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Crystal A. Gadegbeku, MD, FAHA


Crystal A. Gadegbeku, MD, FAHA


Section Chief, Nephrology, Hypertension and Kidney Transplantation

Associate Professor, Medicine

Co-Director, Center for Bioethics, Urban Health, and Policy

Telephone:  215-707-7937

FAX: 215-707-9697

Email: crystal.gadegbeku@tuhs.temple.edu


Department of Medicine, Section of Nephrology, Hypertension and Kidney Transplantation

Center for Bioethics, Urban Health, and Policy


Educational Background:



BA, Chemistry (minor in Music), Bucknell University, Lewisburg, PA


MD, University of Virginia School of Medicine, Charlottesville, VA


Internship and Residency, University of Virginia Hospital, Charlottesville, VA


Fellowship, University of Virginia Hospital, Charlottesville, VA

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clinical Interests:

  • Chronic kidney disease
  • Hypertension in chronic kidney disease
  • Pregnancy in chronic kidney disease
  • Assessment of renal function

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board certification(s):


  • Internal medicine
  • Nephrology

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professional affiliations:


  • American Society of Nephrology
  • International Society of Nephrology
  • American Heart Association - Council for High Blood Pressure Research
  • American Heart Association - Kidney Council
  • International Society of Hypertension in Blacks

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research interests:

  • Clinical investigation of defects in vascular biology associated with hypertension and accelerated vascular disease in patients with kidney disease. Currently, studies explore the role of vascular nitric oxide in regulating alpha-adrenergic vasoreactivity and the impact of nitric oxide system defects (associated with kidney disease) on adrenergic vascular responsiveness.
  • Translational investigation of kidney disease and kidney disease progression.
  • Investigation on recruitment and retention of diverse populations into cardiovascular/renal clinical research.

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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

25814173. Lee IJ, Hilliard BA, Ulas M, Yu D, Vangala C, Rao S, Lee J, Gadegbeku C, Cohen PL, Monocyte and plasma expression of TAM ligand and receptor in renal failure: Links to unregulated immunity and chronic inflammation. Clin Immunol :()2015 Mar 24

25354239. Spinale JM, Mariani LH, Kapoor S, Zhang J, Weyant R, Song PX, Wong HN, Troost JP, Gadegbeku CA, Gipson DS, Kretzler M, Nihalani D, Holzman LB, A reassessment of soluble urokinase-type plasminogen activator receptor in glomerular disease. Kidney Int 87:3(564-74)2015 Mar

24925724. Martini S, Nair V, Keller BJ, Eichinger F, Hawkins JJ, Randolph A, Böger CA, Gadegbeku CA, Fox CS, Cohen CD, Kretzler M, Integrative biology identifies shared transcriptional networks in CKD. J Am Soc Nephrol 25:11(2559-72)2014 Nov

24812423. Grunwald JE, Pistilli M, Ying GS, Daniel E, Maguire MG, Xie D, Whittock-Martin R, Parker Ostroff C, Lo JC, Townsend RR, Gadegbeku CA, Lash JP, Fink JC, Rahman M, Feldman HI, Kusek JW, Retinopathy and progression of CKD: The CRIC study. Clin J Am Soc Nephrol 9:7(1217-24)2014 Jul

24613295. Mariani LH, White MT, Shults J, Anderson CA, Feldman HI, Wolf M, Reese PP, Denburg MR, Townsend RR, Lo JC, Cappola AR, Carlow D, Gadegbeku CA, Steigerwalt S, Leonard MB, Increasing use of vitamin D supplementation in the chronic renal insufficiency cohort study. J Ren Nutr 24:3(186-93)2014 May

