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Soochong Kim, DVM, PhD

Assistant Professor, Physiology

Telephone:  215-707-3695

Fax:  215-707-0170

Office: Medical Research Building Room 213

Email: skim0026@temple.edu

Department of Physiology

DVM, Kyungpook National University, Taegu, Korea, 1992

 

MS, Veterinary Pathology, Oklahoma State University, Stillwater, OK, 1996

 

PhD, Veterinary Pathology, Oklahoma State University, Stillwater, OK, 1999

 

Postdoctoral Fellowship, Temple University School of Medicine, Philadelphia,, PA, 1999-2002

 

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We have been involved in work leading to molecular mechanism of platelet activation which is crucial to understanding the cell membrane receptors and the mechanisms of agonist-mediated signal transduction pathways in platelet activation, leading to better medications to prevent heart attacks and strokes.

Thrombin, generated at the site of vascular damage by extrinsic and intrinsic coagulation cascades, is an important agonist for platelet activation, yet the signal transduction mechanisms involved in thrombin-mediated human platelet fibrinogen receptor activation are yet to be elucidated.  Thus, we are focused on characterizing the signaling requirements that mediate platelet activation by thrombin and thrombin receptor-activating peptides to better understand hemostasis and thrombosis.

Protein kinase B (PKB/Akt) is a serine-threonine kinase that has been established as an important signaling intermediate in regulating cell survival, cell cycle progression, as well as agonist-induced platelet activation.  We have shown that Gi-coupled P2Y12 ADP receptor is responsible for a significant proportion of activation of Akt in platelets.  We are now further elucidating the signaling events involved in Akt activation and its role in platelet activation mediated by various agonists in human and mouse platelets.

We are also examining the role of Src family kinases in signal transduction mechanisms in platelets.

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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

19700402. Kim S, Mangin P, Dangelmaier C, Lillian R, Jackson SP, Daniel JL, Kunapuli SP, The role of PI 3-K{beta} in glycoprotein VI-mediated akt activation in platelets. J Biol Chem :()2009 Aug 21

19587372. Chari R, Kim S, Murugappan S, Sanjay A, Daniel JL, Kunapuli SP, Lyn, PKC-delta, SHIP-1 interactions regulate GPVI-mediated platelet-dense granule secretion. Blood 114:14(3056-63)2009 Oct 1

19286657. Bynagari YS, Nagy B Jr, Tuluc F, Bhavaraju K, Kim S, Vijayan KV, Kunapuli SP, Mechanism of activation and functional role of protein kinase Ceta in human platelets. J Biol Chem 284:20(13413-21)2009 May 15

19164598. Nagy B Jr, Bhavaraju K, Getz T, Bynagari YS, Kim S, Kunapuli SP, Impaired activation of platelets lacking protein kinase C-theta isoform. Blood 113:11(2557-67)2009 Mar 12

19073150. Jin J, Mao Y, Thomas D, Kim S, Daniel JL, Kunapuli SP, RhoA downstream of G(q) and G(12/13) pathways regulates protease-activated receptor-mediated dense granule release in platelets. Biochem Pharmacol 77:5(835-44)2009 Mar 1

19012179. Kahner BN, Dorsam RT, Kim S, Shankar H, Kitamura D, Kunapuli SP, Hematopoietic lineage cell-specific protein-1 (HS1) regulates PAR-mediated ERK activation and thromboxane generation in platelets. Platelets 19:8(614-23)2008 Dec

18068154. Bhavaraju K, Kim S, Daniel JL, Kunapuli SP, Evaluation of [3-(1-methyl-1H-indol-3-yl-methylene)-2-oxo-2, 3-dihydro-1H-indole-5-sulfonamide] (OXSI-2), as a Syk-selective inhibitor in platelets. Eur J Pharmacol 580:3(285-90)2008 Feb 12

17827385. Kim S, Garcia A, Jackson SP, Kunapuli SP, Insulin-like growth factor-1 regulates platelet activation through PI3-Kalpha isoform. Blood 110:13(4206-13)2007 Dec 15

17579181. Kahner BN, Dorsam RT, Mada SR, Kim S, Stalker TJ, Brass LF, Daniel JL, Kitamura D, Kunapuli SP, Hematopoietic lineage cell specific protein 1 (HS1) is a functionally important signaling molecule in platelet activation. Blood 110:7(2449-56)2007 Oct 1

17298299. Garcia A, Shankar H, Murugappan S, Kim S, Kunapuli SP, Regulation and functional consequences of ADP receptor-mediated ERK2 activation in platelets. Biochem J 404:2(299-308)2007 Jun 1

16995904. Jalagadugula G, Dhanasekaran DN, Kim S, Kunapuli SP, Rao AK, Early growth response transcription factor EGR-1 regulates Galphaq gene in megakaryocytic cells. J Thromb Haemost 4:12(2678-86)2006 Dec

16857990. Shankar H, Kahner BN, Prabhakar J, Lakhani P, Kim S, Kunapuli SP, G-protein-gated inwardly rectifying potassium channels regulate ADP-induced cPLA2 activity in platelets through Src family kinases. Blood 108:9(3027-34)2006 Nov 1

16460446. Shankar H, Garcia A, Prabhakar J, Kim S, Kunapuli SP, P2Y12 receptor-mediated potentiation of thrombin-induced thromboxane A2 generation in platelets occurs through regulation of Erk1/2 activation. J Thromb Haemost 4:3(638-47)2006 Mar

16234484. Ding Z, Kim S, Kunapuli SP, Identification of a potent inverse agonist at a constitutively active mutant of human P2Y12 receptor. Mol Pharmacol 69:1(338-45)2006 Jan

16223779. Kim S, Jin J, Kunapuli SP, Relative contribution of G-protein-coupled pathways to protease-activated receptor-mediated Akt phosphorylation in platelets. Blood 107:3(947-54)2006 Feb 1

15869601. Quinton TM, Kim S, Jin J, Kunapuli SP, Lipid rafts are required in Galpha(i) signaling downstream of the P2Y12 receptor during ADP-mediated platelet activation. J Thromb Haemost 3:5(1036-41)2005 May

15546949. Dorsam RT, Kim S, Murugappan S, Rachoor S, Shankar H, Jin J, Kunapuli SP, Differential requirements for calcium and Src family kinases in platelet GPIIb/IIIa activation and thromboxane generation downstream of different G-protein pathways. Blood 105:7(2749-56)2005 Apr 1

15142872. Shankar H, Murugappan S, Kim S, Jin J, Ding Z, Wickman K, Kunapuli SP, Role of G protein-gated inwardly rectifying potassium channels in P2Y12 receptor-mediated platelet functional responses. Blood 104:5(1335-43)2004 Sep 1

15140134. Quinton TM, Murugappan S, Kim S, Jin J, Kunapuli SP, Different G protein-coupled signaling pathways are involved in alpha granule release from human platelets. J Thromb Haemost 2:6(978-84)2004 Jun

14973136. Quinton TM, Kim S, Derian CK, Jin J, Kunapuli SP, Plasmin-mediated activation of platelets occurs by cleavage of protease-activated receptor 4. J Biol Chem 279:18(18434-9)2004 Apr 30

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