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Lee-Yuan Liu-Chen, PhD

Professor, Pharmacology

Telephone:  215-707-4188

Fax:  215-707-6661

Email: lee-yuan.liu-chen@temple.edu

Department of Pharmacology

Center for Substance Abuse Research

BS, National Taiwan University, Taipei, Taiwan 1976

 

MS, University of Minnesota (Mayo Clinic), Rochester, MN 1980

 

PhD, Massachusetts Institue of Technology, Cambridge, MA 1983

 

Postdoctoral Fellowship, Massachusetts General Hospital/Harvard Medical School, Boston, MA 1984

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• Biochemistry and molecular and cellular pharmacology of opioid receptors.
• Mechanisms underlying drug abuse.

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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

23856011. Huang P, Chiu YT, Chen C, Wang Y, Liu-Chen LY, A G protein-coupled receptor (GPCR) in red: live cell imaging of the kappa opioid receptor-tdTomato fusion protein (KOPR-tdT) in neuronal cells. J Pharmacol Toxicol Methods :()2013 Jul 12

23624231. Xu W, Chen C, Li JG, Dimattio K, Wang Y, Unterwald E, Liu-Chen LY, PKA and ERK1/2 are involved in dopamine D1 receptor-induced heterologous desensitization of the d opioid receptor. Life Sci 92:23(1101-9)2013 Jun 21

23446450. Van't Veer A, Bechtholt AJ, Onvani S, Potter D, Wang Y, Liu-Chen LY, Schütz G, Chartoff EH, Rudolph U, Cohen BM, Carlezon WA Jr, Ablation of Kappa-Opioid Receptors from Brain Dopamine Neurons has Anxiolytic-Like Effects and Enhances Cocaine-Induced Plasticity. Neuropsychopharmacology 38:8(1585-97)2013 Jul

23086943. Schattauer SS, Miyatake M, Shankar H, Zietz C, Levin JR, Liu-Chen LY, Gurevich VV, Rieder MJ, Chavkin C, Ligand directed signaling differences between rodent and human ?-opioid receptors. J Biol Chem 287:50(41595-607)2012 Dec 7

22989890. Li JG, Chen C, Huang P, Wang Y, Liu-Chen LY, 14-3-3? Protein regulates anterograde transport of the human ?-opioid receptor (hKOPR). J Biol Chem 287:45(37778-92)2012 Nov 2

22863678. Rasakham K, McGillivray KL, Liu-Chen LY, Sex differences in U50,488H-induced phosphorylation of p44/42 mitogen-activated protein kinase in the guinea pig brain. Neuroscience 223:(447-56)2012 Oct 25

22862850. Wang YJ, Huang P, Blendy JA, Liu-Chen LY, Brain region- and sex-specific alterations in DAMGO-stimulated [³⁵ S]GTP?S binding in mice with Oprm1 A112G. Addict Biol :()2012 Aug 2

22736766. Rives ML, Rossillo M, Liu-Chen LY, Javitch JA, 6'-Guanidinonaltrindole (6'-GNTI) is a G protein-biased ?-opioid receptor agonist that inhibits arrestin recruitment. J Biol Chem 287:32(27050-4)2012 Aug 3

22652295. Lisek R, Xu W, Yuvasheva E, Chiu YT, Reitz AB, Liu-Chen LY, Rawls SM, Mephedrone ('bath salt') elicits conditioned place preference and dopamine-sensitive motor activation. Drug Alcohol Depend 126:1-2(257-62)2012 Nov 1

22240251. Wang YJ, Huang P, Ung A, Blendy JA, Liu-Chen LY, Reduced expression of the µ opioid receptor in some, but not all, brain regions in mice with OPRM1 A112G. Neuroscience 205:(178-84)2012 Mar 15

22204910. Béguin C, Potuzak J, Xu W, Liu-Chen LY, Streicher JM, Groer CE, Bohn LM, Carlezon WA Jr, Cohen BM, Differential signaling properties at the kappa opioid receptor of 12-epi-salvinorin A and its analogues. Bioorg Med Chem Lett 22:2(1023-6)2012 Jan 15

