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Walter J. Koch, PhD

Walter J. Koch, PhD


William Wikoff Smith Endowed Chair in Cardiovascular Medicine

Chairperson, Pharmacology

Professor, Pharmacology

Professor, Center for Translational Medicine

Director, Center for Translational Medicine

Telephone:  215-707-9820

Fax:  215-707-9890

Email: walter.koch@temple.edu


Department of Pharmacology

Center for Translational Medicine


Educational Background:



BS, Pharmacy (Cum Laude), University of Toledo College of Pharmacy, Toledo, OH, 1984


PhD, Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH, 1990


Howard Hughes Medical Institute Postdoctoral Fellowship, Duke University Medical Center (laboratory of Dr. Robert J. Lefkowitz), 1991-1995

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professional affiliations:


  • Member, Heart Failure Society of America, 2000-present
  • Member, American Society of Gene and Cell Therapy, 2000-present
  • Member, American Society for Pharmacology and Experimental Therapeutics, 1998-present
  • Member, International Society for Heart Research, 1997-present
  • Member, American Society for Biochemistry and Molecular Biology, 1994-present
  • Member, Basic Science Council, American Heart Association, 1994-present
  • Professional Member, American Heart Association, 1994-present

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Research Interests:


The Koch laboratory currently is investigating molecular mechanisms involved in the regulation of signaling through cardiovascular adrenergic receptors (ARs) and the role this plays in heart disease, primarily heart failure (HF). The lab s research primarily targets a family of kinases known to regulate ARs and other G protein-coupled receptors (GPCRs) known as the GPCR kinases (GRKs). These GRKs appear to be critically involved in normal and failing heart function and we are manipulating the expression and activity of GRKs in the cardiovascular system. To do this, we utilize novel genetically engineered mouse models and also adenoviral-mediated myocardial gene delivery. Signaling information delineated to be involved in the pathogenesis of heart disease is utilized to design potential novel molecular therapeutic strategies for heart disease. This includes an ultimate goal of the laboratory to develop gene therapy protocols for HF utilizing novel intracoronary delivery techniques. These delivery techniques as well as "proof of concept" testing of molecular targets in the heart are currently being carried out in vivo in models of HF. In addition to HF, programs are ongoing in the laboratory to investigate novel ways to protect the heart against ischemia-induced myocyte apoptosis and also molecular ways to improve the function of the transplanted human heart. Another program in the lab is the investigation of the role of GPCR signaling in pathological vascular smooth muscle proliferation such as what occurs during arterial restenosis following angioplasty. New directions in the lab have us interested in novel non-GPCR binding partners for GRKs and are using a variety of in vitro techniques to discover and investigate these with a future plan to determine any cardiovascular physiological relevance of these GRK targets.


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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

26611208. Zhang X, Ai X, Nakayama H, Chen B, Harris DM, Tang M, Xie Y, Szeto C, Li Y, Li Y, Zhang H, Eckhart AD, Koch WJ, Molkentin JD, Chen X, Persistent increases in Ca2+ influx through Cav1.2 shortens action potential and causes Ca2+ overload-induced afterdepolarizations and arrhythmias. Basic Res Cardiol 111:1(4)2016 Jan

26604244. Cannavo A, Liccardo D, Lymperopoulos A, Gambino G, D'amico ML, Rengo F, Koch WJ, Leosco D, Ferrara N, Rengo G, ▀ARKct gene-therapy improves ▀2-adrenergic receptor-dependent neoangiogenesis following hindlimb ischemia. J Pharmacol Exp Ther :()2015 Nov 24

26549357. Kishore R, Krishnamurthy P, Garikipati VN, Benedict C, Nickoloff E, Khan M, Johnson J, Gumpert AM, Koch WJ, Verma SK, Interleukin-10 inhibits chronic angiotensin II-induced pathological autophagy. J Mol Cell Cardiol :()2015 Nov 6

26515328. Traynham CJ, Cannavo A, Zhou Y, Vouga A, Woodall BP, Hullmann JE, Ibetti J, Gold JI, Chuprun JK, Gao E, Koch WJ, Differential Role of G Protein-Coupled Receptor Kinase 5 in Physiological Versus Pathological Cardiac Hypertrophy. Circ Res :()2015 Oct 29

