in T cells to affect myeloid cell lineage differentiation. J Immunol 194:5(2369-79)2015 Mar 1

25627758. Lee CS, Montalmont B, O'Hara JA, Syed A, Chaussard C, McGaha TL, Pakstis DL, Lee JH, Shutt KA, Doi Y, Screening for methicillin-resistant Staphylococcus aureus colonization using sponges. Infect Control Hosp Epidemiol 36:1(28-33)2015 Jan

25569240. Young RM, Burkett-Cadena ND, McGaha TW Jr, Rodriguez-Perez MA, Toé LD, Adeleke MA, Sanfo M, Soungalo T, Katholi CR, Noblet R, Fadamiro H, Torres-Estrada JL, Salinas-Carmona MC, Baker B, Unnasch TR, Cupp EW, Identification of human semiochemicals attractive to the major vectors of onchocerciasis. PLoS Negl Trop Dis 9:1(e3450)2015 Jan

25521938. Lemos H, Huang L, McGaha T, Mellor AL, STING, nanoparticles, autoimmune disease and cancer: a novel paradigm for immunotherapy? Expert Rev Clin Immunol 11:1(155-65)2015 Jan

25143264. Lemos H, Huang L, McGaha TL, Mellor AL, Cytosolic DNA sensing via the stimulator of interferon genes adaptor: Yin and Yang of immune responses to DNA. Eur J Immunol 44:10(2847-53)2014 Oct

25122007. Jha V, Workman CJ, McGaha TL, Li L, Vas J, Vignali DA, Monestier M, Lymphocyte Activation Gene-3 (LAG-3) negatively regulates environmentally-induced autoimmunity. PLoS One 9:8(e104484)2014

24591636. Ravishankar B, Shinde R, Liu H, Chaudhary K, Bradley J, Lemos HP, Chandler P, Tanaka M, Munn DH, Mellor AL, McGaha TL, Marginal zone CD169+ macrophages coordinate apoptotic cell-driven cellular recruitment and tolerance. Proc Natl Acad Sci U S A 111:11(4215-20)2014 Mar 18

24248597. Liu H, Huang L, Bradley J, Liu K, Bardhan K, Ron D, Mellor AL, Munn DH, McGaha TL, GCN2-dependent metabolic stress is essential for endotoxemic cytokine induction and pathology. Mol Cell Biol 34:3(428-38)2014 Feb

23986532. Huang L, Li L, Lemos H, Chandler PR, Pacholczyk G, Baban B, Barber GN, Hayakawa Y, McGaha TL, Ravishankar B, Munn DH, Mellor AL, Cutting edge: DNA sensing via the STING adaptor in myeloid dendritic cells induces potent tolerogenic responses. J Immunol 191:7(3509-13)2013 Oct 1

23515049. Chaudhary K, Kleven DT, McGaha TL, Madaio MP, A human monoclonal antibody against the collagen type IV a3NC1 domain is a non-invasive optical biomarker for glomerular diseases. Kidney Int 84:2(403-8)2013 Aug

23377225. Ravishankar B, McGaha TL, O death where is thy sting? Immunologic tolerance to apoptotic self. Cell Mol Life Sci 70:19(3571-89)2013 Oct

22889220. McGaha TL, Huang L, Lemos H, Metz R, Mautino M, Prendergast GC, Mellor AL, Amino acid catabolism: a pivotal regulator of innate and adaptive immunity. Immunol Rev 249:1(135-57)2012 Sep

22516958. Huang L, Lemos HP, Li L, Li M, Chandler PR, Baban B, McGaha TL, Ravishankar B, Lee JR, Munn DH, Mellor AL, Engineering DNA nanoparticles as immunomodulatory reagents that activate regulatory T cells. J Immunol 188:10(4913-20)2012 May 15

22461695. Yang D, Torres CM, Bardhan K, Zimmerman M, McGaha TL, Liu K, Decitabine and vorinostat cooperate to sensitize colon carcinoma cells to Fas ligand-induced apoptosis in vitro and tumor suppression in vivo. J Immunol 188:9(4441-9)2012 May 1

22355111. Ravishankar B, Liu H, Shinde R, Chandler P, Baban B, Tanaka M, Munn DH, Mellor AL, Karlsson MC, McGaha TL, Tolerance to apoptotic cells is regulated by indoleamine 2,3-dioxygenase. Proc Natl Acad Sci U S A 109:10(3909-14)2012 Mar 6

22283427. McGaha TL, Ma Z, Ravishankar B, Gabunia K, McMenamin M, Madaio MP, Heterologous protein incites abnormal plasma cell accumulation and autoimmunity in MRL-MpJ mice. Autoimmunity 45:4(279-89)2012 Jun

22135456. Enoksson SL, Grasset EK, Hägglöf T, Mattsson N, Kaiser Y, Gabrielsson S, McGaha TL, Scheynius A, Karlsson MC, The inflammatory cytokine IL-18 induces self-reactive innate antibody responses regulated by natural killer T cells. Proc Natl Acad Sci U S A 108:51(E1399-407)2011 Dec 20