24306482. Mehta NN, Matthews GJ, Krishnamoorthy P, Shah R, McLaughlin C, Patel P, Budoff M, Chen J, Wolman M, Go A, He J, Kanetsky PA, Master SR, Rader DJ, Raj D, Gadegbeku CA, Shah R, Schreiber M, Fischer MJ, Townsend RR, Kusek J, Feldman HI, Foulkes AS, Reilly MP, Higher plasma CXCL12 levels predict incident myocardial infarction and death in chronic kidney disease: findings from the Chronic Renal Insufficiency Cohort study. Eur Heart J 35:31(2115-22)2014 Aug 14

24107579. Reese PP, Cappola AR, Shults J, Townsend RR, Gadegbeku CA, Anderson C, Baker JF, Carlow D, Sulik MJ, Lo JC, Go AS, Ky B, Mariani L, Feldman HI, Leonard MB, Physical performance and frailty in chronic kidney disease. Am J Nephrol 38:4(307-15)2013

23748358. Ky B, Shults J, Keane MG, Sutton MS, Wolf M, Feldman HI, Reese PP, Anderson CA, Townsend RR, Deo R, Lo J, Gadegbeku C, Carlow D, Sulik MJ, Leonard MB, FGF23 modifies the relationship between vitamin D and cardiac remodeling. Circ Heart Fail 6:4(817-24)2013 Jul

23727086. Ferguson JF, Matthews GJ, Townsend RR, Raj DS, Kanetsky PA, Budoff M, Fischer MJ, Rosas SE, Kanthety R, Rahman M, Master SR, Qasim A, Li M, Mehta NN, Shen H, Mitchell BD, O'Connell JR, Shuldiner AR, Ho WK, Young R, Rasheed A, Danesh J, He J, Kusek JW, Ojo AO, Flack J, Go AS, Gadegbeku CA, Wright JT Jr, Saleheen D, Feldman HI, Rader DJ, Foulkes AS, Reilly MP, Candidate gene association study of coronary artery calcification in chronic kidney disease: findings from the CRIC study (Chronic Renal Insufficiency Cohort). J Am Coll Cardiol 62:9(789-98)2013 Aug 27

23411431. Bansal N, Keane M, Delafontaine P, Dries D, Foster E, Gadegbeku CA, Go AS, Hamm LL, Kusek JW, Ojo AO, Rahman M, Tao K, Wright JT, Xie D, Hsu CY, A longitudinal study of left ventricular function and structure from CKD to ESRD: the CRIC study. Clin J Am Soc Nephrol 8:3(355-62)2013 Mar

23325076. Gadegbeku CA, Gipson DS, Holzman LB, Ojo AO, Song PX, Barisoni L, Sampson MG, Kopp JB, Lemley KV, Nelson PJ, Lienczewski CC, Adler SG, Appel GB, Cattran DC, Choi MJ, Contreras G, Dell KM, Fervenza FC, Gibson KL, Greenbaum LA, Hernandez JD, Hewitt SM, Hingorani SR, Hladunewich M, Hogan MC, Hogan SL, Kaskel FJ, Lieske JC, Meyers KE, Nachman PH, Nast CC, Neu AM, Reich HN, Sedor JR, Sethna CB, Trachtman H, Tuttle KR, Zhdanova O, Zilleruelo GE, Kretzler M, Design of the Nephrotic Syndrome Study Network (NEPTUNE) to evaluate primary glomerular nephropathy by a multidisciplinary approach. Kidney Int 83:4(749-56)2013 Apr

22980963. He J, Reilly M, Yang W, Chen J, Go AS, Lash JP, Rahman M, DeFilippi C, Gadegbeku C, Kanthety R, Tao K, Hamm LL, Ojo A, Townsend R, Budoff M, Risk factors for coronary artery calcium among patients with chronic kidney disease (from the Chronic Renal Insufficiency Cohort Study). Am J Cardiol 110:12(1735-41)2012 Dec 15

