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Erhe Gao, MD, PhD


Erhe Gao, MD, PhD


Professor (Research)

Center for Translational Medicine

Telephone:  215-707-9435

Fax:  215-707-9890

Email: erhe.gao@temple.edu


Center for Translational Medicine


Educational Background:


MD, Second Military Medical University, Shanghai, China, 1983 (MD, ECFMG Certificate, Philadelphia, PA, 1999)


Internship, Shanghai Hospital, Second Military Medical University, Shanghai, China, 1981-1983


Residency, General Surgery, Nanfan Hospital, NanFang Medical University, Guangzhou, China, 1983-1985


Residency, General Surgery, Xuanwu Hospital, Capital University of Medical Science, Beijing, China, 1985-1988


Fellowship, Gastrointestinal Surgery, Xuanwu Hospital, Capital University of Medical Sciences, Beijing, China, 1988-1990


PhD, Drexel University College of Medicine, Philadelphia, PA, 1997


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professional affiliations:


  • Member, American Heart Association, 2001-present
  • Member, International Society for Heart Research (ISHR), 2011-present

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Research Interests:


Dr. Gao is a key investigator for several of Dr. Koch's federally funded research awards. He is primarily responsible for mouse, rat and rabbit physiology and gene delivery to rats, rabbits and pigs. He is responsible and extensively trained in cardiac physiology and cardiac surgery, specifically in rat and mouse models such as myocardial infarction.


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book chapters:


Cheung JY, Zhang X-Q, Song J, Gao E, Chan TO, Rabinowitz JE, Koch WJ, Feldman AM and Wang JF. Coordinated Regulation of Cardiac Na+/Ca2+ Exchanger and Na+-K+-ATPase by Phospholemman (FXYD1). Advances in Experimental Medicine and Biology by Springer-Verlag. In press. 2011.

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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

25239306. Lucas E, Jurado-Pueyo M, Fortuño MA, Fernández-Veledo S, Vila-Bedmar R, Jiménez-Borreguero LJ, Lazcano JJ, Gao E, Gómez-Ambrosi J, Frühbeck G, Koch WJ, Díez J, Mayor F Jr, Murga C, Downregulation of G protein-coupled receptor kinase 2 levels enhances cardiac insulin sensitivity and switches on cardioprotective gene expression patterns. Biochim Biophys Acta :()2014 Sep 18

25205804. Tilley DG, Zhu W, Myers VD, Barr LA, Gao E, Li X, Song J, Carter RL, Makarewich CA, Yu D, Troupes CD, Grisanti LA, Coleman RC, Koch WJ, Houser SR, Cheung JY, Feldman AM, ß-Adrenergic Receptor-Mediated Cardiac Contractility is Inhibited via Vasopressin Type 1A-Receptor-Dependent Signaling. Circulation :()2014 Sep 9

25126943. Ohm IK, Gao E, Belland Olsen M, Alfsnes K, Bliksøen M, Ogaard J, Ranheim T, Nymo SH, Holmen YD, Aukrust P, Yndestad A, Vinge LE, Toll-Like Receptor 9-Activation during Onset of Myocardial Ischemia Does Not Influence Infarct Extension. PLoS One 9:8(e104407)2014

25125302. Ahmad F, Lal H, Zhou J, Vagnozzi RJ, Yu JE, Shang X, Woodgett JR, Gao E, Force T, Cardiomyocyte-specific deletion of gsk3a mitigates post-myocardial infarction remodeling, contractile dysfunction, and heart failure. J Am Coll Cardiol 64:7(696-706)2014 Aug 19

25047165. Makarewich CA, Zhang H, Davis J, Correll RN, Trappanese DM, Hoffman NE, Troupes CD, Berretta RM, Kubo H, Madesh M, Chen X, Gao E, Molkentin JD, Houser SR, Transient receptor potential channels contribute to pathological structural and functional remodeling after myocardial infarction. Circ Res 115:6(567-80)2014 Aug 29

