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Martin G. Keane, MD

 

Martin G. Keane, MD

 

Medical Director, Echocardiography Laboratory,
Temple University Hospital

Director, Echocardiography Research/Quantitative
Echo, Temple University Hospital

Professor, Medicine

Telephone:  215-707-9587

Email: martin.keane@tuhs.temple.edu

 

Department of Medicine, Section of Cardiology

 

Educational Background:

AB, Princeton University, Princeton, NJ, 1985

 

MD, New York University School of Medicine, New York, NY, 1989

 

Internship, Internal Medicine, Brigham & Women's Hospital, Boston, MA, 1990

 

Residency, Internal Medicine, Brigham & Women's Hospital, Boston, MA, 1992

 

Fellowship, Cardiology, Hospital of the University of Pennsylvania, Philadelphia, PA, 1995

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Research Interests:

  • Bicuspid aortic valve disease and bicuspid aortopathy
  • Proximal aortic disease
  • LV hypertrophy
  • Cardiac manifestations of chronic kidney disease

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clinical Interests:

  • Noninvasive cardiovascular imaging (echocardiography)
  • Cardiovascular epidemiology
  • Clinical cardiology
  • Aortic valve disease
  • Bicuspid aortic valves
  • Aortic diseases
  • Hypertensive heart disease
  • Left ventricular remodeling
  • Diastolic heart failure
  • Cardiac diseases of chronic renal disease

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board certification(s):

  • Board certified in Internal Medicine and Cardiovascular Disease

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professional Affiliations:

  • Fellow, American College of Cardiology
  • Fellow, American Heart Association
  • Fellow, American Society of Echocardiography
  • American College of Physicians
 

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Books/Book Chapters:

 

Keane MG: Chronic aortic dissection. Echocardiography in Practice: A Case-Oriented Approach. Wiegers SE, Plappert T, and St. John Sutton MG (eds.). Dunitz Publishers, London, Page: 442-444, chpt 128, 2000.

 

Keane MG: Marfan syndrome and acute type A dissection. Echocardiography in Practice: A Case-Oriented Approach. Wiegers SE, Plappert T, and St. John Sutton MG (eds.). Dunitz Publishers, London, Page: 410-414, chpt 118, 2000.

 

Keane MG: Diastolic dysfunction. Echocardiography in Practice: A Case-Oriented Approach. Wiegers SE, Plappert T, and St. John Sutton MG (eds.). Dunitz Publishers, London, Page: 280-282, chpt 81, 2000.

 

Scott CH, Keane MG, Ferrari VA: Echocardiographic examination of the thoracic aorta. Seminars in Roentgenology. Miller W (eds.). 36(4): 325-333, 2001 Notes: Review.

 

Keane MG: Diastolic dysfunction: Basic diagnostic and management guidelines. Heart Failure: A Clinician's Guide to Ambulatory Diagnosis and Treatment. Jessup ML and Loh E (eds.). The Humana Press, Page: 321-328, chpt 20, 2003.

 

Keane MG, Kizer JR, Popjes E, Goldberg L, Loh E: Congestive heart failure. Cardiovascular Imaging: A Companion to Braunwald's "Heart Disease." Saunders, Spring 2004 Notes: chpt 10.

 

Keane MG, Wiegers SE: Echocardiography of Aortic Insufficiency. Cardiovascular Interventions in Clinical Practice. Haas J, Schafers HJ, Sievert H, Waksman R (eds.). Wiley-Blackwell, Oxford, UK, Page: 134-143, May 2010 Notes: ISBN: 978-1-4051-8277-5.

 

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PUBMED PUBLICATIONS :


Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

24752431. Deo R, Yang W, Khan AM, Bansal N, Zhang X, Leonard MB, Keane MG, Soliman EZ, Steigerwalt S, Townsend RR, Shlipak MG, Feldman HI, Serum Aldosterone and Death, End-Stage Renal Disease, and Cardiovascular Events in Blacks and Whites: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study. Hypertension :()2014 Apr 21

24605026. Keane MG, Bramis K, Pereira SP, Fusai GK, Systematic review of novel ablative methods in locally advanced pancreatic cancer. World J Gastroenterol 20:9(2267-78)2014 Mar 7

