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Keith Latham, PhD

Professor, Biochemistry

Professor, Fels Institute for Cancer Research and Molecular Biology

Telephone:  215-707-7577

Fax:  215-707-6989

Email: klatham@temple.edu

Additional Web Sites:  www.temple.edu/lathamlab, www.preger.org

Department of Biochemistry

Fels Institute for Cancer Research and Molecular Biology

Center for Substance Abuse Research

University of Virginia

 

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My research focuses on understanding the remarkable properties of the mammalian oocyte, which exists as a highly differentiated cell type endowed with the unique capacity for creating an embryonic genome from the two terminally differentiated gamete genomes, activating that embryonic genome, and regulating its function during much of the preimplantation period.  My research seeks to understand these fundamental, life-generating processes at the molecular level, by employing a combination of microsurgery, quantitative gene expression analyses, and structural studies.  My research program currently is comprised of several NIH-funded research programs, focused on the following areas:

1. Understanding the limits of nuclear reprogramming in cloned embryos made by nuclear transfer
2. Understanding the mechanisms regulating cell death in the newly fertilized embryo
3. Understanding the potential effect of assisted reproduction technologies on progeny
4. Understanding determinants of oocyte quality
5. Understanding the composition and molecular controls of meiotic spindles
6. The continued development of a National Resource for the study of gene expression and regulation in non-human primate embryos.

Additional studies related to the control of gene transcription in the newly fertilized embryo are also ongoing.

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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

19661122. Liang CG, Han Z, Cheng Y, Zhong Z, Latham KE, Effects of ooplasm transfer on paternal genome function in mice. Hum Reprod 24:11(2718-28)2009 Nov

19229137. Engel N, Tront JS, Erinle T, Nguyen N, Latham KE, Sapienza C, Hoffman B, Liebermann DA, Conserved DNA methylation in Gadd45a(-/-) mice. Epigenetics 4:2(98-9)2009 Feb

19129515. Hao L, Vassena R, Wu G, Han Z, Cheng Y, Latham KE, Sapienza C, The unfolded protein response contributes to preimplantation mouse embryo death in the DDK syndrome. Biol Reprod 80:5(944-53)2009 May

19073997. Cheng Y, Wang K, Kellam LD, Lee YS, Liang CG, Han Z, Mtango NR, Latham KE, Effects of ooplasm manipulation on DNA methylation and growth of progeny in mice. Biol Reprod 80:3(464-72)2009 Mar

18842187. Mtango NR, Harvey AJ, Latham KE, Brenner CA, Molecular control of mitochondrial function in developing rhesus monkey oocytes and preimplantation-stage embryos. Reprod Fertil Dev 20:7(846-59)2008

18703408. Mtango NR, Potireddy S, Latham KE, Oocyte quality and maternal control of development. Int Rev Cell Mol Biol 268:(223-90)2008

18697858. Lee YS, Latham KE, Vandevoort CA, Effects of in vitro maturation on gene expression in rhesus monkey oocytes. Physiol Genomics 35:2(145-58)2008 Oct 8

18646051. Mtango NR, Potireddy S, Latham KE, Expression of microRNA processing machinery genes in rhesus monkey oocytes and embryos of different developmental potentials. Mol Reprod Dev 76:3(255-69)2009 Mar

18577693. Han Z, Vassena R, Chi MM, Potireddy S, Sutovsky M, Moley KH, Sutovsky P, Latham KE, Role of glucose in cloned mouse embryo development. Am J Physiol Endocrinol Metab 295:4(E798-809)2008 Oct

18562704. Han Z, Mtango NR, Patel BG, Sapienza C, Latham KE, Hybrid vigor and transgenerational epigenetic effects on early mouse embryo phenotype. Biol Reprod 79:4(638-48)2008 Oct

17914069. Mtango NR, Latham KE, Differential expression of cell cycle genes in rhesus monkey oocytes and embryos of different developmental potentials. Biol Reprod 78:2(254-66)2008 Feb

17694452. Han Z, Vandevoort CA, Latham KE, Therapeutic cloning: status and prospects. Curr Opin Mol Ther 9:4(392-7)2007 Aug

17551977. Vassena R, Han Z, Gao S, Latham KE, Deficiency in recapitulation of stage-specific embryonic gene transcription in two-cell stage cloned mouse embryos. Mol Reprod Dev 74:12(1548-56)2007 Dec

17550997. Mtango NR, Latham KE, Ubiquitin proteasome pathway gene expression varies in rhesus monkey oocytes and embryos of different developmental potential. Physiol Genomics 31:1(1-14)2007 Sep 19

17416905. Zheng P, Vassena R, Latham KE, Effects of in vitro oocyte maturation and embryo culture on the expression of glucose transporters, glucose metabolism and insulin signaling genes in rhesus monkey oocytes and preimplantation embryos. Mol Hum Reprod 13:6(361-71)2007 Jun

17234177. Vassena R, Han Z, Gao S, Baldwin DA, Schultz RM, Latham KE, Tough beginnings: alterations in the transcriptome of cloned embryos during the first two cell cycles. Dev Biol 304:1(75-89)2007 Apr 1

17147927. Latham KE, The Primate Embryo Gene Expression Resource in embryology and stem cell biology. Reprod Fertil Dev 18:8(807-10)2006

16860309. Potireddy S, Vassena R, Patel BG, Latham KE, Analysis of polysomal mRNA populations of mouse oocytes and zygotes: dynamic changes in maternal mRNA utilization and function. Dev Biol 298:1(155-66)2006 Oct 1

16310175. Miyara F, Han Z, Gao S, Vassena R, Latham KE, Non-equivalence of embryonic and somatic cell nuclei affecting spindle composition in clones. Dev Biol 289:1(206-17)2006 Jan 1

16155959. Vassena R, Dee Schramm R, Latham KE, Species-dependent expression patterns of DNA methyltransferase genes in mammalian oocytes and preimplantation embryos. Mol Reprod Dev 72:4(430-6)2005 Dec

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