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Thomas L. Force, MD


Thomas L. Force, MD


Professor, Medicine

Professor, Center for Translational Medicine

Clinical Director, Center for Translational Medicine

Telephone:  215-707-9829

Fax: 215-707-9890

Email: thomas.force@temple.edu



Department of Medicine, Section of Cardiology

Center for Translational Medicine


Educational Background:


Undergraduate degree: Harvard College, Cambridge, MA, 1973


MD, Harvard Medical School, Boston, MA, 1978


Internship/Residency, Internal Medicine, University of Vermont, Burlington, VT, 1978-1981


Clinical Fellowship, Brigham & Women's Hospital, West Roxbury VA Medical Center, Boston, MA, 1981-1983


Research Fellowship, Brigham & Women's Hospital, Boston, MA, 1983-1984

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  • Internal Medicine
  • Cardiovascular Diseases

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  • President Elect, Heart Failure Society of America
  • Fellow, American Heart Association
  • International Society for Heart Research
  • European Society of Cardiology

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Research Interests:


Dr. Force’s lab focuses on the regulation of normal and stress-induced cardiomyocyte hypertrophy. Specifically, we study the signal transduction pathways that regulate growth responses, focusing on protein kinase cascades. Most recently, we have studied the role of glycogen synthase kinase-3beta, which is a potent negative regulator of growth, and its downstream targets, which include beta-catenin and its co-factors, the Tcf family of transcription factors, and the family of nuclear factors of activated T cells (NF-ATs), in hypertrophic growth. In addition, we study signaling mechanisms that regulate the response of the cell to ischemic injury. Making use of novel small molecule inhibitors, we have recently identified a novel mechanism by which the JNK family of stress-activated protein kinases regulate activity of the pro-survival kinase, Akt/PKB, and, via this mechanism, cardiomyocyte survival following ischemia/reperfusion.


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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

24738084. Davari A, Sadeghi M, Influence of different bonding agents and composite resins on fracture resistance of reattached incisal tooth fragment. J Dent (Shiraz) 15:1(6-14)2014 Mar

24738038. Garbuzenko OB, Mainelis G, Taratula O, Minko T, Inhalation treatment of lung cancer: the influence of composition, size and shape of nanocarriers on their lung accumulation and retention. Cancer Biol Med 11:1(44-55)2014 Mar

24738015. Fan LL, He XK, Han Y, Du L, Zhao L, Zhe J, Continuous size-based separation of microparticles in a microchannel with symmetric sharp corner structures. Biomicrofluidics 8:2(024108)2014 Mar

24737986. Kang D, Xu F, Hu XF, Dong B, Xiao Y, Xiao TQ, 3D Online Submicron Scale Observation of Mixed Metal Powder's Microstructure Evolution in High Temperature and Microwave Compound Fields. ScientificWorldJournal 2014:(684081)2014

24737920. Qi W, Li R, Ma T, Kirk Shung K, Zhou Q, Chen Z, Confocal acoustic radiation force optical coherence elastography using a ring ultrasonic transducer. Appl Phys Lett 104:12(123702)2014 Mar 24

24737776. Tanaka S, Harada K, Ida Y, Tomita K, Kato I, Arai F, Ueta T, Noda Y, Sugita N, Mitsuishi M, Quantitative assessment of manual and robotic microcannulation for eye surgery using new eye model. Int J Med Robot :()2014 Apr 16

24737756. Clark KP, Ryan LJ, Weyand PG, Foot speed, foot-strike and footwear:linking gait mechanics and running ground reaction forces. J Exp Biol :()2014 Apr 15

24737674. Wang Z, Ji A, Endlein T, Samuel D, Yao N, Wang Z, Dai Z, The role of fore- and hindlimbs during jumping in the Dybowski's frog (Rana dybowskii). J Exp Zool A Ecol Genet Physiol :()2014 Apr 15

24737601. Gwon HR, Chang ST, Choi CK, Jung JY, Kim JM, Lee SH, Development of a new contactless dielectrophoresis system for active particle manipulation using movable liquid electrodes. Electrophoresis :()2014 Apr 15

24737552. Pichler S, SICKNESS ABSENCE, MORAL HAZARD, AND THE BUSINESS CYCLE. Health Econ :()2014 Apr 16

24737048. Lin HM, Liu CL, Pan YN, Huang CH, Shih SL, Wei SH, Chen CS, Biomechanical analysis and design of a dynamic spinal fixator using topology optimization: a finite element analysis. Med Biol Eng Comput :()2014 Apr 16

24736976. Yang W, Yan Z, Hongjing Z, Dexiang L, Zengxun L, Xiaojing C, Yi L, Jichao J, Jintong L, Fang P, The Toxic Effect of Lithium Ion on Neurons (PC12 cells) and Aß42 Molecules. Biol Trace Elem Res :()2014 Apr 16

