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Nae Dun, PhDNae Dun, PhD

 

Professor, Pharmacology

Telephone:  215-707- 3498

FAX: 215-707-9890

Email: nae.dun@temple.edu

 

Department of Pharmacology

 

Educational Background:

 

B.Sc., University of Illinois 1969

 

Ph.D. Loyola University Chicago, 1975

 

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Research Interests:

 

Brain recording

 

The goal of our research program is to identify the neural substrate involved in the regulation of blood pressure and heart rate. Our current research focuses on the identification and characterization of novel ligands and receptors, and neural circuitry relevant to control of circulation.    

 

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PUBMED PUBLICATIONS :


Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

24567901. Marcelin G, Jo YH, Li X, Schwartz GJ, Zhang Y, Dun NJ, Lyu RM, Blouet C, Chang JK, Chua S Jr, Central action of FGF19 reduces hypothalamic AGRP/NPY neuron activity and improves glucose metabolism. Mol Metab 3:1(19-28)2014 Feb

23823979. Chan KH, Chen YH, Zhang Y, Wong YH, Dun NJ, Angiotensin-[1-12] interacts with angiotensin type I receptors. Neuropharmacology 81:(267-73)2014 Jun

23470775. Dun SL, Lyu RM, Chen YH, Chang JK, Luo JJ, Dun NJ, Irisin-immunoreactivity in neural and non-neural cells of the rodent. Neuroscience 240:(155-62)2013 Jun 14

23348787. Chu C, Huang X, Chen CT, Zhao Y, Luo JJ, Gray BD, Pak KY, Dun NJ, In vivo imaging of brain infarct with the novel fluorescent probe PSVue 794 in a rat middle cerebral artery occlusion-reperfusion model. Mol Imaging 12:1(8-16)2013 Jan-Feb

22858342. Deliu E, Brailoiu GC, Arterburn JB, Oprea TI, Benamar K, Dun NJ, Brailoiu E, Mechanisms of G protein-coupled estrogen receptor-mediated spinal nociception. J Pain 13:8(742-54)2012 Aug

22196236. Brailoiu GC, Deliu E, Hooper R, Dun NJ, Undieh AS, Adler MW, Benamar K, Brailoiu E, Agonist-selective effects of opioid receptor ligands on cytosolic calcium concentration in rat striatal neurons. Drug Alcohol Depend 123:1-3(277-81)2012 Jun 1

21126550. Inan S, Dun NJ, Cowan A, Investigation of gastrin-releasing peptide as a mediator for 5'-guanidinonaltrindole-induced compulsive scratching in mice. Peptides 32:2(286-92)2011 Feb

20086172. Ariazi EA, Brailoiu E, Yerrum S, Shupp HA, Slifker MJ, Cunliffe HE, Black MA, Donato AL, Arterburn JB, Oprea TI, Prossnitz ER, Dun NJ, Jordan VC, The G protein-coupled receptor GPR30 inhibits proliferation of estrogen receptor-positive breast cancer cells. Cancer Res 70:3(1184-94)2010 Feb 1

20056135. Dun SL, Brailoiu GC, Tica AA, Yang J, Chang JK, Brailoiu E, Dun NJ, Neuronostatin is co-expressed with somatostatin and mobilizes calcium in cultured rat hypothalamic neurons. Neuroscience 166:2(455-63)2010 Mar 17

19958820. Huang X, Yang J, Chang JK, Dun NJ, Amylin suppresses acetic acid-induced visceral pain and spinal c-fos expression in the mouse. Neuroscience 165:4(1429-38)2010 Feb 17

19940116. Brailoiu E, Hooper R, Cai X, Brailoiu GC, Keebler MV, Dun NJ, Marchant JS, Patel S, An ancestral deuterostome family of two-pore channels mediates nicotinic acid adenine dinucleotide phosphate-dependent calcium release from acidic organelles. J Biol Chem 285:5(2897-901)2010 Jan 29

19620632. Brailoiu E, Churamani D, Cai X, Schrlau MG, Brailoiu GC, Gao X, Hooper R, Boulware MJ, Dun NJ, Marchant JS, Patel S, Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling. J Cell Biol 186:2(201-9)2009 Jul 27

19549515. Inan S, Dun NJ, Cowan A, Inhibitory effect of lidocaine on pain and itch using formalin-induced nociception and 5'-guanidinonaltrindole-induced scratching models in mice: behavioral and neuroanatomical evidence. Eur J Pharmacol 616:1-3(141-6)2009 Aug 15

19524022. Inan S, Dun NJ, Cowan A, Nalfurafine prevents 5'-guanidinonaltrindole- and compound 48/80-induced spinal c-fos expression and attenuates 5'-guanidinonaltrindole-elicited scratching behavior in mice. Neuroscience 163:1(23-33)2009 Sep 29

19373968. Brailoiu E, Dun SL, Gao X, Brailoiu GC, Li JG, Luo JJ, Yang J, Chang JK, Liu-Chen LY, Dun NJ, C-peptide of preproinsulin-like peptide 7: localization in the rat brain and activity in vitro. Neuroscience 159:2(492-500)2009 Mar 17

