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Phillip L. Cohen, MD


Philip L. Cohen, MD


Section Chief, Rheumatology

Professor, Medicine

Professor, Microbiology and Immunology

Telephone:  215-707-0791

FAX: 215-707-3508

Email: philco@temple.edu


Department of Medicine, Section of Rheumatology

Department of Microbiology and Immunology

Temple Autoimmunity Center


Educational Background:


BS, City College of New York, New York City, NY, 1968


MD, Yale University School of Medicine, New Haven, CT, 1972


Internship, Columbia-Presbyterian Medical Center, New York City, NY, 1972-1973


Research Associate, Laboratory of Immunology, NIAID, 1973-1975


Residency, Columbia-Presbyterian Medical Center, New York City, NY, 1975-1976


Fellowship, Rheumatology, University of Texas Southwestern Medical Center, Dallas, TX, 1976-1978

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clinical Interests:


  • Systemic lupus
  • Sjögren's syndrome
  • Rheumatoid arthritis

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research Interests:


  • Systemic autoimmunity
  • Apoptosis and its disorders

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board certification(s):


  • Internal Medicine, 1977
  • Rheumatology, 1978

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professional affiliations:

  • American Association of Immunologists
  • American College of Rheumatology
  • American Society for Clinical Investigation
  • College of Physicians of Philadelphia
  • Philadelphia Rheumatism Association

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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

26392462. Shao WH, Gamero AM, Zhen Y, Lobue MJ, Priest SO, Albandar HJ, Cohen PL, Stat1 Regulates Lupus-like Chronic Graft-versus-Host Disease Severity via Interactions with Stat3. J Immunol 195:9(4136-43)2015 Nov 1

26254265. Cohen PL, Comment on "Aminoacyl tRNA Synthetase-Interacting Multifunctional Protein 1 Acts as a Novel B Cell-Activating Factor In Vitro and In Vivo". J Immunol 195:4(1339)2015 Aug 15

25972766. Zizzo G, Cohen PL, The PPAR-? antagonist GW9662 elicits differentiation of M2c-like cells and upregulation of the MerTK/Gas6 axis: a key role for PPAR-? in human macrophage polarization. J Inflamm (Lond) 12:(36)2015

25814173. Lee IJ, Hilliard BA, Ulas M, Yu D, Vangala C, Rao S, Lee J, Gadegbeku CA, Cohen PL, Monocyte and plasma expression of TAM ligand and receptor in renal failure: Links to unregulated immunity and chronic inflammation. Clin Immunol 158:2(231-41)2015 Jun

25107306. Singh N, Traisak P, Martin KA, Kaplan MJ, Cohen PL, Denny MF, Genomic alterations in abnormal neutrophils isolated from adult patients with systemic lupus erythematosus. Arthritis Res Ther 16:4(R165)2014 Aug 8

24768065. Shao WH, Zhen Y, Finkelman FD, Cohen PL, The Mertk receptor tyrosine kinase promotes T-B interaction stimulated by IgD B-cell receptor cross-linking. J Autoimmun 53:(78-84)2014 Sep

24678775. Shao WH, Cohen PL, The role of tyrosine kinases in systemic lupus erythematosus and their potential as therapeutic targets. Expert Rev Clin Immunol 10:5(573-82)2014 May

24650765. Hilliard BA, Zizzo G, Ulas M, Linan MK, Schreiter J, Cohen PL, Increased expression of Mer tyrosine kinase in circulating dendritic cells and monocytes of lupus patients: correlations with plasma interferon activity and steroid therapy. Arthritis Res Ther 16:2(R76)2014 Mar 21

24517398. Hershberg U, Meng W, Zhang B, Haff N, St Clair EW, Cohen PL, McNair PD, Li L, Levesque MC, Luning Prak ET, Persistence and selection of an expanded B-cell clone in the setting of rituximab therapy for Sjögren's syndrome. Arthritis Res Ther 16:1(R51)2014 Feb 11

24325951. Zizzo G, Guerrieri J, Dittman LM, Merrill JT, Cohen PL, Circulating levels of soluble MER in lupus reflect M2c activation of monocytes/macrophages, autoantibody specificities and disease activity. Arthritis Res Ther 15:6(R212)2013

23644550. Hu F, Mu R, Zhu J, Shi L, Li Y, Liu X, Shao W, Li G, Li M, Su Y, Cohen PL, Qiu X, Li Z, Hypoxia and hypoxia-inducible factor-1a provoke toll-like receptor signalling-induced inflammation in rheumatoid arthritis. Ann Rheum Dis 73:5(928-36)2014 May

23596310. Zizzo G, Cohen PL, IL-17 stimulates differentiation of human anti-inflammatory macrophages and phagocytosis of apoptotic neutrophils in response to IL-10 and glucocorticoids. J Immunol 190:10(5237-46)2013 May 15

