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Raul A. Dela Cadena, MD

Assistant Dean, Recruitment and Retention

Associate Professor, Physiology

Associate Professor, Sol Sherry Thrombosis Research Center

Telephone:  215-707- 3595

Fax:  215-707-3597

Office: RAR Carlisle Street

Email: cadena@temple.edu

Department of Physiology

Sol Sherry Thrombosis Research Center

LaSalle School of Medicine, Mexico City, MX

1984, M.D .

 

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Role of Thrombospondin-1 on the Assembly of the Prothrombinase Complex on the Surface of Neutrophils, Monocytes and Fibroblasts (NIH-NCMHD 1R24MD001096-02).   The purpose of our studies is to determine the role of TSP-1 on the generation of thrombin and FXa on the membrane surface of cells playing a major role in the pathophysiology of rheumatoid arthritis.   Our laboratory has documented the ability of neutrophils and fibroblast to synthesize FV and to express it on their surface in a structural form equipped with cofactor activity and thus capable of supporting the generation of FXa and thrombin.   Our laboratory has developed a working hypothesis where TSP-1 interactions with FV and growth factors leads to angiogenesis, the hallmark of RA.   In order to test our working hypothesis our laboratory currently is engage in studies involving: a) cell lines grown in-vitro; b) an animal model of erosive arthritis; and c) clinical studies involving patients afflicted with rheumatoid arthritis.

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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

19485899. Rico MC, Rough JJ, Del Carpio-Cano FE, Kunapuli SP, Dela Cadena RA, The Axis of Thrombospondin-1, Transforming Growth Factor Beta and Connective Tissue Growth Factor: An Emerging Therapeutic Target in Rheumatoid Arthritis. Curr Vasc Pharmacol :()2010 Jan 1

18674744. Rico MC, Manns JM, Driban JB, Uknis AB, Kunapuli SP, Dela Cadena RA, Thrombospondin-1 and transforming growth factor beta are pro-inflammatory molecules in rheumatoid arthritis. Transl Res 152:2(95-8)2008 Aug

17219411. Rico MC, Castaneda JL, Manns JM, Uknis AB, Sainz IM, Safadi FF, Popoff SN, Dela Cadena RA, Amelioration of inflammation, angiogenesis and CTGF expression in an arthritis model by a TSP1-derived peptide treatment. J Cell Physiol 211:2(504-12)2007 May

16869004. Manns JM, Uknis AB, Rico MC, Agelan A, Castaneda J, Arango I, Barbe MF, Safadi FF, Popoff SN, DeLa Cadena RA, A peptide from thrombospondin 1 modulates experimental erosive arthritis by regulating connective tissue growth factor. Arthritis Rheum 54:8(2415-22)2006 Aug

16181989. Isordia-Salas I, Manns JM, Sainz I, Parekh H, DeLa Cadena RA, Thromsbospondin-1 binds to the heavy chain of elastase activated coagulation factor V (FVaHNE) and enhances thrombin generation on the surface of a promyelocytic cell line. Thromb Res 116:6(533-43)2005

16059911. Sainz IM, Isordia-Salas I, Castaneda JL, Agelan A, Liu B, DeLa Cadena RA, Pixley RA, Adam A, Sartor RB, Colman RW, Modulation of inflammation by kininogen deficiency in a rat model of inflammatory arthritis. Arthritis Rheum 52:8(2549-52)2005 Aug

15331420. Espinola RG, Uknis A, Sainz IM, Isordia-Salas I, Pixley R, DeLa Cadena R, Long W, Agelan A, Gaughan J, Adam A, Colman RW, A monoclonal antibody to high-molecular weight kininogen is therapeutic in a rodent model of reactive arthritis. Am J Pathol 165:3(969-76)2004 Sep

