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Kamel Khalili, PhDKamel Khalili, PhD


Laura H. Carnell Professor and Chair

Department of Neuroscience

Director, Center for Neurovirology

Director, Comprehensive NeuroAIDS Center

Location: Room 741 MERB

Telephone:  215-707-5192

Fax:  215-707-4888

Email: kamel.khalili@temple.edu


Department of Neuroscience

Center for Neurovirology

Comprehensive NeuroAIDS Center


Educational Background:


PhD, Microbiology - 1983

University of Pennsylvania School of Medicine

Philadelphia, PA


Postdoctoral Fellowship, Molecular Biology - 1984

The Wistar Institute

Philadelphia, PA


Fogarty Scholar, Molecular Virology -1987

National Cancer Institute

National Institutes of Health

Bethesda, MD


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Research Interests:


The research program in my laboratory consists of three areas associated with neurodegeneration, neuroproliferation and neuroinflammation. In all three areas, the aim is to understand the biological events involved in control of neural cell function, growth and differentiation. To achieve this goal, we use human neurotropic viruses, including JCV and HIV, both of which greatly impact on the normal function of a variety of neural cells, as probes to determine the mechanism involved in the control of gene expression and signal transduction in the brain. As expression and replication of these pathogenic viruses in brain induces a broad range of reversible and irreversible injuries, the outcome of our studies provides fundamental information regarding the neuropathogenesis of HIV- and JCV-induced disorders, and offers excellent opportunities for the development of better diagnostic tests and effective therapeutic modalities. Our strategies are transformative in nature and employ a broad range of molecular and cellular techniques in in vitro studies, animal models and clinical samples. Our most current areas of research lie in understanding the effect of viruses on pathways involved in protein quality control, chromosomal instability upon virus infection of the CNS, pathways involved in neurodegeneration upon HIV infection and the neuroprotective role of glial cells, particularly oligodendrocytes in healthy and disease states, and the identification of cellular factors and signaling events that lead to uncontrolled proliferation of glial cells and the development of malignancies of the brain.


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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

26553431. Regan PM, Sariyer IK, Langford TD, Datta PK, Khalili K, Morphine-Induced MOR-1X and ASF/SF2 Expression Is Independent of Transcriptional Regulation: Implications for MOR-1X Signaling. J Cell Physiol :()2015 Nov 10

26538064. Zhang Y, Yin C, Zhang T, Li F, Yang W, Kaminski R, Fagan PR, Putatunda R, Young WB, Khalili K, Hu W, CRISPR/gRNA-directed synergistic activation mediator (SAM) induces specific, persistent and robust reactivation of the HIV-1 latent reservoirs. Sci Rep 5:(16277)2015 Nov 5

26529364. Regan PM, Langford TD, Khalili K, Regulation and Functional Implications of Opioid Receptor Splicing in Opioid Pharmacology and HIV Pathogenesis. J Cell Physiol :()2015 Nov 3

26492598. Pozniak PD, Darbinyan A, Khalili K, TNF-a/TNFR2 Regulatory Axis Stimulates EphB2-Mediated Neuroregeneration Via Activation of NF-?B. J Cell Physiol :()2015 Oct 22

26360417. Wollebo HS, Bellizzi A, Kaminski R, Hu W, White MK, Khalili K, CRISPR/Cas9 System as an Agent for Eliminating Polyomavirus JC Infection. PLoS One 10:9(e0136046)2015

26300236. Cheung JY, Gordon J, Wang J, Song J, Zhang XQ, Tilley DG, Gao E, Koch WJ, Rabinowitz J, Klotman PE, Khalili K, Feldman AM, Cardiac Dysfunction in HIV-1 Transgenic Mouse: Role of Stress and BAG3. Clin Transl Sci 8:4(305-10)2015 Aug

26176554. Saribas AS, Khalili K, Sariyer IK, Dysregulation of autophagy by HIV-1 Nef in human astrocytes. Cell Cycle 14:18(2899-904)2015 Sep 17

26041694. White MK, Gordon J, Berger JR, Khalili K, Animal Models for Progressive Multifocal Leukoencephalopathy. J Cell Physiol 230:12(2869-74)2015 Dec

25977188. White MK, Hu W, Khalili K, The CRISPR/Cas9 genome editing methodology as a weapon against human viruses. Discov Med 19:105(255-62)2015 Apr

25925243. Knezevic T, Myers VD, Gordon J, Tilley DG, Sharp TE 3rd, Wang J, Khalili K, Cheung JY, Feldman AM, BAG3: a new player in the heart failure paradigm. Heart Fail Rev 20:4(423-34)2015 Jul

25791343. Wollebo HS, Bellizzi A, Cossari DH, Safak M, Khalili K, White MK, Epigenetic regulation of polyomavirus JC involves acetylation of specific lysine residues in NF-?B p65. J Neurovirol 21:6(679-87)2015 Dec

