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Judith Daniels

Judith Daniels (Litvin), PhD

 

Associate Professor, Anatomy and Cell Biology

Associate Professor, Fels Institute for Cancer Research and Molecular Biology

Chair, Curriculum Committee

Ombudsperson, Temple University School of Medicine

Vice Chair of Education, Anatomy and Cell Biology

Telephone:  215-707-2070

Fax:  215-707-2966

Email: judith.litvin@temple.edu

 

Department of Anatomy and Cell Biology

Fels Institute for Cancer Research and Molecular Biology

Cardiovascular Research Center

 

Educational Background:

 

Queens College-CUNY, Flushing, NY

Biology, B.A, 1972-1976

 

Framingham State College, Framingham, MA

Nutrition, M.S., 1976-1979

 

University of North Carolina School of Public Health
Department of Nutrition, Chapel Hill, NC

Ph.D. Nutrition-Biochemistry, 1980-1983

(Thesis Advisor: Dr. Boyd Switzer)

The Pharmaco-kinetics of Ethanol Consumption During Pregnancy and the Biochemical Effects on Fetuses

 

University of Virginia Medical School, Charlottesville, VA

Department of Anatomy and Cell Biology

Post-doctoral Fellowship, 1984-1987

(Sponsor:  Dr. Mary Lou King)

The Role of Cell Surface Molecules during Gastrulation in Xenopus

 

University of Virginia, Charlottesville, VA

Department of Biology

Post-doctoral Fellowship

(Sponsor:  Dr. Irwin Konigsberg)

Control of myosin heavy chain isoform expression in the quail skeletal muscle system

 

Cornell University Medical School, New York City, NY

Department of Cell Biology and Anatomy

Post-doctoral Fellowship

(Sponsor:  Dr. David M. Bader)

Regulation of cardiac muscle-specific gene expression

 

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Research Interests:

 

Dr. Judith Litvin, Associate Professor in the Department of Anatomy and Cell Biology, is Chair of the Curriculum Committee, Vice Chair of Education in the Department of Anatomy and Cell Biology, Ombudsperson at Temple's School of Medicine, Educator at the Medical, Dental, Podiatry and Graduate levels and is nationally and internationally recognized as a cellular and molecular developmental biologist. Dr. Litvin has mentored students at the high school, college and graduate school levels. Many of her students have won regional and national prizes for their work performed in her laboratory. She has been a leader in the advancement of graduate education within her department and at the medical school, has organized a workshop for chairpersons and section-chiefs to promote and teach the importance of ‘mentorship’ and continues to work towards providing faculty with tools to promote progress and advancement.

 

Dr. Litvin is trained as a cellular and molecular developmental biologist. Her research initially focused on the study of grastrulation in Xenopus laevis and later on muscle develpment. First, on skeletal muscle development and later on cardiac or heart muscle development. She is recognized in the field of avian heart development, specifically for her studies and reports on the location of cardiac progenitor cells early in the developmental process. Recently, her interests have moved to the identifiaction of genes expressed early in heart development and their role(s) in pathologies in the adult heart. One such molecule is Periostin-Like-Factor. Interestingly, it is also expressed in bone as are many other recently identified molecules. Since the bone-heart connection is intruiging and a natural extension of her research interests she has started to examine the role of PLF in bone formation and disease.

 

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PUBMED PUBLICATIONS :


Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

24583543. Jain NX, Barr-Gillespie AE, Clark BD, Kietrys DM, Wade CK, Litvin J, Popoff SN, Barbe MF, Bone loss from high repetitive high force loading is prevented by ibuprofen treatment. J Musculoskelet Neuronal Interact 14:1(78-94)2014 Mar

24146092. Conway SJ, Izuhara K, Kudo Y, Litvin J, Markwald R, Ouyang G, Arron JR, Holweg CT, Kudo A, The role of periostin in tissue remodeling across health and disease. Cell Mol Life Sci 71:7(1279-88)2014 Apr

22675458. Abdelmagid SM, Barr AE, Rico M, Amin M, Litvin J, Popoff SN, Safadi FF, Barbe MF, Performance of repetitive tasks induces decreased grip strength and increased fibrogenic proteins in skeletal muscle: role of force and inflammation. PLoS One 7:5(e38359)2012

20715172. Contié S, Voorzanger-Rousselot N, Litvin J, Clézardin P, Garnero P, Increased expression and serum levels of the stromal cell-secreted protein periostin in breast cancer bone metastases. Int J Cancer 128:2(352-60)2011 Jan 15