24899689. Lal H, Ahmad F, Zhou J, Yu JE, Vagnozzi RJ, Guo Y, Yu D, Tsai EJ, Woodgett J, Gao E, Force T, Cardiac fibroblast glycogen synthase kinase-3ß regulates ventricular remodeling and dysfunction in ischemic heart. Circulation 130:5(419-30)2014 Jul 29

24852843. Yan W, Zhang F, Zhang R, Zhang X, Wang Y, Zhou F, Xia Y, Liu P, Gao C, Wang H, Zhang L, Zhou J, Gao F, Gao E, Koch WJ, Wang H, Cheng H, Qu Y, Tao L, Adiponectin regulates SR Ca(2+) cycling following ischemia/reperfusion via sphingosine 1-phosphate-CaMKII signaling in mice. J Mol Cell Cardiol 74:(183-92)2014 Sep

24833748. Rohde D, Schön C, Boerries M, Didrihsone I, Ritterhoff J, Kubatzky KF, Völkers M, Herzog N, Mähler M, Tsoporis JN, Parker TG, Linke B, Giannitsis E, Gao E, Peppel K, Katus HA, Most P, S100A1 is released from ischemic cardiomyocytes and signals myocardial damage via Toll-like receptor 4. EMBO Mol Med 6:6(778-94)2014 May 15

24816261. Carbe CJ, Cheng L, Addya S, Gold JI, Gao E, Koch WJ, Riobo NA, Gi proteins mediate activation of the canonical hedgehog pathway in the myocardium. Am J Physiol Heart Circ Physiol 307:1(H66-72)2014 Jul 1

24718482. Duran JM, Makarewich CA, Trappanese D, Gross P, Husain S, Dunn J, Lal H, Sharp TE, Starosta T, Vagnozzi RJ, Berretta RM, Barbe M, Yu D, Gao E, Kubo H, Force T, Houser SR, Sorafenib cardiotoxicity increases mortality after myocardial infarction. Circ Res 114:11(1700-12)2014 May 23

24702056. Huang ZM, Gao E, Chuprun JK, Koch WJ, GRK2 in the Heart: A GPCR Kinase and Beyond. Antioxid Redox Signal :()2014 May 13

24587164. Turunen MP, Husso T, Musthafa H, Laidinen S, Dragneva G, Laham-Karam N, Honkanen S, Paakinaho A, Laakkonen JP, Gao E, Vihinen-Ranta M, Liimatainen T, Ylä-Herttuala S, Epigenetic upregulation of endogenous VEGF-A reduces myocardial infarct size in mice. PLoS One 9:2(e89979)2014

24486513. Wang J, Song J, Gao E, Zhang XQ, Gu T, Yu D, Koch WJ, Feldman AM, Cheung JY, Induced overexpression of phospholemman S68E mutant improves cardiac contractility and mortality after ischemia-reperfusion. Am J Physiol Heart Circ Physiol 306:7(H1066-77)2014 Apr 1

24397980. Wang Y, Wang X, Lau WB, Yuan Y, Booth D, Li JJ, Scalia R, Preston K, Gao E, Koch W, Ma XL, Adiponectin inhibits tumor necrosis factor-a-induced vascular inflammatory response via caveolin-mediated ceramidase recruitment and activation. Circ Res 114:5(792-805)2014 Feb 28

24174526. Islam KN, Bae JW, Gao E, Koch WJ, Regulation of nuclear factor ?B (NF-?B) in the nucleus of cardiomyocytes by G protein-coupled receptor kinase 5 (GRK5). J Biol Chem 288:50(35683-9)2013 Dec 13

24170934. Huang ZM, Gao E, Fonseca FV, Hayashi H, Shang X, Hoffman NE, Chuprun JK, Tian X, Tilley DG, Madesh M, Lefer DJ, Stamler JS, Koch WJ, Convergence of G protein-coupled receptor and S-nitrosylation signaling determines the outcome to cardiac ischemic injury. Sci Signal 6:299(ra95)2013 Oct 29

