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Peter Crino, MD, PhD

Peter Crino, MD, PhD


Vice Chair for Research, Neurology

Professor, Neurology

Professor, Shriners Hospitals Pediatric Research Center

Telephone: 215-707-3040

Fax: 215-707-8235

Email: peter.crino@tuhs.temple.edu


Department of Neurology

Shriners Hospitals Pediatric Research Center


Educational Background:


BA, Psychology/Philosophy, Binghamton University, Binghamton, NY


MD, Yale University, New Haven, CT


Internship, Yale New Haven Hospital, New Haven, CT


PhD, Boston University, Boston, MA


Residency, Neurology, University of Pennsylvania, Philadelphia, PA


Fellowship, Epilepsy, University of Pennsylvania, Philadelphia, PA


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board certification(s):

  • American Board of Psychiatry and Neurology, 1996 and 2006
  • American Clinical Neurophysiology Society, 2011

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professional affiliations:

  • American Academy of Neurology
  • American Epilepsy Society

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  • Epilepsy
  • Autism
  • Brain development


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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

26459113. Srivastava IN, Shperdheja J, Baybis M, Ferguson T, Crino PB, mTOR pathway inhibition prevents neuroinflammation and neuronal death in a mouse model of cerebral palsy. Neurobiol Dis 85:(144-154)2015 Oct 13

26285051. Sim JC, Scerri T, Fanjul-Fernández M, Riseley JR, Gillies G, Pope K, van Roozendaal H, Heng JI, Mandelstam SA, McGillivray G, MacGregor D, Kannan L, Maixner W, Harvey AS, Amor DJ, Delatycki MB, Crino PB, Bahlo M, Lockhart PJ, Leventer RJ, Familial cortical dysplasia caused by mutation in the mTOR regulator NPRL3. Ann Neurol :()2015 Aug 18

26235615. Moon UY, Park JY, Park R, Cho JY, Hughes LJ, McKenna J 3rd, Goetzl L, Cho SH, Crino PB, Gambello MJ, Kim S, Impaired Reelin-Dab1 Signaling Contributes to Neuronal Migration Deficits of Tuberous Sclerosis Complex. Cell Rep 12:6(965-78)2015 Aug 11

26070982. Jinks RN, Puffenberger EG, Baple E, Harding B, Crino P, Fogo AB, Wenger O, Xin B, Koehler AE, McGlincy MH, Provencher MM, Smith JD, Tran L, Al Turki S, Chioza BA, Cross H, Harlalka GV, Hurles ME, Maroofian R, Heaps AD, Morton MC, Stempak L, Hildebrandt F, Sadowski CE, Zaritsky J, Campellone K, Morton DH, Wang H, Crosby A, Strauss KA, Recessive nephrocerebellar syndrome on the Galloway-Mowat syndrome spectrum is caused by homozygous protein-truncating mutations of WDR73. Brain 138:Pt 8(2173-90)2015 Aug

26060899. Crino PB, Focal Cortical Dysplasia. Semin Neurol 35:3(201-8)2015 Jun

26013804. Crino PB, The enlarging spectrum of focal cortical dysplasias. Brain 138:Pt 6(1446-8)2015 Jun

26000329. Scerri T, Riseley JR, Gillies G, Pope K, Burgess R, Mandelstam SA, Dibbens L, Chow CW, Maixner W, Harvey AS, Jackson GD, Amor DJ, Delatycki MB, Crino PB, Berkovic SF, Scheffer IE, Bahlo M, Lockhart PJ, Leventer RJ, Familial cortical dysplasia type IIA caused by a germline mutation in DEPDC5. Ann Clin Transl Neurol 2:5(575-80)2015 May

25878179. Leventer RJ, Scerri T, Marsh AP, Pope K, Gillies G, Maixner W, MacGregor D, Harvey AS, Delatycki MB, Amor DJ, Crino P, Bahlo M, Lockhart PJ, Hemispheric cortical dysplasia secondary to a mosaic somatic mutation in MTOR. Neurology 84:20(2029-32)2015 May 19

25833943. Crino PB, mTOR signaling in epilepsy: insights from malformations of cortical development. Cold Spring Harb Perspect Med 5:4()2015 Apr 1

24122905. Crino PB, Viral infection and focal cortical dysplasia. Reply. Ann Neurol 75:4(616-7)2014 Apr

23892008. Lim KC, Crino PB, Focal malformations of cortical development: new vistas for molecular pathogenesis. Neuroscience 252:(262-76)2013 Nov 12

