FAculty directory

Back to alphabetical index

Alan Cowan, PhD

Professor, Pharmacology

Professor, Anesthesiology

Telephone:  215-707- 4110

Fax:  215-707-7068

Email: acowan@temple.edu

Department of Pharmacology

Department of Anesthesiology

Center for Substance Abuse Research

University of Glasgow, Scotland: BSc Pharmacy, 1964

 

Royal College of Science and Technology: ARCST Pharmacy, 1964

 

University of Strathclyde, Glasgow: PhD Pharmacology, 1968

Return to top

• The pharmacological interface between pain and itch
• Development of kappa agonists as antipruritic agents
• Behavioral and gut pharmacology of bombesin-like peptides, icilin and tegaserod

Return to top

Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

20061095. Tallarida RJ, Cowan A, Raffa RB, On deriving the dose-effect relation of an unknown second component: An example using buprenorphine preclinical data. Drug Alcohol Depend :()2010 Jan 8

19733208. Huang P, Liu-Chen LY, Unterwald EM, Cowan A, Hyperlocomotion and paw tremors are two highly quantifiable signs of SR141716-precipitated withdrawal from delta9-tetrahydrocannabinol in C57BL/6 mice. Neurosci Lett 465:1(66-70)2009 Nov 6

19549515. Inan S, Dun NJ, Cowan A, Inhibitory effect of lidocaine on pain and itch using formalin-induced nociception and 5'-guanidinonaltrindole-induced scratching models in mice: behavioral and neuroanatomical evidence. Eur J Pharmacol 616:1-3(141-6)2009 Aug 15

19524022. Inan S, Dun NJ, Cowan A, Nalfurafine prevents 5'-guanidinonaltrindole- and compound 48/80-induced spinal c-fos expression and attenuates 5'-guanidinonaltrindole-elicited scratching behavior in mice. Neuroscience 163:1(23-33)2009 Sep 29

19248800. Werkheiser J, Cowan A, Gomez T, Henry C, Parekh S, Chau S, Baron DA, Rawls SM, Icilin-induced wet-dog shakes in rats are dependent on NMDA receptor activation and nitric oxide production. Pharmacol Biochem Behav 92:3(543-8)2009 May

18942041. Ung D, Cowan A, Parkman HP, Nagar S, Lack of interaction between metoclopramide and morphine in vitro and in mice. Xenobiotica 38:11(1365-76)2008 Nov

18925386. Inan S, Lee DY, Liu-Chen LY, Cowan A, Comparison of the diuretic effects of chemically diverse kappa opioid agonists in rats: nalfurafine, U50,488H, and salvinorin A. Naunyn Schmiedebergs Arch Pharmacol 379:3(263-70)2009 Mar

18789801. Xiong Z, Yan Y, Song J, Fang P, Yin Y, Yang Y, Cowan A, Wang H, Yang XF, Expression of TCTP antisense in CD25(high) regulatory T cells aggravates cuff-injured vascular inflammation. Atherosclerosis 203:2(401-8)2009 Apr

18508723. Xiong Z, Song J, Yan Y, Huang Y, Cowan A, Wang H, Yang XF, Higher expression of Bax in regulatory T cells increases vascular inflammation. Front Biosci 13:(7143-55)2008 May 1

18155835. Ding Z, Cowan A, Rawls SM, 5-HT reuptake and 5-HT2 receptors modulate capsaicin-evoked hypothermia in rats. Neurosci Lett 430:3(191-6)2008 Jan 17

18089845. Wang Y, Chen Y, Xu W, Lee DY, Ma Z, Rawls SM, Cowan A, Liu-Chen LY, 2-Methoxymethyl-salvinorin B is a potent kappa opioid receptor agonist with longer lasting action in vivo than salvinorin A. J Pharmacol Exp Ther 324:3(1073-83)2008 Mar

18064600. Radzievsky AA, Gordiienko OV, Alekseev S, Szabo I, Cowan A, Ziskin MC, Electromagnetic millimeter wave induced hypoalgesia: frequency dependence and involvement of endogenous opioids. Bioelectromagnetics 29:4(284-95)2008 May

17976579. Ding Z, Gomez T, Werkheiser JL, Cowan A, Rawls SM, Icilin induces a hyperthermia in rats that is dependent on nitric oxide production and NMDA receptor activation. Eur J Pharmacol 578:2-3(201-8)2008 Jan 14

17150231. Werkheiser JL, Rawls SM, Cowan A, Nalfurafine, the kappa opioid agonist, inhibits icilin-induced wet-dog shakes in rats and antagonizes glutamate release in the dorsal striatum. Neuropharmacology 52:3(925-30)2007 Mar

17018247. Ding Z, Cowan A, Tallarida R, Rawls SM, Capsaicin and nitric oxide synthase inhibitor interact to evoke a hypothermic synergy. Neurosci Lett 409:1(41-6)2006 Nov 27

16945367. Werkheiser JL, Rawls SM, Cowan A, Mu and kappa opioid receptor agonists antagonize icilin-induced wet-dog shaking in rats. Eur J Pharmacol 547:1-3(101-5)2006 Oct 10

16919318. Inan S, Cowan A, Nalfurafine, a kappa opioid receptor agonist, inhibits scratching behavior secondary to cholestasis induced by chronic ethynylestradiol injections in rats. Pharmacol Biochem Behav 85:1(39-43)2006 Sep

16893609. Hummel M, Schroeder J, Liu-Chen LY, Cowan A, Unterwald EM, An antisense oligodeoxynucleotide to the mu opioid receptor attenuates cocaine-induced behavioral sensitization and reward in mice. Neuroscience 142:2(481-91)2006 Oct 13

16647109. Rawls SM, Ding Z, Cowan A, Role of TRPV1 and cannabinoid CB1 receptors in AM 404-evoked hypothermia in rats. Pharmacol Biochem Behav 83:4(508-16)2006 Apr

16622598. Werkheiser JL, Rawls SM, Cowan A, Icilin evokes a dose- and time-dependent increase in glutamate within the dorsal striatum of rats. Amino Acids 30:3(307-9)2006 May

Return to top