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Steven R. Houser, PhD, FAHAsteven r houser, phd, faha


Senior Associate Dean, Research

Vera J. Goodfriend Endowed Chair, Cardiovascular Research

Director, Cardiovascular Research Center (CVRC)

Chair and Professor, Physiology

Professor, Medicine

Telephone: 215-707-3278

Fax: 215-707-0170

Office: MERB 1041

Email: srhouser@temple.edu


Dean's Staff

Department of Physiology

Cardiovascular Research Center


Educational Background:



BA, Biology and Chemistry, Eastern College 


PhD, Physiology, Temple University School of Medicine


Postdoctoral Fellowship, Cardiology, Temple University School of Medicine

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Research Interests:


The research in the Houser laboratory is focused on those processes that maintain the electrical and contractile properties of the normal heart and the defects in these processes that lead to electrical instability (arrhythmias and sudden death) and poor cardiac pump performance congestive heart failure). We are currently continuing our studies of the determinants of cellular electrical and mechanical defects in diseased cardiac myocytes. In addition, we are exploring the idea that a major factor that determines the overall state of cardiac myocyte function is a balance between new myocyte formation (cardiac regeneration) and programmed myocyte death (apoptosis).


Our cell physiology studies are exploring the idea that activation of Ca2+ dependent signaling pathways (mainly through CAMKII) regulate Ca2+ handling proteins in diseased myocytes. We have developed techniques in live cells to track Ca2+ dependent activation of NFAT and are characterizing the associated alterations in cell function. These studies are being performed in collaboration with Dr. Jeffrey Molkentin at the University of Cincinnati. The second and third areas of new research are centered on the new idea that there is myocyte turnover in the adult heart. Therefore, we are studying the factors that regulate cell death (mainly through apoptosis, with Dr. Richard Kitsis) and new myocyte formation (via cardiac progenitor cells, with Drs Annarosa Leri and Piero Anversa). We have identified cardiac stem/progenitor cells in feline and human hearts and plan for a rapid expansion of this novel (and controversial) area. We will specifically explore the hypothesis that hypertrophy in response to pressure overload involves new myocyte formation in addition to enlargement of terminally differentiated myocytes. Our newest data shows that expression of T-type Ca2+ channels is linked to differentiation of cardiac stem cells into new cardiac myocytes. Ca2+ influx through these channels also appears to be linked to proliferation of new myocytes.


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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

26486160. Chirico EN, Ding D, Muthukumaran G, Houser SR, Starosta T, Mu A, Margulies KB, Libonati JR, Acute aerobic exercise increases exogenously infused bone marrow cell retention in the heart. Physiol Rep 3:10()2015 Oct

26472818. Mohsin S, Troupes CD, Starosta T, Sharp TE, Agra EJ, Smith SC, Duran JM, Zalavadia N, Zhou Y, Kubo H, Berretta RM, Houser SR, Unique Features of Cortical Bone Stem Cells Associated with Repair of the Injured Heart. Circ Res :()2015 Oct 15

26450916. Glukhov AV, Balycheva M, Sanchez-Alonso JL, Ilkan Z, Alvarez-Laviada A, Bhogal N, Diakonov I, Schobesberger S, Sikkel MB, Bhargava A, Faggian G, Punjabi PP, Houser SR, Gorelik J, Direct Evidence for Microdomain-Specific Localization and Remodeling of Functional L-Type Calcium Channels in Rat and Human Atrial Myocytes. Circulation :()2015 Oct 8

26387735. Shanmughapriya S, Rajan S, Hoffman NE, Higgins AM, Tomar D, Nemani N, Hines KJ, Smith DJ, Eguchi A, Vallem S, Shaikh F, Cheung M, Leonard NJ, Stolakis RS, Wolfers MP, Ibetti J, Chuprun JK, Jog NR, Houser SR, Koch WJ, Elrod JW, Madesh M, SPG7 Is an Essential and Conserved Component of the Mitochondrial Permeability Transition Pore. Mol Cell 60:1(47-62)2015 Oct 1

26383970. Smith SC, Zhang X, Zhang X, Gross P, Starosta T, Mohsin S, Franti M, Gupta P, Hayes D, Myzithras M, Kahn J, Tanner J, Weldon SM, Khalil A, Guo X, Sabri A, Chen X, MacDonnell S, Houser SR, GDF11 Does Not Rescue Aging-Related Pathological Hypertrophy. Circ Res 117:11(926-32)2015 Nov 6