23616120. Parker WE, Orlova KA, Parker WH, Birnbaum JF, Krymskaya VP, Goncharov DA, Baybis M, Helfferich J, Okochi K, Strauss KA, Crino PB, Rapamycin prevents seizures after depletion of STRADA in a rare neurodevelopmental disorder. Sci Transl Med 5:182(182ra53)2013 Apr 24

23386324. Crino PB, Evolving neurobiology of tuberous sclerosis complex. Acta Neuropathol 125:3(317-32)2013 Mar

23293627. Pollard JR, Eidelman O, Mueller GP, Dalgard CL, Crino PB, Anderson CT, Brand EJ, Burakgazi E, Ivaturi SK, Pollard HB, The TARC/sICAM5 Ratio in Patient Plasma is a Candidate Biomarker for Drug Resistant Epilepsy. Front Neurol 3:(181)2012

23280839. Chen J, Tsai V, Parker WE, Aronica E, Baybis M, Crino PB, Detection of human papillomavirus in human focal cortical dysplasia type IIB. Ann Neurol 72:6(881-92)2012 Dec

23081885. Tsai V, Parker WE, Orlova KA, Baybis M, Chi AW, Berg BD, Birnbaum JF, Estevez J, Okochi K, Sarnat HB, Flores-Sarnat L, Aronica E, Crino PB, Fetal brain mTOR signaling activation in tuberous sclerosis complex. Cereb Cortex 24:2(315-27)2014 Feb

22327361. Marcotte L, Aronica E, Baybis M, Crino PB, Cytoarchitectural alterations are widespread in cerebral cortex in tuberous sclerosis complex. Acta Neuropathol 123:5(685-93)2012 May

21890410. Crino PB, mTOR: A pathogenic signaling pathway in developmental brain malformations. Trends Mol Med 17:12(734-42)2011 Dec

21224066. Parker WE, Orlova KA, Heuer GG, Baybis M, Aronica E, Frost M, Wong M, Crino PB, Enhanced epidermal growth factor, hepatocyte growth factor, and vascular endothelial growth factor expression in tuberous sclerosis complex. Am J Pathol 178:1(296-305)2011 Jan

20613634. Orlova KA, Tsai V, Baybis M, Heuer GG, Sisodiya S, Thom M, Strauss K, Aronica E, Storm PB, Crino PB, Early progenitor cell marker expression distinguishes type II from type I focal cortical dysplasias. J Neuropathol Exp Neurol 69:8(850-63)2010 Aug

20498439. Crino PB, Aronica E, Baltuch G, Nathanson KL, Biallelic TSC gene inactivation in tuberous sclerosis complex. Neurology 74:21(1716-23)2010 May 25

20424326. Orlova KA, Parker WE, Heuer GG, Tsai V, Yoon J, Baybis M, Fenning RS, Strauss K, Crino PB, STRADalpha deficiency results in aberrant mTORC1 signaling during corticogenesis in humans and mice. J Clin Invest 120:5(1591-602)2010 May

20331708. Crino PB, The pathophysiology of tuberous sclerosis complex. Epilepsia 51 Suppl 1:(27-9)2010 Feb

20146692. Orlova KA, Crino PB, The tuberous sclerosis complex. Ann N Y Acad Sci 1184:(87-105)2010 Jan

20123192. Bishay VL, Crino PB, Wein AJ, Malkowicz SB, Trerotola SO, Soulen MC, Stavropoulos SW, Embolization of giant renal angiomyolipomas: technique and results. J Vasc Interv Radiol 21:1(67-72)2010 Jan

19761448. Crino PB, Focal brain malformations: seizures, signaling, sequencing. Epilepsia 50 Suppl 9:(3-8)2009 Oct

19127311. Crino PB, Do we have a cure for tuberous sclerosis complex? Epilepsy Curr 8:6(159-62)2008 Nov-Dec

18494264. Crino PB, Focal brain malformations: a spectrum of disorders along the mTOR cascade. Novartis Found Symp 288:(260-72; discussion 272-81)2007

18428502. Eberwine J, Crino P, Analysis of mRNA populations from single live and fixed cells of the central nervous system. Curr Protoc Neurosci Chapter 5:(Unit 5.3)2001 May

17711980. Lamparello P, Baybis M, Pollard J, Hol EM, Eisenstat DD, Aronica E, Crino PB, Developmental lineage of cell types in cortical dysplasia with balloon cells. Brain 130:Pt 9(2267-76)2007 Sep

