FAculty directory

Back to alphabetical index

Tracy L. McGaha, PhD

Assistant Professor, Medicine

Telephone:  215-707-0740

FAX: 215-707-4148

Email: tmcgaha@temple.edu

Department of Medicine, Section of Rheumatology

BS, Microbiology, University of Oklahoma, Norman, OK, 1996

 

MS, Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 1998

 

PhD, Biomedical Sciences, New York University, New York City, NY, 2002

 

Postdoctoral Fellowships, Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York City, NY, 2002-2006; Department of Pathology and Immunology, The University of Geneva, Geneva, Switzerland, 2006

Return to top

• American Association for the Advancement of Science
• American Association of Immunologists

Return to top

• Mechanisms of pathology progression in auto-immune inflammatory disease
• Epigenetic modifications of mesenchymal cells in fibrotic lesions
• The role of marginal zone macrophages in the maintenance of peripheral tolerance
• B cell maturation in the germinal center

Return to top

Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

19281880. Wermeling F, Karlsson MC, McGaha TL, An anatomical view on macrophages in tolerance. Autoimmun Rev 9:1(49-52)2009 Sep

18390752. McGaha TL, Karlsson MC, Ravetch JV, FcgammaRIIB deficiency leads to autoimmunity and a defective response to apoptosis in Mrl-MpJ mice. J Immunol 180:8(5670-9)2008 Apr 15

18180376. Belnoue E, Pihlgren M, McGaha TL, Tougne C, Rochat AF, Bossen C, Schneider P, Huard B, Lambert PH, Siegrist CA, APRIL is critical for plasmablast survival in the bone marrow and poorly expressed by early-life bone marrow stromal cells. Blood 111:5(2755-64)2008 Mar 1

16492804. Ehlers M, Fukuyama H, McGaha TL, Aderem A, Ravetch JV, TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE. J Exp Med 203:3(553-61)2006 Mar 20

16380822. Bhogal RK, Stoica CM, McGaha TL, Bona CA, Molecular aspects of regulation of collagen gene expression in fibrosis. J Clin Immunol 25:6(592-603)2005 Nov

15681388. McGaha TL, Sorrentino B, Ravetch JV, Restoration of tolerance in lupus by targeted inhibitory receptor expression. Science 307:5709(590-3)2005 Jan 28

15507113. Kodera T, Radu D, McGaha T, Zwolo P, Stoica C, Cheroute H, Pollock RR, Bona C, Cellular and molecular studies of B cells exhibiting reverse somatic mutation throughout life. Genes Cells 9:11(1005-16)2004 Nov

15115312. Zhu H, Bona C, McGaha TL, Polymorphisms of the TGF-beta1 promoter in tight skin (TSK) mice. Autoimmunity 37:1(51-5)2004 Feb

12905482. McGaha TL, Le M, Kodera T, Stoica C, Zhu J, Paul WE, Bona CA, Molecular mechanisms of interleukin-4-induced up-regulation of type I collagen gene expression in murine fibroblasts. Arthritis Rheum 48:8(2275-84)2003 Aug

12849012. McGaha TL, Bona CA, Role of profibrogenic cytokines secreted by T cells in fibrotic processes in scleroderma. Autoimmun Rev 1:3(174-81)2002 May

12482197. McGaha T, Kodera T, Phelps R, Spiera H, Pines M, Bona C, Effect of halofuginone on the development of tight skin (TSK) syndrome. Autoimmunity 35:4(277-82)2002 Jul

12384935. McGaha TL, Kodera T, Spiera H, Stan AC, Pines M, Bona CA, Halofuginone inhibition of COL1A2 promoter activity via a c-Jun-dependent mechanism. Arthritis Rheum 46:10(2748-61)2002 Oct

11891315. Kodera T, McGaha TL, Phelps R, Paul WE, Bona CA, Disrupting the IL-4 gene rescues mice homozygous for the tight-skin mutation from embryonic death and diminishes TGF-beta production by fibroblasts. Proc Natl Acad Sci U S A 99:6(3800-5)2002 Mar 19

11874485. McGaha TL, Phelps RG, Spiera H, Bona C, Halofuginone, an inhibitor of type-I collagen synthesis and skin sclerosis, blocks transforming-growth-factor-beta-mediated Smad3 activation in fibroblasts. J Invest Dermatol 118:3(461-70)2002 Mar

11168809. McGaha T, Saito S, Phelps RG, Gordon R, Noben-Trauth N, Paul WE, Bona C, Lack of skin fibrosis in tight skin (TSK) mice with targeted mutation in the interleukin-4R alpha and transforming growth factor-beta genes. J Invest Dermatol 116:1(136-43)2001 Jan

10899865. McGaha T, Murphy JW, CTLA-4 down-regulates the protective anticryptococcal cell-mediated immune response. Infect Immun 68:8(4624-30)2000 Aug

Return to top