26241845. Correll RN, Goonasekera SA, van Berlo JH, Burr AR, Accornero F, Zhang H, Makarewich CA, York AJ, Sargent MA, Chen X, Houser SR, Molkentin JD, STIM1 elevation in the heart results in aberrant Ca(2+) handling and cardiomyopathy. J Mol Cell Cardiol 87:(38-47)2015 Oct

26235810. Garikipati VN, Krishnamurthy P, Verma SK, Khan M, Abramova T, Mackie AR, Qin G, Benedict C, Nickoloff E, Johnson J, Gao E, Losordo DW, Houser SR, Koch WJ, Kishore R, Negative Regulation of miR-375 by Interleukin-10 Enhances Bone Marrow-Derived Progenitor Cell-Mediated Myocardial Repair and Function After Myocardial Infarction. Stem Cells :()2015 Jul 31

26231084. Makarewich CA, Troupes CD, Schumacher SM, Gross P, Koch WJ, Crandall DL, Houser SR, Comparative effects of urocortins and stresscopin on cardiac myocyte contractility. J Mol Cell Cardiol 86:(179-86)2015 Sep

26160630. Woitek F, Zentilin L, Hoffman NE, Powers JC, Ottiger I, Parikh S, Kulczycki AM, Hurst M, Ring N, Wang T, Shaikh F, Gross P, Singh H, Kolpakov MA, Linke A, Houser SR, Rizzo V, Sabri A, Madesh M, Giacca M, Recchia FA, Intracoronary Cytoprotective Gene Therapy: A Study of VEGF-B167 in a Pre-Clinical Animal Model of Dilated Cardiomyopathy. J Am Coll Cardiol 66:2(139-53)2015 Jul 14

26119731. Luongo TS, Lambert JP, Yuan A, Zhang X, Gross P, Song J, Shanmughapriya S, Gao E, Jain M, Houser SR, Koch WJ, Cheung JY, Madesh M, Elrod JW, The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability Transition. Cell Rep 12:1(23-34)2015 Jul 7

26044252. Sallam K, Li Y, Sager PT, Houser SR, Wu JC, Finding the rhythm of sudden cardiac death: new opportunities using induced pluripotent stem cell-derived cardiomyocytes. Circ Res 116:12(1989-2004)2015 Jun 5

25918050. Zhang XQ, Wang J, Song J, Rabinowitz J, Chen X, Houser SR, Peterson BZ, Tucker AL, Feldman AM, Cheung JY, Regulation of L-type calcium channel by phospholemman in cardiac myocytes. J Mol Cell Cardiol 84:(104-11)2015 Jul

25904597. Khan M, Nickoloff E, Abramova T, Johnson J, Verma SK, Krishnamurthy P, Mackie AR, Vaughan E, Garikipati VN, Benedict C, Ramirez V, Lambers E, Ito A, Gao E, Misener S, Luongo T, Elrod J, Qin G, Houser SR, Koch WJ, Kishore R, Embryonic stem cell-derived exosomes promote endogenous repair mechanisms and enhance cardiac function following myocardial infarction. Circ Res 117:1(52-64)2015 Jun 19

25854700. Nelson J, Wu Y, Jiang X, Berretta R, Houser S, Choi E, Wang J, Huang J, Yang X, Wang H, Hyperhomocysteinemia suppresses bone marrow CD34+/VEGF receptor 2+ cells and inhibits progenitor cell mobilization and homing to injured vasculature-a role of ▀1-integrin in progenitor cell migration and adhesion. FASEB J 29:7(3085-99)2015 Jul

25740181. Wiegers SE, Houser SR, Pearson HE, Untalan A, Cheung JY, Fisher SG, Kaiser LR, Feldman AM, A Metric-Based System for Evaluating the Productivity of Preclinical Faculty at an Academic Medical Center in the Era of Clinical and Translational Science. Clin Transl Sci 8:4(357-61)2015 Aug

25684108. Taghavi S, Sharp TE 3rd, Duran JM, Makarewich CA, Berretta RM, Starosta T, Kubo H, Barbe M, Houser SR, Autologous c-Kit+ Mesenchymal Stem Cell Injections Provide Superior Therapeutic Benefit as Compared to c-Kit+ Cardiac-Derived Stem Cells in a Feline Model of Isoproterenol-Induced Cardiomyopathy. Clin Transl Sci 8:5(425-31)2015 Oct

