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Peter Crino, MD, PhD

Peter Crino, MD, PhD


Professor, Neurology

Professor, Shriners Hospitals Pediatric Research Center

Telephone: 215-707-3040

Fax: 215-707-8235

Email: peter.crino@tuhs.temple.edu


Department of Neurology

Shriners Hospitals Pediatric Research Center


Educational Background:


BA, Psychology/Philosophy, Binghamton University, Binghamton, NY


MD, Yale University, New Haven, CT


Internship, Yale New Haven Hospital, New Haven, CT


PhD, Boston University, Boston, MA


Fellowships, Neurology and Epilepsy, University of Pennsylvania, Philadelphia, PA


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board certification(s):

  • American Board of Psychiatry and Neurology, 1996 and 2006
  • American Clinical Neurophysiology Society, 2011

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professional affiliations:

  • American Academy of Neurology
  • American Epilepsy Society

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  • Epilepsy
  • Autism
  • Brain development


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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

24122905. Crino PB, Viral infection and focal cortical dysplasia. Reply. Ann Neurol 75:4(616-7)2014 Apr

23892008. Lim KC, Crino PB, Focal malformations of cortical development: new vistas for molecular pathogenesis. Neuroscience 252:(262-76)2013 Nov 12

23616120. Parker WE, Orlova KA, Parker WH, Birnbaum JF, Krymskaya VP, Goncharov DA, Baybis M, Helfferich J, Okochi K, Strauss KA, Crino PB, Rapamycin prevents seizures after depletion of STRADA in a rare neurodevelopmental disorder. Sci Transl Med 5:182(182ra53)2013 Apr 24

23386324. Crino PB, Evolving neurobiology of tuberous sclerosis complex. Acta Neuropathol 125:3(317-32)2013 Mar

23293627. Pollard JR, Eidelman O, Mueller GP, Dalgard CL, Crino PB, Anderson CT, Brand EJ, Burakgazi E, Ivaturi SK, Pollard HB, The TARC/sICAM5 Ratio in Patient Plasma is a Candidate Biomarker for Drug Resistant Epilepsy. Front Neurol 3:(181)2012

23280839. Chen J, Tsai V, Parker WE, Aronica E, Baybis M, Crino PB, Detection of human papillomavirus in human focal cortical dysplasia type IIB. Ann Neurol 72:6(881-92)2012 Dec

23081885. Tsai V, Parker WE, Orlova KA, Baybis M, Chi AW, Berg BD, Birnbaum JF, Estevez J, Okochi K, Sarnat HB, Flores-Sarnat L, Aronica E, Crino PB, Fetal brain mTOR signaling activation in tuberous sclerosis complex. Cereb Cortex 24:2(315-27)2014 Feb

22327361. Marcotte L, Aronica E, Baybis M, Crino PB, Cytoarchitectural alterations are widespread in cerebral cortex in tuberous sclerosis complex. Acta Neuropathol 123:5(685-93)2012 May

21890410. Crino PB, mTOR: A pathogenic signaling pathway in developmental brain malformations. Trends Mol Med 17:12(734-42)2011 Dec

21224066. Parker WE, Orlova KA, Heuer GG, Baybis M, Aronica E, Frost M, Wong M, Crino PB, Enhanced epidermal growth factor, hepatocyte growth factor, and vascular endothelial growth factor expression in tuberous sclerosis complex. Am J Pathol 178:1(296-305)2011 Jan

20613634. Orlova KA, Tsai V, Baybis M, Heuer GG, Sisodiya S, Thom M, Strauss K, Aronica E, Storm PB, Crino PB, Early progenitor cell marker expression distinguishes type II from type I focal cortical dysplasias. J Neuropathol Exp Neurol 69:8(850-63)2010 Aug

20498439. Crino PB, Aronica E, Baltuch G, Nathanson KL, Biallelic TSC gene inactivation in tuberous sclerosis complex. Neurology 74:21(1716-23)2010 May 25

