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Kamel Khalili, PhDKamel Khalili, PhD

 

Laura H. Carnell Professor and Chair

Department of Neuroscience

Director, Center for Neurovirology

Director, Comprehensive NeuroAIDS Center

Location: Room 741 MERB

Telephone:  215-707-5192

Fax:  215-707-4888

Email: kamel.khalili@temple.edu

 

Department of Neuroscience

Center for Neurovirology

Comprehensive NeuroAIDS Center

 

Educational Background:

 

PhD, Microbiology - 1983

University of Pennsylvania School of Medicine

Philadelphia, PA

 

Postdoctoral Fellowship, Molecular Biology - 1984

The Wistar Institute

Philadelphia, PA

 

Fogarty Scholar, Molecular Virology -1987

National Cancer Institute

National Institutes of Health

Bethesda, MD

 

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Research Interests:

 

The research program in my laboratory consists of three areas associated with neurodegeneration, neuroproliferation and neuroinflammation. In all three areas, the aim is to understand the biological events involved in control of neural cell function, growth and differentiation. To achieve this goal, we use human neurotropic viruses, including JCV and HIV, both of which greatly impact on the normal function of a variety of neural cells, as probes to determine the mechanism involved in the control of gene expression and signal transduction in the brain. As expression and replication of these pathogenic viruses in brain induces a broad range of reversible and irreversible injuries, the outcome of our studies provides fundamental information regarding the neuropathogenesis of HIV- and JCV-induced disorders, and offers excellent opportunities for the development of better diagnostic tests and effective therapeutic modalities. Our strategies are transformative in nature and employ a broad range of molecular and cellular techniques in in vitro studies, animal models and clinical samples. Our most current areas of research lie in understanding the effect of viruses on pathways involved in protein quality control, chromosomal instability upon virus infection of the CNS, pathways involved in neurodegeneration upon HIV infection and the neuroprotective role of glial cells, particularly oligodendrocytes in healthy and disease states, and the identification of cellular factors and signaling events that lead to uncontrolled proliferation of glial cells and the development of malignancies of the brain.

 

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PUBMED PUBLICATIONS :


Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

24982317. White MK, Pagano JS, Khalili K, Viruses and Human Cancers: a Long Road of Discovery of Molecular Paradigms. Clin Microbiol Rev 27:3(463-481)2014 Jul

24847939. Kaminski R, Wollebo HS, Datta PK, White MK, Amini S, Khalili K, Interplay of Rad51 with NF-?B pathway stimulates expression of HIV-1. PLoS One 9:5(e98304)2014

24623017. Feldman AM, Begay RL, Knezevic T, Myers VD, Slavov DB, Zhu W, Gowan K, Graw SL, Jones KL, Tilley DG, Coleman RC, Walinsky P, Cheung JY, Mestroni L, Khalili K, Taylor MR, Decreased Levels of BAG3 in a Family With a Rare Variant and in Idiopathic Dilated Cardiomyopathy. J Cell Physiol :()2014 Mar 13

24277482. Pozniak PD, White MK, Khalili K, TNF-a/NF-?B signaling in the CNS: possible connection to EPHB2. J Neuroimmune Pharmacol 9:2(133-41)2014 Mar

23971673. Wollebo HS, Woldemichaele B, Khalili K, Safak M, White MK, Epigenetic regulation of polyomavirus JC. Virol J 10:(264)2013 Aug 23

23955241. Darbinian N, Khalili K, Amini S, Neuroprotective activity of pDING in response to HIV-1 Tat. J Cell Physiol 229:2(153-61)2014 Feb

23874603. Barrero CA, Datta PK, Sen S, Deshmane S, Amini S, Khalili K, Merali S, HIV-1 Vpr modulates macrophage metabolic pathways: a SILAC-based quantitative analysis. PLoS One 8:7(e68376)2013

23805194. Gordon J, Sariyer IK, De La Fuente-Granada M, Augelli BJ, Otte J, Azizi SA, Amini S, Khalili K, Krynska B, Neural Crest Cells Isolated from the Bone Marrow of Transgenic Mice Express JCV T-Antigen. PLoS One 8:6(e65947)2013

23516356. White MK, Gordon J, Khalili K, The rapidly expanding family of human polyomaviruses: recent developments in understanding their life cycle and role in human pathology. PLoS Pathog 9:3(e1003206)2013 Mar

23086711. Darbinyan A, Kaminski R, White MK, Darbinian-Sarkissian N, Khalili K, Polyomavirus JC infection inhibits differentiation of oligodendrocyte progenitor cells. J Neurosci Res 91:1(116-27)2013 Jan

23001849. Kogan M, Deshmane S, Sawaya BE, Gracely EJ, Khalili K, Rappaport J, Inhibition of NF-?B activity by HIV-1 Vpr is dependent on Vpr binding protein. J Cell Physiol 228:4(781-90)2013 Apr