21864297. Huang P, Chen C, Mague SD, Blendy JA, Liu-Chen LY, A common single nucleotide polymorphism A118G of the µ opioid receptor alters its N-glycosylation and protein stability. Biochem J 441:1(379-86)2012 Jan 1

21841040. Wang YJ, Rasakham K, Huang P, Chudnovskaya D, Cowan A, Liu-Chen LY, Sex difference in ?-opioid receptor (KOPR)-mediated behaviors, brain region KOPR level and KOPR-mediated guanosine 5'-O-(3-[35S]thiotriphosphate) binding in the guinea pig. J Pharmacol Exp Ther 339:2(438-50)2011 Nov

21545805. Zhu J, Spencer TJ, Liu-Chen LY, Biederman J, Bhide PG, Methylphenidate and µ opioid receptor interactions: a pharmacological target for prevention of stimulant abuse. Neuropharmacology 61:1-2(283-92)2011 Jul-Aug

21388957. Chen C, Wang Y, Huang P, Liu-Chen LY, Effects of C-terminal modifications of GEC1 protein and gamma-aminobutyric acid type A (GABA(A)) receptor-associated protein (GABARAP), two microtubule-associated proteins, on kappa opioid receptor expression. J Biol Chem 286:17(15106-15)2011 Apr 29

20951148. Rasakham K, Liu-Chen LY, Sex differences in kappa opioid pharmacology. Life Sci 88:1-2(2-16)2011 Jan 3

20801035. Lee DY, Yang L, Xu W, Deng G, Guo L, Liu-Chen LY, Synthesis and biological evaluation of C-2 halogenated analogs of salvinorin A. Bioorg Med Chem Lett 20:19(5749-52)2010 Oct 1

20363293. Huang P, Liu-Chen LY, Kirby LG, Anxiety-like effects of SR141716-precipitated delta9-tetrahydrocannabinol withdrawal in mice in the elevated plus-maze. Neurosci Lett 475:3(165-8)2010 May 21

19733208. Huang P, Liu-Chen LY, Unterwald EM, Cowan A, Hyperlocomotion and paw tremors are two highly quantifiable signs of SR141716-precipitated withdrawal from delta9-tetrahydrocannabinol in C57BL/6 mice. Neurosci Lett 465:1(66-70)2009 Nov 6

19528658. Mague SD, Isiegas C, Huang P, Liu-Chen LY, Lerman C, Blendy JA, Mouse model of OPRM1 (A118G) polymorphism has sex-specific effects on drug-mediated behavior. Proc Natl Acad Sci U S A 106:26(10847-52)2009 Jun 30

19482639. Huang P, Liu-Chen LY, Detecting the mu opioid receptor in brain following SDS-PAGE with multiple approaches. Front Biosci (Elite Ed) 1:(220-7)2009 Jun 1

19416973. Wang Q, Liu-Chen LY, Traynor JR, Differential modulation of mu- and delta-opioid receptor agonists by endogenous RGS4 protein in SH-SY5Y cells. J Biol Chem 284:27(18357-67)2009 Jul 3

19373968. Brailoiu E, Dun SL, Gao X, Brailoiu GC, Li JG, Luo JJ, Yang J, Chang JK, Liu-Chen LY, Dun NJ, C-peptide of preproinsulin-like peptide 7: localization in the rat brain and activity in vitro. Neuroscience 159:2(492-500)2009 Mar 17

19273091. Chen Y, Liu-Chen LY, Chaperone-like effects of cell-permeant ligands on opioid receptors. Front Biosci 14:(634-43)2009 Jan 1

19211245. Yang L, Xu W, Chen F, Liu-Chen LY, Ma Z, Lee DY, Synthesis and biological evaluation of C-12 triazole and oxadiazole analogs of salvinorin A. Bioorg Med Chem Lett 19:5(1301-4)2009 Mar 1

