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John M. Daly, MD john daly, md


Harry C. Donahoo Professor of Surgery

Surgical Director, William Maul Measey Institute for Clinical Simulation and Patient Safety

Emeritus Dean, Temple University School of Medicine

Telephone:  215-707-8773

Email: johndaly@temple.edu



Department of Surgery, Division of Surgical Oncology

William Maul Measey Institute for Clinical Simulation and Patient Safety


Educational Background:


A.B. (cum laude), LaSalle University, Philadelphia, PA, 1969


MD, Temple University School of Medicine, Philadelphia, PA, 1973


Internship, Hermann Hospital, University of Texas at Houston


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clinical Interests:


Surgical Oncology


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board certification(s):

  • American Board of Surgery, 1978
  • Recertification, American Board of Surgery, 1988 and 1999

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professional affiliations:


  • Association for Cancer Research
  • American Cancer Society
  • American College of Surgeons
  • American Gastroenterological Society
  • American Institute of Nutrition
  • American Medical Association
  • American Society for Clinical Nutrition
  • American Society of Clinical Oncology
  • American Society for Parenteral and Enteral Nutrition, President 1985-86
  • American Surgical Association
  • Association for Academic Surgery
  • Association for Advancement of Science
  • College of Physicians, Philadelphia
  • Collegium Internationale Chirurgiae Digestivae
  • Eastern Surgical Society
  • Federation of American Societies for Experimental Biology and Medicine
  • International Society of Surgery
  • International Surgical Group
  • New York Cancer Society
  • New York Clinical Society
  • New York Surgical Society
  • Pennsylvania Oncologic Society
  • Philadelphia Academy of Surgery
  • Philadelphia College of Physicians
  • Society for Surgery of the Alimentary Tract
  • Society of Clinical Surgery
  • Society of Pelvic Surgeons
  • Society of Surgical Oncology
  • Society of University Surgeons
  • Surgical Biology Club III
  • Surgical Infection Society
  • William S. Halsted Surgical Society

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editorial boards (past and current):


  • Annals of Surgery
  • Journal of Bone and Soft Tissue Sarcomas
  • Journal of Critical Care Nutrition (JCCN)
  • Journal of Oncology
  • Journal of Parenteral and Enteral Nutrition
  • Journal of Surgical Research (1982-1988)
  • Journal of the American College of Surgeons
  • MVP Video Journal of General Surgery
  • Nutrition: An International Journal of Applied and Basic Nutritional Science
  • Oncology & Biotechnology News
  • Seminars in Surgical Oncology
  • Surgical Infections
  • Surgical Oncology
  • Associate Section Editor: Annals of Surgical Oncology, Raven Press, 1993-1999
  • Associate Editor: HPB (Hepatic, Pancreatic and Biliary) Surgery, Harwood
    Academic Publishers, 1994 to present
  • Associate Editor: Cancer, J. Wiley & Sons, Inc., 1996-1999
  • Editorial Board: Annals of Surgical Oncology, Raven Press, 1993-2000
  • Editorial Board: Surgery, Mosby, Inc., 1996-1999
  • Editorial Board: YourDoctor.com, YourDoctor, Inc., 2000
  • Editorial Board: New Surgery, Landes Bioscience, 2000-2003
  • Editorial Board: Contemporary Surgery, Dowden Publishing, 1996-present
  • Editorial Board: Current Cancer Therapy Reviews
  • Editorial Board: Yearbook of Surgery, 2002 - Present
  • Editorial Advisory Board: Cancer, J. Wiley & Sons, Inc., 1999-present
  • Editorial Advisory Board: The Cornell Illustrated Encyclopedia of Health, Time-Life, Inc. and The Reference Works, Inc., 2000-2002
  • Editor: Atlas of Surgical Oncology (Daly and Cady), J.B. Lippincott, 1993
  • Editor: Current Opinion in General Surgery Current Science, 1993-1994
  • Editor: Microspheres and Regional Cancer Therapy (Willmott and Daly),
    CRC Press, 1993
  • Editor: Essential Surgical Immunology (Redmond, Grace, Daly, Bouchier-
    Hayes), Butterworth-Heineman Publishing, Ltd., 1996
  • Editor: Principles of Surgery, 7th Edition (Schwartz, Daly, Fisher), 1998
  • Editor: Current Surgery, Elsevier Science Inc., 1998-present
  • Editor: Management of Upper Gastrointestinal Cancer (Daly, Hennessy, Reynolds), W.B. Saunders Company, Ltd., London, 1999
  • Editor: Surgical Oncology, Contemporary Principles & Practices (Bland, Daly, Karakousis), McGraw-Hill Companies, Inc., 2001
  • Editor: Gastrointestinal Oncology: Principles and Practice (Kelsen, Daly, Kern, Levin, Tepper), Lippincott Williams & Wilkins, 2002
  • Editor-in-Chief, Contemporary Surgery, Dowden Publishing, 1996-present
  • Associate Editor: Hepato-Gastroenterology, 2004