25600142. McCormick ME, Collins C, Makarewich CA, Chen Z, Rojas M, Willis MS, Houser SR, Tzima E, Platelet endothelial cell adhesion molecule-1 mediates endothelial-cardiomyocyte communication and regulates cardiac function. J Am Heart Assoc 4:1(e001210)2015 Jan 19

25595735. Roof SR, Ho HT, Little SC, Ostler JE, Brundage EA, Periasamy M, Villamena FA, Gy÷rke S, Biesiadecki BJ, Heymes C, Houser SR, Davis JP, Ziolo MT, Obligatory role of neuronal nitric oxide synthase in the heart's antioxidant adaptation with exercise. J Mol Cell Cardiol 81:(54-61)2015 Apr

25480109. Trappanese DM, Liu Y, McCormick RC, Cannavo A, Nanayakkara G, Baskharoun MM, Jarrett H, Woitek FJ, Tillson DM, Dillon AR, Recchia FA, Balligand JL, Houser SR, Koch WJ, Dell'Italia LJ, Tsai EJ, Chronic ▀1-adrenergic blockade enhances myocardial ▀3-adrenergic coupling with nitric oxide-cGMP signaling in a canine model of chronic volume overload: new insight into mechanisms of cardiac benefit with selective ▀1-blocker therapy. Basic Res Cardiol 110:1(456)2015 Jan

25411155. Benjamin I, Brown N, Burke G, Correa A, Houser SR, Jones DW, Loscalzo J, Vasan RS, Whitman GR, American Heart Association Cardiovascular Genome-Phenome Study: foundational basis and program. Circulation 131:1(100-12)2015 Jan 6

25332207. Hullmann JE, Grisanti LA, Makarewich CA, Gao E, Gold JI, Chuprun JK, Tilley DG, Houser SR, Koch WJ, GRK5-mediated exacerbation of pathological cardiac hypertrophy involves facilitation of nuclear NFAT activity. Circ Res 115:12(976-85)2014 Dec 5

25205804. Tilley DG, Zhu W, Myers VD, Barr LA, Gao E, Li X, Song J, Carter RL, Makarewich CA, Yu D, Troupes CD, Grisanti LA, Coleman RC, Koch WJ, Houser SR, Cheung JY, Feldman AM, ▀-adrenergic receptor-mediated cardiac contractility is inhibited via vasopressin type 1A-receptor-dependent signaling. Circulation 130:20(1800-11)2014 Nov 11

25077561. Doonan PJ, Chandramoorthy HC, Hoffman NE, Zhang X, Cßrdenas C, Shanmughapriya S, Rajan S, Vallem S, Chen X, Foskett JK, Cheung JY, Houser SR, Madesh M, LETM1-dependent mitochondrial Ca2+ flux modulates cellular bioenergetics and proliferation. FASEB J 28:11(4936-49)2014 Nov

25047165. Makarewich CA, Zhang H, Davis J, Correll RN, Trappanese DM, Hoffman NE, Troupes CD, Berretta RM, Kubo H, Madesh M, Chen X, Gao E, Molkentin JD, Houser SR, Transient receptor potential channels contribute to pathological structural and functional remodeling after myocardial infarction. Circ Res 115:6(567-80)2014 Aug 29

24977749. Taghavi S, Jayarajan SN, Ferrer LM, Vora H, McKee C, Milner RE, Gaughan JP, Dujon J, Sjoholm LO, Pathak A, Rappold JF, Santora TA, Houser SR, Goldberg AJ, "Permissive hypoventilation" in a swine model of hemorrhagic shock. J Trauma Acute Care Surg 77:1(14-9)2014 Jul

24935962. Anderson ME, Goldhaber J, Houser SR, Puceat M, Sussman MA, Embryonic stem cell-derived cardiac myocytes are not ready for human trials. Circ Res 115:3(335-8)2014 Jul 18

24931551. Barr LA, Makarewich CA, Berretta RM, Gao H, Troupes CD, Woitek F, Recchia F, Kubo H, Force T, Houser SR, Imatinib activates pathological hypertrophy by altering myocyte calcium regulation. Clin Transl Sci 7:5(360-7)2014 Oct

24855152. Mitacchione G, Powers JC, Grifoni G, Woitek F, Lam A, Ly L, Settanni F, Makarewich CA, McCormick R, Trovato L, Houser SR, Granata R, Recchia FA, The gut hormone ghrelin partially reverses energy substrate metabolic alterations in the failing heart. Circ Heart Fail 7:4(643-51)2014 Jul