26506135. Sato PY, Chuprun JK, Ibetti J, Cannavo A, Drosatos K, Elrod JW, Koch WJ, GRK2 compromises cardiomyocyte mitochondrial function by diminishing fatty acid-mediated oxygen consumption and increasing superoxide levels. J Mol Cell Cardiol :()2015 Oct 23

26387735. Shanmughapriya S, Rajan S, Hoffman NE, Higgins AM, Tomar D, Nemani N, Hines KJ, Smith DJ, Eguchi A, Vallem S, Shaikh F, Cheung M, Leonard NJ, Stolakis RS, Wolfers MP, Ibetti J, Chuprun JK, Jog NR, Houser SR, Koch WJ, Elrod JW, Madesh M, SPG7 Is an Essential and Conserved Component of the Mitochondrial Permeability Transition Pore. Mol Cell 60:1(47-62)2015 Oct 1

26300236. Cheung JY, Gordon J, Wang J, Song J, Zhang XQ, Tilley DG, Gao E, Koch WJ, Rabinowitz J, Klotman PE, Khalili K, Feldman AM, Cardiac Dysfunction in HIV-1 Transgenic Mouse: Role of Stress and BAG3. Clin Transl Sci 8:4(305-10)2015 Aug

26235810. Garikipati VN, Krishnamurthy P, Verma SK, Khan M, Abramova T, Mackie AR, Qin G, Benedict C, Nickoloff E, Johnson J, Gao E, Losordo DW, Houser SR, Koch WJ, Kishore R, Negative Regulation of miR-375 by Interleukin-10 Enhances Bone Marrow-Derived Progenitor Cell-Mediated Myocardial Repair and Function After Myocardial Infarction. Stem Cells :()2015 Jul 31

26231084. Makarewich CA, Troupes CD, Schumacher SM, Gross P, Koch WJ, Crandall DL, Houser SR, Comparative effects of urocortins and stresscopin on cardiac myocyte contractility. J Mol Cell Cardiol 86:(179-86)2015 Sep

26119731. Luongo TS, Lambert JP, Yuan A, Zhang X, Gross P, Song J, Shanmughapriya S, Gao E, Jain M, Houser SR, Koch WJ, Cheung JY, Madesh M, Elrod JW, The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability Transition. Cell Rep 12:1(23-34)2015 Jul 7

26037251. Zhang Y, Zhao J, Li R, Lau WB, Yuan YX, Liang B, Li R, Gao EH, Koch WJ, Ma XL, Wang YJ, AdipoRon, the first orally active adiponectin receptor activator, attenuates postischemic myocardial apoptosis through both AMPK-mediated and AMPK-independent signalings. Am J Physiol Endocrinol Metab 309:3(E275-82)2015 Aug 1

26032411. Homan KT, Waldschmidt HV, Glukhova A, Cannavo A, Song J, Cheung JY, Koch WJ, Larsen SD, Tesmer JJ, Crystal Structure of G Protein-coupled Receptor Kinase 5 in Complex with a Rationally Designed Inhibitor. J Biol Chem 290:34(20649-59)2015 Aug 21

26005840. Ritterhoff J, V÷lkers M, Seitz A, Spaich K, Gao E, Peppel K, Pleger ST, Zimmermann WH, Friedrich O, Fink RH, Koch WJ, Katus HA, Most P, S100A1 DNA-based Inotropic Therapy Protects Against Proarrhythmogenic Ryanodine Receptor 2 Dysfunction. Mol Ther 23:8(1320-30)2015 Aug

25939245. Laury-Kleintop LD, Mulgrew JR, Heletz I, Nedelcoviciu RA, Chang MY, Harris DM, Koch WJ, Schneider MD, Muller AJ, Prendergast GC, Cardiac-specific disruption of Bin1 in mice enables a model of stress- and age-associated dilated cardiomyopathy. J Cell Biochem 116:11(2541-51)2015 Nov

25904597. Khan M, Nickoloff E, Abramova T, Johnson J, Verma SK, Krishnamurthy P, Mackie AR, Vaughan E, Garikipati VN, Benedict C, Ramirez V, Lambers E, Ito A, Gao E, Misener S, Luongo T, Elrod J, Qin G, Houser SR, Koch WJ, Kishore R, Embryonic stem cell-derived exosomes promote endogenous repair mechanisms and enhance cardiac function following myocardial infarction. Circ Res 117:1(52-64)2015 Jun 19