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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

24169156. Daly JM, A marriage of databases produces knowledge offspring. Ann Surg 258:6(845-6)2013 Dec

21826405. Breslow JM, Monroy MA, Daly JM, Meissler JJ, Gaughan J, Adler MW, Eisenstein TK, Morphine, but not trauma, sensitizes to systemic Acinetobacter baumannii infection. J Neuroimmune Pharmacol 6:4(551-65)2011 Dec

21787965. Jayarajan S, Daly JM, The relationships of nutrients, routes of delivery, and immunocompetence. Surg Clin North Am 91:4(737-53, vii)2011 Aug

20504359. Rough JJ, Monroy MA, Yerrum S, Daly JM, Anti-proliferative effect of LXR agonist T0901317 in ovarian carcinoma cells. J Ovarian Res 3:(13)2010 May 26

19167980. Rough J, Engdahl R, Opperman K, Yerrum S, Monroy MA, Daly JM, beta2 Adrenoreceptor blockade attenuates the hyperinflammatory response induced by traumatic injury. Surgery 145:2(235-42)2009 Feb

17597158. Duff MD, Mestre J, Maddali S, Yan ZP, Stapleton P, Daly JM, Analysis of gene expression in the tumor-associated macrophage. J Surg Res 142:1(119-28)2007 Sep

17532302. Engdahl R, Monroy MA, Daly JM, 15-Deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) mediates repression of TNF-alpha by decreasing levels of acetylated histone H3 and H4 at its promoter. Biochem Biophys Res Commun 359:1(88-93)2007 Jul 20

17510607. Monroy MA, Opperman KK, Pucciarelli M, Yerrum S, Berg DA, Daly JM, THE PPARgamma ligand 15d-PGJ2 modulates macrophage activation after injury in a murine trauma model. Shock 28:2(186-91)2007 Aug

17387850. Lee CN, Daly JM, Provider volume and clinical outcomes in surgery: issues and implications. Bull Am Coll Surg 87:6(21-6)2002 Jun

16189641. Daly JM, Society of surgical oncology heritage award: introduction--honoring Samuel Alonzo Wells, Jr., MD. Ann Surg Oncol 12:11(861-3)2005 Nov

16093099. Maddali S, Daly JM, Gastrojejunostomy in pancreatic cancer: is it worthwhile? Curr Surg 59:1(17-21)2002 Jan-Feb

15933632. Matsuda T, Freeman TA, Hilbert DW, Duff M, Fuortes M, Stapleton PP, Daly JM, Lysis-deficient bacteriophage therapy decreases endotoxin and inflammatory mediator release and improves survival in a murine peritonitis model. Surgery 137:6(639-46)2005 Jun

15890324. Yan Z, Stapleton PP, Freeman TA, Fuortes M, Daly JM, Enhanced expression of cyclooxygenase-2 and prostaglandin E2 in response to endotoxin after trauma is dependent on MAPK and NF-kappaB mechanisms. Cell Immunol 232:1-2(116-26)2004 Nov-Dec

15523398. Maddali S, Stapleton PP, Freeman TA, Smyth GP, Duff M, Yan Z, Daly JM, Neuroendocrine responses mediate macrophage function after trauma. Surgery 136:5(1038-46)2004 Nov

15522307. Stapleton PP, Strong VE, Freeman TA, Winter J, Yan Z, Daly JM, Gender affects macrophage cytokine and prostaglandin E2 production and PGE2 receptor expression after trauma. J Surg Res 122:1(1-7)2004 Nov