20703083. Chawla R, Procknow JA, Tantravahi RV, Khurana JS, Litvin J, Reddy EP, Cooperativity of Cdk4R24C and Ras in melanoma development. Cell Cycle 9:16(3305-14)2010 Aug 15

20634902. Reddy HK, Graña X, Dhanasekaran DN, Litvin J, Reddy EP, Requirement of Cdk4 for v-Ha-ras-Induced Breast Tumorigenesis and Activation of the v-ras-Induced Senescence Program by the R24C Mutation. Genes Cancer 1:1(69-80)2010 Jan

20567965. Contié S, Voorzanger-Rousselot N, Litvin J, Bonnet N, Ferrari S, Clézardin P, Garnero P, Development of a new ELISA for serum periostin: evaluation of growth-related changes and bisphosphonate treatment in mice. Calcif Tissue Int 87:4(341-50)2010 Oct

19743505. Fedorczyk JM, Barr AE, Rani S, Gao HG, Amin M, Amin S, Litvin J, Barbe MF, Exposure-dependent increases in IL-1beta, substance P, CTGF, and tendinosis in flexor digitorum tendons with upper extremity repetitive strain injury. J Orthop Res 28:3(298-307)2010 Mar

19620321. Rani S, Barbe MF, Barr AE, Litvin J, Induction of periostin-like factor and periostin in forearm muscle, tendon, and nerve in an animal model of work-related musculoskeletal disorder. J Histochem Cytochem 57:11(1061-73)2009 Nov

19095091. Rani S, Barbe MF, Barr AE, Litvin J, Periostin-like-factor and Periostin in an animal model of work-related musculoskeletal disorder. Bone 44:3(502-12)2009 Mar

19006175. Zhu S, Barbe MF, Liu C, Hadjiargyrou M, Popoff SN, Rani S, Safadi FF, Litvin J, Periostin-like-factor in osteogenesis. J Cell Physiol 218:3(584-92)2009 Mar

18040074. Zhu S, Barbe MF, Amin N, Rani S, Popoff SN, Safadi FF, Litvin J, Immunolocalization of Periostin-like factor and Periostin during embryogenesis. J Histochem Cytochem 56:4(329-45)2008 Apr

17092992. Litvin J, Chen X, Keleman S, Zhu S, Autieri M, Expression and function of periostin-like factor in vascular smooth muscle cells. Am J Physiol Cell Physiol 292:5(C1672-80)2007 May

16414453. Litvin J, Blagg A, Mu A, Matiwala S, Montgomery M, Berretta R, Houser S, Margulies K, Periostin and periostin-like factor in the human heart: possible therapeutic targets. Cardiovasc Pathol 15:1(24-32)2006 Jan-Feb

16339779. Aksoy MO, Yang Y, Ji R, Reddy PJ, Shahabuddin S, Litvin J, Rogers TJ, Kelsen SG, CXCR3 surface expression in human airway epithelial cells: cell cycle dependence and effect on cell proliferation. Am J Physiol Lung Cell Mol Physiol 290:5(L909-18)2006 May

16288002. Reddy HK, Mettus RV, Rane SG, Graña X, Litvin J, Reddy EP, Cyclin-dependent kinase 4 expression is essential for neu-induced breast tumorigenesis. Cancer Res 65:22(10174-8)2005 Nov 15

16240445. Litvin J, Zhu S, Norris R, Markwald R, Periostin family of proteins: therapeutic targets for heart disease. Anat Rec A Discov Mol Cell Evol Biol 287:2(1205-12)2005 Dec

15258926. Litvin J, Selim AH, Montgomery MO, Lehmann K, Rico MC, Devlin H, Bednarik DP, Safadi FF, Expression and function of periostin-isoforms in bone. J Cell Biochem 92:5(1044-61)2004 Aug 1

15155273. Kelsen SG, Aksoy MO, Yang Y, Shahabuddin S, Litvin J, Safadi F, Rogers TJ, The chemokine receptor CXCR3 and its splice variant are expressed in human airway epithelial cells. Am J Physiol Lung Cell Mol Physiol 287:3(L584-91)2004 Sep

11814677. Redkar A, deRiel JK, Xu YS, Montgomery M, Patwardhan V, Litvin J, Characterization of cardiac muscle factor 1 sequence motifs: retinoblastoma protein binding and nuclear localization. Gene 282:1-2(53-64)2002 Jan 9

11493546. Redkar A, Montgomery M, Litvin J, Fate map of early avian cardiac progenitor cells. Development 128:12(2269-79)2001 Jun