24132636. Vagnozzi RJ, Gatto GJ Jr, Kallander LS, Hoffman NE, Mallilankaraman K, Ballard VL, Lawhorn BG, Stoy P, Philp J, Graves AP, Naito Y, Lepore JJ, Gao E, Madesh M, Force T, Inhibition of the cardiomyocyte-specific kinase TNNI3K limits oxidative stress, injury, and adverse remodeling in the ischemic heart. Sci Transl Med 5:207(207ra141)2013 Oct 16

24058479. Fan Q, Huang ZM, Boucher M, Shang X, Zuo L, Brinks H, Lau WB, Zhang J, Chuprun JK, Gao E, Inhibition of Fas-associated death domain-containing protein (FADD) protects against myocardial ischemia/reperfusion injury in a heart failure mouse model. PLoS One 8:9(e73537)2013

24030395. Zhao J, Wang F, Zhang Y, Jiao L, Lau WB, Wang L, Liu B, Gao E, Koch WJ, Ma XL, Wang Y, Sevoflurane preconditioning attenuates myocardial ischemia/reperfusion injury via caveolin-3-dependent cyclooxygenase-2 inhibition. Circulation 128:11 Suppl 1(S121-9)2013 Sep 10

24030394. Sun Y, Yi W, Yuan Y, Lau WB, Yi D, Wang X, Wang Y, Su H, Wang X, Gao E, Koch WJ, Ma XL, C1q/tumor necrosis factor-related protein-9, a novel adipocyte-derived cytokine, attenuates adverse remodeling in the ischemic mouse heart via protein kinase A activation. Circulation 128:11 Suppl 1(S113-20)2013 Sep 10

24029943. Gao E, Koch WJ, A novel and efficient model of coronary artery ligation in the mouse. Methods Mol Biol 1037:(299-311)2013

23878371. Brailoiu GC, Benamar K, Arterburn JB, Gao E, Rabinowitz JE, Koch WJ, Brailoiu E, Aldosterone increases cardiac vagal tone via G protein-coupled oestrogen receptor activation. J Physiol 591:Pt 17(4223-35)2013 Sep 1

23805205. Fan Q, Chen M, Zuo L, Shang X, Huang MZ, Ciccarelli M, Raake P, Brinks H, Chuprun KJ, Dorn GW 2nd, Koch WJ, Gao E, Myocardial Ablation of G Protein-Coupled Receptor Kinase 2 (GRK2) Decreases Ischemia/Reperfusion Injury through an Anti-Intrinsic Apoptotic Pathway. PLoS One 8:6(e66234)2013

23549082. Zhou J, Freeman TA, Ahmad F, Shang X, Mangano E, Gao E, Farber J, Wang Y, Ma XL, Woodgett J, Vagnozzi RJ, Lal H, Force T, GSK-3a is a central regulator of age-related pathologies in mice. J Clin Invest 123:4(1821-32)2013 Apr 1

23472081. Gold JI, Martini JS, Hullmann J, Gao E, Chuprun JK, Lee L, Tilley DG, Rabinowitz JE, Bossuyt J, Bers DM, Koch WJ, Nuclear translocation of cardiac G protein-Coupled Receptor kinase 5 downstream of select Gq-activating hypertrophic ligands is a calmodulin-dependent process. PLoS One 8:3(e57324)2013

23465561. Wang Y, Zhao J, Zhang Y, Lau WB, Jiao LY, Liu B, Yuan Y, Wang X, Tao L, Gao E, Koch WJ, Ma XL, Differential regulation of TNF receptor 1 and receptor 2 in adiponectin expression following myocardial ischemia. Int J Cardiol 168:3(2201-6)2013 Oct 3

23376831. Miller BA, Wang J, Hirschler-Laszkiewicz I, Gao E, Song J, Zhang XQ, Koch WJ, Madesh M, Mallilankaraman K, Gu T, Chen SJ, Keefer K, Conrad K, Feldman AM, Cheung JY, The second member of transient receptor potential-melastatin channel family protects hearts from ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol 304:7(H1010-22)2013 Apr 1