22965589. Grunwald JE, Alexander J, Ying GS, Maguire M, Daniel E, Whittock-Martin R, Parker C, McWilliams K, Lo JC, Go A, Townsend R, Gadegbeku CA, Lash JP, Fink JC, Rahman M, Feldman H, Kusek JW, Xie D, Jaar BG, Retinopathy and chronic kidney disease in the Chronic Renal Insufficiency Cohort (CRIC) study. Arch Ophthalmol 130:9(1136-44)2012 Sep

22907951. Lee IJ, Hilliard B, Swami A, Madara JC, Rao S, Patel T, Gaughan JP, Lee J, Gadegbeku CA, Choi ET, Cohen PL, Growth arrest-specific gene 6 (Gas6) levels are elevated in patients with chronic renal failure. Nephrol Dial Transplant 27:11(4166-72)2012 Nov

22516527. Grunwald JE, Ying GS, Maguire M, Pistilli M, Daniel E, Alexander J, Whittock-Martin R, Parker C, Mohler E, Lo JC, Townsend R, Gadegbeku CA, Lash JP, Fink JC, Rahman M, Feldman H, Kusek JW, Xie D, Coleman M, Keane MG, Association between retinopathy and cardiovascular disease in patients with chronic kidney disease (from the Chronic Renal Insufficiency Cohort [CRIC] Study). Am J Cardiol 110:2(246-53)2012 Jul 15

22402803. Hu B, Gadegbeku C, Lipkowitz MS, Rostand S, Lewis J, Wright JT, Appel LJ, Greene T, Gassman J, Astor BC, Kidney function can improve in patients with hypertensive CKD. J Am Soc Nephrol 23:4(706-13)2012 Apr

22082678. von Leitner EC, Klinke A, Atzler D, Slocum JL, Lund N, Kielstein JT, Maas R, Schmidt-Haupt R, Pekarova M, Hellwinkel O, Tsikas D, D'Alecy LG, Lau D, Willems S, Kubala L, Ehmke H, Meinertz T, Blankenberg S, Schwedhelm E, Gadegbeku CA, Böger RH, Baldus S, Sydow K, Pathogenic cycle between the endogenous nitric oxide synthase inhibitor asymmetrical dimethylarginine and the leukocyte-derived hemoprotein myeloperoxidase. Circulation 124:24(2735-45)2011 Dec 13

21985788. Faul C, Amaral AP, Oskouei B, Hu MC, Sloan A, Isakova T, Gutiérrez OM, Aguillon-Prada R, Lincoln J, Hare JM, Mundel P, Morales A, Scialla J, Fischer M, Soliman EZ, Chen J, Go AS, Rosas SE, Nessel L, Townsend RR, Feldman HI, St John Sutton M, Ojo A, Gadegbeku C, Di Marco GS, Reuter S, Kentrup D, Tiemann K, Brand M, Hill JA, Moe OW, Kuro-O M, Kusek JW, Keane MG, Wolf M, FGF23 induces left ventricular hypertrophy. J Clin Invest 121:11(4393-408)2011 Nov

21940840. Scialla JJ, Leonard MB, Townsend RR, Appel L, Wolf M, Budoff MJ, Chen J, Lustigova E, Gadegbeku CA, Glenn M, Hanish A, Raj D, Rosas SE, Seliger SL, Weir MR, Parekh RS, Correlates of osteoprotegerin and association with aortic pulse wave velocity in patients with chronic kidney disease. Clin J Am Soc Nephrol 6:11(2612-9)2011 Nov

21389978. Isakova T, Wahl P, Vargas GS, Gutiérrez OM, Scialla J, Xie H, Appleby D, Nessel L, Bellovich K, Chen J, Hamm L, Gadegbeku C, Horwitz E, Townsend RR, Anderson CA, Lash JP, Hsu CY, Leonard MB, Wolf M, Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease. Kidney Int 79:12(1370-8)2011 Jun

21088670. Griffin FC, Gadegbeku CA, Sowers MR, Vitamin D and subsequent systolic hypertension among women. Am J Hypertens 24:3(316-21)2011 Mar