25716921. Khalili K, Kaminski R, Gordon J, Cosentino L, Hu W, Genome editing strategies: potential tools for eradicating HIV-1/AIDS. J Neurovirol 21:3(310-21)2015 Jun

25623836. Wollebo HS, White MK, Gordon J, Berger JR, Khalili K, Persistence and pathogenesis of the neurotropic polyomavirus JC. Ann Neurol 77:4(560-70)2015 Apr

25602755. Sen S, Kaminiski R, Deshmane S, Langford D, Khalili K, Amini S, Datta PK, Role of hexokinase-1 in the survival of HIV-1-infected macrophages. Cell Cycle 14:7(980-9)2015

25310191. White MK, Kaminski R, Khalili K, Wollebo HS, Rad51 activates polyomavirus JC early transcription. PLoS One 9:10(e110122)2014

25204229. Merabova N, Sariyer IK, Saribas AS, Knezevic T, Gordon J, Turco MC, Rosati A, Weaver M, Landry J, Khalili K, WW domain of BAG3 is required for the induction of autophagy in glioma cells. J Cell Physiol 230:4(831-41)2015 Apr

25151063. Otlu O, De Simone FI, Otalora YL, Khalili K, Sariyer IK, The agnoprotein of polyomavirus JC is released by infected cells: evidence for its cellular uptake by uninfected neighboring cells. Virology 468-470:(88-95)2014 Nov

25049410. Hu W, Kaminski R, Yang F, Zhang Y, Cosentino L, Li F, Luo B, Alvarez-Carbonell D, Garcia-Mesa Y, Karn J, Mo X, Khalili K, RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection. Proc Natl Acad Sci U S A 111:31(11461-6)2014 Aug 5

24982317. White MK, Pagano JS, Khalili K, Viruses and human cancers: a long road of discovery of molecular paradigms. Clin Microbiol Rev 27:3(463-81)2014 Jul

24847939. Kaminski R, Wollebo HS, Datta PK, White MK, Amini S, Khalili K, Interplay of Rad51 with NF-?B pathway stimulates expression of HIV-1. PLoS One 9:5(e98304)2014

24623017. Feldman AM, Begay RL, Knezevic T, Myers VD, Slavov DB, Zhu W, Gowan K, Graw SL, Jones KL, Tilley DG, Coleman RC, Walinsky P, Cheung JY, Mestroni L, Khalili K, Taylor MR, Decreased levels of BAG3 in a family with a rare variant and in idiopathic dilated cardiomyopathy. J Cell Physiol 229:11(1697-702)2014 Nov

25893137. Merali S, Barrero CA, Sacktor NC, Haughey NJ, Datta PK, Langford D, Khalili K, Polyamines: Predictive Biomarker for HIV-Associated Neurocognitive Disorders. J AIDS Clin Res 5:6(1000312)2014

24277482. Pozniak PD, White MK, Khalili K, TNF-a/NF-?B signaling in the CNS: possible connection to EPHB2. J Neuroimmune Pharmacol 9:2(133-41)2014 Mar

23971673. Wollebo HS, Woldemichaele B, Khalili K, Safak M, White MK, Epigenetic regulation of polyomavirus JC. Virol J 10:(264)2013 Aug 23

23955241. Darbinian N, Khalili K, Amini S, Neuroprotective activity of pDING in response to HIV-1 Tat. J Cell Physiol 229:2(153-61)2014 Feb

23874603. Barrero CA, Datta PK, Sen S, Deshmane S, Amini S, Khalili K, Merali S, HIV-1 Vpr modulates macrophage metabolic pathways: a SILAC-based quantitative analysis. PLoS One 8:7(e68376)2013

23805194. Gordon J, Sariyer IK, De La Fuente-Granada M, Augelli BJ, Otte J, Azizi SA, Amini S, Khalili K, Krynska B, Neural Crest Cells Isolated from the Bone Marrow of Transgenic Mice Express JCV T-Antigen. PLoS One 8:6(e65947)2013

23516356. White MK, Gordon J, Khalili K, The rapidly expanding family of human polyomaviruses: recent developments in understanding their life cycle and role in human pathology. PLoS Pathog 9:3(e1003206)2013 Mar

23086711. Darbinyan A, Kaminski R, White MK, Darbinian-Sarkissian N, Khalili K, Polyomavirus JC infection inhibits differentiation of oligodendrocyte progenitor cells. J Neurosci Res 91:1(116-27)2013 Jan

23001849. Kogan M, Deshmane S, Sawaya BE, Gracely EJ, Khalili K, Rappaport J, Inhibition of NF-?B activity by HIV-1 Vpr is dependent on Vpr binding protein. J Cell Physiol 228:4(781-90)2013 Apr

