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Deborah Crabbe, MD

 

Deborah Crabbe, MD

 

Associate Professor, Medicine

Telephone:  215-707-2006

Fax:  215-707-5737

Email: deborah.crabbe@temple.edu

 

 

Department of Medicine, Section of Cardiology

 

Educational Background:

 

BS, Engineering, Michigan State University College of Engineering

 

MD, Howard University College of Medicine

 

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Research Interests:

 

Gender Differences in Cardiac Function in Health and Disease. Since 1984, more women than men have died from cardiovascular related disease. Observation has shown that the incidence of cardiovascular disease increases with the duration of menopause. Yet, fundamental questions still exist regarding relevant gender-based differences in the pathophysiology and clinical management of cardiac disease. Furthermore, even less information is available on how the duration of menopause impacts on the progression of cardiovascular disease.

 

This significant gap in knowledge has grave consequences in the care of women with heart disease. The absence of enough credible information regarding sex-based differences in the pathophysiology of cardiac-related illness limits the ability of the medical community to design more effective treatment strategies which may offer additional advantages for women. With this in mind, my research interests center on understanding the role of sex-related differences in cardiac function in health and disease. Specifically, my work is centered on understanding the impact of hormones in the pathophysiology of cardiac dysfunction. My laboratory employs noninvasive imaging and isovolumetric methods to evaluate cardiac mechanical determinants of diastolic and systolic function using whole heart preparations. This work is currently funded by the National Heart, Lung and Blood Institute.              

 

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clinical Interests:

 

  • Heart disease in women
  • Cardiovascular disease in underserved populations
  • Echocardiography
  • General cardiology

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Board Certification(S):

 

Board certified in Internal Medicine and Cardiovascular Diseases

 

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professional affiliation(s):

 

American Heart Association

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PUBMED PUBLICATIONS :


Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

24193297. Kretzschmar J, Babbitt DM, Diaz KM, Feairheller DL, Sturgeon KM, Perkins AM, Veerabhadrappa P, Williamson ST, Ling C, Lee H, Grimm H, Thakkar SR, Crabbe DL, Kashem MA, Brown MD, A standardized exercise intervention differentially affects premenopausal and postmenopausal African-American women. Menopause :()2013 Nov 4

23691280. Babbitt DM, Diaz KM, Feairheller DL, Sturgeon KM, Perkins AM, Veerabhadrappa P, Williamson ST, Kretzschmar J, Ling C, Lee H, Grimm H, Thakkar SR, Crabbe DL, Kashem MA, Brown MD, Endothelial activation microparticles and inflammation status improve with exercise training in african americans. Int J Hypertens 2013:(538017)2013

23615389. Diaz KM, Veerabhadrappa P, Kashem MA, Thakkar SR, Feairheller DL, Sturgeon KM, Ling C, Williamson ST, Kretzschmar J, Lee H, Grimm H, Babbitt DM, Vin C, Fan X, Crabbe DL, Brown MD, Visit-to-visit and 24-h blood pressure variability: association with endothelial and smooth muscle function in African Americans. J Hum Hypertens 27:11(671-7)2013 Nov

22879049. Wang B, Cheheltani R, Rosano J, Crabbe DL, Kiani MF, Targeted delivery of VEGF to treat myocardial infarction. Adv Exp Med Biol 765:(307-14)2013

22844388. Rosano JM, Cheheltani R, Wang B, Vora H, Kiani MF, Crabbe DL, Targeted Delivery of VEGF after a Myocardial Infarction Reduces Collagen Deposition and Improves Cardiac Function. Cardiovasc Eng Technol 3:2(237-247)2012 Jun

21814215. Diaz KM, Veerabhadrappa P, Kashem MA, Feairheller DL, Sturgeon KM, Williamson ST, Crabbe DL, Brown MD, Relationship of visit-to-visit and ambulatory blood pressure variability to vascular function in African Americans. Hypertens Res 35:1(55-61)2012 Jan

21677701. Veerabhadrappa P, Diaz KM, Feairheller DL, Sturgeon KM, Williamson ST, Crabbe DL, Kashem AM, Brown MD, Endothelial-dependent flow-mediated dilation in African Americans with masked-hypertension. Am J Hypertens 24:10(1102-7)2011 Oct

21274440. Diaz KM, Feairheller DL, Sturgeon KM, Veerabhadrappa P, Williamson ST, Crabbe DL, Brown MD, Increased nitric oxide and attenuated diastolic blood pressure variability in african americans with mildly impaired renal function. Int J Hypertens 2010:(137206)2011 Jan 9

