FAculty directory

Back to alphabetical index

Madesh Muniswamy , PhD

Assistant Professor, Biochemistry

Telephone:  215-707-5465

Fax:  215-707-7536

Email: madeshm@temple.edu

Department of Biochemistry

BS, Biochemistry, University of Madras, India, 1991

 

MS, Biochemistry, University of Madras, India, 1993

 

PhD, Bio-Medical Sciences, The Wellcome Trust Research Laboratory, 1998

 

Return to top

• Tumor metabolism
• Oxidative stress biology
• Calcium signaling and endothelial biology
• Mitochondria physiology in health and disease

Return to top

• American Society for Biochemistry and Molecular Biology
• American Advancement for the Advancement of Science
• American Association for Cancer Research

Return to top

Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

19897030. Davis CW, Hawkins BJ, Ramasamy S, Irrinki KM, Cameron BA, Islam K, Daswani VP, Doonan PJ, Manevich Y, Madesh M, Nitration of the Mitochondrial Complex I Subunit NDUFB8 Elicits RIP1 and 3-Mediated Necrosis. Free Radic Biol Med :()2009 Nov 5

19855129. Levin MD, Lu MM, Petrenko NB, Hawkins BJ, Gupta TH, Lang D, Buckley PT, Jochems J, Liu F, Spurney CF, Yuan LJ, Jacobson JT, Brown CB, Huang L, Beermann F, Margulies KB, Madesh M, Eberwine JH, Epstein JA, Patel VV, Melanocyte-like cells in the heart and pulmonary veins contribute to atrial arrhythmia triggers. J Clin Invest 119:11(3420-36)2009 Nov

19332555. Madesh M, Zong WX, Hawkins BJ, Ramasamy S, Venkatachalam T, Mukhopadhyay P, Doonan PJ, Irrinki KM, Rajesh M, Pacher P, Thompson CB, Execution of superoxide-induced cell death by the proapoptotic Bcl-2-related proteins Bid and Bak. Mol Cell Biol 29:11(3099-112)2009 Jun

19329538. Kolla V, Gonzales LW, Bailey NA, Wang P, Angampalli S, Godinez MH, Madesh M, Ballard PL, Carcinoembryonic cell adhesion molecule 6 in human lung: regulated expression of a multifunctional type II cell protein. Am J Physiol Lung Cell Mol Physiol 296:6(L1019-30)2009 Jun

19217411. Roy SS, Madesh M, Davies E, Antonsson B, Danial N, Hajnóczky G, Bad targets the permeability transition pore independent of Bax or Bak to switch between Ca2+-dependent cell survival and death. Mol Cell 33:3(377-88)2009 Feb 13

18648233. Yang H, Liang G, Hawkins BJ, Madesh M, Pierwola A, Wei H, Inhalational anesthetics induce cell damage by disruption of intracellular calcium homeostasis with different potencies. Anesthesiology 109:2(243-50)2008 Aug

18573285. Milovanova T, Chatterjee S, Hawkins BJ, Hong N, Sorokina EM, Debolt K, Moore JS, Madesh M, Fisher AB, Caveolae are an essential component of the pathway for endothelial cell signaling associated with abrupt reduction of shear stress. Biochim Biophys Acta 1783:10(1866-75)2008 Oct

18212570. Wei H, Liang G, Yang H, Wang Q, Hawkins B, Madesh M, Wang S, Eckenhoff RG, The common inhalational anesthetic isoflurane induces apoptosis via activation of inositol 1,4,5-trisphosphate receptors. Anesthesiology 108:2(251-60)2008 Feb

17950837. Dziubla TD, Shuvaev VV, Hong NK, Hawkins BJ, Madesh M, Takano H, Simone E, Nakada MT, Fisher A, Albelda SM, Muzykantov VR, Endothelial targeting of semi-permeable polymer nanocarriers for enzyme therapies. Biomaterials 29:2(215-27)2008 Jan

17853886. Mukhopadhyay P, Rajesh M, Haskó G, Hawkins BJ, Madesh M, Pacher P, Simultaneous detection of apoptosis and mitochondrial superoxide production in live cells by flow cytometry and confocal microscopy. Nat Protoc 2:9(2295-301)2007

17724077. Hawkins BJ, Solt LA, Chowdhury I, Kazi AS, Abid MR, Aird WC, May MJ, Foskett JK, Madesh M, G protein-coupled receptor Ca2+-linked mitochondrial reactive oxygen species are essential for endothelial/leukocyte adherence. Mol Cell Biol 27:21(7582-93)2007 Nov

17692540. Jones RG, Bui T, White C, Madesh M, Krawczyk CM, Lindsten T, Hawkins BJ, Kubek S, Frauwirth KA, Wang YL, Conway SJ, Roderick HL, Bootman MD, Shen H, Foskett JK, Thompson CB, The proapoptotic factors Bax and Bak regulate T Cell proliferation through control of endoplasmic reticulum Ca(2+) homeostasis. Immunity 27:2(268-80)2007 Aug

17540762. Cheong N, Zhang H, Madesh M, Zhao M, Yu K, Dodia C, Fisher AB, Savani RC, Shuman H, ABCA3 is critical for lamellar body biogenesis in vivo. J Biol Chem 282:33(23811-7)2007 Aug 17

17360969. Hawkins BJ, Madesh M, Kirkpatrick CJ, Fisher AB, Superoxide flux in endothelial cells via the chloride channel-3 mediates intracellular signaling. Mol Biol Cell 18:6(2002-12)2007 Jun

16429131. Muthumani K, Choo AY, Zong WX, Madesh M, Hwang DS, Premkumar A, Thieu KP, Emmanuel J, Kumar S, Thompson CB, Weiner DB, The HIV-1 Vpr and glucocorticoid receptor complex is a gain-of-function interaction that prevents the nuclear localization of PARP-1. Nat Cell Biol 8:2(170-9)2006 Feb

16415354. Cheong N, Madesh M, Gonzales LW, Zhao M, Yu K, Ballard PL, Shuman H, Functional and trafficking defects in ATP binding cassette A3 mutants associated with respiratory distress syndrome. J Biol Chem 281:14(9791-800)2006 Apr 7

16186254. Madesh M, Hawkins BJ, Milovanova T, Bhanumathy CD, Joseph SK, Ramachandrarao SP, Sharma K, Kurosaki T, Fisher AB, Selective role for superoxide in InsP3 receptor-mediated mitochondrial dysfunction and endothelial apoptosis. J Cell Biol 170:7(1079-90)2005 Sep 26

16179951. White C, Li C, Yang J, Petrenko NB, Madesh M, Thompson CB, Foskett JK, The endoplasmic reticulum gateway to apoptosis by Bcl-X(L) modulation of the InsP3R. Nat Cell Biol 7:10(1021-8)2005 Oct

16107509. Milovanova T, Chatterjee S, Manevich Y, Kotelnikova I, Debolt K, Madesh M, Moore JS, Fisher AB, Lung endothelial cell proliferation with decreased shear stress is mediated by reactive oxygen species. Am J Physiol Cell Physiol 290:1(C66-76)2006 Jan

15937149. Kazerounian S, Pitari GM, Shah FJ, Frick GS, Madesh M, Ruiz-Stewart I, Schulz S, Hajnóczky G, Waldman SA, Proliferative signaling by store-operated calcium channels opposes colon cancer cell cytostasis induced by bacterial enterotoxins. J Pharmacol Exp Ther 314:3(1013-22)2005 Sep

Return to top