22984599. Sariyer IK, Merabova N, Patel PK, Knezevic T, Rosati A, Turco MC, Khalili K, Bag3-induced autophagy is associated with degradation of JCV oncoprotein, T-Ag. PLoS One 7:9(e45000)2012

22749879. Wollebo HS, Melis S, Khalili K, Safak M, White MK, Cooperative roles of NF-?B and NFAT4 in polyomavirus JC regulation at the KB control element. Virology 432:1(146-54)2012 Oct 10

22545125. Zhang Y, Li F, Liu S, Wang H, Mahavadi S, Murthy KS, Khalili K, Hu W, MEKK1-MKK4-JNK-AP1 pathway negatively regulates Rgs4 expression in colonic smooth muscle cells. PLoS One 7:4(e35646)2012

22544282. Macaluso M, Caracciolo V, Rizzo V, Sun A, Montanari M, Russo G, Bellipanni G, Khalili K, Giordano A, Integrating role of T antigen, Rb2/p130, CTCF and BORIS in mediating non-canonical endoplasmic reticulum-dependent death pathways triggered by chronic ER stress in mouse medulloblastoma. Cell Cycle 11:9(1841-50)2012 May 1

22496891. Noch E, Sariyer IK, Gordon J, Khalili K, JC virus T-antigen regulates glucose metabolic pathways in brain tumor cells. PLoS One 7:4(e35054)2012

22234809. Noch E, Khalili K, Oncogenic viruses and tumor glucose metabolism: like kids in a candy store. Mol Cancer Ther 11:1(14-23)2012 Jan

22082208. Tavazzi E, Ferrante P, Khalili K, Progressive multifocal leukoencephalopathy: an unexpected complication of modern therapeutic monoclonal antibody therapies. Clin Microbiol Infect 17:12(1776-80)2011 Dec

22052333. Bookland MJ, Darbinian N, Weaver M, Amini S, Khalili K, Growth inhibition of malignant glioblastoma by DING protein. J Neurooncol 107:2(247-56)2012 Apr

22034138. Regan PM, Dave RS, Datta PK, Khalili K, Epigenetics of -opioid receptors: intersection with HIV-1 infection of the central nervous system. J Cell Physiol 227:7(2832-41)2012 Jul

22034072. Merabova N, Kaminski R, Krynska B, Amini S, Khalili K, Darbinyan A, JCV agnoprotein-induced reduction in CXCL5/LIX secretion by oligodendrocytes is associated with activation of apoptotic signaling in neurons. J Cell Physiol 227:8(3119-27)2012 Aug

22023789. Deshmane SL, Amini S, Sen S, Khalili K, Sawaya BE, Regulation of the HIV-1 promoter by HIF-1a and Vpr proteins. Virol J 8:(477)2011 Oct 24

21936015. Tavazzi E, White MK, Khalili K, Progressive multifocal leukoencephalopathy: clinical and molecular aspects. Rev Med Virol 22:1(18-32)2012 Jan

21311094. White MK, Khalili K, Could NSP5a3a be a target for head and neck cancer? Oncotarget 1:6(386)2010 Oct

21297941. Sariyer IK, Khalili K, Regulation of human neurotropic JC virus replication by alternative splicing factor SF2/ASF in glial cells. PLoS One 6:1(e14630)2011 Jan 31

21233200. Gentilella A, Khalili K, BAG3 expression in glioblastoma cells promotes accumulation of ubiquitinated clients in an Hsp70-dependent manner. J Biol Chem 286:11(9205-15)2011 Mar 18

21227915. White MK, Khalili K, Pathogenesis of progressive multifocal leukoencephalopathy--revisited. J Infect Dis 203:5(578-86)2011 Mar 1

21185609. Wollebo HS, Safak M, Del Valle L, Khalili K, White MK, Role for tumor necrosis factor-a in JC virus reactivation and progressive multifocal leukoencephalopathy. J Neuroimmunol 233:1-2(46-53)2011 Apr

21117063. Darbinian N, Gomberg R, Mullen L, Garcia S, White MK, Khalili K, Amini S, Suppression of HIV-1 transcriptional elongation by a DING phosphatase. J Cell Biochem 112:1(225-32)2011 Jan

21084864. Noch E, Bookland M, Khalili K, Astrocyte-elevated gene-1 (AEG-1) induction by hypoxia and glucose deprivation in glioblastoma. Cancer Biol Ther 11:1(32-9)2011 Jan 1

20948313. Kaminski R, Cheeseboro L, Amini S, Johnson EM, White MK, Khalili K, Darbinyan A, Role of Pura in the cellular response to ultraviolet-C radiation. Cell Cycle 9:20(4164-73)2010 Oct 15

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