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Keith Latham, PhD

Professor, Biochemistry

Professor, Fels Institute for Cancer Research and Molecular Biology

Telephone:  215-707-7577

Fax:  215-707-6989

Email: klatham@temple.edu

Additional Web Sites:  www.temple.edu/lathamlab, www.preger.org

Department of Biochemistry

Fels Institute for Cancer Research and Molecular Biology

Center for Substance Abuse Research

University of Virginia

 

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My research focuses on understanding the remarkable properties of the mammalian oocyte, which exists as a highly differentiated cell type endowed with the unique capacity for creating an embryonic genome from the two terminally differentiated gamete genomes, activating that embryonic genome, and regulating its function during much of the preimplantation period.  My research seeks to understand these fundamental, life-generating processes at the molecular level, by employing a combination of microsurgery, quantitative gene expression analyses, and structural studies.  My research program currently is comprised of several NIH-funded research programs, focused on the following areas:

1. Understanding the limits of nuclear reprogramming in cloned embryos made by nuclear transfer
2. Understanding the mechanisms regulating cell death in the newly fertilized embryo
3. Understanding the potential effect of assisted reproduction technologies on progeny
4. Understanding determinants of oocyte quality
5. Understanding the composition and molecular controls of meiotic spindles
6. The continued development of a National Resource for the study of gene expression and regulation in non-human primate embryos.

Additional studies related to the control of gene transcription in the newly fertilized embryo are also ongoing.

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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

19661122. Liang CG, Han Z, Cheng Y, Zhong Z, Latham KE, Effects of ooplasm transfer on paternal genome function in mice. Hum Reprod 24:11(2718-28)2009 Nov

19641179. Vandevoort CA, Mtango NR, Lee YS, Smith GW, Latham KE, Differential Effects of Follistatin on Nonhuman Primate Oocyte Maturation and Pre-Implantation Embryo Development In Vitro. Biol Reprod :()2009 Jul 29

19593791. Denegre J, Florman H, Latham KE, Prather R, Swanson W, Williams C, Wessel G, MR&D: The conference, 2009. Mol Reprod Dev 76:9()2009 Jul 10

19358276. Latham KE, Meet the Editors. Mol Reprod Dev 76:6()2009 Apr 8

19276391. Nyholt de Prada JK, Lee YS, Latham KE, Chaffin CL, VandeVoort CA, Role for cumulus cell-produced EGF-like ligands during primate oocyte maturation in vitro. Am J Physiol Endocrinol Metab 296:5(E1049-58)2009 May

19229137. Engel N, Tront JS, Erinle T, Nguyen N, Latham KE, Sapienza C, Hoffman B, Liebermann DA, Conserved DNA methylation in Gadd45a(-/-) mice. Epigenetics 4:2(98-9)2009 Feb

19129515. Hao L, Vassena R, Wu G, Han Z, Cheng Y, Latham KE, Sapienza C, The unfolded protein response contributes to preimplantation mouse embryo death in the DDK syndrome. Biol Reprod 80:5(944-53)2009 May

19073997. Cheng Y, Wang K, Kellam LD, Lee YS, Liang CG, Han Z, Mtango NR, Latham KE, Effects of ooplasm manipulation on DNA methylation and growth of progeny in mice. Biol Reprod 80:3(464-72)2009 Mar

18842187. Mtango NR, Harvey AJ, Latham KE, Brenner CA, Molecular control of mitochondrial function in developing rhesus monkey oocytes and preimplantation-stage embryos. Reprod Fertil Dev 20:7(846-59)2008

18703408. Mtango NR, Potireddy S, Latham KE, Oocyte quality and maternal control of development. Int Rev Cell Mol Biol 268:(223-90)2008

18697858. Lee YS, Latham KE, Vandevoort CA, Effects of in vitro maturation on gene expression in rhesus monkey oocytes. Physiol Genomics 35:2(145-58)2008 Oct 8

18646051. Mtango NR, Potireddy S, Latham KE, Expression of microRNA processing machinery genes in rhesus monkey oocytes and embryos of different developmental potentials. Mol Reprod Dev 76:3(255-69)2009 Mar

18614575. Wan LB, Pan H, Hannenhalli S, Cheng Y, Ma J, Fedoriw A, Lobanenkov V, Latham KE, Schultz RM, Bartolomei MS, Maternal depletion of CTCF reveals multiple functions during oocyte and preimplantation embryo development. Development 135:16(2729-38)2008 Aug

18577693. Han Z, Vassena R, Chi MM, Potireddy S, Sutovsky M, Moley KH, Sutovsky P, Latham KE, Role of glucose in cloned mouse embryo development. Am J Physiol Endocrinol Metab 295:4(E798-809)2008 Oct

18562704. Han Z, Mtango NR, Patel BG, Sapienza C, Latham KE, Hybrid vigor and transgenerational epigenetic effects on early mouse embryo phenotype. Biol Reprod 79:4(638-48)2008 Oct

18024232. Kuzmin A, Han Z, Golding MC, Mann MR, Latham KE, Varmuza S, The PcG gene Sfmbt2 is paternally expressed in extraembryonic tissues. Gene Expr Patterns 8:2(107-16)2008 Jan

17914069. Mtango NR, Latham KE, Differential expression of cell cycle genes in rhesus monkey oocytes and embryos of different developmental potentials. Biol Reprod 78:2(254-66)2008 Feb

17694452. Han Z, Vandevoort CA, Latham KE, Therapeutic cloning: status and prospects. Curr Opin Mol Ther 9:4(392-7)2007 Aug

17551977. Vassena R, Han Z, Gao S, Latham KE, Deficiency in recapitulation of stage-specific embryonic gene transcription in two-cell stage cloned mouse embryos. Mol Reprod Dev 74:12(1548-56)2007 Dec

17550997. Mtango NR, Latham KE, Ubiquitin proteasome pathway gene expression varies in rhesus monkey oocytes and embryos of different developmental potential. Physiol Genomics 31:1(1-14)2007 Sep 19

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