25834229. Sato PY, Chuprun JK, Schwartz M, Koch WJ, The evolving impact of g protein-coupled receptor kinases in cardiac health and disease. Physiol Rev 95:2(377-404)2015 Apr

25787974. Augello MA, Berman-Booty LD, Carr R 3rd, Yoshida A, Dean JL, Schiewer MJ, Feng FY, Tomlins SA, Gao E, Koch WJ, Benovic JL, Diehl JA, Knudsen KE, Consequence of the tumor-associated conversion to cyclin D1b. EMBO Mol Med 7:5(628-47)2015 Mar 18

25787764. Tian Y, Liu Y, Wang T, Zhou N, Kong J, Chen L, Snitow M, Morley M, Li D, Petrenko N, Zhou S, Lu M, Gao E, Koch WJ, Stewart KM, Morrisey EE, A microRNA-Hippo pathway that promotes cardiomyocyte proliferation and cardiac regeneration in mice. Sci Transl Med 7:279(279ra38)2015 Mar 18

25739765. Schumacher SM, Gao E, Zhu W, Chen X, Chuprun JK, Feldman AM, G Tesmer JJ, Koch WJ, Paroxetine-mediated GRK2 inhibition reverses cardiac dysfunction and remodeling after myocardial infarction. Sci Transl Med 7:277(277ra31)2015 Mar 4

25696921. Wang Y, Gao E, Lau WB, Wang Y, Liu G, Li JJ, Wang X, Yuan Y, Koch WJ, Ma XL, G-protein-coupled receptor kinase 2-mediated desensitization of adiponectin receptor 1 in failing heart. Circulation 131:16(1392-404)2015 Apr 21

25631300. Dabul S, Bathgate-Siryk A, Valero TR, Jafferjee M, Sturchler E, McDonald P, Koch WJ, Lymperopoulos A, Suppression of adrenal ▀arrestin1-dependent aldosterone production by ARBs: head-to-head comparison. Sci Rep 5:(8116)2015 Jan 29

25576627. Hoffman NE, Miller BA, Wang J, Elrod JW, Rajan S, Gao E, Song J, Zhang XQ, Hirschler-Laszkiewicz I, Shanmughapriya S, Koch WJ, Feldman AM, Madesh M, Cheung JY, Ca▓? entry via Trpm2 is essential for cardiac myocyte bioenergetics maintenance. Am J Physiol Heart Circ Physiol 308:6(H637-50)2015 Mar 15

25505600. Tolonen AM, Magga J, Szabˇ Z, Viitala P, Gao E, Moilanen AM, Ohukainen P, Vainio L, Koch WJ, Kerkelń R, Ruskoaho H, Serpi R, Inhibition of Let-7 microRNA attenuates myocardial remodeling and improves cardiac function postinfarction in mice. Pharmacol Res Perspect 2:4(e00056)2014 Aug

25485901. Grisanti LA, Repas AA, Talarico JA, Gold JI, Carter RL, Koch WJ, Tilley DG, Temporal and gefitinib-sensitive regulation of cardiac cytokine expression via chronic ▀-adrenergic receptor stimulation. Am J Physiol Heart Circ Physiol 308:4(H316-30)2015 Feb 15

25480109. Trappanese DM, Liu Y, McCormick RC, Cannavo A, Nanayakkara G, Baskharoun MM, Jarrett H, Woitek FJ, Tillson DM, Dillon AR, Recchia FA, Balligand JL, Houser SR, Koch WJ, Dell'Italia LJ, Tsai EJ, Chronic ▀1-adrenergic blockade enhances myocardial ▀3-adrenergic coupling with nitric oxide-cGMP signaling in a canine model of chronic volume overload: new insight into mechanisms of cardiac benefit with selective ▀1-blocker therapy. Basic Res Cardiol 110:1(456)2015 Jan

25340299. Homan KT, Wu E, Cannavo A, Koch WJ, Tesmer JJ, Identification and characterization of amlexanox as a G protein-coupled receptor kinase 5 inhibitor. Molecules 19:10(16937-49)2014 Oct 22