24723657. Houser SR, Role of RyR2 phosphorylation in heart failure and arrhythmias: protein kinase A-mediated hyperphosphorylation of the ryanodine receptor at serine 2808 does not alter cardiac contractility or cause heart failure and arrhythmias. Circ Res 114:8(1320-7; discussion 1327)2014 Apr 11

24718482. Duran JM, Makarewich CA, Trappanese D, Gross P, Husain S, Dunn J, Lal H, Sharp TE, Starosta T, Vagnozzi RJ, Berretta RM, Barbe M, Yu D, Gao E, Kubo H, Force T, Houser SR, Sorafenib cardiotoxicity increases mortality after myocardial infarction. Circ Res 114:11(1700-12)2014 May 23

24703919. Tong CW, Ahmad T, Brittain EL, Bunch TJ, Damp JB, Dardas T, Hijar A, Hill JA, Hilliard AA, Houser SR, Jahangir E, Kates AM, Kim D, Lindman BR, Ryan JJ, Rzeszut AK, Sivaram CA, Valente AM, Freeman AM, Challenges facing early career academic cardiologists. J Am Coll Cardiol 63:21(2199-208)2014 Jun 3

24583314. Rafiq K, Kolpakov MA, Seqqat R, Guo J, Guo X, Qi Z, Yu D, Mohapatra B, Zutshi N, An W, Band H, Sanjay A, Houser SR, Sabri A, c-Cbl inhibition improves cardiac function and survival in response to myocardial ischemia. Circulation 129:20(2031-43)2014 May 20

24566221. Grisanti LA, Talarico JA, Carter RL, Yu JE, Repas AA, Radcliffe SW, Tang HA, Makarewich CA, Houser SR, Tilley DG, ▀-Adrenergic receptor-mediated transactivation of epidermal growth factor receptor decreases cardiomyocyte apoptosis through differential subcellular activation of ERK1/2 and Akt. J Mol Cell Cardiol 72:(39-51)2014 Jul

24115067. Molkentin JD, Houser SR, Are resident c-Kit+ cardiac stem cells really all that are needed to mend a broken heart? Circ Res 113:9(1037-9)2013 Oct 12

23801066. Duran JM, Makarewich CA, Sharp TE, Starosta T, Zhu F, Hoffman NE, Chiba Y, Madesh M, Berretta RM, Kubo H, Houser SR, Bone-derived stem cells repair the heart after myocardial infarction through transdifferentiation and paracrine signaling mechanisms. Circ Res 113:5(539-52)2013 Aug 16

23743021. Wang F, Gao H, Kubo H, Fan X, Zhang H, Berretta R, Chen X, Sharp T, Starosta T, Makarewich C, Li Y, Molkentin JD, Houser SR, T-type Ca▓? channels regulate the exit of cardiac myocytes from the cell cycle after birth. J Mol Cell Cardiol 62:(122-30)2013 Sep

23609274. Taghavi S, Jayarajan SN, Khoche S, Duran JM, Cruz-Schiavone GE, Milner RE, Holt-Bright L, Gaughan JP, Rappold JF, Sjoholm LO, Dujon J, Pathak A, Santora TA, Houser SR, Goldberg AJ, Examining prehospital intubation for penetrating trauma in a swine hemorrhagic shock model. J Trauma Acute Care Surg 74:5(1246-51)2013 May

23348743. Gandhirajan RK, Meng S, Chandramoorthy HC, Mallilankaraman K, Mancarella S, Gao H, Razmpour R, Yang XF, Houser SR, Chen J, Koch WJ, Wang H, Soboloff J, Gill DL, Madesh M, Blockade of NOX2 and STIM1 signaling limits lipopolysaccharide-induced vascular inflammation. J Clin Invest 123:2(887-902)2013 Feb

23159931. Mancarella S, Potireddy S, Wang Y, Gao H, Gandhirajan RK, Autieri M, Scalia R, Cheng Z, Wang H, Madesh M, Houser SR, Gill DL, Targeted STIM deletion impairs calcium homeostasis, NFAT activation, and growth of smooth muscle. FASEB J 27:3(893-906)2013 Mar

23067355. Duran JM, Taghavi S, Berretta RM, Makarewich CA, Sharp Iii T, Starosta T, Udeshi F, George JC, Kubo H, Houser SR, A characterization and targeting of the infarct border zone in a swine model of myocardial infarction. Clin Transl Sci 5:5(416-21)2012 Oct