22984599. Sariyer IK, Merabova N, Patel PK, Knezevic T, Rosati A, Turco MC, Khalili K, Bag3-induced autophagy is associated with degradation of JCV oncoprotein, T-Ag. PLoS One 7:9(e45000)2012

22749879. Wollebo HS, Melis S, Khalili K, Safak M, White MK, Cooperative roles of NF-?B and NFAT4 in polyomavirus JC regulation at the KB control element. Virology 432:1(146-54)2012 Oct 10

22545125. Zhang Y, Li F, Liu S, Wang H, Mahavadi S, Murthy KS, Khalili K, Hu W, MEKK1-MKK4-JNK-AP1 pathway negatively regulates Rgs4 expression in colonic smooth muscle cells. PLoS One 7:4(e35646)2012

22544282. Macaluso M, Caracciolo V, Rizzo V, Sun A, Montanari M, Russo G, Bellipanni G, Khalili K, Giordano A, Integrating role of T antigen, Rb2/p130, CTCF and BORIS in mediating non-canonical endoplasmic reticulum-dependent death pathways triggered by chronic ER stress in mouse medulloblastoma. Cell Cycle 11:9(1841-50)2012 May 1

22496891. Noch E, Sariyer IK, Gordon J, Khalili K, JC virus T-antigen regulates glucose metabolic pathways in brain tumor cells. PLoS One 7:4(e35054)2012

22234809. Noch E, Khalili K, Oncogenic viruses and tumor glucose metabolism: like kids in a candy store. Mol Cancer Ther 11:1(14-23)2012 Jan

22082208. Tavazzi E, Ferrante P, Khalili K, Progressive multifocal leukoencephalopathy: an unexpected complication of modern therapeutic monoclonal antibody therapies. Clin Microbiol Infect 17:12(1776-80)2011 Dec

22052333. Bookland MJ, Darbinian N, Weaver M, Amini S, Khalili K, Growth inhibition of malignant glioblastoma by DING protein. J Neurooncol 107:2(247-56)2012 Apr

22034138. Regan PM, Dave RS, Datta PK, Khalili K, Epigenetics of ĩ-opioid receptors: intersection with HIV-1 infection of the central nervous system. J Cell Physiol 227:7(2832-41)2012 Jul

22034072. Merabova N, Kaminski R, Krynska B, Amini S, Khalili K, Darbinyan A, JCV agnoprotein-induced reduction in CXCL5/LIX secretion by oligodendrocytes is associated with activation of apoptotic signaling in neurons. J Cell Physiol 227:8(3119-27)2012 Aug

22023789. Deshmane SL, Amini S, Sen S, Khalili K, Sawaya BE, Regulation of the HIV-1 promoter by HIF-1a and Vpr proteins. Virol J 8:(477)2011 Oct 24

21936015. Tavazzi E, White MK, Khalili K, Progressive multifocal leukoencephalopathy: clinical and molecular aspects. Rev Med Virol 22:1(18-32)2012 Jan

21311094. White MK, Khalili K, Could NSP5a3a be a target for head and neck cancer? Oncotarget 1:6(386)2010 Oct

21297941. Sariyer IK, Khalili K, Regulation of human neurotropic JC virus replication by alternative splicing factor SF2/ASF in glial cells. PLoS One 6:1(e14630)2011 Jan 31

21233200. Gentilella A, Khalili K, BAG3 expression in glioblastoma cells promotes accumulation of ubiquitinated clients in an Hsp70-dependent manner. J Biol Chem 286:11(9205-15)2011 Mar 18

21227915. White MK, Khalili K, Pathogenesis of progressive multifocal leukoencephalopathy--revisited. J Infect Dis 203:5(578-86)2011 Mar 1

21185609. Wollebo HS, Safak M, Del Valle L, Khalili K, White MK, Role for tumor necrosis factor-a in JC virus reactivation and progressive multifocal leukoencephalopathy. J Neuroimmunol 233:1-2(46-53)2011 Apr

21117063. Darbinian N, Gomberg R, Mullen L, Garcia S, White MK, Khalili K, Amini S, Suppression of HIV-1 transcriptional elongation by a DING phosphatase. J Cell Biochem 112:1(225-32)2011 Jan

21084864. Noch E, Bookland M, Khalili K, Astrocyte-elevated gene-1 (AEG-1) induction by hypoxia and glucose deprivation in glioblastoma. Cancer Biol Ther 11:1(32-9)2011 Jan 1

20948313. Kaminski R, Cheeseboro L, Amini S, Johnson EM, White MK, Khalili K, Darbinyan A, Role of Pura in the cellular response to ultraviolet-C radiation. Cell Cycle 9:20(4164-73)2010 Oct 15

