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Steven G. Kelsen, MD


Steven G. Kelsen, MD


Professor, Thoracic Medicine and Surgery

Director, Allergy Clinical Services

Director, Basic Science Research Program


Department of Thoracic Medicine and Surgery, Section of Critical Care and Sleep Medicine

Center for Inflammation, Translational and Clinical Lung Research


Educational Background:


MD, Hahnemann Medical College, Philadelphia, PA, 1964


Residency, Boston City Hospital, Boston, MA, 1970


Residency, New York Hospital, Cornell Medical Center, New York, NY, 1971


Fellowship, Cardiovascular-Pulmonary Disease, Department of Medicine, University of Pennsylvania School of Medicine, 1973

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clinical Interests:

  • Pulmonary and allergic diseases
  • COPD
  • Asthma and allergic rhinitis/sinusitis

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board certification(s):


  • Pulmonary Medicine
  • Board eligible in Allergy/Immunology

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professional affiliations:

  • American Society of Clinical Investigation
  • Interurban Clinical Club
  • American Thoracic Society
  • American College of Chest Physicians
  • American Physiological Society
  • American Federation for Clinical Research
  • New York Academy of Science
  • American College of Physicians (Fellow)

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research interests:

  • Pulmonary and allergic diseases
  • COPD
  • Asthma and allergic rhinitis/sinusitis

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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

26576744. Silkoff PE, Strambu I, Laviolette M, Singh D, FitzGerald JM, Lam S, Kelsen S, Eich A, Ludwig-Sengpiel A, Hupp GC, Backer V, Porsbjerg C, Girodet PO, Berger P, Leigh R, Kline JN, Dransfield M, Calhoun W, Hussaini A, Khatri S, Chanez P, Susulic VS, Barnathan ES, Curran M, Das AM, Brodmerkel C, Baribaud F, Loza MJ, Asthma characteristics and biomarkers from the Airways Disease Endotyping for Personalized Therapeutics (ADEPT) longitudinal profiling study. Respir Res 16:1(142)2015 Nov 17

25646735. Kim V, Oros M, Durra H, Kelsen S, Aksoy M, Cornwell WD, Rogers TJ, Criner GJ, Chronic bronchitis and current smoking are associated with more goblet cells in moderate to severe COPD and smokers without airflow obstruction. PLoS One 10:2(e0116108)2015

24111704. Merali S, Barrero CA, Bowler RP, Chen DE, Criner G, Braverman A, Litwin S, Yeung A, Kelsen SG, Analysis of the plasma proteome in COPD: Novel low abundance proteins reflect the severity of lung remodeling. COPD 11:2(177-89)2014 Apr

24040906. Alicea-Alvarez N, Swanson-Biearman B, Kelsen SG, A review of barriers to effective asthma management in Puerto Ricans: cultural, healthcare system and pharmacogenomic issues. J Asthma 51:1(97-105)2014 Feb

23082855. Patel BB, Barrero CA, Braverman A, Kim PD, Jones KA, Chen DE, Bowler RP, Merali S, Kelsen SG, Yeung AT, Assessment of two immunodepletion methods: off-target effects and variations in immunodepletion efficiency may confound plasma proteomics. J Proteome Res 11:12(5947-58)2012 Dec 7

22846757. Kelsen SG, Respiratory epithelial cell responses to cigarette smoke: the unfolded protein response. Pulm Pharmacol Ther 25:6(447-52)2012 Dec

22186744. Bohm M, Malik Z, Sebastiano C, Thomas R, Gaughan J, Kelsen S, Richter JE, Mucosal eosinophilia: prevalence and racial/ethnic differences in symptoms and endoscopic findings in adults over 10 years in an urban hospital. J Clin Gastroenterol 46:7(567-74)2012 Aug

21746883. Irrinki KM, Mallilankaraman K, Thapa RJ, Chandramoorthy HC, Smith FJ, Jog NR, Gandhirajan RK, Kelsen SG, Houser SR, May MJ, Balachandran S, Madesh M, Requirement of FADD, NEMO, and BAX/BAK for aberrant mitochondrial function in tumor necrosis factor alpha-induced necrosis. Mol Cell Biol 31:18(3745-58)2011 Sep

20353444. Bohm M, Richter JE, Kelsen S, Thomas R, Esophageal dilation: simple and effective treatment for adults with eosinophilic esophagitis and esophageal rings and narrowing. Dis Esophagus 23:5(377-85)2010 Jul

20340163. Duan X, Kelsen SG, Clarkson AB Jr, Ji R, Merali S, SILAC analysis of oxidative stress-mediated proteins in human pneumocytes: new role for treacle. Proteomics 10:11(2165-74)2010 Jun

19218194. Kelsen SG, Aksoy MO, Georgy M, Hershman R, Ji R, Li X, Hurford M, Solomides C, Chatila W, Kim V, Lymphoid follicle cells in chronic obstructive pulmonary disease overexpress the chemokine receptor CXCR3. Am J Respir Crit Care Med 179:9(799-805)2009 May 1

