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Jian Huang, MD, PhD
Assistant Professor, Pathology and Laboratory Medicine
Department of Pathology and Laboratory Medicine
BA, Peking University Health Sciences Center, Bejing, China, 1995
MD, Peking University Health Sciences Center, Bejing, China, 1997
PhD (Molecular Biology), State University of New York, Downstate Medical Center, Brooklyn, NY, 2005
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Hematopoietic stem cells (HSCs) are able to self-renew and differentiate into blood cell lineages. Understanding the regulatory mechanisms of HSC self-renewal and differentiation is important both for basic stem cell biology and improving quality of stem cell transplantation in clinical settings. We are very interested in understanding how self-renewal and differentiation are regulated in HSCs at both the cellular and molecular level.
Specifically, our research has focused on three main topics: 1. Understanding the role of Wnt signaling in the regulation of HSCs self-renewal, and the contribution of Wnt signaling to leukemogenesis; 2. Identifying new factors and signaling pathways involved in regulating HSC self-renewal using ex vivo culture system; 3. Investigating the role of epigenetic regulation in HSCs function. We use both transgenic and humanized NSG model as the major research system.
The knowledge gained from these studies will provide new insights into the mechanisms of the regulation of HSCs self-renewal and differentiation, as well as the molecular and cellular biology of leukemia stem cells. It will be valuable for the diagnosis and prevention of hematopoietic diseases and the development of innovative therapeutics for many hematopoietic disorders.
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25672217. Liu X, Niu Y, Yuan H, Huang J, Fu L, AMPK binds to Sestrins and mediates the effect of exercise to increase insulin-sensitivity through autophagy. Metabolism :()2015 Jan 31
25284014. Land RH, Rayne AK, Vanderbeck AN, Barlowe TS, Manjunath S, Gross M, Eiger S, Klein PS, Cunningham NR, Huang J, Emerson SG, Punt JA, The Orphan Nuclear Receptor NR4A1 Specifies a Distinct Subpopulation of Quiescent Myeloid-Biased Long-Term HSCs. Stem Cells 33:1(278-88)2015 Jan
24092877. Valvezan AJ, Huang J, Lengner CJ, Pack M, Klein PS, Oncogenic mutations in adenomatous polyposis coli (Apc) activate mechanistic target of rapamycin complex 1 (mTORC1) in mice and zebrafish. Dis Model Mech 7:1(63-71)2014 Jan
23601684. Yang Q, Monticelli LA, Saenz SA, Chi AW, Sonnenberg GF, Tang J, De Obaldia ME, Bailis W, Bryson JL, Toscano K, Huang J, Haczku A, Pear WS, Artis D, Bhandoola A. T cell factor 1 is required for group 2 innate lymphoid cell generation. Immunity. 2013 Apr 18;38(4):694-704.
23142822. Huang J, Nguyen-McCarty M, Hexner EO, Danet-Desnoyers G, Klein PS, Maintenance of hematopoietic stem cells through regulation of Wnt and mTOR pathways. Nat Med 18:12(1778-85)2012 Dec
21821916. O'Brien WT, Huang J, Buccafusca R, Garskof J, Valvezan AJ, Berry GT, Klein PS, Glycogen synthase kinase-3 is essential for ß-arrestin-2 complex formation and lithium-sensitive behaviors in mice. J Clin Invest 121:9(3756-62)2011 Sep
19959876. Huang J, Zhang Y, Bersenev A, O'Brien WT, Tong W, Emerson SG, Klein PS, Pivotal role for glycogen synthase kinase-3 in hematopoietic stem cell homeostasis in mice. J Clin Invest 119:12(3519-29)2009 Dec
17912251. Schloesser RJ, Huang J, Klein PS, Manji HK, Cellular plasticity cascades in the pathophysiology and treatment of bipolar disorder. Neuropsychopharmacology 33:1(110-33)2008 Jan
16294042. Huang J, Liang B, Qiu J, Laurent BC, ATP-dependent chromatin-remodeling complexes in DNA double-strand break repair: remodeling, pairing and (re)pairing. Cell Cycle 4:12(1713-5)2005 Dec
16024655. Chai B, Huang J, Cairns BR, Laurent BC, Distinct roles for the RSC and Swi/Snf ATP-dependent chromatin remodelers in DNA double-strand break repair. Genes Dev 19:14(1656-61)2005 Jul 15
15254404. Huang J, Laurent BC, A Role for the RSC chromatin remodeler in regulating cohesion of sister chromatid arms. Cell Cycle 3:8(973-5)2004 Aug
15023343. Huang J, Hsu JM, Laurent BC, The RSC nucleosome-remodeling complex is required for Cohesin's association with chromosome arms. Mol Cell 13:5(739-50)2004 Mar 12
12697820. Hsu JM, Huang J, Meluh PB, Laurent BC, The yeast RSC chromatin-remodeling complex is required for kinetochore function in chromosome segregation. Mol Cell Biol 23:9(3202-15)2003 May
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