20885987. Veerabhadrappa P, Diaz KM, Feairheller DL, Sturgeon KM, Williamson S, Crabbe DL, Kashem A, Ahrensfield D, Brown MD, Enhanced blood pressure variability in a high cardiovascular risk group of African Americans: FIT4Life Study. J Am Soc Hypertens 4:4(187-95)2010 Jul-Aug

20628261. Feairheller DL, Sturgeon KM, Diaz KM, Veerabhadrappa P, Williamson ST, Crabbe DL, Brown MD, Prehypertensive African-American women have preserved nitric oxide and renal function but high cardiovascular risk. Kidney Blood Press Res 33:4(282-90)2010

19845805. Gleeson D, Crabbe DL, Emerging concepts in cardiovascular disease risk assessment: where do women fit in? J Am Acad Nurse Pract 21:9(480-7)2009 Sep

19535683. Scott RC, Rosano JM, Ivanov Z, Wang B, Chong PL, Issekutz AC, Crabbe DL, Kiani MF, Targeting VEGF-encapsulated immunoliposomes to MI heart improves vascularity and cardiac function. FASEB J 23:10(3361-7)2009 Oct

18426386. Scott RC, Crabbe D, Krynska B, Ansari R, Kiani MF, Aiming for the heart: targeted delivery of drugs to diseased cardiac tissue. Expert Opin Drug Deliv 5:4(459-70)2008 Apr

17431084. Renna BF, MacDonnell SM, Reger PO, Crabbe DL, Houser SR, Libonati JR, Relative systolic dysfunction in female spontaneously hypertensive rat myocardium. J Appl Physiol (1985) 103:1(353-8)2007 Jul

16672836. Renna BF, Kubo H, MacDonnell SM, Crabbe DL, Reger PO, Houser SR, Libonati JR, Enhanced acidotic myocardial Ca2+ responsiveness with training in hypertension. Med Sci Sports Exerc 38:5(847-55)2006 May

15967848. MacDonnell SM, Kubo H, Crabbe DL, Renna BF, Reger PO, Mohara J, Smithwick LA, Koch WJ, Houser SR, Libonati JR, Improved myocardial beta-adrenergic responsiveness and signaling with exercise training in hypertension. Circulation 111:25(3420-8)2005 Jun 28

15865856. Crabbe DL, Harris NK, Hypertrophy in the female heart. Curr Cardiol Rep 7:3(173-7)2005 May

14587633. Yang J, Pham SM, Crabbe DL, High-resolution Micro-CT evaluation of mid- to long-term effects of estrogen deficiency on rat trabecular bone. Acad Radiol 10:10(1153-8)2003 Oct

13679356. Yang J, Pham SM, Crabbe DL, Effects of oestrogen deficiency on rat mandibular and tibial microarchitecture. Dentomaxillofac Radiol 32:4(247-51)2003 Jul

12957615. Kashem A, Kashem S, Santamore WP, Crabbe DL, Margulies KB, Melvin DB, Goldman BI, Early and late results of left ventricular reshaping by passive cardiac-support device in canine heart failure. J Heart Lung Transplant 22:9(1046-53)2003 Sep

12930271. Kashem A, Santamore WP, Hassan S, Melvin DB, Crabbe DL, Margulies KB, Goldman BI, Llort F, Krieger C, Lesniak J, CardioClasp changes left ventricular shape acutely in enlarged canine heart. J Card Surg 18 Suppl 2:(S49-60)2003 Jul-Aug

12579110. Kashem A, Hassan S, Crabbe DL, Melvin DB, Santamore WP, Left ventricular reshaping: effects on the pressure-volume relationship. J Thorac Cardiovasc Surg 125:2(391-9)2003 Feb

12535826. Crabbe DL, Dipla K, Ambati S, Zafeiridis A, Gaughan JP, Houser SR, Margulies KB, Gender differences in post-infarction hypertrophy in end-stage failing hearts. J Am Coll Cardiol 41:2(300-6)2003 Jan 15

12058999. Kashem A, Santamore WP, Hassan S, Crabbe DL, Marculies KB, Melvin DB, CardioClasp: a new passive device to reshape cardiac enlargement. ASAIO J 48:3(253-9)2002 May-Jun

8890818. Hansen CL, Crabbe D, Rubin S, Lower diagnostic accuracy of thallium-201 SPECT myocardial perfusion imaging in women: an effect of smaller chamber size. J Am Coll Cardiol 28:5(1214-9)1996 Nov 1

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