20890127. Rom I, Darbinyan A, White MK, Rappaport J, Sawaya BE, Amini S, Khalili K, Activation of HIV-1 LTR by Rad51 in microglial cells. Cell Cycle 9:18(3715-22)2010 Sep 15

20881234. Li F, Hu DY, Liu S, Mahavadi S, Yen W, Murthy KS, Khalili K, Hu W, RNA-binding protein HuR regulates RGS4 mRNA stability in rabbit colonic smooth muscle cells. Am J Physiol Cell Physiol 299:6(C1418-29)2010 Dec

20564181. Dave RS, Khalili K, Morphine treatment of human monocyte-derived macrophages induces differential miRNA and protein expression: impact on inflammation and oxidative stress in the central nervous system. J Cell Biochem 110:4(834-45)2010 Jul 1

20554301. Tremolada S, Akan S, Otte J, Khalili K, Ferrante P, Chaudhury PR, Woodle ES, Trofe-Clark J, White MK, Gordon J, Rare subtypes of BK virus are viable and frequently detected in renal transplant recipients with BK virus-associated nephropathy. Virology 404:2(312-8)2010 Sep 1

20336718. Del Valle L, Khalili K, Detection of human polyomavirus proteins, T-antigen and agnoprotein, in human tumor tissue arrays. J Med Virol 82:5(806-11)2010 May

20336668. Caracciolo V, Macaluso M, D'Agostino L, Montanari M, Scheff J, Reiss K, Khalili K, Giordano A, Cross-talk between T-Ag presence and pRb family and p53/p73 signaling in mouse and human medulloblastoma. J Cell Biochem 110:1(182-90)2010 May

20190567. Del Valle L, Piņa-Oviedo S, Perez-Liz G, Augelli BJ, Azizi SA, Khalili K, Gordon J, Krynska B, Bone marrow-derived mesenchymal stem cells undergo JCV T-antigen mediated transformation and generate tumors with neuroectodermal characteristics. Cancer Biol Ther 9:4(286-94)2010 Feb

20181935. Rom S, Rom I, Passiatore G, Pacifici M, Radhakrishnan S, Del Valle L, Piņa-Oviedo S, Khalili K, Eletto D, Peruzzi F, CCL8/MCP-2 is a target for mir-146a in HIV-1-infected human microglial cells. FASEB J 24:7(2292-300)2010 Jul

19945517. Li F, Murthy KS, Khalili K, Hu W, Cloning and characterization of rabbit Rgs4 promoter in gut smooth muscle. Gene 451:1-2(45-53)2010 Feb 1

19777443. Gentilella A, Khalili K, Autoregulation of co-chaperone BAG3 gene transcription. J Cell Biochem 108:5(1117-24)2009 Dec 1

19770591. Noch E, Khalili K, Molecular mechanisms of necrosis in glioblastoma: the role of glutamate excitotoxicity. Cancer Biol Ther 8:19(1791-7)2009 Oct

19747512. Romagnoli L, Wollebo HS, Deshmane SL, Mukerjee R, Del Valle L, Safak M, Khalili K, White MK, Modulation of JC virus transcription by C/EBPbeta. Virus Res 146:1-2(97-106)2009 Dec

19739100. Amini S, Merabova N, Khalili K, Darbinian N, p38SJ, a novel DINGG protein protects neuronal cells from alcohol induced injury and death. J Cell Physiol 221:3(499-504)2009 Dec

19640999. White MK, Safak M, Khalili K, Regulation of gene expression in primate polyomaviruses. J Virol 83:21(10846-56)2009 Nov

19442856. Sariyer IK, Safak M, Gordon J, Khalili K, Generation and characterization of JCV permissive hybrid cell lines. J Virol Methods 159:1(122-6)2009 Jul

19360424. Piņa-Oviedo S, Khalili K, Del Valle L, Hypoxia inducible factor-1 alpha activation of the JCV promoter: role in the pathogenesis of progressive multifocal leukoencephalopathy. Acta Neuropathol 118:2(235-47)2009 Aug

19343785. Darbinian N, Czernik M, Darbinyan A, Elias M, Chabriere E, Bonasu S, Khalili K, Amini S, Evidence for phosphatase activity of p27SJ and its impact on the cell cycle. J Cell Biochem 107:3(400-7)2009 Jun 1

19328187. Rom I, Deshmane SL, Mukerjee R, Khalili K, Amini S, Sawaya BE, HIV-1 Vpr deregulates calcium secretion in neural cells. Brain Res 1275:(81-6)2009 Jun 12

19282432. Basile A, Darbinian N, Kaminski R, White MK, Gentilella A, Turco MC, Khalili K, Evidence for modulation of BAG3 by polyomavirus JC early protein. J Gen Virol 90:Pt 7(1629-40)2009 Jul

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