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Kenneth F. Mangan, MD, FACP
Director, Temple Bone Marrow Transplant Program
Associate Professor, Microbiology and Immunology
Department of Medicine, Bone Marrow Transplant Program
Department of Microbiology and Immunology
Dr. Mangan is a 1973 graduate of George Washington University School of Medicine in Washington, D.C. He completed his medical internship and residency at George Washington University Medical Center and Affiliated Hospitals and was board certified in Internal Medicine at ABIM in 1976. He received his clinical and research subspecialty training in Hematology at Tufts-New England Medical Center in Boston, Massachusetts (from 1976-1979) under Drs. Robert Schwartz and Jane Desforges, where he was awarded a National Leukemia Associated Fellowship.
He was board certified in hematology in 1978 and joined the faculty at Albany Medical College where he continued his clinical and laboratory research studies on the regulation of haematopoiesis by immune-lymphocytes. In 1981, he joined the faculty of the University of Pittsburgh, where he continued his clinical and laboratory research studies related to bone marrow and blood stem cell transplantation. He was recruited to the faculty of Temple University where he was promoted to Professor of Medicine.
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clinical and research Interests:
Over the last 18 years, Dr. Mangan developed a first class Adult Allogeneic and Autologous Bone Marrow and Blood Stem Cell Transplant program, which has transplanted over 900 patients with hematologic malignancies, marrow failure states, and selected solid tumors. His lifetime experience in autologous and allogeneic transplants includes over 1,000 patients.
Dr. Mangan has been recognized for his clinical expertise in transplantation by his peers as a perennial Philadelphia "Top Doc" and by "Best Doctors of America". Dr. Mangan as been awarded numerous grants from federal agencies, private industry and foundations.
In April 2000, Dr. Mangan moved his transplant program to the Fox Chase-Jeanes Hospital campus in Northeast Philadelphia following the affiliation and merger of the Temple University-Fox Chase Cancer Center oncology programs. His current research focus is the development of submyeloablative allogeneic transplant regimens for hematologic malignancies and selected solid tumors.
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Dr. Mangan served as president of the Pennsylvania Hematology-Oncology Society from 1995-1998. During his tenure as President of this society, he chaired a committee that established statewide clinical guidelines for marrow transplantation which were eventually adopted by the Pennsylvania Medical Society.
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publications, editorial boards and lectures:
Dr. Mangan has published over 180 journal articles, book chapters, and/or abstracts in his field and has served on the editorial boards of several prestigious journals, including Bone Marrow Transplantation, Blood, Stem Cells, Journal of Clinical Oncology, and Experimental Hematology. He is frequent lecturer on topics related to bone marrow transplantation and hematopoiesis.
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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)
23415769. Doshi M, Woodwell S, Kelleher K, Mangan K, Axelrod P, An outbreak of norovirus infection in a bone marrow transplant unit. Am J Infect Control 41:9(820-3)2013 Sep
17900280. Wirk B, Klumpp TR, Ulicny J, Herman JH, Gajewski JL, Martin ME, Emmons RV, Mangan KF, Lack of effect of donor-recipient Rh mismatch on outcomes after allogeneic hematopoietic stem cell transplantation. Transfusion 48:1(163-8)2008 Jan
16964267. Klumpp TR, Herman JH, Ulicny J, Emmons RV, Martin ME, Mangan KF, Lack of effect of donor-recipient ABO mismatching on outcome following allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant 38:9(615-20)2006 Nov
11281398. Schlossberg H, Klumpp T, Sabol P, Herman J, Mangan K, Severe cutaneous ulceration following treatment with thalidomide for GVHD. Bone Marrow Transplant 27:2(229-30)2001 Jan
10413273. Klumpp TR, Herman JH, Gaughan JP, Russo RR, Christman RA, Goldberg SL, Ackerman SJ, Bleecker GC, Mangan KF, Clinical consequences of alterations in platelet transfusion dose: a prospective, randomized, double-blind trial. Transfusion 39:7(674-81)1999 Jul
20426554. Mangan KF, Leonardo J, Mullaney MT, Terstappen LW, Rao C, Liberti P, A rapid two-step method for elimination of bcl-2/IgH positive non-Hodgkin's lymphoma cells from human blood or marrow stem cells, employing immunomagnetic purging with streptavidin-coated ferrofluids. Cytotherapy 1:4(287-93)1999
9850024. Goldberg SL, Klumpp TR, Magdalinski AJ, Mangan KF, Value of the pretransplant evaluation in predicting toxic day-100 mortality among blood stem-cell and bone marrow transplant recipients. J Clin Oncol 16:12(3796-802)1998 Dec