23866478. Shirazi MH, Marsh P, Keane MG, Khushal A, Insall R, Laparoscopic total extra-peritoneal inguinal hernia repairs by a surgeon experienced at laparoscopic cholecystectomy. J Pak Med Assoc 62:12(1301-4)2012 Dec

23748358. Ky B, Shults J, Keane MG, Sutton MS, Wolf M, Feldman HI, Reese PP, Anderson CA, Townsend RR, Deo R, Lo J, Gadegbeku C, Carlow D, Sulik MJ, Leonard MB, FGF23 modifies the relationship between vitamin D and cardiac remodeling. Circ Heart Fail 6:4(817-24)2013 Jul

23623915. Hahn RT, Pibarot P, Stewart WJ, Weissman NJ, Gopalakrishnan D, Keane MG, Anwaruddin S, Wang Z, Bilsker M, Lindman BR, Herrmann HC, Kodali SK, Makkar R, Thourani VH, Svensson LG, Akin JJ, Anderson WN, Leon MB, Douglas PS, Comparison of transcatheter and surgical aortic valve replacement in severe aortic stenosis: a longitudinal study of echocardiography parameters in cohort A of the PARTNER trial (placement of aortic transcatheter valves). J Am Coll Cardiol 61:25(2514-21)2013 Jun 25

23291148. Mishra RK, Li Y, DeFilippi C, Fischer MJ, Yang W, Keane M, Chen J, He J, Kallem R, Horwitz EJ, Rafey M, Raj DS, Go AS, Shlipak MG, Association of cardiac troponin T with left ventricular structure and function in CKD. Am J Kidney Dis 61:5(701-9)2013 May

22965589. Grunwald JE, Alexander J, Ying GS, Maguire M, Daniel E, Whittock-Martin R, Parker C, McWilliams K, Lo JC, Go A, Townsend R, Gadegbeku CA, Lash JP, Fink JC, Rahman M, Feldman H, Kusek JW, Xie D, Jaar BG, Retinopathy and chronic kidney disease in the Chronic Renal Insufficiency Cohort (CRIC) study. Arch Ophthalmol 130:9(1136-44)2012 Sep

22658574. Anderson AH, Yang W, Hsu CY, Joffe MM, Leonard MB, Xie D, Chen J, Greene T, Jaar BG, Kao P, Kusek JW, Landis JR, Lash JP, Townsend RR, Weir MR, Feldman HI, Estimating GFR among participants in the Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Kidney Dis 60:2(250-61)2012 Aug

22516527. Grunwald JE, Ying GS, Maguire M, Pistilli M, Daniel E, Alexander J, Whittock-Martin R, Parker C, Mohler E, Lo JC, Townsend R, Gadegbeku CA, Lash JP, Fink JC, Rahman M, Feldman H, Kusek JW, Xie D, Coleman M, Keane MG, Association between retinopathy and cardiovascular disease in patients with chronic kidney disease (from the Chronic Renal Insufficiency Cohort [CRIC] Study). Am J Cardiol 110:2(246-53)2012 Jul 15

22497791. Fischer MJ, Xie D, Jordan N, Kop WJ, Krousel-Wood M, Kurella Tamura M, Kusek JW, Ford V, Rosen LK, Strauss L, Teal VL, Yaffe K, Powe NR, Lash JP, Factors associated with depressive symptoms and use of antidepressant medications among participants in the Chronic Renal Insufficiency Cohort (CRIC) and Hispanic-CRIC Studies. Am J Kidney Dis 60:1(27-38)2012 Jul

22497559. Ky B, Plappert T, Kirkpatrick J, Silvestry FE, Ferrari VA, Keane MG, Wiegers SE, Chirinos JA, St John Sutton M, Left ventricular remodeling in human heart failure: quantitative echocardiographic assessment of 1,794 patients. Echocardiography 29:7(758-65)2012 Aug

21985788. Faul C, Amaral AP, Oskouei B, Hu MC, Sloan A, Isakova T, Gutiérrez OM, Aguillon-Prada R, Lincoln J, Hare JM, Mundel P, Morales A, Scialla J, Fischer M, Soliman EZ, Chen J, Go AS, Rosas SE, Nessel L, Townsend RR, Feldman HI, St John Sutton M, Ojo A, Gadegbeku C, Di Marco GS, Reuter S, Kentrup D, Tiemann K, Brand M, Hill JA, Moe OW, Kuro-O M, Kusek JW, Keane MG, Wolf M, FGF23 induces left ventricular hypertrophy. J Clin Invest 121:11(4393-408)2011 Nov