25340284. Scimia MC, Sydnes KE, Zuppo DA, Koch WJ, Methods to improve cardiac gene therapy expression. Expert Rev Cardiovasc Ther 12:11(1317-26)2014 Nov

25332207. Hullmann JE, Grisanti LA, Makarewich CA, Gao E, Gold JI, Chuprun JK, Tilley DG, Houser SR, Koch WJ, GRK5-mediated exacerbation of pathological cardiac hypertrophy involves facilitation of nuclear NFAT activity. Circ Res 115:12(976-85)2014 Dec 5

25277999. He Q, Pu J, Yuan A, Lau WB, Gao E, Koch WJ, Ma XL, He B, Activation of liver-X-receptor a but not liver-X-receptor ▀ protects against myocardial ischemia/reperfusion injury. Circ Heart Fail 7:6(1032-41)2014 Nov

25239306. Lucas E, Jurado-Pueyo M, Fortu˝o MA, Fernßndez-Veledo S, Vila-Bedmar R, JimÚnez-Borreguero LJ, Lazcano JJ, Gao E, Gˇmez-Ambrosi J, FrŘhbeck G, Koch WJ, DÝez J, Mayor F Jr, Murga C, Downregulation of G protein-coupled receptor kinase 2 levels enhances cardiac insulin sensitivity and switches on cardioprotective gene expression patterns. Biochim Biophys Acta 1842:12 Pt A(2448-56)2014 Dec

25205804. Tilley DG, Zhu W, Myers VD, Barr LA, Gao E, Li X, Song J, Carter RL, Makarewich CA, Yu D, Troupes CD, Grisanti LA, Coleman RC, Koch WJ, Houser SR, Cheung JY, Feldman AM, ▀-adrenergic receptor-mediated cardiac contractility is inhibited via vasopressin type 1A-receptor-dependent signaling. Circulation 130:20(1800-11)2014 Nov 11

24852843. Yan W, Zhang F, Zhang R, Zhang X, Wang Y, Zhou F, Xia Y, Liu P, Gao C, Wang H, Zhang L, Zhou J, Gao F, Gao E, Koch WJ, Wang H, Cheng H, Qu Y, Tao L, Adiponectin regulates SR Ca(2+) cycling following ischemia/reperfusion via sphingosine 1-phosphate-CaMKII signaling in mice. J Mol Cell Cardiol 74:(183-92)2014 Sep

24816261. Carbe CJ, Cheng L, Addya S, Gold JI, Gao E, Koch WJ, Riobo NA, Gi proteins mediate activation of the canonical hedgehog pathway in the myocardium. Am J Physiol Heart Circ Physiol 307:1(H66-72)2014 Jul 1

24812353. Woodall MC, Ciccarelli M, Woodall BP, Koch WJ, G protein-coupled receptor kinase 2: a link between myocardial contractile function and cardiac metabolism. Circ Res 114:10(1661-70)2014 May 9

24794045. Scimia MC, Blass BE, Koch WJ, Apelin receptor: its responsiveness to stretch mechanisms and its potential for cardiovascular therapy. Expert Rev Cardiovasc Ther 12:6(733-41)2014 Jun

24702056. Huang ZM, Gao E, Chuprun JK, Koch WJ, GRK2 in the heart: a GPCR kinase and beyond. Antioxid Redox Signal 21:14(2032-43)2014 Nov 10

24683488. Carter RL, Grisanti LA, Yu JE, Repas AA, Woodall M, Ibetti J, Koch WJ, Jacobson MA, Tilley DG, Dynamic mass redistribution analysis of endogenous ▀-adrenergic receptor signaling in neonatal rat cardiac fibroblasts. Pharmacol Res Perspect 2:1()2014 Feb

24521102. Brailoiu GC, Deliu E, Rabinowitz JE, Tilley DG, Koch WJ, Brailoiu E, Urotensin II promotes vagal-mediated bradycardia by activating cardiac-projecting parasympathetic neurons of nucleus ambiguus. J Neurochem 129:4(628-36)2014 May