10822265. Patwardhan V, Fernandez S, Montgomery M, Litvin J, The rostro-caudal position of cardiac myocytes affect their fate. Dev Dyn 218:1(123-35)2000 May

9689445. Montgomery MO, Jiao Y, Phillips SJ, Singh G, Xu J, Balsara R, Litvin J, Alterations in sheep fetal right ventricular tissue with induced hemodynamic pressure overload. Basic Res Cardiol 93:3(192-200)1998 Jun

9109487. Toscani A, Mettus RV, Coupland R, Simpkins H, Litvin J, Orth J, Hatton KS, Reddy EP, Arrest of spermatogenesis and defective breast development in mice lacking A-myb. Nature 386:6626(713-7)1997 Apr 17

9099875. Montgomery MO, Litvin J, The cardiac-muscle specific enhancer-promoter of slow/cardiac troponin C binds HMG-2. Gene 187:2(159-64)1997 Mar 18

8808690. Latham KE, Litvin J, Orth JM, Patel B, Mettus R, Reddy EP, Temporal patterns of A-myb and B-myb gene expression during testis development. Oncogene 13:6(1161-8)1996 Sep 19

8787752. Wei Y, Bader D, Litvin J, Identification of a novel cardiac-specific transcript critical for cardiac myocyte differentiation. Development 122:9(2779-89)1996 Sep

8084617. Mettus RV, Litvin J, Wali A, Toscani A, Latham K, Hatton K, Reddy EP, Murine A-myb: evidence for differential splicing and tissue-specific expression. Oncogene 9:10(3077-86)1994 Oct

8026637. Montgomery MO, Litvin J, Gonzalez-Sanchez A, Bader D, Staging of commitment and differentiation of avian cardiac myocytes. Dev Biol 164:1(63-71)1994 Jul

8462740. Litvin J, Montgomery MO, Goldhamer DJ, Emerson CP Jr, Bader DM, Identification of DNA-binding protein(s) in the developing heart. Dev Biol 156:2(409-17)1993 Apr

21239285. Litvin J, Montgomery M, Gonzalez-Sanchez A, Bisaha JG, Bader D, Commitment and differentiation of cardiac myocytes. Trends Cardiovasc Med 2:1(27-32)1992 Jan-Feb

2193766. Litvin J, Grant B, Davis L, King ML, Developmental expression of regionally specific cell surface antigens in the Xenopus gastrula. Dev Genet 11:1(110-22)1990

2480861. Merrifield PA, Sutherland WM, Litvin J, Konigsberg IR, Temporal and tissue-specific expression of myosin heavy chain isoforms in developing and adult avian muscle. Dev Genet 10:5(372-85)1989

3279863. Litvin J, Switzer BR, Pharmacokinetics of ethanol in the guinea pig. Alcohol Clin Exp Res 12:1(71-6)1988 Feb

3046909. Litvin J, King ML, Expression and segregation of nucleoplasmin during development in Xenopus. Development 102:1(9-21)1988 Jan

10281490. Litvin J, Rubenstein M, AMS performance management system "passes the test". Provider 13:4(44-5)1987 Apr

6803845. Metcalfe DD, Litvin J, Wasserman SI, The isolation, identification and characterization of sulfated glycosaminoglycans synthesized in vitro by human eosinophils. Biochim Biophys Acta 715:2(196-204)1982 Apr 13

6120159. Litvin JM, Cuttone JM, Metastatic carcinoma simulating Bell's palsy. IMJ Ill Med J 161:1(21-2)1982 Jan

7247179. Cuttone JM, Litvin J, McDonald JE, Carcinoma metastatic to an extraocular muscle. Ann Ophthalmol 13:2(213-6)1981 Feb

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Teaching:

 

Temple University School of Medicine

 

Medical Histology lectures on the Cardiovascular, Respiratory and Gastrointestinal Systems.


SERA/HCOP Remedial Histology for Medical Students.


Development and Function of the Musculoskeletal System. Lectures on ‘Development of Muscle’ and ‘Development of the Limb.’


Cell Structure and Function. Lectures on The Cardiovascular, Respiratory and Gastrointestinal Systems.


Cellular and Molecular Biology. Co-Director. Core Course


Molecular Physiology. Lectures on ‘Regulation of Transcription.’ Department of Physiology


Principles of Development. Lectures on the Regulation of Gastrulation in Amphibians and Birds, and Regulation of Muscle Development. 2004


Reading in Cell Biology. Course Director and Lecturer: A course to teach students to think critically and improve skills in both written and verbal presentations.