21972400. Llano R, Winsor-Hines D, Patel DB, Seifert PS, Hamamdzic D, Wilson GJ, Wang H, Keane MG, Huibregtse BA, Wilensky RL, Vascular responses to drug-eluting and bare metal stents in diabetic/hypercholesterolemic and nonatherosclerotic porcine coronary arteries. Circ Cardiovasc Interv 4:5(438-46)2011 Oct 1

21939832. Gertz ZM, Raina A, Saghy L, Zado ES, Callans DJ, Marchlinski FE, Keane MG, Silvestry FE, Evidence of atrial functional mitral regurgitation due to atrial fibrillation: reversal with arrhythmia control. J Am Coll Cardiol 58:14(1474-81)2011 Sep 27

21896829. Ricardo AC, Lash JP, Fischer MJ, Lora CM, Budoff M, Keane MG, Kusek JW, Martinez M, Nessel L, Stamos T, Ojo A, Rahman M, Soliman EZ, Yang W, Feldman HI, Go AS, Cardiovascular disease among hispanics and non-hispanics in the chronic renal insufficiency cohort (CRIC) study. Clin J Am Soc Nephrol 6:9(2121-31)2011 Sep

21885465. Zamorano JL, Badano LP, Bruce C, Chan KL, Gonçalves A, Hahn RT, Keane MG, La Canna G, Monaghan MJ, Nihoyannopoulos P, Silvestry FE, Vanoverschelde JL, Gillam LD, EAE/ASE recommendations for the use of echocardiography in new transcatheter interventions for valvular heart disease. Eur Heart J 32:17(2189-214)2011 Sep

21867869. Zamorano JL, Badano LP, Bruce C, Chan KL, Gonçalves A, Hahn RT, Keane MG, La Canna G, Monaghan MJ, Nihoyannopoulos P, Silvestry FE, Vanoverschelde JL, Gillam LD, EAE/ASE recommendations for the use of echocardiography in new transcatheter interventions for valvular heart disease. J Am Soc Echocardiogr 24:9(937-65)2011 Sep

21841044. Zamorano JL, Badano LP, Bruce C, Chan KL, Gonçalves A, Hahn RT, Keane MG, La Canna G, Monaghan MJ, Nihoyannopoulos P, Silvestry FE, Vanoverschelde JL, Gillam LD, Vahanian A, Di Bello V, Buck T, EAE/ASE recommendations for the use of echocardiography in new transcatheter interventions for valvular heart disease. Eur J Echocardiogr 12:8(557-84)2011 Aug

21705121. Fischer MJ, Go AS, Lora CM, Ackerson L, Cohan J, Kusek JW, Mercado A, Ojo A, Ricardo AC, Rosen LK, Tao K, Xie D, Feldman HI, Lash JP, CKD in Hispanics: Baseline characteristics from the CRIC (Chronic Renal Insufficiency Cohort) and Hispanic-CRIC Studies. Am J Kidney Dis 58:2(214-27)2011 Aug

21564279. Ogbara J, Logani S, Ky B, Chirinos JA, Silvestry FE, Eberman K, Moss JD, Ferrari VA, Keane MG, St John Sutton M, Wiegers SE, Kirkpatrick JN, The utility of prescreening transesophageal echocardiograms: a prospective study. Echocardiography 28:7(767-73)2011 Aug

21490035. Gertz ZM, Raina A, Mountantonakis SE, Zado ES, Callans DJ, Marchlinski FE, Keane MG, Silvestry FE, The impact of mitral regurgitation on patients undergoing catheter ablation of atrial fibrillation. Europace 13:8(1127-32)2011 Aug

20868818. Wang P, Acker MA, Bilello M, Melhem ER, Stambrook E, Ratcliffe SJ, Floyd TF, Sex, aging, and preexisting cerebral ischemic disease in patients with aortic stenosis. Ann Thorac Surg 90:4(1230-5)2010 Oct