19147366. Béguin C, Duncan KK, Munro TA, Ho DM, Xu W, Liu-Chen LY, Carlezon WA Jr, Cohen BM, Modification of the furan ring of salvinorin A: identification of a selective partial agonist at the kappa opioid receptor. Bioorg Med Chem 17:3(1370-80)2009 Feb 1

19130621. Wang Y, Xu W, Huang P, Chavkin C, Van Bockstaele EJ, Liu-Chen LY, Effects of acute agonist treatment on subcellular distribution of kappa opioid receptor in rat spinal cord. J Neurosci Res 87:7(1695-702)2009 May 15

19001416. Chen Y, Chen C, Kotsikorou E, Lynch DL, Reggio PH, Liu-Chen LY, GEC1-kappa opioid receptor binding involves hydrophobic interactions: GEC1 has chaperone-like effect. J Biol Chem 284:3(1673-85)2009 Jan 16

18950900. Woodruff-Pak DS, Lehr MA, Li JG, Liu-Chen LY, Young and older good learners have higher levels of brain nicotinic receptor binding. Neurobiol Aging 31:6(1032-43)2010 Jun

18930741. Wang Y, Van Bockstaele EJ, Liu-Chen LY, In vivo trafficking of endogenous opioid receptors. Life Sci 83:21-22(693-9)2008 Nov 21

18925386. Inan S, Lee DY, Liu-Chen LY, Cowan A, Comparison of the diuretic effects of chemically diverse kappa opioid agonists in rats: nalfurafine, U50,488H, and salvinorin A. Naunyn Schmiedebergs Arch Pharmacol 379:3(263-70)2009 Mar

18830156. Ma ZZ, Xu W, Jensen NH, Roth BL, Liu-Chen LY, Lee DY, Isoquinoline alkaloids isolated from Corydalis yanhusuo and their binding affinities at the dopamine D1 receptor. Molecules 13:9(2303-12)2008 Sep 25

18256594. Li JG, Lehr M, Liu-Chen LY, Woodruff-Pak DS, Nicotinic acetylcholine receptors and modulation of learning in 4- and 27-month-old rabbits. Neuropsychopharmacology 33:12(2820-30)2008 Nov

18212250. Li JG, Haines DS, Liu-Chen LY, Agonist-promoted Lys63-linked polyubiquitination of the human kappa-opioid receptor is involved in receptor down-regulation. Mol Pharmacol 73:4(1319-30)2008 Apr

18166466. Ma Z, Xu W, Liu-Chen LY, Lee DY, Novel coumarin glycoside and phenethyl vanillate from Notopterygium forbesii and their binding affinities for opioid and dopamine receptors. Bioorg Med Chem 16:6(3218-23)2008 Mar 15

18089845. Wang Y, Chen Y, Xu W, Lee DY, Ma Z, Rawls SM, Cowan A, Liu-Chen LY, 2-Methoxymethyl-salvinorin B is a potent kappa opioid receptor agonist with longer lasting action in vivo than salvinorin A. J Pharmacol Exp Ther 324:3(1073-83)2008 Mar

17981041. Munro TA, Duncan KK, Xu W, Wang Y, Liu-Chen LY, Carlezon WA Jr, Cohen BM, Béguin C, Standard protecting groups create potent and selective kappa opioids: salvinorin B alkoxymethyl ethers. Bioorg Med Chem 16:3(1279-86)2008 Feb 1

17980352. Huang P, Xu W, Yoon SI, Chen C, Chong PL, Unterwald EM, Liu-Chen LY, Agonist treatment did not affect association of mu opioid receptors with lipid rafts and cholesterol reduction had opposite effects on the receptor-mediated signaling in rat brain and CHO cells. Brain Res 1184:(46-56)2007 Dec 12

17980152. Huang P, Chen C, Xu W, Yoon SI, Unterwald EM, Pintar JE, Wang Y, Chong PL, Liu-Chen LY, Brain region-specific N-glycosylation and lipid rafts association of the rat mu opioid receptor. Biochem Biophys Res Commun 365:1(82-8)2008 Jan 4

