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Lee-Yuan Liu-Chen, PhD

Professor, Pharmacology

Telephone:  215-707-4188

Fax:  215-707-7068

Email: lee-yuan.liu-chen@temple.edu

Department of Pharmacology

Center for Substance Abuse Research

BS, National Taiwan University, Taipei, Taiwan 1976

 

MS, University of Minnesota (Mayo Clinic), Rochester, MN 1980

 

PhD, Massachusetts Institue of Technology, Cambridge, MA 1983

 

Postdoctoral Fellowship, General Hospital/Harvard Medical School, Boston, MA 1984

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• Biochemistry and molecular and cellular pharmacology of opioid receptors.
• Mechanisms underlying drug abuse.

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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

19733208. Huang P, Liu-Chen LY, Unterwald EM, Cowan A, Hyperlocomotion and paw tremors are two highly quantifiable signs of SR141716-precipitated withdrawal from delta9-tetrahydrocannabinol in C57BL/6 mice. Neurosci Lett 465:1(66-70)2009 Nov 6

19528658. Mague SD, Isiegas C, Huang P, Liu-Chen LY, Lerman C, Blendy JA, Mouse model of OPRM1 (A118G) polymorphism has sex-specific effects on drug-mediated behavior. Proc Natl Acad Sci U S A 106:26(10847-52)2009 Jun 30

19482639. Huang P, Liu-Chen LY, Detection of the endogenous mu opioid receptor (mopr) in brain. Front Biosci (Elite Ed) 1:(220-7)2009 Jun 1

19416973. Wang Q, Liu-Chen LY, Traynor JR, Differential modulation of mu- and delta-opioid receptor agonists by endogenous RGS4 protein in SH-SY5Y cells. J Biol Chem 284:27(18357-67)2009 Jul 3

19373968. Brailoiu E, Dun SL, Gao X, Brailoiu GC, Li JG, Luo JJ, Yang J, Chang JK, Liu-Chen LY, Dun NJ, C-peptide of preproinsulin-like peptide 7: localization in the rat brain and activity in vitro. Neuroscience 159:2(492-500)2009 Mar 17

19273091. Chen Y, Liu-Chen LY, Chaperone-like effects of cell-permeant ligands on opioid receptors. Front Biosci 14:(634-43)2009 Jan 1

19211245. Yang L, Xu W, Chen F, Liu-Chen LY, Ma Z, Lee DY, Synthesis and biological evaluation of C-12 triazole and oxadiazole analogs of salvinorin A. Bioorg Med Chem Lett 19:5(1301-4)2009 Mar 1

19147366. Béguin C, Duncan KK, Munro TA, Ho DM, Xu W, Liu-Chen LY, Carlezon WA Jr, Cohen BM, Modification of the furan ring of salvinorin A: identification of a selective partial agonist at the kappa opioid receptor. Bioorg Med Chem 17:3(1370-80)2009 Feb 1

19130621. Wang Y, Xu W, Huang P, Chavkin C, Van Bockstaele EJ, Liu-Chen LY, Effects of acute agonist treatment on subcellular distribution of kappa opioid receptor in rat spinal cord. J Neurosci Res 87:7(1695-702)2009 May 15

19001416. Chen Y, Chen C, Kotsikorou E, Lynch DL, Reggio PH, Liu-Chen LY, GEC1-kappa opioid receptor binding involves hydrophobic interactions: GEC1 has chaperone-like effect. J Biol Chem 284:3(1673-85)2009 Jan 16

18950900. Woodruff-Pak DS, Lehr MA, Li JG, Liu-Chen LY, Young and older good learners have higher levels of brain nicotinic receptor binding. Neurobiol Aging :()2008 Oct 22

18930741. Wang Y, Van Bockstaele EJ, Liu-Chen LY, In vivo trafficking of endogenous opioid receptors. Life Sci 83:21-22(693-9)2008 Nov 21

18925386. Inan S, Lee DY, Liu-Chen LY, Cowan A, Comparison of the diuretic effects of chemically diverse kappa opioid agonists in rats: nalfurafine, U50,488H, and salvinorin A. Naunyn Schmiedebergs Arch Pharmacol 379:3(263-70)2009 Mar

18830156. Ma ZZ, Xu W, Jensen NH, Roth BL, Liu-Chen LY, Lee DY, Isoquinoline alkaloids isolated from Corydalis yanhusuo and their binding affinities at the dopamine D1 receptor. Molecules 13:9(2303-12)2008 Sep 25

18256594. Li JG, Lehr M, Liu-Chen LY, Woodruff-Pak DS, Nicotinic acetylcholine receptors and modulation of learning in 4- and 27-month-old rabbits. Neuropsychopharmacology 33:12(2820-30)2008 Nov

18212250. Li JG, Haines DS, Liu-Chen LY, Agonist-promoted Lys63-linked polyubiquitination of the human kappa-opioid receptor is involved in receptor down-regulation. Mol Pharmacol 73:4(1319-30)2008 Apr

18166466. Ma Z, Xu W, Liu-Chen LY, Lee DY, Novel coumarin glycoside and phenethyl vanillate from Notopterygium forbesii and their binding affinities for opioid and dopamine receptors. Bioorg Med Chem 16:6(3218-23)2008 Mar 15

18089845. Wang Y, Chen Y, Xu W, Lee DY, Ma Z, Rawls SM, Cowan A, Liu-Chen LY, 2-Methoxymethyl-salvinorin B is a potent kappa opioid receptor agonist with longer lasting action in vivo than salvinorin A. J Pharmacol Exp Ther 324:3(1073-83)2008 Mar

17981041. Munro TA, Duncan KK, Xu W, Wang Y, Liu-Chen LY, Carlezon WA Jr, Cohen BM, Béguin C, Standard protecting groups create potent and selective kappa opioids: salvinorin B alkoxymethyl ethers. Bioorg Med Chem 16:3(1279-86)2008 Feb 1

17980352. Huang P, Xu W, Yoon SI, Chen C, Chong PL, Unterwald EM, Liu-Chen LY, Agonist treatment did not affect association of mu opioid receptors with lipid rafts and cholesterol reduction had opposite effects on the receptor-mediated signaling in rat brain and CHO cells. Brain Res 1184:(46-56)2007 Dec 12

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Research Technologist: Chongguang Chen
Associate Scientists Jian-Guo Li, Ph.D., Peng Huang, Ph.D. and Wei Xu, Ph.D.
Postdoctoral Fellow: Yulin Wang, M.D.
Graduate Students: Yong Chen, Judy Lin

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