20424326. Orlova KA, Parker WE, Heuer GG, Tsai V, Yoon J, Baybis M, Fenning RS, Strauss K, Crino PB, STRADalpha deficiency results in aberrant mTORC1 signaling during corticogenesis in humans and mice. J Clin Invest 120:5(1591-602)2010 May

20331708. Crino PB, The pathophysiology of tuberous sclerosis complex. Epilepsia 51 Suppl 1:(27-9)2010 Feb

20146692. Orlova KA, Crino PB, The tuberous sclerosis complex. Ann N Y Acad Sci 1184:(87-105)2010 Jan

20123192. Bishay VL, Crino PB, Wein AJ, Malkowicz SB, Trerotola SO, Soulen MC, Stavropoulos SW, Embolization of giant renal angiomyolipomas: technique and results. J Vasc Interv Radiol 21:1(67-72)2010 Jan

19761448. Crino PB, Focal brain malformations: seizures, signaling, sequencing. Epilepsia 50 Suppl 9:(3-8)2009 Oct

19127311. Crino PB, Do we have a cure for tuberous sclerosis complex? Epilepsy Curr 8:6(159-62)2008 Nov-Dec

18494264. Crino PB, Focal brain malformations: a spectrum of disorders along the mTOR cascade. Novartis Found Symp 288:(260-72; discussion 272-81)2007

18428502. Eberwine J, Crino P, Analysis of mRNA populations from single live and fixed cells of the central nervous system. Curr Protoc Neurosci Chapter 5:(Unit 5.3)2001 May

17711980. Lamparello P, Baybis M, Pollard J, Hol EM, Eisenstat DD, Aronica E, Crino PB, Developmental lineage of cell types in cortical dysplasia with balloon cells. Brain 130:Pt 9(2267-76)2007 Sep

17571352. Crino PB, Gene expression, genetics, and genomics in epilepsy: some answers, more questions. Epilepsia 48 Suppl 2:(42-50)2007

17437409. Samadani U, Judkins AR, Akpalu A, Aronica E, Crino PB, Differential cellular gene expression in ganglioglioma. Epilepsia 48:4(646-53)2007 Apr

17054681. Crino PB, Becker AJ, Gene profiling in temporal lobe epilepsy tissue and dysplastic lesions. Epilepsia 47:10(1608-16)2006 Oct

17028374. Marcotte L, Crino PB, The neurobiology of the tuberous sclerosis complex. Neuromolecular Med 8:4(531-46)2006

17005952. Crino PB, Nathanson KL, Henske EP, The tuberous sclerosis complex. N Engl J Med 355:13(1345-56)2006 Sep 28

16196383. Yu J, Baybis M, Lee A, McKhann G 2nd, Chugani D, Kupsky WJ, Aronica E, Crino PB, Targeted gene expression analysis in hemimegalencephaly: activation of beta-catenin signaling. Brain Pathol 15:3(179-86)2005 Jul

15921235. Crino PB, Molecular pathogenesis of focal cortical dysplasia and hemimegalencephaly. J Child Neurol 20:4(330-6)2005 Apr

15571509. Baybis M, Lynch D, Lee A, Patel A, McKhann G 2nd, Chugani D, J Kupsky W, Aronica E, Crino PB, Altered expression of neurotransmitter-receptor subunit and uptake site mRNAs in hemimegalencephaly. Epilepsia 45:12(1517-24)2004 Dec

15563019. Crino PB, Molecular pathogenesis of tuber formation in tuberous sclerosis complex. J Child Neurol 19:9(716-25)2004 Sep

15455405. Baybis M, Yu J, Lee A, Golden JA, Weiner H, McKhann G 2nd, Aronica E, Crino PB, mTOR cascade activation distinguishes tubers from focal cortical dysplasia. Ann Neurol 56:4(478-87)2004 Oct

15309192. Crino PB, Reelin' in Genes for Cortical Dysplasia. Epilepsy Curr 1:2(61-65)2001 Nov

15250594. Crino PB, Malformations of cortical development: molecular pathogenesis and experimental strategies. Adv Exp Med Biol 548:(175-91)2004

