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Prasun K. Datta, PhD

Assistant Professor, Neuroscience

Assistant Professor, Neurovirology

Location: Room 747 MERB

Telephone:  215-707-4938

Fax:  215-707-4888

Email: dattapk@temple.edu

Department of Neuroscience

Center for Neurovirology

PhD, Zoology, University of Calcutta, Calcutta, India

 

Postdoctoral Fellowship, Department of Pharmacology and Molecular Biology, Chicago Medical School, Chicago, IL

 

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• American Association of Advancement of Science
• International Society of Neurovirology
• Society on NeuroImmune Pharmacology
• International Complement Society

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Our research interest is in elucidating the regulation and role of the Complement system in NeuroAIDS. The complement system is one of the key players in the innate immune defense against pathogens. The complement system to-date is composed of more than 30 plasma proteins and glycoproteins, soluble or membrane-bound receptors and negative regulators. Complement activation during the innate immune response leads not only to the opsonization and lysis of the pathogen, but also in the generation of anaphylatoxins C3a and C5a which trigger a range of chemotactic and pro-inflammatory responses. Complement activation in excess can promote inflammation and tissue damage. Numerous studies in the last one and half decade have demonstrated that the complement system is activated by HIV and the system plays a significant role in HIV pathogenesis. C3 up-regulation has been demonstrated in brain of SIV-infected macaques and in mice model of HIV infection. However, the role of HIV induced cytokines such as IL-1ß and TNF-α and viral proteins such as Vpr and Nef in C3 gene regulation are unknown. Whether complement activation is injurious or protective is also a question for debate.

There are currently three projects that our efforts are focused on. The first project is on elucidating the mechanism of IL-1ß and TNF-α? and viral proteins such as Vpr and Nef mediated C3 regulation.

The second project is aimed at understanding the role of complement in neuronal survival. Our studies demonstrate that C3 may play a neuroprotective role.

The third project is to elucidate the role of substances of abuse such as opiates in the regulation of complement system in SIV macaque model of NeuroAIDS.

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Datta PK and Lianos EA. Role of Eicosanoids in Glomerular, Tubular and Vascular injury. In: Massry, SG, and Glassock, RJ. (Eds), Textbook of Nephrology, 4th Edition, 2000, Chapter 37, Part 4, William & Wilkins, Baltimore, MD.

Datta, PK and Lianos, EA. 2002. Regulation and role of Heme oxygenase-1 in glomerulonephritis. In: Heme Oxygenase in Biology and Medicine, Abraham, NG, Alam, J and Nath, KA. (Eds), Springer, pp 251-258.

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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

18247123. Maranto J, Rappaport J, Datta PK, Regulation of complement component C3 in astrocytes by IL-1beta and morphine. J Neuroimmune Pharmacol 3:1(43-51)2008 Mar

17002920. Datta PK, Lianos EA, Nitric oxide induces metallothionein-I gene expression in mesangial cells. Transl Res 148:4(180-7)2006 Oct

16978830. Datta PK, Rappaport J, HIV and complement: hijacking an immune defense. Biomed Pharmacother 60:9(561-8)2006 Nov

16636306. Datta PK, Sharma M, Duann P, Lianos EA, Effect of nitric oxide synthase inhibition on proteinuria in glomerular immune injury. Exp Biol Med (Maywood) 231:5(576-84)2006 May

16601358. Datta PK, Reddy S, Sharma M, Lianos EA, Differential nephron HO-1 expression following glomerular epithelial cell injury. Nephron Exp Nephrol 103:4(e131-8)2006

16503246. Datta PK, Duann P, Lianos EA, Long-term effect of heme oxygenase (HO)-1 induction in glomerular immune injury. J Lab Clin Med 147:3(150-5)2006 Mar

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