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Friedrich Kueppers, MD


Friedrich Kueppers, MD


Professor, Thoracic Medicine and Surgery



Department of Thoracic Medicine and Surgery, Section of Critical Care and Sleep Medicine


Educational Background:


Medical Degree, University of Düsseldorf, Düsseldorf, Germany, 1961


Residency, Surgery, St. Joseph Hospital, Bochum, Germany, 1962

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clinical Interests:

  • Regulation of A1-antitrypsin production
  • Inflammatory cytokines
  • Genetics

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board certification(s):


Pulmonary and Critical Care Medicine

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professional affiliations:

  • American Society of Clinical Investigation
  • American Association for the Advancement of Sciences
  • American Genetic Association
  • American Society of Human Genetics
  • American Thoracic Society
  • Central Society for Clinical Research
  • College of Physicians of Philadelphia (Fellow)
  • Harvey Society, New York
  • Society of Sigma Xi, Rockefeller Chapter

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research interests:

  • Regulation of A1-antitrypsin production
  • Inflammatory cytokines
  • Genetics

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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

22686467. Li L, Kueppers F, Hildebrand W, Buchli R, Gaughan J, Elevated soluble HLA II protein levels in patients with alpha-1 antitrypsin deficiency with or without COPD. Exp Lung Res 38:6(302-6)2012 Aug

21226542. Kueppers F, The role of augmentation therapy in alpha-1 antitrypsin deficiency. Curr Med Res Opin 27:3(579-88)2011 Mar

17136996. Kim V, Kueppers F, D'Alonzo GE Jr, Severe, early-onset emphysema with normal alphal-antitrypsin levels in nonsmokers: a clinical dilemma. COPD 1:2(313-9)2004

15915418. Ufberg JW, Bushra JS, Karras DJ, Satz WA, Kueppers F, Aspiration of gastric contents: association with prehospital intubation. Am J Emerg Med 23:3(379-82)2005 May

15666273. Ufberg JW, Bushra JS, Patel D, Wong E, Karras DJ, Kueppers F, A new pepsin assay to detect pulmonary aspiration of gastric contents among newly intubated patients. Am J Emerg Med 22:7(612-4)2004 Nov

15101906. Friedman R, Li V, Kueppers F, Atkinson G, Oral ketamine in hepatocellular carcinoma. Pain Med 1:2(181-2)2000 Jun

14561007. Potluri S, Friedenberg F, Parkman HP, Chang A, MacNeal R, Manus C, Bromer MQ, Malik A, Fisher RS, Nugent T, Thangada VK, Kueppers F, Miller LS, Comparison of a salivary/sputum pepsin assay with 24-hour esophageal pH monitoring for detection of gastric reflux into the proximal esophagus, oropharynx, and lung. Dig Dis Sci 48:9(1813-7)2003 Sep

10836296. Thomas RM, Schiano TD, Kueppers F, Black M, Alpha1-antichymotrypsin globules within hepatocytes in patients with chronic hepatitis C and cirrhosis. Hum Pathol 31:5(575-7)2000 May

8917040. Badellino MM, Buckman RF Jr, Malaspina PJ, Eynon CA, O'Brien GM, Kueppers F, Detection of pulmonary aspiration of gastric contents in an animal model by assay of peptic activity in bronchoalveolar fluid. Crit Care Med 24:11(1881-5)1996 Nov

8202889. Travaline JM, Criner GJ, Ming PM, Kueppers F, Anterior mediastinal mass in a young man. Thorax 49:3(283-4)1994 Mar

8281750. Kueppers F, McConnell IW, Kramek BA, Polymorphism of alpha-1 antitrypsin in dogs. Comp Biochem Physiol B 106:3(531-3)1993 Nov

1429867. Yuan ZA, Soprano KJ, Kueppers F, Alpha-1 antitrypsin response of stimulated alveolar macrophages. J Cell Biochem 49:4(410-6)1992 Aug

1581073. Christensen GC, Lev A, Ryan J, Wang M, Phillips S, Wachtfogel YT, Kueppers F, Kelsen SG, Rabbit trachealis tension responses to receptor-mediated agonists are diminished by elastase. Am J Respir Cell Mol Biol 6:5(498-503)1992 May

1768743. Smith MF Jr, Kueppers F, Lee JC, Differential regulation of interleukin-1 alpha and interleukin-1 beta mRNA expression in human monocytes: evidence for protein kinase C-dependent and -independent pathways. Lymphokine Cytokine Res 10:5(397-403)1991 Oct

2784471. Smith MF Jr, Kueppers FR, Young PR, Lee JC, A rapid and quantitative method for the determination of interleukin-1 alpha and -beta mRNA expression in human monocytes and macrophages. J Immunol Methods 118:2(265-72)1989 Mar 31

3257651. Colman RW, Flores DN, De La Cadena RA, Scott CF, Cousens L, Barr PJ, Hoffman IB, Kueppers F, Fisher D, Idell S, Recombinant alpha 1-antitrypsin Pittsburgh attenuates experimental gram-negative septicemia. Am J Pathol 130:2(418-26)1988 Feb

3500185. Walsh PN, Sinha D, Kueppers F, Seaman FS, Blankstein KB, Regulation of factor XIa activity by platelets and alpha 1-protease inhibitor. J Clin Invest 80:6(1578-86)1987 Dec

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