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Steven S. Geier, PhD


Steven S. Geier, PhD


Professor, Pathology and Laboratory Medicine

Director, Immunogenetics

Telephone:  215-707-1764

Fax:  215-707-3389

Email: steven.geier@tuhs.temple.edu



Department of Pathology and Laboratory Medicine


Educational Background:


AB, Chemistry and Zoology, University of California, Berkeley, CA, 1972


PhD, Microbiology and Immunology, Duke University, Durham, NC, 1978


Research Fellowship, Immunotherapy of Cancer, Department of Surgery, Duke University, 1978-1981


Research Fellowship, Structure, function and recognition of mouse H-2 class I determinants, Departments of Cell Biology and Microbiology and Immunology, Albert Einstein College of Medicine, 1981-1984


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CLINICAL Interests:


  • Immunogenetics
  • HLA
  • Transplantation

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RESEARCH Interests:


  • Immunogenetics and immunobiology of solid organ and bone marrow transplantation
  • Transplantation infectious disease

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board certification(s):


  • Diplomate, American Board of Histocompatability and Immunogenetics

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professional affiliations:


  • Chair, MPSC Advisory Histocompatibility Subcommittee.
  • ASHI Quarterly Associate Editor.
  • Advisory Board of Donor Alliance (Colorado Organ Procurement Organization)
  • American Society for Histocompatability and Immunogenetics
  • United Network for Organ Sharing (UNOS) Membership and Professional Standards Committee

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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

26281139. Rao S, Ghanta M, Lee IJ, Gillespie A, Parekh HK, Geier SS, Zeng X, Karachristos A, Lau KN, Karhadkar S, Di Carlo A, Sifontis NM, Constantinescu S, Impact of Donor Specific HLA Antibody Monitoring After Kidney Transplantation. Clin Transpl :(143-51)2014

21977885. Shafer TJ, Schkade D, Schkade L, Geier SS, Orlowski JP, Klintmalm G, Zero risk tolerance costs lives: loss of transplantable organs due to human immunodeficiency virus nucleic acid testing of potential donors. Prog Transplant 21:3(236-47; quiz 248)2011 Sep

19131548. Kelher MR, Masuno T, Moore EE, Damle S, Meng X, Song Y, Liang X, Niedzinski J, Geier SS, Khan SY, Gamboni-Robertson F, Silliman CC, Plasma from stored packed red blood cells and MHC class I antibodies causes acute lung injury in a 2-event in vivo rat model. Blood 113:9(2079-87)2009 Feb 26

11319589. Lamb LS Jr, Musk P, Ye Z, van Rhee F, Geier SS, Tong JJ, King KM, Henslee-Downey PJ, Human gammadelta(+) T lymphocytes have in vitro graft vs leukemia activity in the absence of an allogeneic response. Bone Marrow Transplant 27:6(601-6)2001 Mar

10784626. Godder KT, Hazlett LJ, Abhyankar SH, Chiang KY, Christiansen NP, Bridges KD, Lee CG, Geier SS, Goon-Johnson KS, Gee AP, Pati AR, Parrish RS, Henslee-Downey PJ, Partially mismatched related-donor bone marrow transplantation for pediatric patients with acute leukemia: younger donors and absence of peripheral blasts improve outcome. J Clin Oncol 18:9(1856-66)2000 May

19746645. Lamb LS Jr, Gee AP, Hazlett LJ, Musk P, Parrish RS, O'Hanlon TP, Geier SS, Folk RS, Harris WG, McPherson K, Lee C, Henslee-Downey PJ, Influence of T cell depletion method on circulating gammadelta T cell reconstitution and potential role in the graft-versus-leukemia effect. Cytotherapy 1:1(7-19)1999

9678806. Godder KT, Abhyankar SH, Lamb LS, Best RG, Geier SS, Pati AR, Gee AP, Henslee-Downey PJ, Donor leukocyte infusion for treatment of graft rejection post partially mismatched related donor bone marrow transplant. Bone Marrow Transplant 22:1(111-3)1998 Jul

9535038. Lamb LS Jr, Gee AP, Henslee-Downey PJ, Geier SS, Hazlett L, Pati AR, Godder K, Abhyankar SA, Turner MW, Lee C, Harris WG, Parrish RS, Phenotypic and functional reconstitution of peripheral blood lymphocytes following T cell-depleted bone marrow transplantation from partially mismatched related donors. Bone Marrow Transplant 21:5(461-71)1998 Mar

9160695. Henslee-Downey PJ, Abhyankar SH, Parrish RS, Pati AR, Godder KT, Neglia WJ, Goon-Johnson KS, Geier SS, Lee CG, Gee AP, Use of partially mismatched related donors extends access to allogeneic marrow transplant. Blood 89:10(3864-72)1997 May 15