22921230. Gao H, Wang F, Wang W, Makarewich CA, Zhang H, Kubo H, Berretta RM, Barr LA, Molkentin JD, Houser SR, Ca(2+) influx through L-type Ca(2+) channels and transient receptor potential channels activates pathological hypertrophy signaling. J Mol Cell Cardiol 53:5(657-67)2012 Nov

22846936. Taghavi S, Duran JM, Jayarajan S, Cruz-Schiavone GE, Milner RE, Gaughan JP, Sjoholm LO, Pathak A, Santora TA, Houser SR, Goldberg AJ, Still making the case against prehospital intubation: a rat hemorrhagic shock model. J Trauma Acute Care Surg 73:2(332-7; discussion 337)2012 Aug

22628578. Zhang D, Fang P, Jiang X, Nelson J, Moore JK, Kruger WD, Berretta RM, Houser SR, Yang X, Wang H, Severe hyperhomocysteinemia promotes bone marrow-derived and resident inflammatory monocyte differentiation and atherosclerosis in LDLr/CBS-deficient mice. Circ Res 111:1(37-49)2012 Jun 22

22611476. Taghavi S, Duran JM, Berretta RM, Makarewich CA, Udeshi F, Sharp TE, Kubo H, Houser SR, George JC, Validation of transcatheter left ventricular electromechanical mapping for assessment of cardiac function and targeted transendocardial injection in a porcine ischemia-reperfusion model. Am J Transl Res 4:2(240-6)2012

22609523. Seqqat R, Guo X, Rafiq K, Kolpakov MA, Guo J, Koch WJ, Houser SR, Dell'italia LJ, Sabri A, Beta1-adrenergic receptors promote focal adhesion signaling downregulation and myocyte apoptosis in acute volume overload. J Mol Cell Cardiol 53:2(240-9)2012 Aug

22302787. Makarewich CA, Correll RN, Gao H, Zhang H, Yang B, Berretta RM, Rizzo V, Molkentin JD, Houser SR, A caveolae-targeted L-type Ca▓+ channel antagonist inhibits hypertrophic signaling without reducing cardiac contractility. Circ Res 110:5(669-74)2012 Mar 2

22302785. Zhang H, Makarewich CA, Kubo H, Wang W, Duran JM, Li Y, Berretta RM, Koch WJ, Chen X, Gao E, Valdivia HH, Houser SR, Hyperphosphorylation of the cardiac ryanodine receptor at serine 2808 is not involved in cardiac dysfunction after myocardial infarction. Circ Res 110:6(831-40)2012 Mar 16

22203672. Rafiq K, Guo J, Vlasenko L, Guo X, Kolpakov MA, Sanjay A, Houser SR, Sabri A, c-Cbl ubiquitin ligase regulates focal adhesion protein turnover and myofibril degeneration induced by neutrophil protease cathepsin G. J Biol Chem 287:8(5327-39)2012 Feb 17

21746883. Irrinki KM, Mallilankaraman K, Thapa RJ, Chandramoorthy HC, Smith FJ, Jog NR, Gandhirajan RK, Kelsen SG, Houser SR, May MJ, Balachandran S, Madesh M, Requirement of FADD, NEMO, and BAX/BAK for aberrant mitochondrial function in tumor necrosis factor alpha-induced necrosis. Mol Cell Biol 31:18(3745-58)2011 Sep

21454756. Angert D, Berretta RM, Kubo H, Zhang H, Chen X, Wang W, Ogorek B, Barbe M, Houser SR, Repair of the injured adult heart involves new myocytes potentially derived from resident cardiac stem cells. Circ Res 108:10(1226-37)2011 May 13

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Postdoctoral Fellows

Lab phone number 215-707-3275

Hui Gao                                    hui.gau@temple.edu

Hajime Kubo, PhD                 hajime.kubo@temple.edu

Hongyu Zhang                        hongyu.zhang@temple.edu


Graduate Students

Larry Barr                                  larry.barr@temple.edu

Jason Duran                            jason.duran@temple.edu

Catherine Makarewich           cat.makarewish@gmail.com

Thomas Sharp                        tuc72715@temple.edu

Fang Wang                               tub50225@temple.edu

Hongyu Zhang                         hongyu.zhang@temple.edu


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laboratory personnel:


Remus Berretta

Lab Manager

T:  215-707-6501

F:  215-707-0170

Email address:  remus.berretta@temple.edu


Tim Starosta

Laboratory Assistant

Email address: tua92387@temple.edu


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