18817430. Duan X, Kelsen SG, Merali S, Proteomic analysis of oxidative stress-responsive proteins in human pneumocytes: insight into the regulation of DJ-1 expression. J Proteome Res 7:11(4955-61)2008 Nov

18375741. Ji R, Lee CM, Gonzales LW, Yang Y, Aksoy MO, Wang P, Brailoiu E, Dun N, Hurford MT, Kelsen SG, Human type II pneumocyte chemotactic responses to CXCR3 activation are mediated by splice variant A. Am J Physiol Lung Cell Mol Physiol 294:6(L1187-96)2008 Jun

18259970. Reddy PJ, Aksoy MO, Yang Y, Li XX, Ji R, Kelsen SG, Inhibition by salmeterol and cilomilast of fluticasone-enhanced IP-10 release in airway epithelial cells. COPD 5:1(5-11)2008 Feb

18079489. Kelsen SG, Duan X, Ji R, Perez O, Liu C, Merali S, Cigarette smoke induces an unfolded protein response in the human lung: a proteomic approach. Am J Respir Cell Mol Biol 38:5(541-50)2008 May

16467404. Shahabuddin S, Ji R, Wang P, Brailoiu E, Dun N, Yang Y, Aksoy MO, Kelsen SG, CXCR3 chemokine receptor-induced chemotaxis in human airway epithelial cells: role of p38 MAPK and PI3K signaling pathways. Am J Physiol Cell Physiol 291:1(C34-9)2006 Jul

16339779. Aksoy MO, Yang Y, Ji R, Reddy PJ, Shahabuddin S, Litvin J, Rogers TJ, Kelsen SG, CXCR3 surface expression in human airway epithelial cells: cell cycle dependence and effect on cell proliferation. Am J Physiol Lung Cell Mol Physiol 290:5(L909-18)2006 May

15358691. Yang Y, Bin W, Aksoy MO, Kelsen SG, Regulation of interleukin-1beta and interleukin-1beta inhibitor release by human airway epithelial cells. Eur Respir J 24:3(360-6)2004 Sep

11897997. Aksoy MO, Mardini IA, Yang Y, Bin W, Zhou S, Kelsen SG, Glucocorticoid effects on the beta-adrenergic receptor-adenylyl cyclase system of human airway epithelium. J Allergy Clin Immunol 109:3(491-7)2002 Mar

11597920. Aksoy MO, Bin W, Yang Y, Yun-You D, Kelsen SG, Nuclear factor-kappa B augments beta(2)-adrenergic receptor expression in human airway epithelial cells. Am J Physiol Lung Cell Mol Physiol 281:5(L1271-8)2001 Nov

11238007. Bin W, Aksoy MO, Yang Y, Kelsen SG, IL-1beta enhances beta2-adrenergic receptor expression in human airway epithelial cells by activating PKC. Am J Physiol Lung Cell Mol Physiol 280:4(L675-9)2001 Apr

10883747. Kelsen SG, Aksoy MO, Brennan K, Ciccolella D, Borbely B, Chronic effects of inhaled albuterol on beta-adrenoceptor system function in human respiratory cells. J Asthma 37:4(361-70)2000 Jun

21312119. Kelsen SG, Ciccolella D, Brennan K, Brush Biopsy and Culture of Airway Epithelial Cells: -Adrenergic Receptor System Function. Methods Mol Med 44:(41-52)2000

10609625. Kelsen SG, Church NL, Gillman SA, Lanier BQ, Emmett AH, Rickard KA, Anderson WH, Salmeterol added to inhaled corticosteroid therapy is superior to doubling the dose of inhaled corticosteroids: a randomized clinical trial. J Asthma 36:8(703-15)1999 Dec

10568418. Criner GJ, Travaline JM, Holt GA, Bosse CG, Kelsen SG, Variability of electrophrenic diaphragm twitch stimulation over time in normal subjects. Respir Physiol 118:1(39-47)1999 Oct 15

10498049. Ciccolella DE, Brennan K, Kelsen SG, Criner GJ, Dose-response characteristics of nebulized albuterol in the treatment of acutely ill, hospitalized asthmatics. J Asthma 36:6(539-46)1999 Sep

10359890. Aksoy MO, Li X, Borenstein M, Yi Y, Kelsen SG, Effects of topical corticosteroids on inflammatory mediator-induced eicosanoid release by human airway epithelial cells. J Allergy Clin Immunol 103:6(1081-91)1999 Jun

9316506. Kelsen SG, Anakwe O, Aksoy MO, Reddy PJ, Dhanasekaran N, IL-1 beta alters beta-adrenergic receptor adenylyl cyclase system function in human airway epithelial cells. Am J Physiol 273:3 Pt 1(L694-700)1997 Sep

9176257. Kelsen SG, Anakwe OO, Aksoy MO, Reddy PJ, Dhanesekaran N, Penn R, Benovic JL, Chronic effects of catecholamines on the beta 2-adrenoreceptor system in cultured human airway epithelial cells. Am J Physiol 272:5 Pt 1(L916-24)1997 May