24736804. Liu W, Li Y, Feng S, Ning J, Wang J, Gou M, Chen H, Xu F, Du Y, Magnetically controllable 3D microtissues based on magnetic microcryogels. Lab Chip :()2014 Apr 15

24736773. Mosti MP, Carlsen T, Aas E, Hoff J, Stunes AK, Syversen U, Maximal strength training improves bone mineral density and neuromuscular performance in young adult women. J Strength Cond Res :()2014 Apr 14

24736772. Floría P, Gómez-Landero LA, Suárez-Arrones L, Harrison AJ, Kinetic and kinematic analysis for assessing the differences in counter-movement jump performance in Rugby players. J Strength Cond Res :()2014 Apr 14

24736688. Yang W, Chen B, Cui X, High-Resolution Mapping of Anthropogenic Heat in China from 1992 to 2010. Int J Environ Res Public Health 11:4(4066-4077)2014 Apr 14

24736650. Chang HW, Chieh HF, Lin CJ, Su FC, Tsai MJ, The Relationships between Foot Arch Volumes and Dynamic Plantar Pressure during Midstance of Walking in Preschool Children. PLoS One 9:4(e94535)2014

24736615. Renga B, Francisci D, Schiaroli E, Carino A, Cipriani S, D'Amore C, Sidoni A, Sordo RD, Ferri I, Lucattelli M, Lunghi B, Baldelli F, Fiorucci S, The HIV Matrix Protein p17 Promotes the Activation of Human Hepatic Stellate Cells through Interactions with CXCR2 and Syndecan-2. PLoS One 9:4(e94798)2014

24736166. Chen YF, Zhou D, Metzger T, Gallup M, Jeanne M, Gould DB, Anderson MS, McNamara NA, Spontaneous Development of Autoimmune Uveitis is CCR2 Dependent. Am J Pathol :()2014 Apr 12

24736106. Feller T, Kellermayer MS, Kiss B, Nano-thrombelastography of fibrin during blood plasma clotting. J Struct Biol :()2014 Apr 12

24735876. Watanabe S, Goshima G, Friction on MAP Determines Its Traveling Direction on Microtubules. Dev Cell 29:1(5-6)2014 Apr 14

24735830. Yang X, Rodriguez M, Pabon L, Fischer KA, Reinecke H, Regnier M, Sniadecki NJ, Ruohola-Baker H, Murry CE, Tri-iodo-L-thyronine Promotes the Maturation of Human Cardiomyocytes-Derived from Induced Pluripotent Stem Cells. J Mol Cell Cardiol :()2014 Apr 12

24735465. Ploscariu N, Kuczera K, Malek KE, Wawrzyniuk M, Dey A, Szoszkiewicz R, Single Molecule Studies of Force-Induced S2 Site Exposure in the Mammalian Notch Negative Regulatory Domain. J Phys Chem B :()2014 Apr 15

24735315. Huš M, Urbic T, The hydrophobic effect in a simple isotropic water-like model: Monte Carlo study. J Chem Phys 140:14(144904)2014 Apr 14

24735300. Palumbo M, Fries SG, Pasturel A, Alfè D, Anharmonicity, mechanical instability, and thermodynamic properties of the Cr-Re s-phase. J Chem Phys 140:14(144502)2014 Apr 14

24735236. Ram K, Re-activating modern traditions of justice: mobilising around health in rural Tamil Nadu, South India. Cult Health Sex :(1-13)2014 Apr 16

24735222. Wang Q, Li JH, Liu JB, Liu BX, Favored Composition Design and Atomic Structure Characterization for Ternary Al-Cu-Y Metallic Glasses via Proposed Interatomic Potential. J Phys Chem B :()2014 Apr 15

24735125. Larsen ST, Andersen NK, Søgaard E, Taboryski R, Structure irregularity impedes drop roll-off at superhydrophobic surfaces. Langmuir :()2014 Apr 15

24735094. Miller T, Teplyakov AV, Attachment Chemistry of PCBM to Primary Amine-Terminated Organic Monolayer on a Si(111) Surface. Langmuir :()2014 Apr 15

24735074. Davis AK, Attarha B, Piefke TJ, Measuring the Strength of the Horned Passalus Beetle, Odontotaenius disjunctus: Revisiting an Old Topic with Modern Technology. J Insect Sci 13:107(1-11)2013 Oct

24735066. Montes Ruiz-Cabello FJ, Trefalt G, Maroni P, Borkovec M, Accurate Predictions of Forces in the Presence of Multivalent Ions by Poisson-Boltzmann Theory. Langmuir :()2014 Apr 15

24734971. Finneran A, O'Sullivan L, Self-selected duty cycle times for grip force, wrist flexion postures and three grip types. Ergonomics 57:4(589-601)2014 Apr

