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Michael Denny, PhD

Assistant Professor, Medicine

Assistant Professor, Microbiology and Immunology

Telephone:  215-707-9509

Email: mfdenny@temple.edu

Department of Medicine, Section of Rheumatology

Department of Microbiology and Immunology

Temple Autoimmunity Center

B.S., Chemistry, Penn State University

 

PhD, Pharmacology and Toxicology, Michigan State University

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I am interested in abnormalities in cell development related to systemic lupus erythematosus.  My research focuses on a pool of abnormal neutrophils found in human lupus patients and their associations with disease manifestations.  In particular, I am investigating the mechanism mediating their development.

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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

21613614. Villanueva E, Yalavarthi S, Berthier CC, Hodgin JB, Khandpur R, Lin AM, Rubin CJ, Zhao W, Olsen SH, Klinker M, Shealy D, Denny MF, Plumas J, Chaperot L, Kretzler M, Bruce AT, Kaplan MJ, Netting neutrophils induce endothelial damage, infiltrate tissues, and expose immunostimulatory molecules in systemic lupus erythematosus. J Immunol 187:1(538-52)2011 Jul 1

20164424. Denny MF, Yalavarthi S, Zhao W, Thacker SG, Anderson M, Sandy AR, McCune WJ, Kaplan MJ, A distinct subset of proinflammatory neutrophils isolated from patients with systemic lupus erythematosus induces vascular damage and synthesizes type I IFNs. J Immunol 184:6(3284-97)2010 Mar 15

17638846. Denny MF, Thacker S, Mehta H, Somers EC, Dodick T, Barrat FJ, McCune WJ, Kaplan MJ, Interferon-alpha promotes abnormal vasculogenesis in lupus: a potential pathway for premature atherosclerosis. Blood 110:8(2907-15)2007 Oct 15

16455965. Denny MF, Chandaroy P, Killen PD, Caricchio R, Lewis EE, Richardson BC, Lee KD, Gavalchin J, Kaplan MJ, Accelerated macrophage apoptosis induces autoantibody formation and organ damage in systemic lupus erythematosus. J Immunol 176:4(2095-104)2006 Feb 15

11698443. Morgan MM, Labno CM, Van Seventer GA, Denny MF, Straus DB, Burkhardt JK, Superantigen-induced T cell:B cell conjugation is mediated by LFA-1 and requires signaling through Lck, but not ZAP-70. J Immunol 167:10(5708-18)2001 Nov 15

10648627. Denny MF, Patai B, Straus DB, Differential T-cell antigen receptor signaling mediated by the Src family kinases Lck and Fyn. Mol Cell Biol 20:4(1426-35)2000 Feb

10430626. Holdorf AD, Green JM, Levin SD, Denny MF, Straus DB, Link V, Changelian PS, Allen PM, Shaw AS, Proline residues in CD28 and the Src homology (SH)3 domain of Lck are required for T cell costimulation. J Exp Med 190:3(375-84)1999 Aug 2

9988764. Denny MF, Kaufman HC, Chan AC, Straus DB, The lck SH3 domain is required for activation of the mitogen-activated protein kinase pathway but not the initiation of T-cell antigen receptor signaling. J Biol Chem 274:8(5146-52)1999 Feb 19

8784818. Denny MF, Atchison WD, Mercurial-induced alterations in neuronal divalent cation homeostasis. Neurotoxicology 17:1(47-61)1996 Spring

8207443. Denny MF, Atchison WD, Methylmercury-induced elevations in intrasynaptosomal zinc concentrations: an 19F-NMR study. J Neurochem 63:1(383-6)1994 Jul

7692622. Denny MF, Hare MF, Atchison WD, Methylmercury alters intrasynaptosomal concentrations of endogenous polyvalent cations. Toxicol Appl Pharmacol 122:2(222-32)1993 Oct

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