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Philip L. Cohen, MD

Section Chief, Rheumatology

Professor, Medicine

Professor, Microbiology and Immunology

Telephone:  215-707-0791

FAX: 215-707-3508

Email: philco@temple.edu

Department of Medicine, Section of Rheumatology

Department of Microbiology and Immunology

Temple Autoimmunity Center

 

BS, City College of New York, New York City, NY, 1968

 

MD, Yale University School of Medicine, New Haven, CT, 1972

 

Internship, Columbia-Presbyterian Medical Center, New York City, NY, 1972-1973

 

Research Associate, Laboratory of Immunology, NIAID, 1973-1975

 

Residency, Columbia-Presbyterian Medical Center, New York City, NY, 1975-1976

 

Fellowship, Rheumatology, University of Texas Southwestern Medical Center, Dallas, TX, 1976-1978

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• Systemic lupus

• Sjögren's syndrome
• Rheumatoid arthritis

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• Systemic autoimmunity
• Apoptosis and its disorders

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• Internal Medicine, 1977
• Rheumatology, 1978

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• American Association of Immunologists
• American College of Rheumatology
• American Society for Clinical Investigation
• College of Physicians of Philadelphia
• Philadelphia Rheumatism Association

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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

23644550. Hu F, Mu R, Zhu J, Shi L, Li Y, Liu X, Shao W, Li G, Li M, Su Y, Cohen PL, Qiu X, Li Z, Hypoxia and hypoxia-inducible factor-1a provoke toll-like receptor signalling-induced inflammation in rheumatoid arthritis. Ann Rheum Dis :()2013 May 3

23596310. Zizzo G, Cohen PL, IL-17 stimulates differentiation of human anti-inflammatory macrophages and phagocytosis of apoptotic neutrophils in response to IL-10 and glucocorticoids. J Immunol 190:10(5237-46)2013 May 15

23519178. Singh N, Birkenbach M, Caza T, Perl A, Cohen PL, Tuberous sclerosis and fulminant lupus in a young woman. J Clin Rheumatol 19:3(134-7)2013 Apr

22942426. Zizzo G, Hilliard BA, Monestier M, Cohen PL, Efficient clearance of early apoptotic cells by human macrophages requires M2c polarization and MerTK induction. J Immunol 189:7(3508-20)2012 Oct 1

22907951. Lee IJ, Hilliard B, Swami A, Madara JC, Rao S, Patel T, Gaughan JP, Lee J, Gadegbeku CA, Choi ET, Cohen PL, Growth arrest-specific gene 6 (Gas6) levels are elevated in patients with chronic renal failure. Nephrol Dial Transplant 27:11(4166-72)2012 Nov

22854104. Shao WH, Zhen Y, Finkelman FD, Eisenberg RA, Cohen PL, Intrinsic unresponsiveness of Mertk-/- B cells to chronic graft-versus-host disease is associated with unmodulated CD1d expression. J Autoimmun 39:4(412-9)2012 Dec

22792128. Chen DR, Cohen PL, Living life without B cells: is repeated B-cell depletion a safe and effective long-term treatment plan for rheumatoid arthritis? Int J Clin Rheumtol 7:2(159-166)2012 Apr 1

22709856. Singh N, Cohen PL, The T cell in Sjogren's syndrome: force majeure, not spectateur. J Autoimmun 39:3(229-33)2012 Sep

22350147. Meng W, Li Y, Xue E, Satoh M, Peck AB, Cohen PL, Eisenberg RA, Luning Prak ET, B-cell tolerance defects in the B6.Aec1/2 mouse model of Sjögren's syndrome. J Clin Immunol 32:3(551-64)2012 Jun

22156197. Hong C, Kidani Y, A-Gonzalez N, Phung T, Ito A, Rong X, Ericson K, Mikkola H, Beaven SW, Miller LS, Shao WH, Cohen PL, Castrillo A, Tontonoz P, Bensinger SJ, Coordinate regulation of neutrophil homeostasis by liver X receptors in mice. J Clin Invest 122:1(337-47)2012 Jan 3

21746964. Meng W, Yunk L, Wang LS, Maganty A, Xue E, Cohen PL, Eisenberg RA, Weigert MG, Mancini SJ, Prak ET, Selection of individual VH genes occurs at the pro-B to pre-B cell transition. J Immunol 187:4(1835-44)2011 Aug 15

21723351. Otvos L Jr, Shao WH, Vanniasinghe AS, Amon MA, Holub MC, Kovalszky I, Wade JD, Doll M, Cohen PL, Manolios N, Surmacz E, Toward understanding the role of leptin and leptin receptor antagonism in preclinical models of rheumatoid arthritis. Peptides 32:8(1567-74)2011 Aug

21371352. Shao WH, Cohen PL, Disturbances of apoptotic cell clearance in systemic lupus erythematosus. Arthritis Res Ther 13:1(202)2011 Feb 28