9285541. Klumpp TR, Goldberg SL, Magdalinski AJ, Mangan KF, Phase II study of high-dose cyclophosphamide, etoposide, and carboplatin (CEC) followed by autologous hematopoietic stem cell rescue in women with metastatic or high-risk non-metastatic breast cancer: multivariate analysis of factors affecting survival and engraftment. Bone Marrow Transplant 20:4(273-81)1997 Aug
9052924. Redei I, Mangan KF, Ming PL, Mullaney MT, Rao PN, Goldberg SL, Klumpp TR, Detection of a dormant 20q- leukemia clone in bone marrow cultures with hematopoietic growth factors: implications for secondary leukemia post-transplant. Bone Marrow Transplant 19:5(521-3)1997 Mar
8879629. Goldberg SL, Shubert J, Rao AK, Redei I, Klumpp TR, Mangan KF, Treatment of hepatic veno-occlusive disease with low-dose tissue plasminogen activator: impact on coagulation profile. Bone Marrow Transplant 18:3(633-6)1996 Sep
8879617. Klumpp TR, Herman JH, Schnell MK, Goldberg SL, Mangan KF, Association between antibodies reactive with neutrophils, rate of neutrophil engraftment, and incidence of post-engraftment neutropenia following BMT. Bone Marrow Transplant 18:3(559-64)1996 Sep
8807111. Klumpp TR, Herman JH, Innis S, Pearlman E, Culling N, Kotz KW, Slachta C, Goldberg SL, Mangan KF, Factors associated with response to platelet transfusion following hematopoietic stem cell transplantation. Bone Marrow Transplant 17:6(1035-41)1996 Jun
7539938. Mangan KF, Peripheral blood stem cell transplantation: from laboratory to clinical practice. Semin Oncol 22:3(202-9)1995 Jun
7538555. Klumpp TR, Mangan KF, Goldberg SL, Pearlman ES, Macdonald JS, Granulocyte colony-stimulating factor accelerates neutrophil engraftment following peripheral-blood stem-cell transplantation: a prospective, randomized trial. J Clin Oncol 13:6(1323-7)1995 Jun
7633845. Goldberg SL, Mangan KF, Klumpp TR, Macdonald JS, Thomas C, Mullaney MT, Au FC, Complications of peripheral blood stem cell harvesting: review of 554 PBSC leukaphereses. J Hematother 4:2(85-90)1995 Apr
8073483. Klumpp TR, Herman JH, Mangan KF, Schnell MK, Goldberg SL, Macdonald JS, Lack of transmission of neutrophil and platelet antibodies by intravenous immunoglobulin in bone marrow transplant patients. Transfusion 34:8(677-9)1994 Aug
7700900. Leopold LH, Shore SK, Newkirk T, Mangan K, Reddy EP, Ribozyme mediated therapy for chronic myelogenous leukemia. Prog Clin Biol Res 389:(175-82)1994
7535452. Mangan KF, Mullaney MT, Klumpp TR, Goldberg SL, Macdonald JS, A retrospective comparison of three different methods for mobilization of peripheral blood stem cells. Prog Clin Biol Res 389:(441-8)1994
7506091. Klumpp TR, Mangan KF, Glenn LD, Malaspina DR, Cropper T, Mullaney M, Macdonald JS, Phase I/II study of high-dose cyclophosphamide, etoposide and cisplatin followed by autologous bone marrow or peripheral blood stem cell transplantation in patients with poor prognosis Hodgkin's disease or non-Hodgkin's lymphoma. Bone Marrow Transplant 12:4(337-45)1993 Oct
8241955. Mangan K, Mullaney M, Klumpp T, Goldberg S, Macdonald J, Mobilization of peripheral blood stem cells by subcutaneous injections of yeast-derived granulocyte macrophage colony stimulating factor: a phase I-II study. Stem Cells 11:5(445-54)1993 Sep
8097937. Klumpp TR, Mangan KF, Glenn LD, Macdonald JS, Phase II pilot study of high-dose busulfan and CY followed by autologous BM or peripheral blood stem cell transplantation in patients with advanced chemosensitive breast cancer. Bone Marrow Transplant 11:4(337-9)1993 Apr
8096407. Mangan KF, Mullaney MT, Barrientos TD, Kernan NA, Serum interleukin-3 levels following autologous or allogeneic bone marrow transplantation: effects of T-cell depletion, blood stem cell infusion, and hematopoietic growth factor treatment. Blood 81:7(1915-22)1993 Apr 1
8467290. Klumpp TR, Herman JH, Mangan KF, Macdonald JS, Graft failure following neutrophil-specific alloantigen mismatched allogeneic BMT. Bone Marrow Transplant 11:3(243-5)1993 Mar
1384319. Klumpp TR, Herman JH, Macdonald JS, Schnell MK, Mullaney M, Mangan KF, Autoimmune neutropenia following peripheral blood stem cell transplantation. Am J Hematol 41:3(215-7)1992 Nov
3141523. Mangan KF, Zeevi A, Duquesnoy R, Shadduck RK, Gewirtz AM, A functional analysis of hematopoietic growth factor production from class I and class II human alloreactive T cell clones. Int J Cell Cloning 6:5(324-40)1988 Sep
3257281. Mangan KF, Stimulating red blood cell production with immunomodulating agents. JAMA 259:5(727-8)1988 Feb 5
3117880. Gewirtz AM, Xu WY, Mangan KF, Role of natural killer cells, in comparison with T lymphocytes and monocytes, in the regulation of normal human megakaryocytopoiesis in vitro. J Immunol 139:9(2915-24)1987 Nov 1
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