19125412. Dun SL, Brailoiu GC, Gao X, Brailoiu E, Arterburn JB, Prossnitz ER, Oprea TI, Dun NJ, Expression of estrogen receptor GPR30 in the rat spinal cord and in autonomic and sensory ganglia. J Neurosci Res 87:7(1610-9)2009 May 15

19090786. Brailoiu GC, Brailoiu E, Parkesh R, Galione A, Churchill GC, Patel S, Dun NJ, NAADP-mediated channel 'chatter' in neurons of the rat medulla oblongata. Biochem J 419:1(91-7, 2 p following 97)2009 Apr 1

18752653. Gao X, Brailoiu GC, Brailoiu E, Dun SL, Yang J, Chang JK, Dun NJ, Copeptin immunoreactivity and calcium mobilisation in hypothalamic neurones of the rat. J Neuroendocrinol 20:11(1242-51)2008 Nov

18404520. Tuluc F, Bredetean O, Brailoiu E, Meshki J, Garcia A, Dun NJ, Kunapuli SP, The priming effect of extracellular UTP on human neutrophils: Role of calcium released from thapsigargin-sensitive intracellular stores. Purinergic Signal 1:4(359-68)2005 Dec

18375741. Ji R, Lee CM, Gonzales LW, Yang Y, Aksoy MO, Wang P, Brailoiu E, Dun N, Hurford MT, Kelsen SG, Human type II pneumocyte chemotactic responses to CXCR3 activation are mediated by splice variant A. Am J Physiol Lung Cell Mol Physiol 294:6(L1187-96)2008 Jun

18314227. Brailoiu E, Jiang X, Brailoiu GC, Yang J, Chang JK, Wang H, Dun NJ, State-dependent calcium mobilization by urotensin-II in cultured human endothelial cells. Peptides 29:5(721-6)2008 May

18164555. Brailoiu GC, Brailoiu E, Chang JK, Dun NJ, Excitatory effects of human immunodeficiency virus 1 Tat on cultured rat cerebral cortical neurons. Neuroscience 151:3(701-10)2008 Feb 6

17715404. Jiang X, Yang F, Brailoiu E, Jakubowski H, Dun NJ, Schafer AI, Yang X, Durante W, Wang H, Differential regulation of homocysteine transport in vascular endothelial and smooth muscle cells. Arterioscler Thromb Vasc Biol 27:9(1976-83)2007 Sep

17627999. Brailoiu GC, Dun SL, Brailoiu E, Inan S, Yang J, Chang JK, Dun NJ, Nesfatin-1: distribution and interaction with a G protein-coupled receptor in the rat brain. Endocrinology 148:10(5088-94)2007 Oct

17470522. Brailoiu E, Dun SL, Brailoiu GC, Mizuo K, Sklar LA, Oprea TI, Prossnitz ER, Dun NJ, Distribution and characterization of estrogen receptor G protein-coupled receptor 30 in the rat central nervous system. J Endocrinol 193:2(311-21)2007 May

17465030. Brailoiu GC, Dun SL, Mizuo K, Brailoiu E, Yang J, Chang JK, Dun NJ, Smooth muscle-associated protein 8: distribution and biological activity in the rat brain. J Neurosci Res 85:8(1789-96)2007 Jun

17187876. Dun SL, Brailoiu E, Hsieh WK, Lai CC, Yang J, Chang JK, Dun NJ, Expression and activity of cocaine- and amphetamine-regulated transcript peptide(1-39) in the rat. Regul Pept 140:1-2(47-54)2007 Apr 5

17088418. Dun SL, Brailoiu GC, Brailoiu E, Yang J, Chang JK, Dun NJ, Distribution and biological activity of obestatin in the rat. J Endocrinol 191:2(481-9)2006 Nov

16707193. Dun SL, Brailoiu GC, Yang J, Chang JK, Dun NJ, Cocaine- and amphetamine-regulated transcript peptide and sympatho-adrenal axis. Peptides 27:8(1949-55)2006 Aug

16650615. Wang Y, Dun SL, Huang P, Chen C, Chen Y, Unterwald EM, Dun NJ, Van Bockstaele EJ, Liu-Chen LY, Distribution and ultrastructural localization of GEC1 in the rat CNS. Neuroscience 140:4(1265-76)2006 Jul 21

16601133. Dun SL, Brailoiu E, Wang Y, Brailoiu GC, Liu-Chen LY, Yang J, Chang JK, Dun NJ, Insulin-like peptide 5: expression in the mouse brain and mobilization of calcium. Endocrinology 147:7(3243-8)2006 Jul

16595650. Brailoiu E, Churamani D, Pandey V, Brailoiu GC, Tuluc F, Patel S, Dun NJ, Messenger-specific role for nicotinic acid adenine dinucleotide phosphate in neuronal differentiation. J Biol Chem 281:23(15923-8)2006 Jun 9