14982747. Kolson DL, Sabnekar P, Baybis M, Crino PB, Gene expression in TUNEL-positive neurons in human immunodeficiency virus-infected brain. J Neurovirol 10 Suppl 1:(102-7)2004

14572449. Maldonado M, Baybis M, Newman D, Kolson DL, Chen W, McKhann G 2nd, Gutmann DH, Crino PB, Expression of ICAM-1, TNF-alpha, NF kappa B, and MAP kinase in tubers of the tuberous sclerosis complex. Neurobiol Dis 14:2(279-90)2003 Nov

12764046. Hua Y, Crino PB, Single cell lineage analysis in human focal cortical dysplasia. Cereb Cortex 13:6(693-9)2003 Jun

12731003. Lee A, Maldonado M, Baybis M, Walsh CA, Scheithauer B, Yeung R, Parent J, Weiner HL, Crino PB, Markers of cellular proliferation are expressed in cortical tubers. Ann Neurol 53:5(668-73)2003 May

12558566. Telfeian AE, Tseng HC, Baybis M, Crino PB, Dichter MA, Differential expression of GABA and glutamate-receptor subunits and enzymes involved in GABA metabolism between electrophysiologically identified hippocampal CA1 pyramidal cells and interneurons. Epilepsia 44:2(143-9)2003 Feb

12083836. Ryzhova EV, Crino P, Shawver L, Westmoreland SV, Lackner AA, González-Scarano F, Simian immunodeficiency virus encephalitis: analysis of envelope sequences from individual brain multinucleated giant cells and tissue samples. Virology 297:1(57-67)2002 May 25

12040902. Crino PB, Gene expression analysis as a strategy to understand the molecular pathogenesis of infantile spasms. Int Rev Neurobiol 49:(367-89)2002

11958376. Crino PB, Miyata H, Vinters HV, Neurodevelopmental disorders as a cause of seizures: neuropathologic, genetic, and mechanistic considerations. Brain Pathol 12:2(212-33)2002 Apr

11906504. Crino PB, Jin H, Shumate MD, Robinson MB, Coulter DA, Brooks-Kayal AR, Increased expression of the neuronal glutamate transporter (EAAT3/EAAC1) in hippocampal and neocortical epilepsy. Epilepsia 43:3(211-8)2002 Mar

11583980. Kyin R, Hua Y, Baybis M, Scheithauer B, Kolson D, Uhlmann E, Gutmann D, Crino PB, Differential cellular expression of neurotrophins in cortical tubers of the tuberous sclerosis complex. Am J Pathol 159:4(1541-54)2001 Oct

11563628. Taylor JP, Sater R, French J, Baltuch G, Crino PB, Transcription of intermediate filament genes is enhanced in focal cortical dysplasia. Acta Neuropathol 102:2(141-8)2001 Aug

11438984. Scherer SS, Xu T, Crino P, Arroyo EJ, Gutmann DH, Ezrin, radixin, and moesin are components of Schwann cell microvilli. J Neurosci Res 65:2(150-64)2001 Jul 15

11370829. Telfeian AE, Philips MF, Crino PB, Judy KD, Postoperative epilepsy in patients undergoing craniotomy for glioblastoma multiforme. J Exp Clin Cancer Res 20:1(5-10)2001 Mar

11294928. Crino PB, Duhaime AC, Baltuch G, White R, Differential expression of glutamate and GABA-A receptor subunit mRNA in cortical dysplasia. Neurology 56:7(906-13)2001 Apr 10

11198298. White R, Hua Y, Scheithauer B, Lynch DR, Henske EP, Crino PB, Selective alterations in glutamate and GABA receptor subunit mRNA expression in dysplastic neurons and giant cells of cortical tubers. Ann Neurol 49:1(67-78)2001 Jan

11096778. Crino PB, Chou K, Epilepsy and Cortical Dysplasias. Curr Treat Options Neurol 2:6(543-552)2000 Nov

11091894. French J, Crino P, Porter RJ, Antiepileptic drugs in the treatment of neocortical epilepsies. Adv Neurol 84:(525-31)2000

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