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Alan Cowan, PhD

Professor, Pharmacology

Professor, Anesthesiology

Telephone:  215-707- 4110

Fax:  215-707-7068

Email: acowan@temple.edu

Department of Pharmacology

Department of Anesthesiology

Center for Substance Abuse Research

University of Glasgow, Scotland: BSc Pharmacy, 1964

 

Royal College of Science and Technology: ARCST Pharmacy, 1964

 

University of Strathclyde, Glasgow: PhD Pharmacology, 1968

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• The pharmacological interface between pain and itch
• Development of kappa agonists as antipruritic agents
• Behavioral and gut pharmacology of bombesin-like peptides, icilin and tegaserod

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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

19733208. Huang P, Liu-Chen LY, Unterwald EM, Cowan A, Hyperlocomotion and paw tremors are two highly quantifiable signs of SR141716-precipitated withdrawal from delta9-tetrahydrocannabinol in C57BL/6 mice. Neurosci Lett 465:1(66-70)2009 Nov 6

19549515. Inan S, Dun NJ, Cowan A, Inhibitory effect of lidocaine on pain and itch using formalin-induced nociception and 5'-guanidinonaltrindole-induced scratching models in mice: behavioral and neuroanatomical evidence. Eur J Pharmacol 616:1-3(141-6)2009 Aug 15

19524022. Inan S, Dun NJ, Cowan A, Nalfurafine prevents 5'-guanidinonaltrindole- and compound 48/80-induced spinal c-fos expression and attenuates 5'-guanidinonaltrindole-elicited scratching behavior in mice. Neuroscience 163:1(23-33)2009 Sep 29

19248800. Werkheiser J, Cowan A, Gomez T, Henry C, Parekh S, Chau S, Baron DA, Rawls SM, Icilin-induced wet-dog shakes in rats are dependent on NMDA receptor activation and nitric oxide production. Pharmacol Biochem Behav 92:3(543-8)2009 May

18942041. Ung D, Cowan A, Parkman HP, Nagar S, Lack of interaction between metoclopramide and morphine in vitro and in mice. Xenobiotica 38:11(1365-76)2008 Nov

18925386. Inan S, Lee DY, Liu-Chen LY, Cowan A, Comparison of the diuretic effects of chemically diverse kappa opioid agonists in rats: nalfurafine, U50,488H, and salvinorin A. Naunyn Schmiedebergs Arch Pharmacol 379:3(263-70)2009 Mar

18789801. Xiong Z, Yan Y, Song J, Fang P, Yin Y, Yang Y, Cowan A, Wang H, Yang XF, Expression of TCTP antisense in CD25(high) regulatory T cells aggravates cuff-injured vascular inflammation. Atherosclerosis 203:2(401-8)2009 Apr

18508723. Xiong Z, Song J, Yan Y, Huang Y, Cowan A, Wang H, Yang XF, Higher expression of Bax in regulatory T cells increases vascular inflammation. Front Biosci 13:(7143-55)2008 May 1

18155835. Ding Z, Cowan A, Rawls SM, 5-HT reuptake and 5-HT2 receptors modulate capsaicin-evoked hypothermia in rats. Neurosci Lett 430:3(191-6)2008 Jan 17

18089845. Wang Y, Chen Y, Xu W, Lee DY, Ma Z, Rawls SM, Cowan A, Liu-Chen LY, 2-Methoxymethyl-salvinorin B is a potent kappa opioid receptor agonist with longer lasting action in vivo than salvinorin A. J Pharmacol Exp Ther 324:3(1073-83)2008 Mar

18064600. Radzievsky AA, Gordiienko OV, Alekseev S, Szabo I, Cowan A, Ziskin MC, Electromagnetic millimeter wave induced hypoalgesia: frequency dependence and involvement of endogenous opioids. Bioelectromagnetics 29:4(284-95)2008 May

17976579. Ding Z, Gomez T, Werkheiser JL, Cowan A, Rawls SM, Icilin induces a hyperthermia in rats that is dependent on nitric oxide production and NMDA receptor activation. Eur J Pharmacol 578:2-3(201-8)2008 Jan 14

17150231. Werkheiser JL, Rawls SM, Cowan A, Nalfurafine, the kappa opioid agonist, inhibits icilin-induced wet-dog shakes in rats and antagonizes glutamate release in the dorsal striatum. Neuropharmacology 52:3(925-30)2007 Mar

17018247. Ding Z, Cowan A, Tallarida R, Rawls SM, Capsaicin and nitric oxide synthase inhibitor interact to evoke a hypothermic synergy. Neurosci Lett 409:1(41-6)2006 Nov 27

16945367. Werkheiser JL, Rawls SM, Cowan A, Mu and kappa opioid receptor agonists antagonize icilin-induced wet-dog shaking in rats. Eur J Pharmacol 547:1-3(101-5)2006 Oct 10

16919318. Inan S, Cowan A, Nalfurafine, a kappa opioid receptor agonist, inhibits scratching behavior secondary to cholestasis induced by chronic ethynylestradiol injections in rats. Pharmacol Biochem Behav 85:1(39-43)2006 Sep

16893609. Hummel M, Schroeder J, Liu-Chen LY, Cowan A, Unterwald EM, An antisense oligodeoxynucleotide to the mu opioid receptor attenuates cocaine-induced behavioral sensitization and reward in mice. Neuroscience 142:2(481-91)2006 Oct 13

16647109. Rawls SM, Ding Z, Cowan A, Role of TRPV1 and cannabinoid CB1 receptors in AM 404-evoked hypothermia in rats. Pharmacol Biochem Behav 83:4(508-16)2006 Apr

16622598. Werkheiser JL, Rawls SM, Cowan A, Icilin evokes a dose- and time-dependent increase in glutamate within the dorsal striatum of rats. Amino Acids 30:3(307-9)2006 May

16566919. Rawls SM, Allebach C, Cowan A, Nitric oxide synthase mediates delta opioid receptor-induced hypothermia in rats. Eur J Pharmacol 536:1-2(109-12)2006 Apr 24

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