24486513. Wang J, Song J, Gao E, Zhang XQ, Gu T, Yu D, Koch WJ, Feldman AM, Cheung JY, Induced overexpression of phospholemman S68E mutant improves cardiac contractility and mortality after ischemia-reperfusion. Am J Physiol Heart Circ Physiol 306:7(H1066-77)2014 Apr 1

24430870. Hoffman NE, Chandramoorthy HC, Shanmughapriya S, Zhang XQ, Vallem S, Doonan PJ, Malliankaraman K, Guo S, Rajan S, Elrod JW, Koch WJ, Cheung JY, Madesh M, SLC25A23 augments mitochondrial Ca▓? uptake, interacts with MCU, and induces oxidative stress-mediated cell death. Mol Biol Cell 25:6(936-47)2014 Mar

24401846. Deliu E, Brailoiu GC, Eguchi S, Hoffman NE, Rabinowitz JE, Tilley DG, Madesh M, Koch WJ, Brailoiu E, Direct evidence of intracrine angiotensin II signaling in neurons. Am J Physiol Cell Physiol 306:8(C736-44)2014 Apr 15

24397980. Wang Y, Wang X, Lau WB, Yuan Y, Booth D, Li JJ, Scalia R, Preston K, Gao E, Koch W, Ma XL, Adiponectin inhibits tumor necrosis factor-a-induced vascular inflammatory response via caveolin-mediated ceramidase recruitment and activation. Circ Res 114:5(792-805)2014 Feb 28

24388546. Rengo G, Pagano G, Parisi V, Femminella GD, de Lucia C, Liccardo D, Cannavo A, Zincarelli C, Komici K, Paolillo S, Fusco F, Koch WJ, Perrone Filardi P, Ferrara N, Leosco D, Changes of plasma norepinephrine and serum N-terminal pro-brain natriuretic peptide after exercise training predict survival in patients with heart failure. Int J Cardiol 171:3(384-9)2014 Feb 15

24361238. Kaikkonen L, Magga J, Ronkainen VP, Koivisto E, Perjes ┴, Chuprun JK, Vinge LE, Kilpi÷ T, Aro J, Ulvila J, Alakoski T, Bibb JA, Szokodi I, Koch WJ, Ruskoaho H, Kerkelń R, p38a regulates SERCA2a function. J Mol Cell Cardiol 67:(86-93)2014 Feb

24334028. Kim IM, Wang Y, Park KM, Tang Y, Teoh JP, Vinson J, Traynham CJ, Pironti G, Mao L, Su H, Johnson JA, Koch WJ, Rockman HA, ▀-arrestin1-biased ▀1-adrenergic receptor signaling regulates microRNA processing. Circ Res 114:5(833-44)2014 Feb 28

24328708. Scimia MC, Gumpert AM, Koch WJ, Cardiovascular gene therapy for myocardial infarction. Expert Opin Biol Ther 14:2(183-95)2014 Feb

24315785. Brinks H, Giraud MN, Segiser A, FerriÚ C, Longnus S, Ullrich ND, Koch WJ, Most P, Carrel TP, Tevaearai HT, Dynamic patterns of ventricular remodeling and apoptosis in hearts unloaded by heterotopic transplantation. J Heart Lung Transplant 33:2(203-10)2014 Feb

24305416. Weber C, Neacsu I, Krautz B, Schlegel P, Sauer S, Raake P, Ritterhoff J, Jungmann A, Remppis AB, Stangassinger M, Koch WJ, Katus HA, MŘller OJ, Most P, Pleger ST, Therapeutic safety of high myocardial expression levels of the molecular inotrope S100A1 in a preclinical heart failure model. Gene Ther 21:2(131-8)2014 Feb

24174526. Islam KN, Bae JW, Gao E, Koch WJ, Regulation of nuclear factor ?B (NF-?B) in the nucleus of cardiomyocytes by G protein-coupled receptor kinase 5 (GRK5). J Biol Chem 288:50(35683-9)2013 Dec 13

24170934. Huang ZM, Gao E, Fonseca FV, Hayashi H, Shang X, Hoffman NE, Chuprun JK, Tian X, Tilley DG, Madesh M, Lefer DJ, Stamler JS, Koch WJ, Convergence of G protein-coupled receptor and S-nitrosylation signaling determines the outcome to cardiac ischemic injury. Sci Signal 6:299(ra95)2013 Oct 29

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