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Thomas L. Force, MD


Thomas L. Force, MD


Professor, Medicine

Professor, Center for Translational Medicine

Clinical Director, Center for Translational Medicine

Telephone:  215-707-9829

Fax: 215-707-9890

Email: thomas.force@temple.edu



Department of Medicine, Section of Cardiology

Center for Translational Medicine


Educational Background:


Undergraduate degree: Harvard College, Cambridge, MA, 1973


MD, Harvard Medical School, Boston, MA, 1978


Internship/Residency, Internal Medicine, University of Vermont, Burlington, VT, 1978-1981


Clinical Fellowship, Brigham & Women's Hospital, West Roxbury VA Medical Center, Boston, MA, 1981-1983


Research Fellowship, Brigham & Women's Hospital, Boston, MA, 1983-1984

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  • Internal Medicine
  • Cardiovascular Diseases

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  • President Elect, Heart Failure Society of America
  • Fellow, American Heart Association
  • International Society for Heart Research
  • European Society of Cardiology

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Research Interests:


Dr. Force’s lab focuses on the regulation of normal and stress-induced cardiomyocyte hypertrophy. Specifically, we study the signal transduction pathways that regulate growth responses, focusing on protein kinase cascades. Most recently, we have studied the role of glycogen synthase kinase-3beta, which is a potent negative regulator of growth, and its downstream targets, which include beta-catenin and its co-factors, the Tcf family of transcription factors, and the family of nuclear factors of activated T cells (NF-ATs), in hypertrophic growth. In addition, we study signaling mechanisms that regulate the response of the cell to ischemic injury. Making use of novel small molecule inhibitors, we have recently identified a novel mechanism by which the JNK family of stress-activated protein kinases regulate activity of the pro-survival kinase, Akt/PKB, and, via this mechanism, cardiomyocyte survival following ischemia/reperfusion.


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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

24754045. Meeting of the International Task Force for Disease Eradication, January 2014. Wkly Epidemiol Rec 89:15(153-60)2014 Apr 11

24753790. Bornschlögl T, Bassereau P, The sense is in the fingertips: The distal end controls filopodial mechanics and dynamics in response to external stimuli. Commun Integr Biol 6:6(e27341)2013 Nov 1

24753737. Choi SB, Kondaraju S, Sang Lee J, Study for optical manipulation of a surfactant-covered droplet using lattice Boltzmann method. Biomicrofluidics 8:2(024104)2014 Mar

24753736. Deng Y, Fan J, Zhou S, Zhou T, Wu J, Li Y, Liu Z, Xuan M, Wu Y, Euler force actuation mechanism for siphon valving in compact disk-like microfluidic chips. Biomicrofluidics 8:2(024101)2014 Mar

24753724. Charlot B, Bardin F, Sanchez N, Roux P, Teixeira S, Schwob E, Elongated unique DNA strand deposition on microstructured substrate by receding meniscus assembly and capillary force. Biomicrofluidics 8:1(014103)2014 Jan

24753722. Dubose J, Lu X, Patel S, Qian S, Woo Joo S, Xuan X, Microfluidic electrical sorting of particles based on shape in a spiral microchannel. Biomicrofluidics 8:1(014101)2014 Jan

24753633. Li S, Lin E, George Z, Terrill D, Mendez H, Santucci J, Yie D, Methods for characterizing magnetic footprints of perpendicular magnetic recording writer heads. J Appl Phys 115:17(17B733)2014 May 7

24753602. Takagi Y, Farrow RE, Billington N, Nagy A, Batters C, Yang Y, Sellers JR, Molloy JE, Myosin-10 produces its power-stroke in two phases and moves processively along a single actin filament under low load. Proc Natl Acad Sci U S A :()2014 Apr 21

24753601. Gremillion KJ, Barton L, Piperno DR, Particularism and the retreat from theory in the archaeology of agricultural origins. Proc Natl Acad Sci U S A :()2014 Apr 21

24753422. Sriram KK, Yeh JW, Lin YL, Chang YR, Chou CF, Direct optical mapping of transcription factor binding sites on field-stretched ?-DNA in nanofluidic devices. Nucleic Acids Res :()2014 Apr 21

24753321. Stankovic I, Krismer F, Jesic A, Antonini A, Benke T, Brown RG, Burn DJ, Holton JL, Kaufmann H, Kostic VS, Ling H, Meissner WG, Poewe W, Semnic M, Seppi K, Takeda A, Weintraub D, Wenning GK, Cognitive impairment in multiple system atrophy: A position statement by the neuropsychology task force of the MDS multiple system atrophy (MODIMSA) study group. Mov Disord :()2014 Apr 18

24753270. Wei C, Lazim R, Zhang D, Importance of polarization effect in the study of metalloproteins: Application of polarized protein specific charge scheme in predicting the reduction potential of azurin. Proteins :()2014 Apr 19