17951511. Béguin C, Potter DN, Dinieri JA, Munro TA, Richards MR, Paine TA, Berry L, Zhao Z, Roth BL, Xu W, Liu-Chen LY, Carlezon WA Jr, Cohen BM, N-methylacetamide analog of salvinorin A: a highly potent and selective kappa-opioid receptor agonist with oral efficacy. J Pharmacol Exp Ther 324:1(188-95)2008 Jan

17711303. Li JG, Chen C, Liu-Chen LY, N-Glycosylation of the human kappa opioid receptor enhances its stability but slows its trafficking along the biosynthesis pathway. Biochemistry 46:38(10960-70)2007 Sep 25

17433292. Xie Z, Li Z, Guo L, Ye C, Li J, Yu X, Yang H, Wang Y, Chen C, Zhang D, Liu-Chen LY, Regulator of G protein signaling proteins differentially modulate signaling of mu and delta opioid receptors. Eur J Pharmacol 565:1-3(45-53)2007 Jun 22

17316701. Chen Y, Chen C, Liu-Chen LY, Dynorphin peptides differentially regulate the human kappa opioid receptor. Life Sci 80:15(1439-48)2007 Mar 20

17212822. Munro TA, Duncan KK, Staples RJ, Xu W, Liu-Chen LY, Béguin C, Carlezon WA Jr, Cohen BM, 8-epi-Salvinorin B: crystal structure and affinity at the kappa opioid receptor. Beilstein J Org Chem 3:(1)2007 Jan 9

17141202. Huang P, Xu W, Yoon SI, Chen C, Chong PL, Liu-Chen LY, Cholesterol reduction by methyl-beta-cyclodextrin attenuates the delta opioid receptor-mediated signaling in neuronal cells but enhances it in non-neuronal cells. Biochem Pharmacol 73:4(534-49)2007 Feb 15

16945525. Lee DY, He M, Liu-Chen LY, Wang Y, Li JG, Xu W, Ma Z, Carlezon WA Jr, Cohen B, Synthesis and in vitro pharmacological studies of new C(4)-modified salvinorin A analogues. Bioorg Med Chem Lett 16:21(5498-502)2006 Nov 1

16893609. Hummel M, Schroeder J, Liu-Chen LY, Cowan A, Unterwald EM, An antisense oligodeoxynucleotide to the mu opioid receptor attenuates cocaine-induced behavioral sensitization and reward in mice. Neuroscience 142:2(481-91)2006 Oct 13

16882876. Chen Y, Chen C, Wang Y, Liu-Chen LY, Ligands regulate cell surface level of the human kappa opioid receptor by activation-induced down-regulation and pharmacological chaperone-mediated enhancement: differential effects of nonpeptide and peptide agonists. J Pharmacol Exp Ther 319:2(765-75)2006 Nov

16777411. Béguin C, Richards MR, Li JG, Wang Y, Xu W, Liu-Chen LY, Carlezon WA Jr, Cohen BM, Synthesis and in vitro evaluation of salvinorin A analogues: effect of configuration at C(2) and substitution at C(18). Bioorg Med Chem Lett 16:17(4679-85)2006 Sep 1

16678548. Lalovic B, Kharasch E, Hoffer C, Risler L, Liu-Chen LY, Shen DD, Pharmacokinetics and pharmacodynamics of oral oxycodone in healthy human subjects: role of circulating active metabolites. Clin Pharmacol Ther 79:5(461-79)2006 May

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Research Technologist: Chongguang Che, cgggc@temple.edu

Associate Scientist: Peng Huang, PhD, peng.huang@temple.edu
Postdoctoral Fellow: Yujun Wang, PhD, yujun@temple.edu
Graduate Students: Yi-Ting Chiu, rubisco85@gmail.com

                                     Kelly DiMattio, tuc21238@temple.edu

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