15325613. Nishikawa M, Stapleton PP, Freeman TA, Gaughan JP, Matsuda T, Daly JM, NS-398 inhibits tumor growth and liver metastasis of colon cancer through induction of apoptosis and suppression of the plasminogen activation system in a mouse model. J Am Coll Surg 199:3(428-35)2004 Sep

15166957. Dempsey DT, Delano M, Bradley K, Kolff J, Fisher C, Caroline D, Gaughan J, Meilahn JE, Daly JM, Laparoscopic esophagomyotomy for achalasia: does anterior hemifundoplication affect clinical outcome? Ann Surg 239:6(779-85; discussion 785-7)2004 Jun

15030957. Stapleton PP, Barry LK, Freeman TA, Mestre JR, Daly JM, Decreased peritoneal macrophage NF-kappaB translocation to the nucleus in protein energy malnutrition--a role for the glucocorticoid response? Clin Nutr 23:2(177-82)2004 Apr

15013364. Smyth GP, Stapleton PP, Freeman TA, Concannon EM, Mestre JR, Duff M, Maddali S, Daly JM, Glucocorticoid pretreatment induces cytokine overexpression and nuclear factor-kappaB activation in macrophages. J Surg Res 116:2(253-61)2004 Feb

15013358. Maddali S, Stapleton PP, Freeman TA, Yan Z, Duff M, Smyth GP, Daly JM, Altered cyclooxygenase-2 expression and nitric oxide metabolism following major elective surgery. J Surg Res 116:2(211-8)2004 Feb

14761908. Daly JM, Society of Surgical Oncology presidential address: volume, outcome, and surgical specialization. Ann Surg Oncol 11:2(107-14)2004 Feb

14530734. Callahan MA, Christos PJ, Gold HT, Mushlin AI, Daly JM, Influence of surgical subspecialty training on in-hospital mortality for gastrectomy and colectomy patients. Ann Surg 238:4(629-36; discussion 636-9)2003 Oct

12734096. Smyth GP, Stapleton PP, Barden CB, Mestre JR, Freeman TA, Duff MD, Maddali S, Yan Z, Daly JM, Renal cell carcinoma induces prostaglandin E2 and T-helper type 2 cytokine production in peripheral blood mononuclear cells. Ann Surg Oncol 10:4(455-62)2003 May

12679317. Duff M, Stapleton PP, Mestre JR, Maddali S, Smyth GP, Yan Z, Freeman TA, Daly JM, Cyclooxygenase-2 inhibition improves macrophage function in melanoma and increases the antineoplastic activity of interferon gamma. Ann Surg Oncol 10:3(305-13)2003 Apr

12665169. Stapleton PP, Barden CB, McCarter MD, Mackrell PJ, Freeman TA, Naama HA, Daly JM, Serum leptin levels in acute protein deprivation. JPEN J Parenter Enteral Nutr 27:2(132-6)2003 Mar-Apr

12632136. Borrazzo EC, Daly JM, Morrisey KP, Fischer E, Belmont M, Hogle NJ, Fowler DL, Hand-assisted laparoscopic splenectomy for giant spleens. Surg Endosc 17:6(918-20)2003 Jun

12375759. Barden CB, Specht MC, McCarter MD, Daly JM, Fahey TJ 3rd, Effects of limited work hours on surgical training. J Am Coll Surg 195:4(531-8)2002 Oct

12374650. Daly JM, Introduction of Dr. John Edward Niederhuber. Ann Surg Oncol 9:8(705-8)2002 Oct

11685192. Mackrell PJ, Daly JM, Mestre JR, Stapleton PP, Howe LR, Subbaramaiah K, Dannenberg AJ, Elevated expression of cyclooxygenase-2 contributes to immune dysfunction in a murine model of trauma. Surgery 130:5(826-33)2001 Nov

11490357. Strong VE, Winter J, Yan Z, Smyth GP, Mestre JR, Maddali S, Schaefer PA, Yurt RW, Stapleton PP, Daly JM, Prostaglandin E2 receptors EP2 and EP4 are down-regulated in human mononuclear cells after injury. Surgery 130:2(249-55)2001 Aug

11448395. Naama HA, Mack VE, Smyth GP, Stapleton PP, Daly JM, Macrophage effector mechanisms in melanoma in an experimental study. Arch Surg 136:7(804-9)2001 Jul