15001555. Sainz IM, Uknis AB, Isordia-Salas I, Dela Cadena RA, Pixley RA, Colman RW, Interactions between bradykinin (BK) and cell adhesion molecule (CAM) expression in peptidoglycan-polysaccharide (PG-PS)-induced arthritis. FASEB J 18:7(887-9)2004 May

11339503. Uknis AB, DeLa Cadena RA, Janardham R, Sartor RB, Whalley ET, Colman RW, Bradykinin receptor antagonists type 2 attenuate the inflammatory changes in peptidoglycan-induced acute arthritis in the Lewis rat. Inflamm Res 50:3(149-55)2001 Mar

11039850. Majluf-Cruz A, Manns JM, Uknis AB, Yang X, Colman RW, Harris RB, Frazier W, Lawler J, DeLa Cadena RA, Residues F16-G33 and A784-N823 within platelet thrombospondin-1 play a major role in binding human neutrophils: evaluation by two novel binding assays. J Lab Clin Med 136:4(292-302)2000 Oct

9926286. Colman RW, Sartor RB, Adam AA, DeLa Cadena RA, Stadnicki A, The plasma kallikrein-kinin system in sepsis, inflammatory arthritis, and enterocolitis. Clin Rev Allergy Immunol 16:4(365-84)1998 Winter

9798662. Kaplan R, DeLa Cadena RA, Mechanism of the coagulopathy associated with acute promyelocytic leukemia -clinical conference-. Am J Hematol 59:3(234-7)1998 Nov

9684796. DeLa Cadena RA, Majluf-Cruz A, Stadnicki A, Tropea M, Reda D, Agosti JM, Colman RW, Suffredini AF, Recombinant tumor necrosis factor receptor p75 fusion protein (TNFR:Fc) alters endotoxin-induced activation of the kinin, fibrinolytic, and coagulation systems in normal humans. Thromb Haemost 80:1(114-8)1998 Jul

9459346. DeLa Cadena RA, Kunapuli SP, Walz DA, Colman RW, Expression of thrombospondin 1 on the surface of activated platelets mediates their interaction with the heavy chains of human kininogens through Lys 244-Pro 254. Thromb Haemost 79:1(186-94)1998 Jan

9428707. Selim TE, Ghoneim HR, Uknis AB, Colman RW, DeLa Cadena RA, High-molecular-mass and low-molecular-mass kininogens block plasmin-induced platelet aggregation by forming a complex with kringle 5 of plasminogen/plasmin. Eur J Biochem 250:2(532-8)1997 Dec 1

9398817. Stadnicki A, Gonciarz M, Niewiarowski TJ, Hartleb J, Rudnicki M, Merrell NB, Dela Cadena RA, Colman RW, Activation of plasma contact and coagulation systems and neutrophils in the active phase of ulcerative colitis. Dig Dis Sci 42:11(2356-66)1997 Nov

9269768. Bradford HN, Dela Cadena RA, Kunapuli SP, Dong JF, Löpez JA, Colman RW, Human kininogens regulate thrombin binding to platelets through the glycoprotein Ib-IX-V complex. Blood 90:4(1508-15)1997 Aug 15

8856173. Stadnicki A, DeLa Cadena RA, Sartor RB, Kettner CA, Colman RW, The contact system in experimental enterocolitis. Immunopharmacology 33:1-3(314-6)1996 Jun

8856155. DeLa Cadena RA, Majluf-Cruz A, Stadnicki A, Agosti JM, Colman RW, Suffredini AF, Activation of the contact and fibrinolytic systems after intravenous administration of endotoxin to normal human volunteers: correlation with the cytokine profile. Immunopharmacology 33:1-3(231-7)1996 Jun

8626672. Kunapuli SP, Bradford HN, Jameson BA, DeLa Cadena RA, Rick L, Wassell RP, Colman RW, Thrombin-induced platelet aggregation is inhibited by the heptapeptide Leu271-Ala277 of domain 3 in the heavy chain of high molecular weight kininogen. J Biol Chem 271:19(11228-35)1996 May 10

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