Seminars in Cell and Developmental Biology. Facilitator for Seminar Series

 

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Trainees:

 

Graduate Students Supervised  as Mentor

 

S. Zhu, “The Role of Periostin-Like-Factor in Osteoblast Differentiation and Bone Formation," 2003-2006.

 

S. Rani “The Function of Periostin-Like-Factor in Osteoblasts from Limbs Exposed to High Repitition High Force Activity," 2006- present.

 

A. Zabedin (co-advisor with Dr. Premkumar Reddy) “ The Role of Cdk4 in Vasculaogenesis and Cancer,” 2004- present.

 

Advisory Dissertation Committees

 

J. Song (Chair) “The Role of CTGF in Mesenchymal Condensation,” present.

 

S. Cinar“ The Role of Osteoactivin in Transdifferentiation of Mesenchymal Cells,” present.

 

Y. Lee“ Maternal Genes that Enhance  IVF," present.

 

J.  Arnott (Chair) “Connective Tissue Growth Factor is a Downstream Target of Transforming Growth Factor Beta 1 in Primary Rat Osteoblasts,”  2006.

 

M.E. Carlile (Chair)  “The Role of Lipid Rafts and Caveolae in Protease Activated Receptor-Induced Signaling,” 2006.

 

F. Francis (Chair) “Mechanisms of slow axonal transport,” 2006.

 

Ying Li (Member) “Vascular Occlusive Disease,”.2006.

 

O. Ogunkua “A Molecular and Bioinformatic Analysis of the Expression of Mouse Axonemal Dynein Heavy Chain 8,” 2003

 

J. Xu. (Chair) “Molecular and Cellular Basis of Aberrant Skeletal Development in Osteopetrosis,” 2000

 

A. Kumar“Role of c-myb and A-myb in growth, differentiation, apoptosis and transformation of myeloid and breast cancer cells,” 2001.

 

S. Roy (Chair) “Visualization of slow axonal transport in living neurons: Novel mechanisms of neurofilament transport,” 2001.

 

E.Foley  Did not complete research in neuroscience,.1997.

            

J. Wang  “Mechanisms for generating the microtubule array in growing dendrites,” 1996.

 

Y. Li “Microtubule Assembly During Axon Growth,” 1996.

 

D. Hermey“Co-Existence of Abnormalities in the Vitamin D-Endocrine and Skeletal Systems in Osteopetrosis,” 1995.

 

Minority, Undergraduate and High School Students Supervised as Mentor:

 

 

Sunny Kumar “Localization of PLF in Emphysema,” 2006-2007.

 

DaEun Im “Expression of Markers of Cardiac Myocyte Hypertrophy in Cells Over-expressing PLF,” 2004-2005.

 

Ludmilar Messidor “Generation of Adenovirus to Over-express PLF,” 2003-2005.

 

Laura Jones “The Effect of PLF over-expression by Adenovirus in Chick Embryonic Hearts,” 2002-2003.

 

Rabia Chaudry  “Immunolocalization of PLF in Chick Embryos,” 1999.

 

Abayomi Walker “Isolation of total protein from Chick Embryos at Different Stages of Development,” 1998-1999.

       

Rhonda Sessons “Immunostaining of Adult Hearts Under Pressure and/or Volume Overload with anti-CMF1,” 1998.

 

Sonalis Fernandez “Fate Mapping the Chick Embryonic Heart,” 1997.

 

Kali Gordon “Immunostaing Chick Hearts during Development with anti-MHC Antibodies,”  1995.

 

Nikki Sistrun  “Identification of Differentially Expressed mRNA during Heart Development,”  1995.

 

Mega Shah  “Localization of CMF1 during Chick Heart Development by Immunostaining,”  1995.

 

Jeannene Goodman “Identification of CMF1 during Heart Development by Western Blot Analysis,” 1993.

 

 

Post Doctoral Fellows Supervised:

 

Ahmed Elokda, MD., 2002-2004.

 

Abhay Redkar, Ph.D., 1997-2001.

 

Vidya Patwardhan, Ph.D., 1997-1999.

 

Yong-Sheng Xu, Ph.D., 1995-1997.

 

Yue Jiao, M.D., 1995-1996.

 

Gautam Singh, M.D. Pediatric Cardiology Fellow, St.Christopher’s Pediatric Department, l994 -1995.

 

Stacy Mazzacco, M.D.  Surgical Resident In collaboration with Dr. John White, 1995-1996.

 

Sherry Scovell, M.D. Surgical Resident In collaboration with Dr. John White, 1996-1997.

 

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