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Linda Knight, PhD

Professor, Radiology

Associate Professor, Sol Sherry Thrombosis Research Center

Telephone:  215-707-4940

Fax:  215-707-8110

Email: lknight@temple.edu

Department of Radiology

Sol Sherry Thrombosis Research Center

University of California, Davis, CA

B.S., 1972 Chemistry (honors)

 

Washington University, St. Louis, MO

M.A., 1974 Nuclear and Radiochemistry

Washington University, St. Louis, MO

P.hD., 1976 Nuclear and Radiochemistry

Washington University, St. Louis, MO

1976-1977

Postdoctoral Fellow, Nuclear and Radiochemistry

 

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Dr. Knight’s work focuses on using in vivo imaging to follow the behavior of molecules and cells in vivo, and to use functional imaging to learn more about physiology.

Major areas of work include:    Development of radiopharmaceuticals which target vascular receptors. One project is to design and evaluate a new diagnostic imaging test for imaging thrombi and emboli. The approach currently under evaluation is based on a radiolabeled peptide which recognizes a receptor on activated platelets. Another project is to evaluate radiolabeled peptides which bind to receptors in the blood vessels of tumors. The goals of this project are to locate a wide variety of solid tumors by imaging, monitor the effects of anti-angiogenic therapy, and eventually treat the tumors with targeted radiotherapy using a therapeutic radionuclide bound to the same peptide.

Assessment of gastrointestinal motility. Physiologic meals can be prepared containing a radiotracer, so that their transit through the GI tract can be detected and quantified by noninvasive imaging. The effects of drugs and other interventions on the motility of segments of the GI tract can be assessed quantitatively in vivo.

Radiolabeling of drugs to determine their behavior in vivo.   Drugs to be administered to the GI tract have been radiolabeled to assess their duration and extent of coverage of GI mucosa in various diseases such as peptic ulcer and colitis.

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Knight LC. Radiolabeled peptides for tumor imaging. In: Handbook of Radiopharmaceuticals: Radiochemistry and Applications. 643-684. MJ Welch and CS Redvanly, eds. Chichester, John Wiley & Sons Ltd, 2003.

Knight LC. Radiopharmacy aspects of gastrointestinal imaging. In: Nuclear Medicine. Volume II, Chapter 54 (2006). RE Henkin, MA Boles, GL Dillehay, JR Halama, SM Karesh, RH Wagner, AM Zimmer, eds. St. Louis, Mosby Year Book.

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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

19172383. Pattillo CB, Venegas B, Donelson FJ, Del Valle L, Knight LC, Chong PL, Kiani MF, Radiation-guided targeting of combretastatin encapsulated immunoliposomes to mammary tumors. Pharm Res 26:5(1093-100)2009 May

18413394. Knight LC, Parkman HP, Maurer AH, Egg Labeling for Gastric-Emptying Studies. J Nucl Med :()2008 Apr 15

18378499. Mekapati J, Knight LC, Maurer AH, Fisher RS, Parkman HP, Transsphincteric pH profile at the gastroesophageal junction. Clin Gastroenterol Hepatol 6:6(630-4)2008 Jun

18194154. Cassilly D, Kantor S, Knight LC, Maurer AH, Fisher RS, Semler J, Parkman HP, Gastric emptying of a non-digestible solid: assessment with simultaneous SmartPill pH and pressure capsule, antroduodenal manometry, gastric emptying scintigraphy. Neurogastroenterol Motil 20:4(311-9)2008 Apr

17942806. Knight LC, Kantor S, Doma S, Parkman HP, Maurer AH, Egg labeling methods for gastric emptying scintigraphy are not equivalent in producing a stable solid meal. J Nucl Med 48:11(1897-900)2007 Nov

17921036. Knight LC, Romano JE, Bright LT, Agelan A, Kantor S, Maurer AH, Platelet binding and biodistribution of [99mTc]rBitistatin in animal species and humans. Nucl Med Biol 34:7(855-63)2007 Oct

17499726. Knight LC, Romano JE, Cosenza SC, Iqbal NM, Marcinkiewicz C, Differences in binding of (99m)Tc-disintegrins to integrin alphavbeta3 on tumor and vascular cells. Nucl Med Biol 34:4(371-81)2007 May

15642483. Knight LC, Romano JE, Functional expression of bitistatin, a disintegrin with potential use in molecular imaging of thromboembolic disease. Protein Expr Purif 39:2(307-19)2005 Feb

15366961. Baidoo KE, Knight LC, Lin KS, Gabriel JL, Romano JE, Design and synthesis of a short-chain bitistatin analogue for imaging thrombi and emboli. Bioconjug Chem 15:5(1068-75)2004 Sep-Oct

15366951. McQuade P, Knight LC, Welch MJ, Evaluation of 64Cu- and 125I-radiolabeled bitistatin as potential agents for targeting alpha v beta 3 integrins in tumor angiogenesis. Bioconjug Chem 15:5(988-96)2004 Sep-Oct

15235061. Simonian HP, Maurer AH, Knight LC, Kantor S, Kontos D, Megalooikonomou V, Fisher RS, Parkman HP, Simultaneous assessment of gastric accommodation and emptying: studies with liquid and solid meals. J Nucl Med 45:7(1155-60)2004 Jul

14973420. Knight LC, Non-oncologic applications of radiolabeled peptides in nuclear medicine. Q J Nucl Med 47:4(279-91)2003 Dec

12897712. McQuade P, KnIght LC, Radiopharmaceuticals for targeting the angiogenesis marker alpha(v)beta(3). Q J Nucl Med 47:3(209-20)2003 Sep

12757160. Gonlachanvit S, Hsu CW, Boden GH, Knight LC, Maurer AH, Fisher RS, Parkman HP, Effect of altering gastric emptying on postprandial plasma glucose concentrations following a physiologic meal in type-II diabetic patients. Dig Dis Sci 48:3(488-97)2003 Mar

12141833. Bromer MQ, Kantor SB, Wagner DA, Knight LC, Maurer AH, Parkman HP, Simultaneous measurement of gastric emptying with a simple muffin meal using [13C]octanoate breath test and scintigraphy in normal subjects and patients with dyspeptic symptoms. Dig Dis Sci 47:7(1657-63)2002 Jul

12135014. Miller LS, Szych GA, Kantor SB, Bromer MQ, Knight LC, Maurer AH, Fisher RS, Parkman HP, Treatment of idiopathic gastroparesis with injection of botulinum toxin into the pyloric sphincter muscle. Am J Gastroenterol 97:7(1653-60)2002 Jul

11516697. Knight LC, Radiolabeled peptide ligands for imaging thrombi and emboli. Nucl Med Biol 28:5(515-26)2001 Jul

10855635. Knight LC, Baidoo KE, Romano JE, Gabriel JL, Maurer AH, Imaging pulmonary emboli and deep venous thrombi with 99mTc-bitistatin, a platelet-binding polypeptide from viper venom. J Nucl Med 41:6(1056-64)2000 Jun

10446101. Parkman HP, Trate DM, Knight LC, Brown KL, Maurer AH, Fisher RS, Cholinergic effects on human gastric motility. Gut 45:3(346-54)1999 Sep

9843182. Knight LC, Romano JE, Maurer AH, In vitro platelet binding compared with in vivo thrombus imaging using alpha(IIb)beta3-targeted radioligands. Thromb Haemost 80:5(845-51)1998 Nov

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