24734946. Marie J, Kovacs D, Pain C, Jouary T, Cota C, Vergier B, Picardo M, Taieb A, Ezzedine K, Cario-André M, Inflammasome activation and vitiligo/nonsegmental vitiligo progression. Br J Dermatol 170:4(816-23)2014 Apr

24734900. Malucelli E, Iotti S, Gianoncelli A, Fratini M, Merolle L, Notargiacomo A, Marraccini C, Sargenti A, Cappadone C, Farruggia G, Bukreeva I, Lombardo M, Trombini C, Maier J, Lagomarsino S, Quantitative Chemical Imaging of the intracellular spatial distribution of fundamental elements and light metals in single cells. Anal Chem :()2014 Apr 15

24734884. Marušic U, Meeusen R, Pišot R, Kavcic V, The brain in micro- and hypergravity: The effects of changing gravity on the brain electrocortical activity. Eur J Sport Sci :(1-10)2014 Apr 15

24734785. Purcell S, Wang YJ, Seo HS, Enzyme-Modified Starch as an Oil Delivery System for Bake-Only Chicken Nuggets. J Food Sci :()2014 Apr 15

24734744. Vijayakumar GN, Electrical and optical characterization of copper oxide/calcium oxide nanocomposite fibers. J Nanosci Nanotechnol 14:4(3117-22)2014 Apr

24734739. Li H, Ding W, Shi Q, Li Y, Zhang P, Feng C, Xia H, Synthesis of polyaniline-coated carbon nanotubes and study on their pH-sensitive conductivity. J Nanosci Nanotechnol 14:4(3087-94)2014 Apr

24734738. Hibino M, Nakano-Nishida T, Chemical force microscopy using functionalized ZnO whisker probe tips. J Nanosci Nanotechnol 14:4(3080-6)2014 Apr

24734729. Kim D, Sawada T, Zhi C, Bando Y, Golberg D, Serizawa T, Dispersion of boron nitride nanotubes in aqueous solution by simple aromatic molecules. J Nanosci Nanotechnol 14:4(3028-33)2014 Apr

24734728. Behura SK, Mahala P, Nayak S, Yang Q, Mukhopadhyay I, Janil O, Fabrication of bi-layer graphene and theoretical simulation for its possible application in thin film solar cell. J Nanosci Nanotechnol 14:4(3022-7)2014 Apr

24734726. Zhang Y, Shi R, Yang P, Synthesis of Ag nanoparticles with tunable sizes using N,N-dimethyl formamide. J Nanosci Nanotechnol 14:4(3011-6)2014 Apr

24734721. Oh HJ, Park SJ, Lim JY, Cho NK, Song JD, Lee W, Lee YJ, Myoung JM, Choi WJ, Fabrication of GaAs/Al0.3Ga0.7As multiple quantum well nanostructures on (100) si substrate using a 1-nm InAs relief layer. J Nanosci Nanotechnol 14:4(2984-9)2014 Apr

24734661. Kleiman A, Lamas DG, Craievich AF, Márquez A, X-ray reflectivity analysis of titanium dioxide thin films grown by cathodic arc deposition. J Nanosci Nanotechnol 14:5(3902-9)2014 May

24734611. Kim TH, Yilmaz C, Somu S, Busnaina A, 3-D perpendicular assembly of single walled carbon nanotubes for complimentary metal oxide semiconductor interconnects. J Nanosci Nanotechnol 14:5(3673-6)2014 May

24734608. Kim J, Shin S, Kim YH, Kim SI, Electrical coating method of graphene oxide. J Nanosci Nanotechnol 14:5(3658-60)2014 May

24734595. Fan X, Zhao S, Yue C, Yang Q, Gong W, Chen Y, Wang H, Jia Q, Xu Z, Xu X, 1,8-Diiodooctane as the processing additive to improve the efficiency of P3HT:PC61BM solar cells. J Nanosci Nanotechnol 14:5(3592-6)2014 May

24734561. Wang W, He D, Zhang X, Duan J, Wu H, Xu H, Wang Y, Synthesis of gold nanoparticles with graphene oxide. J Nanosci Nanotechnol 14:5(3412-6)2014 May

24734557. Fradetal L, Stambouli V, Bano E, Pelissier B, Choi JH, Ollivier M, Latu-Romain L, Boudou T, Pignot-Paintrand I, Bio-functionalization of silicon carbide nanostructures for SiC nanowire-based sensors realization. J Nanosci Nanotechnol 14:5(3391-7)2014 May

24734517. Dulinska-Molak I, Mao H, Kawazoe N, Chen G, Variation of mechanical property of single-walled carbon nanotubes-treated cells explored by atomic force microscopy. J Biomed Nanotechnol 10:4(651-9)2014 Apr

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