23519178. Singh N, Birkenbach M, Caza T, Perl A, Cohen PL, Tuberous sclerosis and fulminant lupus in a young woman. J Clin Rheumatol 19:3(134-7)2013 Apr

22942426. Zizzo G, Hilliard BA, Monestier M, Cohen PL, Efficient clearance of early apoptotic cells by human macrophages requires M2c polarization and MerTK induction. J Immunol 189:7(3508-20)2012 Oct 1

22907951. Lee IJ, Hilliard B, Swami A, Madara JC, Rao S, Patel T, Gaughan JP, Lee J, Gadegbeku CA, Choi ET, Cohen PL, Growth arrest-specific gene 6 (Gas6) levels are elevated in patients with chronic renal failure. Nephrol Dial Transplant 27:11(4166-72)2012 Nov

22854104. Shao WH, Zhen Y, Finkelman FD, Eisenberg RA, Cohen PL, Intrinsic unresponsiveness of Mertk-/- B cells to chronic graft-versus-host disease is associated with unmodulated CD1d expression. J Autoimmun 39:4(412-9)2012 Dec

22792128. Chen DR, Cohen PL, Living life without B cells: is repeated B-cell depletion a safe and effective long-term treatment plan for rheumatoid arthritis? Int J Clin Rheumtol 7:2(159-166)2012 Apr 1

22709856. Singh N, Cohen PL, The T cell in Sjogren's syndrome: force majeure, not spectateur. J Autoimmun 39:3(229-33)2012 Sep

22350147. Meng W, Li Y, Xue E, Satoh M, Peck AB, Cohen PL, Eisenberg RA, Luning Prak ET, B-cell tolerance defects in the B6.Aec1/2 mouse model of Sjögren's syndrome. J Clin Immunol 32:3(551-64)2012 Jun

22156197. Hong C, Kidani Y, A-Gonzalez N, Phung T, Ito A, Rong X, Ericson K, Mikkola H, Beaven SW, Miller LS, Shao WH, Cohen PL, Castrillo A, Tontonoz P, Bensinger SJ, Coordinate regulation of neutrophil homeostasis by liver X receptors in mice. J Clin Invest 122:1(337-47)2012 Jan

21746964. Meng W, Yunk L, Wang LS, Maganty A, Xue E, Cohen PL, Eisenberg RA, Weigert MG, Mancini SJ, Prak ET, Selection of individual VH genes occurs at the pro-B to pre-B cell transition. J Immunol 187:4(1835-44)2011 Aug 15

21723351. Otvos L Jr, Shao WH, Vanniasinghe AS, Amon MA, Holub MC, Kovalszky I, Wade JD, Doll M, Cohen PL, Manolios N, Surmacz E, Toward understanding the role of leptin and leptin receptor antagonism in preclinical models of rheumatoid arthritis. Peptides 32:8(1567-74)2011 Aug

21371352. Shao WH, Cohen PL, Disturbances of apoptotic cell clearance in systemic lupus erythematosus. Arthritis Res Ther 13:1(202)2011 Feb 28

20952679. Rahman ZS, Shao WH, Khan TN, Zhen Y, Cohen PL, Impaired apoptotic cell clearance in the germinal center by Mer-deficient tingible body macrophages leads to enhanced antibody-forming cell and germinal center responses. J Immunol 185:10(5859-68)2010 Nov 15

20822883. Shao WH, Kuan AP, Wang C, Abraham V, Waldman MA, Vogelgesang A, Wittenburg G, Choudhury A, Tsao PY, Miwa T, Eisenberg RA, Cohen PL, Disrupted Mer receptor tyrosine kinase expression leads to enhanced MZ B-cell responses. J Autoimmun 35:4(368-74)2010 Dec

20637106. Suh CH, Hilliard B, Li S, Merrill JT, Cohen PL, TAM receptor ligands in lupus: protein S but not Gas6 levels reflect disease activity in systemic lupus erythematosus. Arthritis Res Ther 12:4(R146)2010

20444650. Shao WH, Zhen Y, Rosenbaum J, Eisenberg RA, McGaha TL, Birkenbach M, Cohen PL, A protective role of Mer receptor tyrosine kinase in nephrotoxic serum-induced nephritis. Clin Immunol 136:2(236-44)2010 Aug

20381429. Choudhury A, Cohen PL, Eisenberg RA, B cells require "nurturing" by CD4 T cells during development in order to respond in chronic graft-versus-host model of systemic lupus erythematosus. Clin Immunol 136:1(105-15)2010 Jul

19631584. Shao WH, Zhen Y, Eisenberg RA, Cohen PL, The Mer receptor tyrosine kinase is expressed on discrete macrophage subpopulations and mainly uses Gas6 as its ligand for uptake of apoptotic cells. Clin Immunol 133:1(138-44)2009 Oct