8964747. Muza SR, Criner GJ, Kelsen SG, Effect of lung volume on the respiratory action of the canine sternomastoid. J Appl Physiol (1985) 80:3(852-6)1996 Mar

8520736. Kelsen SG, Higgins NC, Zhou S, Mardini IA, Benovic JL, Expression and function of the beta-adrenergic receptor coupled-adenylyl cyclase system on human airway epithelial cells. Am J Respir Crit Care Med 152:6 Pt 1(1774-83)1995 Dec

11854789. Kelsen SG, D'Alonzo GE, Acute and Chronic Effects of Misoprostol in the Control of Asthma: A Pilot Study in Five Subjects. Am J Ther 2:10(793-798)1995 Oct

7546770. Aksoy MO, Borenstein M, Li XX, Kelsen SG, Eicosanoid production in rabbit tracheal epithelium by adenine nucleotides: mediation by P2-purinoceptors. Am J Respir Cell Mol Biol 13:4(410-7)1995 Oct

7633725. Tolep K, Higgins N, Muza S, Criner G, Kelsen SG, Comparison of diaphragm strength between healthy adult elderly and young men. Am J Respir Crit Care Med 152:2(677-82)1995 Aug

7874996. Anakwe O, Zhou S, Benovic J, Aksoy M, Kelsen SG, Interleukins impair beta-adrenergic receptor adenylate cyclase (beta AR-AC) system function in human airway epithelial cells. Chest 107:3 Suppl(138S-139S)1995 Mar

7943348. Kelsen SG, Zhou S, Anakwe O, Mardini I, Higgins N, Benovic JL, Expression of the beta-adrenergic receptor-adenylylcyclase system in basal and columnar airway epithelial cells. Am J Physiol 267:4 Pt 1(L456-63)1994 Oct

7916196. Mardini IA, Higgins NC, Zhou S, Benovic JL, Kelsen SG, Functional behavior of the beta-adrenergic receptor-adenylyl cyclase system in rabbit airway epithelium. Am J Respir Cell Mol Biol 11:3(287-95)1994 Sep

7817041. Criner GJ, Muza SR, Kelsen SG, Respiratory action of the canine deep pectoral muscles. Respir Physiol 98:1(43-51)1994 Sep

8192243. Johnson RA, Stauber Z, Hilfer SR, Kelsen SG, Organization of tracheal epithelium in the cartilaginous portion of adult rabbit and its persistence in organ culture. Anat Rec 238:4(463-72)1994 Apr

8110478. Aksoy MO, Kelsen SG, Relaxation of rabbit tracheal smooth muscle by adenine nucleotides: mediation by P2-purinoceptors. Am J Respir Cell Mol Biol 10:2(230-6)1994 Feb

8111577. Kelsen SG, Sexauer WP, Mardini IA, Criner GJ, The comparative effects of elastase-induced emphysema on costal and crural diaphragm and parasternal intercostal muscle contractility. Am J Respir Crit Care Med 149:1(168-73)1994 Jan

8226523. Kelsen SG, Bao S, Thomas AJ, Mardini IA, Criner GJ, Structure of parasternal intercostal muscles in the adult hamster: topographic effects. J Appl Physiol (1985) 75:3(1150-4)1993 Sep

8222556. Tolep K, Kelsen SG, Effect of aging on respiratory skeletal muscles. Clin Chest Med 14:3(363-78)1993 Sep

8481231. Kelsen SG, Johnson RA, Mest S, Stauber Z, Zhou S, Aksoy M, Hilfer SR, Explant culture of rabbit tracheobronchial epithelium: structure and prostaglandin metabolism. Am J Respir Cell Mol Biol 8:5(472-9)1993 May

1490951. Muza SR, Criner GJ, Kelsen SG, Effect of lung volume on the respiratory action of the canine pectoral muscles. J Appl Physiol (1985) 73:6(2408-12)1992 Dec

1320903. Kelsen SG, Mardini IA, Zhou S, Benovic JL, Higgins NC, A technique to harvest viable tracheobronchial epithelial cells from living human donors. Am J Respir Cell Mol Biol 7:1(66-72)1992 Jul

1581073. Christensen GC, Lev A, Ryan J, Wang M, Phillips S, Wachtfogel YT, Kueppers F, Kelsen SG, Rabbit trachealis tension responses to receptor-mediated agonists are diminished by elastase. Am J Respir Cell Mol Biol 6:5(498-503)1992 May

1541194. Mardini IA, Zhou S, Blank K, Kelsen SG, Eicosanoids PGF2 and PGE2 alpha enhance the attachment of rabbit tracheal epithelial cells to a collagen substrate. Chest 101:3 Suppl(25S)1992 Mar

2252258. Zhang YL, Kelsen SG, Effects of aging on diaphragm contractile function in golden hamsters. Am Rev Respir Dis 142:6 Pt 1(1396-401)1990 Dec

2307001. Criner GJ, Muza SR, Silverman MT, Kelsen SG, Neck and pectoral girdle muscle contribution to intrathoracic pressure. Chest 97:3 Suppl(39S)1990 Mar

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