23360826. Lau WB, Zhang Y, Zhao J, Liu B, Wang X, Yuan Y, Christopher TA, Lopez B, Gao E, Koch WJ, Ma XL, Wang Y, Lymphotoxin-a is a novel adiponectin expression suppressor following myocardial ischemia/reperfusion. Am J Physiol Endocrinol Metab 304:6(E661-7)2013 Mar 15

23273595. Wang J, Gao E, Chan TO, Zhang XQ, Song J, Shang X, Koch WJ, Feldman AM, Cheung JY, Induced overexpression of Na(+)/Ca(2+) exchanger does not aggravate myocardial dysfunction induced by transverse aortic constriction. J Card Fail 19:1(60-70)2013 Jan

23224879. Cheung JY, Zhang XQ, Song J, Gao E, Chan TO, Rabinowitz JE, Koch WJ, Feldman AM, Wang J, Coordinated regulation of cardiac Na(+)/Ca (2+) exchanger and Na (+)-K (+)-ATPase by phospholemman (FXYD1). Adv Exp Med Biol 961:(175-90)2013

23212557. Su H, Yuan Y, Wang XM, Lau WB, Wang Y, Wang X, Gao E, Koch WJ, Ma XL, Inhibition of CTRP9, a novel and cardiac-abundantly expressed cell survival molecule, by TNFa-initiated oxidative signaling contributes to exacerbated cardiac injury in diabetic mice. Basic Res Cardiol 108:1(315)2013 Jan

23104882. Zhang X, Szeto C, Gao E, Tang M, Jin J, Fu Q, Makarewich C, Ai X, Li Y, Tang A, Wang J, Gao H, Wang F, Ge XJ, Kunapuli SP, Zhou L, Zeng C, Xiang KY, Chen X, Cardiotoxic and cardioprotective features of chronic ß-adrenergic signaling. Circ Res 112:3(498-509)2013 Feb 1

22859683. Gold JI, Gao E, Shang X, Premont RT, Koch WJ, Determining the absolute requirement of G protein-coupled receptor kinase 5 for pathological cardiac hypertrophy: short communication. Circ Res 111:8(1048-53)2012 Sep 28

22792196. Hamad EA, Zhu W, Chan TO, Myers V, Gao E, Li X, Zhang J, Song J, Zhang XQ, Cheung JY, Koch W, Feldman AM, Cardioprotection of controlled and cardiac-specific over-expression of A(2A)-adenosine receptor in the pressure overload. PLoS One 7:7(e39919)2012

22751436. McClendon AK, Dean JL, Rivadeneira DB, Yu JE, Reed CA, Gao E, Farber JL, Force T, Koch WJ, Knudsen ES, CDK4/6 inhibition antagonizes the cytotoxic response to anthracycline therapy. Cell Cycle 11:14(2747-55)2012 Jul 15

22560293. Louboutin JP, Marusich E, Gao E, Agrawal L, Koch WJ, Strayer DS, Ethanol protects from injury due to ischemia and reperfusion by increasing vascularity via vascular endothelial growth factor. Alcohol 46:5(441-54)2012 Aug

22421363. Li J, Goossens S, van Hengel J, Gao E, Cheng L, Tyberghein K, Shang X, De Rycke R, van Roy F, Radice GL, Loss of aT-catenin alters the hybrid adhering junctions in the heart and leads to dilated cardiomyopathy and ventricular arrhythmia following acute ischemia. J Cell Sci 125:Pt 4(1058-67)2012 Feb 15

22302785. Zhang H, Makarewich CA, Kubo H, Wang W, Duran JM, Li Y, Berretta RM, Koch WJ, Chen X, Gao E, Valdivia HH, Houser SR, Hyperphosphorylation of the cardiac ryanodine receptor at serine 2808 is not involved in cardiac dysfunction after myocardial infarction. Circ Res 110:6(831-40)2012 Mar 16

22252313. Swope D, Cheng L, Gao E, Li J, Radice GL, Loss of cadherin-binding proteins ß-catenin and plakoglobin in the heart leads to gap junction remodeling and arrhythmogenesis. Mol Cell Biol 32:6(1056-67)2012 Mar