21444914. McGaha TL, Chen Y, Ravishankar B, van Rooijen N, Karlsson MC, Marginal zone macrophages suppress innate and adaptive immunity to apoptotic cells in the spleen. Blood 117:20(5403-12)2011 May 19

20980559. Doi Y, Onuoha EO, Adams-Haduch JM, Pakstis DL, McGaha TL, Werner CA, Parker BN, Brooks MM, Shutt KA, Pasculle AW, Muto CA, Harrison LH, Screening for Acinetobacter baumannii colonization by use of sponges. J Clin Microbiol 49:1(154-8)2011 Jan

20444650. Shao WH, Zhen Y, Rosenbaum J, Eisenberg RA, McGaha TL, Birkenbach M, Cohen PL, A protective role of Mer receptor tyrosine kinase in nephrotoxic serum-induced nephritis. Clin Immunol 136:2(236-44)2010 Aug

19281880. Wermeling F, Karlsson MC, McGaha TL, An anatomical view on macrophages in tolerance. Autoimmun Rev 9:1(49-52)2009 Sep

18390752. McGaha TL, Karlsson MC, Ravetch JV, FcgammaRIIB deficiency leads to autoimmunity and a defective response to apoptosis in Mrl-MpJ mice. J Immunol 180:8(5670-9)2008 Apr 15

18180376. Belnoue E, Pihlgren M, McGaha TL, Tougne C, Rochat AF, Bossen C, Schneider P, Huard B, Lambert PH, Siegrist CA, APRIL is critical for plasmablast survival in the bone marrow and poorly expressed by early-life bone marrow stromal cells. Blood 111:5(2755-64)2008 Mar 1

16492804. Ehlers M, Fukuyama H, McGaha TL, Aderem A, Ravetch JV, TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE. J Exp Med 203:3(553-61)2006 Mar 20

16380822. Bhogal RK, Stoica CM, McGaha TL, Bona CA, Molecular aspects of regulation of collagen gene expression in fibrosis. J Clin Immunol 25:6(592-603)2005 Nov

15681388. McGaha TL, Sorrentino B, Ravetch JV, Restoration of tolerance in lupus by targeted inhibitory receptor expression. Science 307:5709(590-3)2005 Jan 28

15507113. Kodera T, Radu D, McGaha T, Zwolo P, Stoica C, Cheroute H, Pollock RR, Bona C, Cellular and molecular studies of B cells exhibiting reverse somatic mutation throughout life. Genes Cells 9:11(1005-16)2004 Nov

15115312. Zhu H, Bona C, McGaha TL, Polymorphisms of the TGF-beta1 promoter in tight skin (TSK) mice. Autoimmunity 37:1(51-5)2004 Feb

12905482. McGaha TL, Le M, Kodera T, Stoica C, Zhu J, Paul WE, Bona CA, Molecular mechanisms of interleukin-4-induced up-regulation of type I collagen gene expression in murine fibroblasts. Arthritis Rheum 48:8(2275-84)2003 Aug

12849012. McGaha TL, Bona CA, Role of profibrogenic cytokines secreted by T cells in fibrotic processes in scleroderma. Autoimmun Rev 1:3(174-81)2002 May

12482197. McGaha T, Kodera T, Phelps R, Spiera H, Pines M, Bona C, Effect of halofuginone on the development of tight skin (TSK) syndrome. Autoimmunity 35:4(277-82)2002 Jul

12384935. McGaha TL, Kodera T, Spiera H, Stan AC, Pines M, Bona CA, Halofuginone inhibition of COL1A2 promoter activity via a c-Jun-dependent mechanism. Arthritis Rheum 46:10(2748-61)2002 Oct

11891315. Kodera T, McGaha TL, Phelps R, Paul WE, Bona CA, Disrupting the IL-4 gene rescues mice homozygous for the tight-skin mutation from embryonic death and diminishes TGF-beta production by fibroblasts. Proc Natl Acad Sci U S A 99:6(3800-5)2002 Mar 19

11874485. McGaha TL, Phelps RG, Spiera H, Bona C, Halofuginone, an inhibitor of type-I collagen synthesis and skin sclerosis, blocks transforming-growth-factor-beta-mediated Smad3 activation in fibroblasts. J Invest Dermatol 118:3(461-70)2002 Mar

11168809. McGaha T, Saito S, Phelps RG, Gordon R, Noben-Trauth N, Paul WE, Bona C, Lack of skin fibrosis in tight skin (TSK) mice with targeted mutation in the interleukin-4R alpha and transforming growth factor-beta genes. J Invest Dermatol 116:1(136-43)2001 Jan

10899865. McGaha T, Murphy JW, CTLA-4 down-regulates the protective anticryptococcal cell-mediated immune response. Infect Immun 68:8(4624-30)2000 Aug

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