20952679. Rahman ZS, Shao WH, Khan TN, Zhen Y, Cohen PL, Impaired apoptotic cell clearance in the germinal center by Mer-deficient tingible body macrophages leads to enhanced antibody-forming cell and germinal center responses. J Immunol 185:10(5859-68)2010 Nov 15

20822883. Shao WH, Kuan AP, Wang C, Abraham V, Waldman MA, Vogelgesang A, Wittenburg G, Choudhury A, Tsao PY, Miwa T, Eisenberg RA, Cohen PL, Disrupted Mer receptor tyrosine kinase expression leads to enhanced MZ B-cell responses. J Autoimmun 35:4(368-74)2010 Dec

20637106. Suh CH, Hilliard B, Li S, Merrill JT, Cohen PL, TAM receptor ligands in lupus: protein S but not Gas6 levels reflect disease activity in systemic lupus erythematosus. Arthritis Res Ther 12:4(R146)2010

20444650. Shao WH, Zhen Y, Rosenbaum J, Eisenberg RA, McGaha TL, Birkenbach M, Cohen PL, A protective role of Mer receptor tyrosine kinase in nephrotoxic serum-induced nephritis. Clin Immunol 136:2(236-44)2010 Aug

20381429. Choudhury A, Cohen PL, Eisenberg RA, B cells require "nurturing" by CD4 T cells during development in order to respond in chronic graft-versus-host model of systemic lupus erythematosus. Clin Immunol 136:1(105-15)2010 Jul

19631584. Shao WH, Zhen Y, Eisenberg RA, Cohen PL, The Mer receptor tyrosine kinase is expressed on discrete macrophage subpopulations and mainly uses Gas6 as its ligand for uptake of apoptotic cells. Clin Immunol 133:1(138-44)2009 Oct

19542457. Yunk L, Meng W, Cohen PL, Eisenberg RA, Luning Prak ET, Antibodies in a heavy chain knock-in mouse exhibit characteristics of early heavy chain rearrangement. J Immunol 183:1(452-61)2009 Jul 1

19017966. Tsao PY, Jiao J, Ji MQ, Cohen PL, Eisenberg RA, T cell-independent spontaneous loss of tolerance by anti-double-stranded DNA B cells in C57BL/6 mice. J Immunol 181:11(7770-7)2008 Dec 1

18713966. Li Y, Chen F, Putt M, Koo YK, Madaio M, Cambier JC, Cohen PL, Eisenberg RA, B cell depletion with anti-CD79 mAbs ameliorates autoimmune disease in MRL/lpr mice. J Immunol 181:5(2961-72)2008 Sep 1

18490777. Shao WH, Eisenberg RA, Cohen PL, The Mer receptor tyrosine kinase is required for the loss of B cell tolerance in the chronic graft-versus-host disease model of systemic lupus erythematosus. J Immunol 180:11(7728-35)2008 Jun 1

18467644. Ait-Oufella H, Pouresmail V, Simon T, Blanc-Brude O, Kinugawa K, Merval R, Offenstadt G, Lesèche G, Cohen PL, Tedgui A, Mallat Z, Defective mer receptor tyrosine kinase signaling in bone marrow cells promotes apoptotic cell accumulation and accelerates atherosclerosis. Arterioscler Thromb Vasc Biol 28:8(1429-31)2008 Aug

18432900. Cohen PL, Maldonado MA, Animal models for SLE. Curr Protoc Immunol Chapter 15:(Unit 15.20)2003 Feb

18325838. Ma Z, Choudhury A, Kang SA, Monestier M, Cohen PL, Eisenberg RA, Accelerated atherosclerosis in ApoE deficient lupus mouse models. Clin Immunol 127:2(168-75)2008 May

17911643. Choudhury A, Cohen PL, Eisenberg RA, Mature B cells preferentially lose tolerance in the chronic graft-versus-host disease model of systemic lupus erythematosus. J Immunol 179:8(5564-70)2007 Oct 15

17082664. Ma Z, Chen F, Madaio MP, Cohen PL, Eisenberg RA, Modulation of autoimmunity by TLR9 in the chronic graft-vs-host model of systemic lupus erythematosus. J Immunol 177:10(7444-50)2006 Nov 15

16941106. Cohen PL, Apoptotic cell death and lupus. Springer Semin Immunopathol 28:2(145-52)2006 Oct

16572440. Cohen PL, Stopping traffic in Sjögren's syndrome. Arthritis Rheum 54:4(1061-2)2006 Apr

16277689. Carl PL, Temple BR, Cohen PL, Most nuclear systemic autoantigens are extremely disordered proteins: implications for the etiology of systemic autoimmunity. Arthritis Res Ther 7:6(R1360-74)2005