11468511. Naama HA, McCarter MD, Mack VE, Evoy DA, Hill AD, Shou J, Daly JM, Suppression of macrophage nitric oxide production by melanoma: mediation by a melanoma-derived product. Melanoma Res 11:3(229-38)2001 Jun

11368536. Mack Strong VE, Mackrell PJ, Concannon EM, Mestre JR, Smyth GP, Schaefer PA, Stapleton PP, Daly JM, NS-398 treatment after trauma modifies NF-kappaB activation and improves survival. J Surg Res 98:1(40-6)2001 Jun 1

11351846. Daly JM, Governors' committee takes on competency challenges. Bull Am Coll Surg 86:1(29-32)2001 Jan

11351844. Daly JM, In defense of the surgical cancer patient: nutrition may be key. Bull Am Coll Surg 86:1(18-23)2001 Jan

11331454. Rivadeneira DE, Grobmyer SR, Naama HA, Mackrell PJ, Mestre JR, Stapleton PP, Daly JM, Malnutrition-induced macrophage apoptosis. Surgery 129:5(617-25)2001 May

11283547. Mackrell PJ, Lee K, Garcia N, Daly JM, Lee CS, Pancreatitis secondary to Ascaris lumbricoides infestation. Surgery 129:4(511-2)2001 Apr

11165887. Stapleton PP, Fujita J, Murphy EM, Naama HA, Daly JM, The influence of restricted calorie intake on peritoneal macrophage function. Nutrition 17:1(41-5)2001 Jan

11150033. Fujita J, Marino MW, Wada H, Jungbluth AA, Mackrell PJ, Rivadeneira DE, Stapleton PP, Daly JM, Effect of TNF gene depletion on liver regeneration after partial hepatectomy in mice. Surgery 129:1(48-54)2001 Jan

11092878. Mestre JR, Mackrell PJ, Rivadeneira DE, Stapleton PP, Tanabe T, Daly JM, Redundancy in the signaling pathways and promoter elements regulating cyclooxygenase-2 gene expression in endotoxin-treated macrophage/monocytic cells. J Biol Chem 276:6(3977-82)2001 Feb 9

11069722. Eisengart CA, Mestre JR, Naama HA, Mackrell PJ, Rivadeneira DE, Murphy EM, Stapleton PP, Daly JM, Prostaglandins regulate melanoma-induced cytokine production in macrophages. Cell Immunol 204:2(143-9)2000 Sep 15

11044525. Grobmyer SR, Rivadeneira DE, Goodman CA, Mackrell P, Lieberman MD, Daly JM, Pancreatic anastomotic failure after pancreaticoduodenectomy. Am J Surg 180:2(117-20)2000 Aug

11028559. Strong VE, Mackrell PJ, Concannon EM, Naama HA, Schaefer PA, Shaftan GW, Stapleton PP, Daly JM, Blocking prostaglandin E2 after trauma attenuates pro-inflammatory cytokines and improves survival. Shock 14:3(374-9)2000 Sep

10898177. Rivadeneira DE, Simmons RM, Christos PJ, Hanna K, Daly JM, Osborne MP, Predictive factors associated with axillary lymph node metastases in T1a and T1b breast carcinomas: analysis in more than 900 patients. J Am Coll Surg 191:1(1-6; discussion 6-8)2000 Jul

10801023. Daly JM, Fry WA, Little AG, Winchester DP, McKee RF, Stewart AK, Fremgen AM, Esophageal cancer: results of an American College of Surgeons Patient Care Evaluation Study. J Am Coll Surg 190:5(562-72; discussion 572-3)2000 May

10738275. Grobmyer SR, Daly JM, Glotzbach RE, Grobmyer AJ 3rd, Role of surgery in the management of postmastectomy extremity angiosarcoma (Stewart-Treves syndrome). J Surg Oncol 73:3(182-8)2000 Mar

10070951. Tucker ON, Dannenberg AJ, Yang EK, Zhang F, Teng L, Daly JM, Soslow RA, Masferrer JL, Woerner BM, Koki AT, Fahey TJ 3rd, Cyclooxygenase-2 expression is up-regulated in human pancreatic cancer. Cancer Res 59:5(987-90)1999 Mar 1

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