24753200. Song Y, Zhong D, Luo J, Tan H, Chen S, Li P, Wang L, Wang T, Binding characteristics and interactive region of 2-phenylpyrazolo[1,5-c]quinazoline with DNA. Luminescence :()2014 Apr 22

24752978. Savelyev A, Mackerell AD Jr, All-atom polarizable force field for DNA based on the classical drude oscillator model. J Comput Chem :()2014 Apr 18

24752893. Ohishi T, Muramatsu Y, Yoshida H, Seimiya H, TRF1 ensures the centromeric function of Aurora-B and proper chromosome segregation. Mol Cell Biol :()2014 Apr 21

24752890. Ellstrand NC, Is gene flow the most important evolutionary force in plants? Am J Bot :()2014 Apr 21

24752838. Choi KY, Jung E, Yun H, Yang YH, Kim BG, Engineering class I cytochrome P450 by gene fusion with NADPH-dependent reductase and S. avermitilis host development for daidzein biotransformation. Appl Microbiol Biotechnol :()2014 Apr 22

24752694. Banas A, Banas K, Breese MB, Loke J, Lim SK, Spectroscopic detection of exogenous materials in latent fingerprints treated with powders and lifted off with adhesive tapes. Anal Bioanal Chem :()2014 Apr 22

24752518. Bai B, Ma J, Wei J, Song J, Wang H, Li M, A simple structural hydrazide-based gelator as a fluoride ion colorimetric sensor. Org Biomol Chem :()2014 Apr 22

24752467. Maharaj D, Bhushan B, Nanomanipulation, nanotribology and nanomechanics of Au nanorods in dry and liquid environments using an AFM and depth sensing nanoindenter. Nanoscale :()2014 Apr 22

24752384. Ekesan S, Kale S, Herzfeld J, Transferable pseudoclassical electrons for aufbau of atomic ions. J Comput Chem :()2014 Apr 21

24752341. Tada M, Ishii-Watabe A, Suzuki T, Kawasaki N, Development of a Cell-Based Assay Measuring the Activation of Fc?RIIa for the Characterization of Therapeutic Monoclonal Antibodies. PLoS One 9:4(e95787)2014

24752228. Ruotsalainen I, Ahtiainen JP, Kidgell DJ, Avela J, Changes in corticospinal excitability during an acute bout of resistance exercise in the elbow flexors. Eur J Appl Physiol :()2014 Apr 22

24752027. Brown HF, Synopsis and Review of the American College of Cardiology Foundation/American Heart Association 2013 ST-Elevation Myocardial Infarction Guideline. AACN Adv Crit Care 25:2(142-50)2014 Apr-Jun

24751872. Smyth WF, Large-scale detection of repetitions. Philos Trans A Math Phys Eng Sci 372:2016(20130138)2014

24751742. Min KS, Oh SH, Park MH, Jeong J, Kim SJ, A Polymer-Based Multichannel Cochlear Electrode Array. Otol Neurotol :()2014 Apr 17

24751657. Finn HT, Brennan SL, Gonano BM, Knox MF, Ryan RC, Siegler JC, Marshall PW, Muscle activation does not increase after a fatigue plateau is reached during 8 sets of resistance exercise in trained individuals. J Strength Cond Res 28:5(1226-34)2014 May

24751539. Bays JL, Peng X, Tolbert CE, Guilluy C, Angell AE, Pan Y, Superfine R, Burridge K, Demali KA, Vinculin phosphorylation differentially regulates mechanotransduction at cell-cell and cell-matrix adhesions. J Cell Biol :()2014 Apr 21

24751289. Liu Y, Dong CF, Yang G, Liu J, Yao S, Li HY, Yuan J, Li S, Le X, Lin Y, Zeng W, Lin H, Zhang X, Chen X, Optimal linear combination of ARFI, transient elastography, and APRI for the assessment of fibrosis in chronic hepatitis B. Liver Int :()2014 Apr 21

24751264. Wang N, Wang X, Jia Y, Li X, Yu J, Ding B, Electrospun nanofibrous chitosan membranes modified with polyethyleneimine for formaldehyde detection. Carbohydr Polym 108:(192-9)2014 Aug 8

24751244. Junka K, Sundman O, Salmi J, Osterberg M, Laine J, Multilayers of cellulose derivatives and chitosan on nanofibrillated cellulose. Carbohydr Polym 108:(34-40)2014 Aug 8

24750971. Claassen CA, Pearson JL, Khodyakov D, Satow PM, Gebbia R, Berman AL, Reidenberg DJ, Feldman S, Molock S, Carras MC, Lento RM, Sherrill J, Pringle B, Dalal S, Insel TR, Reducing the Burden of Suicide in the U.S.: The Aspirational Research Goals of the National Action Alliance for Suicide Prevention Research Prioritization Task Force. Am J Prev Med :()2014 Apr 18