20660819. Townsend RR, Chirinos JA, Parsa A, Weir MA, Sozio SM, Lash JP, Chen J, Steigerwalt SP, Go AS, Hsu CY, Rafey M, Wright JT Jr, Duckworth MJ, Gadegbeku CA, Joffe MP, Central pulse pressure in chronic kidney disease: a chronic renal insufficiency cohort ancillary study. Hypertension 56:3(518-24)2010 Sep

20299372. Grunwald JE, Alexander J, Maguire M, Whittock R, Parker C, McWilliams K, Lo JC, Townsend R, Gadegbeku CA, Lash JP, Fink JC, Rahman M, Feldman H, Kusek J, Ojo A, Prevalence of ocular fundus pathology in patients with chronic kidney disease. Clin J Am Soc Nephrol 5:5(867-73)2010 May

20019670. Townsend RR, Wimmer NJ, Chirinos JA, Parsa A, Weir M, Perumal K, Lash JP, Chen J, Steigerwalt SP, Flack J, Go AS, Rafey M, Rahman M, Sheridan A, Gadegbeku CA, Robinson NA, Joffe M, Aortic PWV in chronic kidney disease: a CRIC ancillary study. Am J Hypertens 23:3(282-9)2010 Mar

19779470. DeLoach SS, Appel LJ, Chen J, Joffe MM, Gadegbeku CA, Mohler ER 3rd, Parsa A, Perumal K, Rafey MA, Steigerwalt SP, Teal V, Townsend RR, Rosas SE, Aortic pulse pressure is associated with carotid IMT in chronic kidney disease: report from Chronic Renal Insufficiency Cohort. Am J Hypertens 22:12(1235-41)2009 Dec

19656160. Valiña-Tóth AL, Lai Z, Yoo W, Abou-Samra A, Gadegbeku CA, Flack JM, Relationship of vitamin D and parathyroid hormone with obesity and body composition in African Americans. Clin Endocrinol (Oxf) 72:5(595-603)2010 May

19541818. Lash JP, Go AS, Appel LJ, He J, Ojo A, Rahman M, Townsend RR, Xie D, Cifelli D, Cohan J, Fink JC, Fischer MJ, Gadegbeku C, Hamm LL, Kusek JW, Landis JR, Narva A, Robinson N, Teal V, Feldman HI, Chronic Renal Insufficiency Cohort (CRIC) Study: baseline characteristics and associations with kidney function. Clin J Am Soc Nephrol 4:8(1302-11)2009 Aug

19201919. Gadegbeku CA, Chertow GM, Cum hoc, ergo propter hoc: health disparities real and imagined. Clin J Am Soc Nephrol 4:2(251-3)2009 Feb

18976304. Luan FL, Steffick DE, Gadegbeku C, Norman SP, Wolfe R, Ojo AO, Graft and patient survival in kidney transplant recipients selected for de novo steroid-free maintenance immunosuppression. Am J Transplant 9:1(160-8)2009 Jan

18796436. Billecke SS, D'Alecy LG, Platel R, Whitesall SE, Jamerson KA, Perlman RL, Gadegbeku CA, Blood content of asymmetric dimethylarginine: new insights into its dysregulation in renal disease. Nephrol Dial Transplant 24:2(489-96)2009 Feb

18661408. Gbadegesin R, Kudelka T, Gadegbeku CA, Brophy P, Smoyer WE, Lin JJ, Arterial compliance in adolescents and young adults receiving chronic hemodialysis. Ren Fail 30:6(591-6)2008

18639652. Gadegbeku CA, Stillman PK, Huffman MD, Jackson JS, Kusek JW, Jamerson KA, Factors associated with enrollment of African Americans into a clinical trial: results from the African American study of kidney disease and hypertension. Contemp Clin Trials 29:6(837-42)2008 Nov