22179058. Zhu W, Petrashevskaya N, Ren S, Zhao A, Chakir K, Gao E, Chuprun JK, Wang Y, Talan M, Dorn GW 2nd, Lakatta EG, Koch WJ, Feldman AM, Xiao RP, Gi-biased ß2AR signaling links GRK2 upregulation to heart failure. Circ Res 110:2(265-74)2012 Jan 20

22100229. Tsuda T, Wu J, Gao E, Joyce J, Markova D, Dong H, Liu Y, Zhang H, Zou Y, Gao F, Miller T, Koch W, Ma X, Chu ML, Loss of fibulin-2 protects against progressive ventricular dysfunction after myocardial infarction. J Mol Cell Cardiol 52:1(273-82)2012 Jan

22086876. Lal H, Zhou J, Ahmad F, Zaka R, Vagnozzi RJ, Decaul M, Woodgett J, Gao E, Force T, Glycogen synthase kinase-3a limits ischemic injury, cardiac rupture, post-myocardial infarction remodeling and death. Circulation 125:1(65-75)2012 Jan 3

21890689. Li X, Mikhalkova D, Gao E, Zhang J, Myers V, Zincarelli C, Lei Y, Song J, Koch WJ, Peppel K, Cheung JY, Feldman AM, Chan TO, Myocardial injury after ischemia-reperfusion in mice deficient in Akt2 is associated with increased cardiac macrophage density. Am J Physiol Heart Circ Physiol 301:5(H1932-40)2011 Nov

21884509. Kerkelä R, Boucher M, Zaka R, Gao E, Harris D, Piuhola J, Song J, Serpi R, Woulfe KC, Cheung JY, O'Leary E, Bonventre JV, Force T, Cytosolic phospholipase A(2)a protects against ischemia/reperfusion injury in the heart. Clin Transl Sci 4:4(236-42)2011 Aug

21518983. Ciccarelli M, Chuprun JK, Rengo G, Gao E, Wei Z, Peroutka RJ, Gold JI, Gumpert A, Chen M, Otis NJ, Dorn GW 2nd, Trimarco B, Iaccarino G, Koch WJ, G protein-coupled receptor kinase 2 activity impairs cardiac glucose uptake and promotes insulin resistance after myocardial ischemia. Circulation 123:18(1953-62)2011 May 10

21193587. Wang J, Gao E, Rabinowitz J, Song J, Zhang XQ, Koch WJ, Tucker AL, Chan TO, Feldman AM, Cheung JY, Regulation of in vivo cardiac contractility by phospholemman: role of Na+/Ca2+ exchange. Am J Physiol Heart Circ Physiol 300:3(H859-68)2011 Mar

21091073. Yi W, Sun Y, Gao E, Wei X, Lau WB, Zheng Q, Wang Y, Yuan Y, Wang X, Tao L, Li R, Koch W, Ma XL, Reduced cardioprotective action of adiponectin in high-fat diet-induced type II diabetic mice and its underlying mechanisms. Antioxid Redox Signal 15:7(1779-88)2011 Oct 1

20966393. Gao E, Lei YH, Shang X, Huang ZM, Zuo L, Boucher M, Fan Q, Chuprun JK, Ma XL, Koch WJ, A novel and efficient model of coronary artery ligation and myocardial infarction in the mouse. Circ Res 107:12(1445-53)2010 Dec 10

20814022. Brinks H, Boucher M, Gao E, Chuprun JK, Pesant S, Raake PW, Huang ZM, Wang X, Qiu G, Gumpert A, Harris DM, Eckhart AD, Most P, Koch WJ, Level of G protein-coupled receptor kinase-2 determines myocardial ischemia/reperfusion injury via pro- and anti-apoptotic mechanisms. Circ Res 107:9(1140-9)2010 Oct 29

20718822. Cheung JY, Zhang XQ, Song J, Gao E, Rabinowitz JE, Chan TO, Wang J, Phospholemman: a novel cardiac stress protein. Clin Transl Sci 3:4(189-96)2010 Aug

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