20601459. Hamamdzic D, Fenning RS, Patel D, Mohler ER 3rd, Orlova KA, Wright AC, Llano R, Keane MG, Shannon RP, Birnbaum MJ, Wilensky RL, Akt pathway is hypoactivated by synergistic actions of diabetes mellitus and hypercholesterolemia resulting in advanced coronary artery disease. Am J Physiol Heart Circ Physiol 299:3(H699-706)2010 Sep

20152246. Testani JM, Khera AV, St John Sutton MG, Keane MG, Wiegers SE, Shannon RP, Kirkpatrick JN, Effect of right ventricular function and venous congestion on cardiorenal interactions during the treatment of decompensated heart failure. Am J Cardiol 105:4(511-6)2010 Feb 15

19966060. Chirinos JA, Segers P, Raina A, Saif H, Swillens A, Gupta AK, Townsend R, Emmi AG Jr, Kirkpatrick JN, Keane MG, Ferrari VA, Wiegers SE, St John Sutton MG, Arterial pulsatile hemodynamic load induced by isometric exercise strongly predicts left ventricular mass in hypertension. Am J Physiol Heart Circ Physiol 298:2(H320-30)2010 Feb

19451350. Chirinos JA, Segers P, Gupta AK, Swillens A, Rietzschel ER, De Buyzere ML, Kirkpatrick JN, Gillebert TC, Wang Y, Keane MG, Townsend R, Ferrari VA, Wiegers SE, St John Sutton M, Time-varying myocardial stress and systolic pressure-stress relationship: role in myocardial-arterial coupling in hypertension. Circulation 119:21(2798-807)2009 Jun 2

19131002. Kirkpatrick JN, Ky B, Rahmouni HW, Chirinos JA, Farmer SA, Fields AV, Ogbara J, Eberman KM, Ferrari VA, Silvestry FE, Keane MG, Opotowsky AR, Sutton MS, Wiegers SE, Application of appropriateness criteria in outpatient transthoracic echocardiography. J Am Soc Echocardiogr 22:1(53-9)2009 Jan

19085935. Llano R, Epstein S, Zhou R, Zhang H, Hamamdzic D, Keane MG, Freyman T, Wilensky RL, Intracoronary delivery of mesenchymal stem cells at high flow rates after myocardial infarction improves distal coronary blood flow and decreases mortality in pigs. Catheter Cardiovasc Interv 73:2(251-7)2009 Feb 1

18506019. Keane MG, Pyeritz RE, Medical management of Marfan syndrome. Circulation 117:21(2802-13)2008 May 27

19804334. Kirkpatrick JN, Keane MG, Future potential of echocardiography in heart failure. Future Cardiol 4:3(299-319)2008 May

18294497. Rahmouni HW, Ky B, Plappert T, Duffy K, Wiegers SE, Ferrari VA, Keane MG, Kirkpatrick JN, Silvestry FE, St John Sutton M, Clinical utility of automated assessment of left ventricular ejection fraction using artificial intelligence-assisted border detection. Am Heart J 155:3(562-70)2008 Mar

18082508. Rahmouni HW, Keane MG, Silvestry FE, St John Sutton MG, Ferrari VA, Scott CH, Wiegers SE, Failure of digital echocardiography to accurately diagnose intracardiac shunts. Am Heart J 155:1(161-5)2008 Jan

18036916. Geirsson A, Bavaria JE, Swarr D, Keane MG, Woo YJ, Szeto WY, Pochettino A, Fate of the residual distal and proximal aorta after acute type a dissection repair using a contemporary surgical reconstruction algorithm. Ann Thorac Surg 84:6(1955-64; discussion 1955-64)2007 Dec

17670711. Hsu VM, Atluri P, Keane MG, Woo YJ, Minimally invasive aortic valve papillary fibroelastoma resection. Interact Cardiovasc Thorac Surg 5:6(779-81)2006 Dec

17617759. Mohler ER 3rd, O'Hare K, Darze ES, Townsend RR, Bridges CR Jr, Keane MG, Cardiovascular function in normotensive offspring of persons with essential hypertension and black race. J Clin Hypertens (Greenwich) 9:7(506-12)2007 Jul