16595370. Brailoiu E, Brailoiu GC, Mameli G, Dolei A, Sawaya BE, Dun NJ, Acute exposure to ethanol potentiates human immunodeficiency virus type 1 Tat-induced Ca(2+) overload and neuronal death in cultured rat cortical neurons. J Neurovirol 12:1(17-24)2006 Feb

16467404. Shahabuddin S, Ji R, Wang P, Brailoiu E, Dun N, Yang Y, Aksoy MO, Kelsen SG, CXCR3 chemokine receptor-induced chemotaxis in human airway epithelial cells: role of p38 MAPK and PI3K signaling pathways. Am J Physiol Cell Physiol 291:1(C34-9)2006 Jul

15910774. Dun SL, Brailoiu GC, Mizuo K, Yang J, Chang JK, Dun NJ, Neuropeptide B immunoreactivity in the central nervous system of the rat. Brain Res 1045:1-2(157-63)2005 May 31

15905175. Mifune M, Ohtsu H, Suzuki H, Nakashima H, Brailoiu E, Dun NJ, Frank GD, Inagami T, Higashiyama S, Thomas WG, Eckhart AD, Dempsey PJ, Eguchi S, G protein coupling and second messenger generation are indispensable for metalloprotease-dependent, heparin-binding epidermal growth factor shedding through angiotensin II type-1 receptor. J Biol Chem 280:28(26592-9)2005 Jul 15

15804440. Brailoiu GC, Dun SL, Yin D, Yang J, Chang JK, Dun NJ, Insulin-like 6 immunoreactivity in the mouse brain and testis. Brain Res 1040:1-2(187-90)2005 Apr 8

15680473. Scruggs P, Lai CC, Scruggs JE, Dun NJ, Cocaine- and amphetamine-regulated transcript peptide potentiates spinal glutamatergic sympathoexcitation in anesthetized rats. Regul Pept 127:1-3(79-85)2005 Apr 15

15593369. Brailoiu GC, Dun SL, Ohsawa M, Yin D, Yang J, Chang JK, Brailoiu E, Dun NJ, KiSS-1 expression and metastin-like immunoreactivity in the rat brain. J Comp Neurol 481:3(314-29)2005 Jan 17

15528210. Brailoiu E, Hoard JL, Filipeanu CM, Brailoiu GC, Dun SL, Patel S, Dun NJ, Nicotinic acid adenine dinucleotide phosphate potentiates neurite outgrowth. J Biol Chem 280:7(5646-50)2005 Feb 18

15234463. Brailoiu E, Hoard J, Brailoiu GC, Chi M, Godbolde R, Dun NJ, Ultra low concentrations of morphine increase neurite outgrowth in cultured rat spinal cord and cerebral cortical neurons. Neurosci Lett 365:1(10-3)2004 Jul 15

15177924. Scruggs P, Filipeanu CM, Yang J, Chang JK, Dun NJ, Interaction of ovokinin(2-7) with vascular bradykinin 2 receptors. Regul Pept 120:1-3(85-91)2004 Aug 15

14530213. Wu SY, Ohtubo Y, Brailoiu GC, Dun NJ, Effects of endomorphin on substantia gelatinosa neurons in rat spinal cord slices. Br J Pharmacol 140:6(1088-96)2003 Nov

12946555. Dun SL, Brailoiu GC, Yang J, Chang JK, Dun NJ, Neuropeptide W-immunoreactivity in the hypothalamus and pituitary of the rat. Neurosci Lett 349:2(71-4)2003 Oct 2

12941382. Brailoiu E, Miyamoto MD, Dun NJ, Inositol derivatives modulate spontaneous transmitter release at the frog neuromuscular junction. Neuropharmacology 45:5(691-701)2003 Oct

12933358. Scruggs P, Dun SL, Dun NJ, Cocaine- and amphetamine-regulated transcript peptide attenuates phenylephrine-induced bradycardia in anesthetized rats. Am J Physiol Regul Integr Comp Physiol 285:6(R1496-503)2003 Dec

12932856. Brailoiu GC, Dun SL, Chi M, Ohsawa M, Chang JK, Yang J, Dun NJ, Beacon/ubiquitin-like 5-immunoreactivity in the hypothalamus and pituitary of the mouse. Brain Res 984:1-2(215-23)2003 Sep 12

12761354. Brailoiu E, Dun NJ, Extra- and intracellular sphingosylphosphorylcholine promote spontaneous transmitter release from frog motor nerve endings. Mol Pharmacol 63:6(1430-6)2003 Jun

12749764. Brailoiu E, Patel S, Dun NJ, Modulation of spontaneous transmitter release from the frog neuromuscular junction by interacting intracellular Ca(2+) stores: critical role for nicotinic acid-adenine dinucleotide phosphate (NAADP). Biochem J 373:Pt 2(313-8)2003 Jul 15

12721114. Brailoiu E, Brailoiu GC, Miyamoto MD, Dun NJ, The vasoactive peptide urotensin II stimulates spontaneous release from frog motor nerve terminals. Br J Pharmacol 138:8(1580-8)2003 Apr

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