8542952. Lamb LS Jr, Szafer F, Henslee-Downey PJ, Walker M, King S, Godder K, Pati AR, Best R, Steinman L, Geier SS, Characterization of acute bone marrow graft rejection in T cell-depleted, partially mismatched related donor bone marrow transplantation. Exp Hematol 23:14(1595-600)1995 Dec

7584147. Sun R, Shepherd SE, Geier SS, Thomson CT, Sheil JM, Nathenson SG, Evidence that the antigen receptors of cytotoxic T lymphocytes interact with a common recognition pattern on the H-2Kb molecule. Immunity 3:5(573-82)1995 Nov

1714428. Howell DN, Burchette JL Jr, Paolini JF, Geier SS, Fuller JA, Sanfilippo F, Characterization of a novel human corneal endothelial antigen. Invest Ophthalmol Vis Sci 32:9(2473-82)1991 Aug

2456331. Lewis J, Foo M, Geier SS, Kumar PA, Nathenson SG, Bluestone JA, Cytotoxic T lymphocyte recognition of novel allodeterminants expressed on in vitro selected H-2Kb mutants. J Immunol 141:3(728-35)1988 Aug 1

3260136. Ajitkumar P, Geier SS, Kesari KV, Borriello F, Nakagawa M, Bluestone JA, Saper MA, Wiley DC, Nathenson SG, Evidence that multiple residues on both the alpha-helices of the class I MHC molecule are simultaneously recognized by the T cell receptor. Cell 54:1(47-56)1988 Jul 1

3734458. Zeff RA, Geier SS, Nathenson SG, Molecular loss variants of the murine major histocompatibility complex: nonexpression of H-2K antigens associated with marked reduction in H-2K mRNA as determined by oligonucleotide hybridization analysis. J Immunol 137:4(1366-70)1986 Aug 15

2426358. Bluestone JA, Langlet C, Geier SS, Nathenson SG, Foo M, Schmitt-Verhulst AM, Somatic cell variants express altered H-2Kb allodeterminants recognized by cytolytic T cell clones. J Immunol 137:4(1244-50)1986 Aug 15

2426357. Geier SS, Zeff RA, McGovern DM, Rajan TV, Nathenson SG, An approach to the study of structure-function relationships of MHC class I molecules: isolation and serologic characterization of H-2Kb somatic cell variants. J Immunol 137:4(1239-43)1986 Aug 15

3511189. Goldman JE, Geier SS, Hirano M, Differentiation of astrocytes and oligodendrocytes from germinal matrix cells in primary culture. J Neurosci 6:1(52-60)1986 Jan

3491786. Nakagawa M, Zeff RA, Geier SS, Bluestone JA, Nathenson SG, Somatic cell variants of H-2Kb: a point mutation in the first extracellular domain results in altered immune recognition. Immunogenetics 24:6(381-5)1986

2410018. Yokoyama K, Geier SS, Uehara H, Nathenson SG, Secondary structure of the murine histocompatibility alloantigen H-2Kb: relationship between heavy chain, beta 2-microglobulin, and antigenic reactivity. Biochemistry 24:12(3002-6)1985 Jun 4

6673203. Schulze DH, Pease LR, Yokoyama K, Geier SS, Pfaffenbach GM, Geliebter J, Zeff RA, Rosenblatt BP, Nathenson SG, Diversity and polymorphism in the MHC appear to be generated by a copy mechanism. Transplant Proc 15:4(2009-12)1983 Dec

6300887. Schulze DH, Pease LR, Geier SS, Reyes AA, Sarmiento LA, Wallace RB, Nathenson SG, Comparison of the cloned H-2Kbm1 variant gene with the H-2Kb gene shows a cluster of seven nucleotide differences. Proc Natl Acad Sci U S A 80:7(2007-11)1983 Apr

6942181. Iglehart JD, Ward EC, Thiel K, Huper G, Geier SS, Bolognesi DP, In vivo antigenic modification of tumor cells. I. Introduction of murine leukemia virus antigens on non-virus-producing murine sarcomas. J Natl Cancer Inst 67:1(107-15)1981 Jul

6444277. Geier SS, Cresswell P, Monocytes as accessory cells in the human mixed lymphocyte response: lack of requirement at high cell densities. Cell Immunol 49:1(190-5)1980 Jan

145900. Geier SS, Cresswell P, Rabbit antiserum to human B-cell alloantigens. II. Mechanism of inhibition of stimulation in the mixed lymphocyte response. Cell Immunol 35:2(392-402)1978 Feb

139207. Geier SS, Cresswell P, Rabbit antisera to human B cell alloantigens: effects on the mixed lymphocyte response. Cell Immunol 28:2(341-54)1977 Feb

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