17571352. Crino PB, Gene expression, genetics, and genomics in epilepsy: some answers, more questions. Epilepsia 48 Suppl 2:(42-50)2007

17437409. Samadani U, Judkins AR, Akpalu A, Aronica E, Crino PB, Differential cellular gene expression in ganglioglioma. Epilepsia 48:4(646-53)2007 Apr

17054681. Crino PB, Becker AJ, Gene profiling in temporal lobe epilepsy tissue and dysplastic lesions. Epilepsia 47:10(1608-16)2006 Oct

17028374. Marcotte L, Crino PB, The neurobiology of the tuberous sclerosis complex. Neuromolecular Med 8:4(531-46)2006

17005952. Crino PB, Nathanson KL, Henske EP, The tuberous sclerosis complex. N Engl J Med 355:13(1345-56)2006 Sep 28

16196383. Yu J, Baybis M, Lee A, McKhann G 2nd, Chugani D, Kupsky WJ, Aronica E, Crino PB, Targeted gene expression analysis in hemimegalencephaly: activation of beta-catenin signaling. Brain Pathol 15:3(179-86)2005 Jul

15921235. Crino PB, Molecular pathogenesis of focal cortical dysplasia and hemimegalencephaly. J Child Neurol 20:4(330-6)2005 Apr

15571509. Baybis M, Lynch D, Lee A, Patel A, McKhann G 2nd, Chugani D, J Kupsky W, Aronica E, Crino PB, Altered expression of neurotransmitter-receptor subunit and uptake site mRNAs in hemimegalencephaly. Epilepsia 45:12(1517-24)2004 Dec

15563019. Crino PB, Molecular pathogenesis of tuber formation in tuberous sclerosis complex. J Child Neurol 19:9(716-25)2004 Sep

15455405. Baybis M, Yu J, Lee A, Golden JA, Weiner H, McKhann G 2nd, Aronica E, Crino PB, mTOR cascade activation distinguishes tubers from focal cortical dysplasia. Ann Neurol 56:4(478-87)2004 Oct

15309192. Crino PB, Reelin' in Genes for Cortical Dysplasia. Epilepsy Curr 1:2(61-65)2001 Nov

15250594. Crino PB, Malformations of cortical development: molecular pathogenesis and experimental strategies. Adv Exp Med Biol 548:(175-91)2004

14982747. Kolson DL, Sabnekar P, Baybis M, Crino PB, Gene expression in TUNEL-positive neurons in human immunodeficiency virus-infected brain. J Neurovirol 10 Suppl 1:(102-7)2004

14572449. Maldonado M, Baybis M, Newman D, Kolson DL, Chen W, McKhann G 2nd, Gutmann DH, Crino PB, Expression of ICAM-1, TNF-alpha, NF kappa B, and MAP kinase in tubers of the tuberous sclerosis complex. Neurobiol Dis 14:2(279-90)2003 Nov

12764046. Hua Y, Crino PB, Single cell lineage analysis in human focal cortical dysplasia. Cereb Cortex 13:6(693-9)2003 Jun

12731003. Lee A, Maldonado M, Baybis M, Walsh CA, Scheithauer B, Yeung R, Parent J, Weiner HL, Crino PB, Markers of cellular proliferation are expressed in cortical tubers. Ann Neurol 53:5(668-73)2003 May

12558566. Telfeian AE, Tseng HC, Baybis M, Crino PB, Dichter MA, Differential expression of GABA and glutamate-receptor subunits and enzymes involved in GABA metabolism between electrophysiologically identified hippocampal CA1 pyramidal cells and interneurons. Epilepsia 44:2(143-9)2003 Feb

12083836. Ryzhova EV, Crino P, Shawver L, Westmoreland SV, Lackner AA, González-Scarano F, Simian immunodeficiency virus encephalitis: analysis of envelope sequences from individual brain multinucleated giant cells and tissue samples. Virology 297:1(57-67)2002 May 25

12040902. Crino PB, Gene expression analysis as a strategy to understand the molecular pathogenesis of infantile spasms. Int Rev Neurobiol 49:(367-89)2002

11958376. Crino PB, Miyata H, Vinters HV, Neurodevelopmental disorders as a cause of seizures: neuropathologic, genetic, and mechanistic considerations. Brain Pathol 12:2(212-33)2002 Apr

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