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Jian Huang MD, PhD

 

Jian Huang, MD, PhD

 

 

Assistant Professor, Pathology and Laboratory Medicine

Telephone: 215-707-2647

Email: jianh@temple.edu

 

Department of Pathology and Laboratory Medicine

 

Educational Background:

 

BA, Peking University Health Sciences Center, Bejing, China, 1995

 

MD, Peking University Health Sciences Center, Bejing, China, 1997

 

PhD (Molecular Biology), State University of New York, Downstate Medical Center, Brooklyn, NY, 2005

 

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research Interests:

 

Hematopoietic stem cells (HSCs) are able to self-renew and differentiate into blood cell lineages. Understanding the regulatory mechanisms of HSC self-renewal and differentiation is important both for basic stem cell biology and improving quality of stem cell transplantation in clinical settings. We are very interested in understanding how self-renewal and differentiation are regulated in HSCs at both the cellular and molecular level.

 

Specifically, our research has focused on three main topics: 1. Understanding the role of Wnt signaling in the regulation of HSCs self-renewal, and the contribution of Wnt signaling to leukemogenesis; 2. Identifying new factors and signaling pathways involved in regulating HSC self-renewal using ex vivo culture system; 3. Investigating the role of epigenetic regulation in HSCs function. We use both transgenic and humanized NSG model as the major research system.

 

The knowledge gained from these studies will provide new insights into the mechanisms of the regulation of HSCs self-renewal and differentiation, as well as the molecular and cellular biology of leukemia stem cells. It will be valuable for the diagnosis and prevention of hematopoietic diseases and the development of innovative therapeutics for many hematopoietic disorders.

 

 

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PUBMED PUBLICATIONS :


Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

25062169. Katich J, Qian X, Zhao YX, Allada K, Aniol K, Annand JR, Averett T, Benmokhtar F, Bertozzi W, Bradshaw PC, Bosted P, Camsonne A, Canan M, Cates GD, Chen C, Chen JP, Chen W, Chirapatpimol K, Chudakov E, Cisbani E, Cornejo JC, Cusanno F, Dalton MM, Deconinck W, de Jager CW, De Leo R, Deng X, Deur A, Ding H, Dolph PA, Dutta C, Dutta D, El Fassi L, Frullani S, Gao H, Garibaldi F, Gaskell D, Gilad S, Gilman R, Glamazdin O, Golge S, Guo L, Hamilton D, Hansen O, Higinbotham DW, Holmstrom T, Huang J, Huang M, Ibrahim HF, Iodice M, Jiang X, Jin G, Jones MK, Kelleher A, Kim W, Kolarkar A, Korsch W, LeRose JJ, Li X, Li Y, Lindgren R, Liyanage N, Long E, Lu HJ, Margaziotis DJ, Markowitz P, Marrone S, McNulty D, Meziani ZE, Michaels R, Moffit B, Muņoz Camacho C, Nanda S, Narayan A, Nelyubin V, Norum B, Oh Y, Osipenko M, Parno D, Peng JC, Phillips SK, Posik M, Puckett AJ, Qiang Y, Rakhman A, Ransome RD, Riordan S, Saha A, Sawatzky B, Schulte E, Shahinyan A, Shabestari MH, Sirca S, Stepanyan S, Subedi R, Sulkosky V, Tang LG, Tobias A, Urciuoli GM, Vilardi I, Wang K, Wang Y, Wojtsekhowski B, Yan X, Yao H, Ye Y, Ye Z, Yuan L, Zhan X, Zhang Y, Zhang YW, Zhao B, Zheng X, Zhu L, Zhu X, Zong X, Measurement of the Target-Normal Single-Spin Asymmetry in Deep-Inelastic Scattering from the Reaction ^{3}He^{?}(e,e^{'})X. Phys Rev Lett 113:2(022502)2014 Jul 11

25062166. Posik M, Flay D, Parno DS, Allada K, Armstrong W, Averett T, Benmokhtar F, Bertozzi W, Camsonne A, Canan M, Cates GD, Chen C, Chen JP, Choi S, Chudakov E, Cusanno F, Dalton MM, Deconinck W, de Jager CW, Deng X, Deur A, Dutta C, El Fassi L, Franklin GB, Friend M, Gao H, Garibaldi F, Gilad S, Gilman R, Glamazdin O, Golge S, Gomez J, Guo L, Hansen O, Higinbotham DW, Holmstrom T, Huang J, Hyde C, Ibrahim HF, Jiang X, Jin G, Katich J, Kelleher A, Kolarkar A, Korsch W, Kumbartzki G, LeRose JJ, Lindgren R, Liyanage N, Long E, Lukhanin A, Mamyan V, McNulty D, Meziani ZE, Michaels R, Mihovilovic M, Moffit B, Muangma N, Nanda S, Narayan A, Nelyubin V, Norum B, Nuruzzaman, Oh Y, Peng JC, Qian X, Qiang Y, Rakhman A, Riordan S, Saha A, Sawatzky B, Shabestari MH, Shahinyan A, Sirca S, Solvignon P, Subedi R, Sulkosky V, Tobias WA, Troth W, Wang D, Wang Y, Wojtsekhowski B, Yan X, Yao H, Ye Y, Ye Z, Yuan L, Zhan X, Zhang Y, Zhang YW, Zhao B, Zheng X, Precision Measurement of the Neutron Twist-3 Matrix Element d_{2}^{n}: Probing Color Forces. Phys Rev Lett 113:2(022002)2014 Jul 11

