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Lawrence E. Goldfinger, PhD

Assistant Professor, Sol Sherry Thrombosis Research Center and

Department of Anatomy and Cell Biology

Telephone:  215-707-8157

Email:  goldfinger@temple.edu

Sol Sherry Thrombosis Research Center

Department of Anatomy and Cell Biology

BS, Biology, Carnegie Mellon University, Pittsburgh, PA, 1995

 

PhD, Cell Biology, Northwestern University Medical School, Chicago, IL, 1999

    

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• American Society for Cell Biology
• American Association for the Advancement of Science

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The ultimate goal of our research is to understand how cells use protein interaction networks to transduce signals from extracellular stimuli to produce specific phenotypic responses. Research interests in the lab are three-fold: 1) to map the signaling networks propagated by the Ras family of small GTPases, with a particular focus on R-Ras signaling and an emphasis on proteomics; 2) to develop models of interpreting these “signaling maps” as a basis for generating predictive algorithms for stimulus-response using bioinformatics approaches; 3) to explore the roles of Ras signaling in the cell biology, physiology and pathophysiology of the vasculature. Currently the lab is investigating the functions of a newly identified R-Ras signaling effector, RLIP76, in endothelial cell biology and in endothelial responses to acute vascular injury.

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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

18784251. Lim CJ, Kain KH, Tkachenko E, Goldfinger LE, Gutierrez E, Allen MD, Groisman A, Zhang J, Ginsberg MH, Integrin-mediated protein kinase A activation at the leading edge of migrating cells. Mol Biol Cell 19:11(4930-41)2008 Nov

18583710. Goldfinger LE, Tzima E, Stockton R, Kiosses WB, Kinbara K, Tkachenko E, Gutierrez E, Groisman A, Nguyen P, Chien S, Ginsberg MH, Localized alpha4 integrin phosphorylation directs shear stress-induced endothelial cell alignment. Circ Res 103:2(177-85)2008 Jul 18

18354782. Goldfinger LE, Choose your own path: specificity in Ras GTPase signaling. Mol Biosyst 4:4(293-9)2008 Apr

18329275. Lee J, Hong J, Nam TG, Peters EC, Orth AP, Geierstanger BH, Goldfinger LE, Ginsberg MH, Cho CY, Schultz PG, A small molecule inhibitor of alpha4 integrin-dependent cell migration. Bioorg Med Chem 17:3(977-80)2009 Feb 1

17439166. Goldfinger LE, Ptak C, Jeffery ED, Shabanowitz J, Han J, Haling JR, Sherman NE, Fox JW, Hunt DF, Ginsberg MH, An experimentally derived database of candidate Ras-interacting proteins. J Proteome Res 6:5(1806-11)2007 May

16966426. Goldfinger LE, Ptak C, Jeffery ED, Shabanowitz J, Hunt DF, Ginsberg MH, RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration. J Cell Biol 174:6(877-88)2006 Sep 11

14570053. Kinbara K, Goldfinger LE, Hansen M, Chou FL, Ginsberg MH, Ras GTPases: integrins' friends or foes? Nat Rev Mol Cell Biol 4:10(767-76)2003 Oct

12913113. Goldfinger LE, Han J, Kiosses WB, Howe AK, Ginsberg MH, Spatial restriction of alpha4 integrin phosphorylation regulates lamellipodial stability and alpha4beta1-dependent cell migration. J Cell Biol 162:4(731-41)2003 Aug 18

12837751. Han J, Rose DM, Woodside DG, Goldfinger LE, Ginsberg MH, Integrin alpha 4 beta 1-dependent T cell migration requires both phosphorylation and dephosphorylation of the alpha 4 cytoplasmic domain to regulate the reversible binding of paxillin. J Biol Chem 278:37(34845-53)2003 Sep 12

11054871. Jones JC, Dehart GW, Gonzales M, Goldfinger LE, Laminins: an overview. Microsc Res Tech 51:3(211-3)2000 Nov 1

10956663. Goldfinger LE, Jiang L, Hopkinson SB, Stack MS, Jones JC, Spatial regulation and activity modulation of plasmin by high affinity binding to the G domain of the alpha 3 subunit of laminin-5. J Biol Chem 275:45(34887-93)2000 Nov 10

10413670. Goldfinger LE, Hopkinson SB, deHart GW, Collawn S, Couchman JR, Jones JC, The alpha3 laminin subunit, alpha6beta4 and alpha3beta1 integrin coordinately regulate wound healing in cultured epithelial cells and in the skin. J Cell Sci 112 ( Pt 16):(2615-29)1999 Aug

9699461. Jones JC, Hopkinson SB, Goldfinger LE, Structure and assembly of hemidesmosomes. Bioessays 20:6(488-94)1998 Jun

9531563. Goldfinger LE, Stack MS, Jones JC, Processing of laminin-5 and its functional consequences: role of plasmin and tissue-type plasminogen activator. J Cell Biol 141:1(255-65)1998 Apr 6

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