20409874. Gadegbeku CA, Dhandayuthapani A, Taylor TP, Shrayyef Z, Gerich J, Garvey WT, Egan BM, Insulin's actions on plasma free fatty acids are normal in patients with stage 2 to 3 chronic kidney disease. J Am Soc Hypertens 1:6(414-22)2007 Nov-Dec

16794488. Gadegbeku CA, Shrayyef MZ, Taylor TP, Egan BM, Mechanism of lipid enhancement of alpha1-adrenoceptor pressor sensitivity in hypertension. J Hypertens 24:7(1383-9)2006 Jul

16731290. Lash JP, Wang X, Greene T, Gadegbeku CA, Hall Y, Jones K, Kusek JW, Sika M, Unruh M, Quality of life in the African American Study of Kidney Disease and Hypertension: effects of blood pressure management. Am J Kidney Dis 47:6(956-64)2006 Jun

16129104. Gadegbeku CA, Lea JP, Jamerson KA, Update on disparities in the pathophysiology and management of hypertension: focus on African Americans. Med Clin North Am 89:5(921-33, 930)2005 Sep

16115844. Taylor TP, Wang W, Shrayyef MZ, Cheek D, Hutchison FN, Gadegbeku CA, Glomerular filtration rate can be accurately predicted using lean mass measured by dual-energy X-ray absorptiometry. Nephrol Dial Transplant 21:1(84-7)2006 Jan

15528942. Ullian ME, Gadegbeku CA, Effects of intravenously administered iron on systemic blood pressure in hemodialysis patients. Nephron Clin Pract 98:3(c83-6)2004

15332217. Gadegbeku CA, Shrayyef MZ, LaPorte FB, Egan BM, Lipids enhance alpha1-adrenoceptor pressor sensitivity in patients with chronic kidney disease. Am J Kidney Dis 44:3(446-54)2004 Sep

14553959. Gadegbeku CA, Shrayyef MZ, Ullian ME, Hemodynamic effects of chronic hemodialysis therapy assessed by pulse waveform analysis. Am J Hypertens 16:10(814-7)2003 Oct

12517686. Gadegbeku CA, Dhandayuthapani A, Shrayyef MZ, Egan BM, Hemodynamic effects of nicotinic acid infusion in normotensive and hypertensive subjects. Am J Hypertens 16:1(67-71)2003 Jan

12152912. Gadegbeku C, Freeman M, Agodoa L, Racial disparities in renal replacement therapy. J Natl Med Assoc 94:8 Suppl(45S-54S)2002 Aug

12074347. Gadegbeku CA, Dhandayuthapani A, Sadler ZE, Egan BM, Raising lipids acutely reduces baroreflex sensitivity. Am J Hypertens 15:6(479-85)2002 Jun

11641299. Haastrup A, Gadegbeku CA, Zhang D, Mukhin YV, Greene EL, Jaffa AA, Egan BM, Lipids stimulate the production of 6-keto-prostaglandin f(1alpha) in human dorsal hand veins. Hypertension 38:4(858-63)2001 Oct

11597040. Shaer AJ, Gadegbeku CA, Tsukamurella peritonitis associated with continuous ambulatory peritoneal dialysis. Clin Nephrol 56:3(241-6)2001 Sep

2117624. Vinores SA, McGehee R, Lee A, Gadegbeku C, Campochiaro PA, Ultrastructural localization of blood-retinal barrier breakdown in diabetic and galactosemic rats. J Histochem Cytochem 38:9(1341-52)1990 Sep

2193194. Vinores SA, Campochiaro PA, Lee A, McGehee R, Gadegbeku C, Green WR, Localization of blood-retinal barrier breakdown in human pathologic specimens by immunohistochemical staining for albumin. Lab Invest 62:6(742-50)1990 Jun

2916645. Vinores SA, Gadegbeku C, Campochiaro PA, Green WR, Immunohistochemical localization of blood-retinal barrier breakdown in human diabetics. Am J Pathol 134:2(231-5)1989 Feb

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