24750692. O'Shea TJ, Cryan PM, Cunningham AA, Fooks AR, Hayman DT, Luis AD, Peel AJ, Plowright RK, Wood JL, Bat flight and zoonotic viruses. Emerg Infect Dis 20:5(741-5)2014 May

24750669. Viallat A, Abkarian M, Red blood cell: from its mechanics to its motion in shear flow. Int J Lab Hematol 36:3(237-43)2014 Jun

24750563. Matsui H, Hiroma T, Hasegawa H, Ogiso Y, Decreased Granulomatous Reaction by Polyurethane Coated Stent in the Trachea. Pediatr Int :()2014 Apr 21

24750501. Zarowiecki M, Linton YM, Post RJ, Bangs MJ, Htun PT, Hlaing T, Seng CM, Baimai V, Ding TH, Sochantha T, Walton C, Repeated landmass reformation limits diversification in the widespread littoral zone mosquito Anopheles sundaicus sensu lato in the Indo-Oriental Region. Mol Ecol :()2014 Apr 21

24750182. Galli M, Cimolin V, Rigoldi C, Pau M, Costici P, Albertini G, The effects of low arched feet on foot rotation during gait in children with Down syndrome. J Intellect Disabil Res :()2013 Aug 19

24750134. Zhang Y, Zhou N, Li N, Sun M, Kim D, Fraden S, Epstein IR, Xu B, Giant Volume Change of Active Gels under Continuous Flow. J Am Chem Soc :()2014 Apr 21

24750083. Schmitt N, Ford JK, Frederick R. Wickert (1912-2013). Am Psychol 69:3(304)2014 Apr

24750082. Baker RR, Jule dewayne moravec (1933-2013). Am Psychol 69:3(303)2014 Apr

24750001. Wang Y, Lan F, Kang X, Shao Y, Li H, Li P, Wu W, Wang J, Chang D, Wang Y, Xia T, Outcome Study of Cobalt Based Stereotactic Body Radiation Therapy for Patients with Inoperable Stage III Non-small Cell Lung Cancer. Technol Cancer Res Treat :()2014 Apr 16

24749974. Kim WH, Son JY, Jang HM, Confinement of Ferroelectric Domain-Wall Motion at Artificially Formed Conducting-Nanofilaments in Epitaxial BiFeO3 Thin Films. ACS Appl Mater Interfaces :()2014 Apr 21

24749857. Petraco N, Commentary on: Crowder C, Rainwater CW, Fridie JS. Microscopic analysis of sharp force trauma in bone and cartilage: a validation study. J Forensic Sci 2013;58(5):1119-26. J Forensic Sci 59:3(871)2014 May

24749806. Nemeth CL, Janebodin K, Yuan AE, Dennis JE, Reyes M, Kim DH, Enhanced Chondrogenic Differentiation of Dental Pulp Stem Cells Using Nanopatterned PEG-GelMA-HA Hydrogels. Tissue Eng Part A :()2014 Apr 22

24749622. Moultos OA, Tsimpanogiannis IN, Panagiotopoulos AZ, Economou IG, Atomistic Molecular Dynamics Simulations of CO2 Diffusivity in H2O for a Wide Range of Temperatures and Pressures. J Phys Chem B :()2014 Apr 21

24749548. Kulkarni DD, Kim S, Chyasnavichyus M, Hu K, Fedorov AG, Tsukruk VV, Chemical Reduction of Individual Graphene Oxide Sheets as Revealed by Electrostatic Force Microscopy. J Am Chem Soc :()2014 Apr 22

24749399. Liu Y, Luo D, Liu S, Fu Y, Kou X, Wang X, Sha Y, Gan Y, Zhou Y, Effect of nanostructure of mineralized collagen scaffolds on their physical properties and osteogenic potential. J Biomed Nanotechnol 10:6(1049-60)2014 Jun

24749396. Yi S, Wang Y, Huang Y, Xia L, Sun L, Lenaghan SC, Zhang M, Tea nanoparticles for immunostimulation and chemo-drug delivery in cancer treatment. J Biomed Nanotechnol 10:6(1016-29)2014 Jun

24749246. [Irreversible chemical AFM-fishing for the detection of low-copied proteins]. Biomed Khim 60:1(28-50)2014 Jan-Feb

24748997. Latt WT, Chang TP, Di Marco A, Pratt P, Kwok KW, Clark J, Yang GZ, A Hand-held Instrument for in vivo Probe-based Confocal Laser Endomicroscopy during Minimally Invasive Surgery. Rep U S 2012:(1982-1987)2012 Oct 12

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