17500002. Geirsson A, Szeto WY, Pochettino A, McGarvey ML, Keane MG, Woo YJ, Augoustides JG, Bavaria JE, Significance of malperfusion syndromes prior to contemporary surgical repair for acute type A dissection: outcomes and need for additional revascularizations. Eur J Cardiothorac Surg 32:2(255-62)2007 Aug

16948765. Suarez EE, Keane MG, Woo YJ, Combined DOR ventriculoplasty and aortic valve replacement in the treatment of post infarction ventricular aneurysm and aortic regurgitation. J Card Surg 21:5(486-8)2006 Sep-Oct

16644861. Sutton MS, Keane MG, Reverse remodelling in heart failure with cardiac resynchronisation therapy. Heart 93:2(167-71)2007 Feb

16365200. Lankipalli RS, Lax K, Keane MG, Toca FM, Bavaria JE, Milas BL, Ferrari VA, Charagundla SR, Silvestry FE, Images in cardiovascular medicine. Infected patent ductus arteriosus. Circulation 112:25(e364-5)2005 Dec 20

12871688. Kizer JR, Muttrej MR, Matthai WH, McConnell J, Nardone H, Sonel AF, Keane MG, Wilensky RL, Role of cardiac troponin T in the long-term risk stratification of patients undergoing percutaneous coronary intervention. Eur Heart J 24:14(1314-22)2003 Jul

12161229. Kizer JR, Silvestry FE, Kimmel SE, Kasner SE, Wiegers SE, Erwin MB, Schwalm SA, Viswanathan MN, Pollard JR, Keane MG, Sutton MG, Racial differences in the prevalence of cardiac sources of embolism in subjects with unexplained stroke or transient ischemic attack evaluated by transesophageal echocardiography. Am J Cardiol 90:4(395-400)2002 Aug 15

11715327. Scott CH, Keane MG, Ferrari VA, Echocardiographic evaluation of the thoracic aorta. Semin Roentgenol 36:4(325-33)2001 Oct

11257079. Mohler ER 3rd, Gannon F, Reynolds C, Zimmerman R, Keane MG, Kaplan FS, Bone formation and inflammation in cardiac valves. Circulation 103:11(1522-8)2001 Mar 20

11082359. Keane MG, Wiegers SE, Plappert T, Pochettino A, Bavaria JE, Sutton MG, Bicuspid aortic valves are associated with aortic dilatation out of proportion to coexistent valvular lesions. Circulation 102:19 Suppl 3(III35-9)2000 Nov 7

11078275. Keane MG, Wiegers SE, Yang E, Ferrari VA, St John Sutton MG, Bavaria JE, Structural determinants of aortic regurgitation in type A dissection and the role of valvular resuspension as determined by intraoperative transesophageal echocardiography. Am J Cardiol 85:5(604-10)2000 Mar 1

10496440. Kimmel SE, Keane MG, Crary JL, Jones J, Kinman JL, Beare J, Sammel M, Sutton MS, Strom BL, Detailed examination of fenfluramine-phentermine users with valve abnormalities identified in Fargo, North Dakota. Am J Cardiol 84:3(304-8)1999 Aug 1

10072234. Scott CH, Sutton MS, Gusani N, Fayad Z, Kraitchman D, Keane MG, Axel L, Ferrari VA, Effect of dobutamine on regional left ventricular function measured by tagged magnetic resonance imaging in normal subjects. Am J Cardiol 83:3(412-7)1999 Feb 1

9717017. St John Sutton M, Otterstat JE, Plappert T, Parker A, Sekarski D, Keane MG, Poole-Wilson P, Lubsen K, Quantitation of left ventricular volumes and ejection fraction in post-infarction patients from biplane and single plane two-dimensional echocardiograms. A prospective longitudinal study of 371 patients. Eur Heart J 19:5(808-16)1998 May

8020258. Keane MG, Ingenito EP, Goldhaber SZ, Utilization of venous thromboembolism prophylaxis in the medical intensive care unit. Chest 106:1(13-4)1994 Jul

2492010. Charney AN, Ingrassia PM, Thaler SM, Keane MG, Effect of systemic pH on models of altered ileal transport in the rat. Gastroenterology 96:2 Pt 1(331-8)1989 Feb

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