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David W. Essex, MD


David W. Essex, MD


Professor, Medicine

Professor, Sol Sherry Thrombosis Research Center

Telephone:  215-707-6356

Fax:  215-707-2783

Email: david.essex@temple.edu


Department of Medicine, Section of Hematology

Sol Sherry Thrombosis Research Center


Educational Background:


BS, Rutgers University, Piscataway, NJ, 1980


MD, Rutgers (Robert Wood Johnson) Medical School, Piscataway, NJ, 1984


Internship, University of Medicine and Dentistry of New Jersey, Newark, NJ, 1984-1985


Residency, University of Medicine and Dentistry of New Jersey, Newark, NJ, 1985-1987


Fellowship, Hematology, Mount Sinai Medical Center, Manhattan, NY, 1987-1989


Research Fellowship, Cardeza Center for Hematologic Research, Jefferson Medical College, Philadelphia, PA, 1989-1991


Fellowship, Oncology, State University of New York Health Science Center at Brooklyn, NY, 1991-1992


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clinical Interests:

  • General hematology
  • Hemostasis and thrombosis

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board certifications:


  • Internal Medicine, 1987
  • Hematology, 2000-2010

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professional affiliations:

  • American Society of Hematology
  • American Heart Association

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Research Interests:


Our overall goal is to examine the role of reactions involving thiols and disulfides, and protein disulfide isomerase in hemostasis, atherosclerosis and wound healing. More specifically, to define the role of thiol-disulfide reactions and platelet protein disulfide isomerases in integrin activation and platelet function. A related project is to characterize a transmembrane electron transport system on the platelet surface that reduces disulfide bonds in platelet surface proteins. A final goal is to characterize oxidative modifications of thiols in conditions associated with oxidative stress.


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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

26529254. Zhou J, Wu Y, Wang L, Rauova L, Hayes VM, Poncz M, Essex DW, The C-terminal CGHC motif of protein disulfide isomerase supports thrombosis. J Clin Invest 2015:()2015 Nov 3

25156521. Zhou J, Wu Y, Wang L, Rauova L, Hayes VM, Poncz M, Essex DW, The disulfide isomerase ERp57 is required for fibrin deposition in vivo. J Thromb Haemost 12:11(1890-7)2014 Nov

24030382. Wang L, Wu Y, Zhou J, Ahmad SS, Mutus B, Garbi N, Hńmmerling G, Liu J, Essex DW, Platelet-derived ERp57 mediates platelet incorporation into a growing thrombus by regulation of the aIIb▀3 integrin. Blood 122:22(3642-50)2013 Nov 21

22207737. Wu Y, Ahmad SS, Zhou J, Wang L, Cully MP, Essex DW, The disulfide isomerase ERp57 mediates platelet aggregation, hemostasis, and thrombosis. Blood 119:7(1737-46)2012 Feb 16

21645227. Manickam N, Ahmad SS, Essex DW, Vicinal thiols are required for activation of the aIIb▀3 platelet integrin. J Thromb Haemost 9:6(1207-15)2011 Jun

19061441. Essex DW, Redox control of platelet function. Antioxid Redox Signal 11:5(1191-225)2009 May

18989530. Ball C, Vijayan KV, Nguyen T, Anthony K, Bray PF, Essex DW, Dong JF, Glutathione regulates integrin alpha(IIb)beta(3)-mediated cell adhesion under flow conditions. Thromb Haemost 100:5(857-63)2008 Nov

18537975. Manickam N, Sun X, Hakala KW, Weintraub ST, Essex DW, Thiols in the alphaIIbbeta3 integrin are necessary for platelet aggregation. Br J Haematol 142:3(457-65)2008 Jul

18028487. Manickam N, Sun X, Li M, Gazitt Y, Essex DW, Protein disulphide isomerase in platelet function. Br J Haematol 140:2(223-9)2008 Jan

17073584. Essex DW, Li M, Redox modification of platelet glycoproteins. Curr Drug Targets 7:10(1233-41)2006 Oct

15242555. Essex DW, The role of thiols and disulfides in platelet function. Antioxid Redox Signal 6:4(736-46)2004 Aug

15142878. Essex DW, Li M, Feinman RD, Miller A, Platelet surface glutathione reductase-like activity. Blood 104:5(1383-5)2004 Sep 1

12791669. Lahav J, Wijnen EM, Hess O, Hamaia SW, Griffiths D, Makris M, Knight CG, Essex DW, Farndale RW, Enzymatically catalyzed disulfide exchange is required for platelet adhesion to collagen via integrin alpha2beta1. Blood 102:6(2085-92)2003 Sep 15