19542457. Yunk L, Meng W, Cohen PL, Eisenberg RA, Luning Prak ET, Antibodies in a heavy chain knock-in mouse exhibit characteristics of early heavy chain rearrangement. J Immunol 183:1(452-61)2009 Jul 1

19017966. Tsao PY, Jiao J, Ji MQ, Cohen PL, Eisenberg RA, T cell-independent spontaneous loss of tolerance by anti-double-stranded DNA B cells in C57BL/6 mice. J Immunol 181:11(7770-7)2008 Dec 1

18713966. Li Y, Chen F, Putt M, Koo YK, Madaio M, Cambier JC, Cohen PL, Eisenberg RA, B cell depletion with anti-CD79 mAbs ameliorates autoimmune disease in MRL/lpr mice. J Immunol 181:5(2961-72)2008 Sep 1

18490777. Shao WH, Eisenberg RA, Cohen PL, The Mer receptor tyrosine kinase is required for the loss of B cell tolerance in the chronic graft-versus-host disease model of systemic lupus erythematosus. J Immunol 180:11(7728-35)2008 Jun 1

18467644. Ait-Oufella H, Pouresmail V, Simon T, Blanc-Brude O, Kinugawa K, Merval R, Offenstadt G, Lesèche G, Cohen PL, Tedgui A, Mallat Z, Defective mer receptor tyrosine kinase signaling in bone marrow cells promotes apoptotic cell accumulation and accelerates atherosclerosis. Arterioscler Thromb Vasc Biol 28:8(1429-31)2008 Aug

18432900. Cohen PL, Maldonado MA, Animal models for SLE. Curr Protoc Immunol Chapter 15:(Unit 15.20)2003 Feb

18325838. Ma Z, Choudhury A, Kang SA, Monestier M, Cohen PL, Eisenberg RA, Accelerated atherosclerosis in ApoE deficient lupus mouse models. Clin Immunol 127:2(168-75)2008 May

17911643. Choudhury A, Cohen PL, Eisenberg RA, Mature B cells preferentially lose tolerance in the chronic graft-versus-host disease model of systemic lupus erythematosus. J Immunol 179:8(5564-70)2007 Oct 15

17082664. Ma Z, Chen F, Madaio MP, Cohen PL, Eisenberg RA, Modulation of autoimmunity by TLR9 in the chronic graft-vs-host model of systemic lupus erythematosus. J Immunol 177:10(7444-50)2006 Nov 15

16941106. Cohen PL, Apoptotic cell death and lupus. Springer Semin Immunopathol 28:2(145-52)2006 Oct

16572440. Cohen PL, Stopping traffic in Sjögren's syndrome. Arthritis Rheum 54:4(1061-2)2006 Apr

16277689. Carl PL, Temple BR, Cohen PL, Most nuclear systemic autoantigens are extremely disordered proteins: implications for the etiology of systemic autoimmunity. Arthritis Res Ther 7:6(R1360-74)2005

15944260. Choudhury A, Maldonado MA, Cohen PL, Eisenberg RA, The role of host CD4 T cells in the pathogenesis of the chronic graft-versus-host model of systemic lupus erythematosus. J Immunol 174:12(7600-9)2005 Jun 15

15789337. Kuan AP, Cohen PL, p53 is required for spontaneous autoantibody production in B6/lpr lupus mice. Eur J Immunol 35:5(1653-60)2005 May

15261337. Cohen PL, Caricchio R, Genetic models for the clearance of apoptotic cells. Rheum Dis Clin North Am 30:3(473-86, viii)2004 Aug

14993405. Cohen PL, Autoimmunity and lymphoproliferation: two genes are worse than one. Mol Interv 2:7(427-30)2002 Nov

14872521. Cohen PL, Self-arthrocentesis in a man with joint pain. Arthritis Rheum 50:2(680)2004 Feb

14634086. Caricchio R, McPhie L, Cohen PL, Ultraviolet B radiation-induced cell death: critical role of ultraviolet dose in inflammation and lupus autoantigen redistribution. J Immunol 171:11(5778-86)2003 Dec 1

12884290. Behrens EM, Gadue P, Gong SY, Garrett S, Stein PL, Cohen PL, The mer receptor tyrosine kinase: expression and function suggest a role in innate immunity. Eur J Immunol 33:8(2160-7)2003 Aug

12857967. Cohen PL, Studies of murine systemic autoimmunity. Immunol Res 27:2-3(179-84)2003

12574397. Suh CH, Freed JH, Cohen PL, T cell reactivity to MHC class II-bound self peptides in systemic lupus erythematosus-prone MRL/lpr mice. J Immunol 170:4(2229-35)2003 Feb 15

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