15944260. Choudhury A, Maldonado MA, Cohen PL, Eisenberg RA, The role of host CD4 T cells in the pathogenesis of the chronic graft-versus-host model of systemic lupus erythematosus. J Immunol 174:12(7600-9)2005 Jun 15

15789337. Kuan AP, Cohen PL, p53 is required for spontaneous autoantibody production in B6/lpr lupus mice. Eur J Immunol 35:5(1653-60)2005 May

15261337. Cohen PL, Caricchio R, Genetic models for the clearance of apoptotic cells. Rheum Dis Clin North Am 30:3(473-86, viii)2004 Aug

14993405. Cohen PL, Autoimmunity and lymphoproliferation: two genes are worse than one. Mol Interv 2:7(427-30)2002 Nov

14872521. Cohen PL, Self-arthrocentesis in a man with joint pain. Arthritis Rheum 50:2(680)2004 Feb

14634086. Caricchio R, McPhie L, Cohen PL, Ultraviolet B radiation-induced cell death: critical role of ultraviolet dose in inflammation and lupus autoantigen redistribution. J Immunol 171:11(5778-86)2003 Dec 1

12884290. Behrens EM, Gadue P, Gong SY, Garrett S, Stein PL, Cohen PL, The mer receptor tyrosine kinase: expression and function suggest a role in innate immunity. Eur J Immunol 33:8(2160-7)2003 Aug

12857967. Cohen PL, Studies of murine systemic autoimmunity. Immunol Res 27:2-3(179-84)2003

12574397. Suh CH, Freed JH, Cohen PL, T cell reactivity to MHC class II-bound self peptides in systemic lupus erythematosus-prone MRL/lpr mice. J Immunol 170:4(2229-35)2003 Feb 15

12124868. Parks CG, Cooper GS, Nylander-French LA, Sanderson WT, Dement JM, Cohen PL, Dooley MA, Treadwell EL, St Clair EW, Gilkeson GS, Hoppin JA, Savitz DA, Occupational exposure to crystalline silica and risk of systemic lupus erythematosus: a population-based, case-control study in the southeastern United States. Arthritis Rheum 46:7(1840-50)2002 Jul

12093878. Cohen PL, Caricchio R, Abraham V, Camenisch TD, Jennette JC, Roubey RA, Earp HS, Matsushima G, Reap EA, Delayed apoptotic cell clearance and lupus-like autoimmunity in mice lacking the c-mer membrane tyrosine kinase. J Exp Med 196:1(135-40)2002 Jul 1

11999880. Cooper GS, Parks CG, Treadwell EL, St Clair EW, Gilkeson GS, Cohen PL, Roubey RA, Dooley MA, Differences by race, sex and age in the clinical and immunologic features of recently diagnosed systemic lupus erythematosus patients in the southeastern United States. Lupus 11:3(161-7)2002

11973615. Caricchio R, D'Adamio L, Cohen PL, Fas, ceramide and serum withdrawal induce apoptosis via a common pathway in a type II Jurkat cell line. Cell Death Differ 9:5(574-80)2002 May

11807643. Aziz KM, Froelich SC, Cohen PL, Sanan A, Keller JT, van Loveren HR, The one-piece orbitozygomatic approach: the MacCarty burr hole and the inferior orbital fissure as keys to technique and application. Acta Neurochir (Wien) 144:1(15-24)2002 Jan

11546899. McPherson CM, Woo D, Cohen PL, Pancioli AM, Kissela BM, Carrozzella JA, Tomsick TA, Zuccarello M, Early carotid endarterectomy for critical carotid artery stenosis after thrombolysis therapy in acute ischemic stroke in the middle cerebral artery. Stroke 32:9(2075-80)2001 Sep

11346799. Scott RS, McMahon EJ, Pop SM, Reap EA, Caricchio R, Cohen PL, Earp HS, Matsushima GK, Phagocytosis and clearance of apoptotic cells is mediated by MER. Nature 411:6834(207-11)2001 May 10

10925319. Dumortier H, Monneaux F, Jahn-Schmid B, Briand JP, Skriner K, Cohen PL, Smolen JS, Steiner G, Muller S, B and T cell responses to the spliceosomal heterogeneous nuclear ribonucleoproteins A2 and B1 in normal and lupus mice. J Immunol 165:4(2297-305)2000 Aug 15

10779775. Freed JH, Marrs A, VanderWall J, Cohen PL, Eisenberg RA, MHC class II-bound self peptides from autoimmune MRL/lpr mice reveal potential T cell epitopes for autoantibody production in murine systemic lupus erythematosus. J Immunol 164:9(4697-705)2000 May 1

10612651. Caricchio R, Cohen PL, Spontaneous and induced apoptosis in systemic lupus erythematosus: multiple assays fail to reveal consistent abnormalities. Cell Immunol 198:1(54-60)1999 Nov 25

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