12515547. Essex DW, Li M, Redox control of platelet aggregation. Biochemistry 42:1(129-36)2003 Jan 14

11835012. O'Neill PA, Bluth M, Gloster ES, Wali D, Priovolos S, DiMaio TM, Essex DW, Catanese CA, Strauss RA, Successful use of recombinant activated factor VII for trauma-associated hemorrhage in a patient without preexisting coagulopathy. J Trauma 52:2(400-5)2002 Feb

11352743. Essex DW, Li M, Miller A, Feinman RD, Protein disulfide isomerase and sulfhydryl-dependent pathways in platelet activation. Biochemistry 40:20(6070-5)2001 May 22

10861819. Jin DK, Nowakowski M, Kramer M, Essex DW, Hyperviscosity syndrome secondary to a myeloma-associated IgG(1)kappa paraprotein strongly reactive against the HIV-1 p24 gag antigen. Am J Hematol 64:3(210-3)2000 Jul

10632467. Essex DW, Li M, A polyclonal antibody to protein disulfide isomerase induces platelet aggregation and secretion. Thromb Res 96:6(445-50)1999 Dec 15

10441134. Essex DW, Miller A, Swiatkowska M, Feinman RD, Protein disulfide isomerase catalyzes the formation of disulfide-linked complexes of vitronectin with thrombin-antithrombin. Biochemistry 38:32(10398-405)1999 Aug 10

10086777. Essex DW, Li M, Protein disulphide isomerase mediates platelet aggregation and secretion. Br J Haematol 104:3(448-54)1999 Mar

9882436. Milev Y, Essex DW, Protein disulfide isomerase catalyzes the formation of disulfide-linked complexes of thrombospondin-1 with thrombin-antithrombin III. Arch Biochem Biophys 361:1(120-6)1999 Jan 1

9690483. Wynn SS, Jin DK, Essex DW, Warfarin-induced skin necrosis occurring four days after discontinuation of warfarin. Haemostasis 27:5(246-50)1997 Sep-Oct

9550555. Allen J, Backstrom KR, Cooper JA, Cooper MC, Detwiler TC, Essex DW, Fritz RP, Means RT Jr, Meier PB, Pearlman SR, Roitman-Johnson B, Seligman PA, Measurement of soluble transferrin receptor in serum of healthy adults. Clin Chem 44:1(35-9)1998 Jan

9495376. Essex DW, Wynn SS, Jin DK, Late-onset warfarin-induced skin necrosis: case report and review of the literature. Am J Hematol 57:3(233-7)1998 Mar

9326233. Wu G, Essex DW, Meloni FJ, Takafuta T, Fujimura K, Konkle BA, Shapiro SS, Human endothelial cells in culture and in vivo express on their surface all four components of the glycoprotein Ib/IX/V complex. Blood 90:7(2660-9)1997 Oct 1

9209007. Essex DW, Jin DK, Bradley TP, Lactic acidosis secondary to severe anemia in a patient with paroxysmal nocturnal hemoglobinuria. Am J Hematol 55:2(110-1)1997 Jun

9129024. Huang EM, Detwiler TC, Milev Y, Essex DW, Thiol-disulfide isomerization in thrombospondin: effects of conformation and protein disulfide isomerase. Blood 89:9(3205-12)1997 May 1

7662965. Essex DW, Chen K, Swiatkowska M, Localization of protein disulfide isomerase to the external surface of the platelet plasma membrane. Blood 86:6(2168-73)1995 Sep 15

7502279. Chen K, Essex DW, Purification of secreted platelet protease nexin I. Thromb Res 79:5-6(527-9)1995 Sep 15

7794766. Chen K, Detwiler TC, Essex DW, Characterization of protein disulphide isomerase released from activated platelets. Br J Haematol 90:2(425-31)1995 Jun

8200976. Kelly MD, Essex DW, Shapiro SS, Meloni FJ, Druck T, Huebner K, Konkle BA, Complementary DNA cloning of the alternatively expressed endothelial cell glycoprotein Ib beta (GPIb beta) and localization of the GPIb beta gene to chromosome 22. J Clin Invest 93:6(2417-24)1994 Jun

1611082. Rajagopalan V, Essex DW, Shapiro SS, Konkle BA, Tumor necrosis factor-alpha modulation of glycoprotein Ib alpha expression in human endothelial and erythroleukemia cells. Blood 80:1(153-61)1992 Jul 1

7186847. Essex DW, Fox JA, Groom JM, The development, factor analysis, and revision of a client satisfaction form. Community Ment Health J 17:3(226-35)1981 Fall

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