24745410. Camsonne A, Katramatou AT, Olson M, Sparveris N, Acha A, Allada K, Anderson BD, Arrington J, Baldwin A, Chen JP, Choi S, Chudakov E, Cisbani E, Craver B, Decowski P, Dutta C, Folts E, Frullani S, Garibaldi F, Gilman R, Gomez J, Hahn B, Hansen JO, Higinbotham DW, Holmstrom T, Huang J, Iodice M, Jiang X, Kelleher A, Khrosinkova E, Kievsky A, Kuchina E, Kumbartzki G, Lee B, LeRose JJ, Lindgren RA, Lott G, Lu H, Marcucci LE, Margaziotis DJ, Markowitz P, Marrone S, Meekins D, Meziani ZE, Michaels R, Moffit B, Norum B, Petratos GG, Puckett A, Qian X, Rondon O, Saha A, Sawatzky B, Segal J, Shabestari M, Shahinyan A, Solvignon P, Subedi RR, Suleiman R, Sulkosky V, Urciuoli GM, Viviani M, Wang Y, Wojtsekhowski BB, Yan X, Yao H, Zhang WM, Zheng X, Zhu L, JLab measurement of the 4He charge form factor at large momentum transfers. Phys Rev Lett 112:13(132503)2014 Apr 4

24092877. Valvezan AJ, Huang J, Lengner CJ, Pack M, Klein PS, Oncogenic mutations in adenomatous polyposis coli (Apc) activate mechanistic target of rapamycin complex 1 (mTORC1) in mice and zebrafish. Dis Model Mech 7:1(63-71)2014 Jan

23142822. Huang J, Nguyen-McCarty M, Hexner EO, Danet-Desnoyers G, Klein PS, Maintenance of hematopoietic stem cells through regulation of Wnt and mTOR pathways. Nat Med 18:12(1778-85)2012 Dec

21821916. O'Brien WT, Huang J, Buccafusca R, Garskof J, Valvezan AJ, Berry GT, Klein PS, Glycogen synthase kinase-3 is essential for ß-arrestin-2 complex formation and lithium-sensitive behaviors in mice. J Clin Invest 121:9(3756-62)2011 Sep

19959876. Huang J, Zhang Y, Bersenev A, O'Brien WT, Tong W, Emerson SG, Klein PS, Pivotal role for glycogen synthase kinase-3 in hematopoietic stem cell homeostasis in mice. J Clin Invest 119:12(3519-29)2009 Dec

17912251. Schloesser RJ, Huang J, Klein PS, Manji HK, Cellular plasticity cascades in the pathophysiology and treatment of bipolar disorder. Neuropsychopharmacology 33:1(110-33)2008 Jan

17053141. Amenomori M, Ayabe S, Bi XJ, Chen D, Cui SW, Danzengluobu, Ding LK, Ding XH, Feng CF, Feng Z, Feng ZY, Gao XY, Geng QX, Guo HW, He HH, He M, Hibino K, Hotta N, Hu H, Hu HB, Huang J, Huang Q, Jia HY, Kajino F, Kasahara K, Katayose Y, Kato C, Kawata K, Labaciren, Le GM, Li AF, Li JY, Lou YQ, Lu H, Lu SL, Meng XR, Mizutani K, Mu J, Munakata K, Nagai A, Nanjo H, Nishizawa M, Ohnishi M, Ohta I, Onuma H, Ouchi T, Ozawa S, Ren JR, Saito T, Saito TY, Sakata M, Sako TK, Sasaki T, Shibata M, Shiomi A, Shirai T, Sugimoto H, Takita M, Tan YH, Tateyama N, Torii S, Tsuchiya H, Udo S, Wang B, Wang H, Wang X, Wang YG, Wu HR, Xue L, Yamamoto Y, Yan CT, Yang XC, Yasue S, Ye ZH, Yu GC, Yuan AF, Yuda T, Zhang HM, Zhang JL, Zhang NJ, Zhang XY, Zhang Y, Zhang Y, Zhaxisangzhu, Zhou XX, Anisotropy and corotation of galactic cosmic rays. Science 314:5798(439-43)2006 Oct 20

16294042. Huang J, Liang B, Qiu J, Laurent BC, ATP-dependent chromatin-remodeling complexes in DNA double-strand break repair: remodeling, pairing and (re)pairing. Cell Cycle 4:12(1713-5)2005 Dec

16024655. Chai B, Huang J, Cairns BR, Laurent BC, Distinct roles for the RSC and Swi/Snf ATP-dependent chromatin remodelers in DNA double-strand break repair. Genes Dev 19:14(1656-61)2005 Jul 15

15254404. Huang J, Laurent BC, A Role for the RSC chromatin remodeler in regulating cohesion of sister chromatid arms. Cell Cycle 3:8(973-5)2004 Aug

15023343. Huang J, Hsu JM, Laurent BC, The RSC nucleosome-remodeling complex is required for Cohesin's association with chromosome arms. Mol Cell 13:5(739-50)2004 Mar 12

12697820. Hsu JM, Huang J, Meluh PB, Laurent BC, The yeast RSC chromatin-remodeling complex is required for kinetochore function in chromosome segregation. Mol Cell Biol 23:9(3202-15)2003 May

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