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Seo-Hee Cho, PhD

Seo-Hee Cho, PhD

 

Assistant Professor, Anatomy and Cell Biology

Assistant Professor, Shriners Hospitals Pediatric Research Center

Telephone: 215-926-9361 (Internal: 7-9361)

Email: seo.hee.cho@temple.edu

 

Anatomy and Cell Biology

Shriners Hospitals Pediatric Research Center

 

Educational Background:

 

Undergraduate degree: Korea University, Seoul, Korea, 1988

 

MS, Korea Advanced Institute of Science and Technology, Daejeon, Korea, 1990

 

PhD, Rutgers University, Piscataway, NJ, 2000

 

Postdoctoral fellowship, Department of Genetics, Harvard Medical School, Boston, MA, 2007

 

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professional affiliations:

 
  • Society for Neuroscience
  • Society for Developmental Biology

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RESEARCH INTERESTS:

 

Mechanisms underlying eye development and retinal degeneration
Cell- and gene-based therapy strategies for degenerative retinal diseases

  • Organ size control
  • Cell size control
  • Tumor suppressors and oncogenes – TSC1/2 – mTOR and Hippo-Yap signaling
  • Polarity complex proteins

Our research goal is to understand the molecular and cellular mechanisms underlying normal development and degenerative retinal diseases, and to establish the intervening strategies. Topics we currently study include: (I) Functional analysis of apical polarity gene Pals1 during retinal and lens development, (II) Pathophysiological study of degenerative retinal diseases, LCA (Leber Congenital Amaurosis) and RP (Retinitis Pigmentosa), to understand disease-causing mechanisms. We are particularly interested in polarity defects in retinal progenitor cells, which cause early-onset, photoreceptor degeneration in LCA type 8, (III) Cell-transplantation and gene-based therapies to to restore vision loss in LCA8-like mouse models in animal settings, (IV) Investigating the function of tumor suppressor-oncogene signal transduction pathways, TSC2-mTOR and Hippo-Yap, in eye development. Fundamental questions that we are trying to answer through these studies include, but are not limited to: (1) How is organ size determined? How are cellular contact inhibition signals translated and coordinated to cell proliferation activity in the nucleus? (2) How is cell size determined? How are differential cell sizes achieved and maintained? (3) What are the functions of the apical polarity complex during CNS development? (4) Can visual impairment in degenerative retinal diseases be rescued by gene- or cell-based therapies? Currently, we are using a combination of molecular and cellular methods, high-throughput (microarray), imaging (including confocal and multi-photon) and mouse genetics approaches (including conditional knock-out technology).

 

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PUBMED PUBLICATIONS:

 

Cho, S.-H., Kim, J.Y., Simons, D.L., Song, J. Y., Le J. H., Swindell, E. C., Jamrich, M., Wu, S. M., and Kim, S. Genetic ablation of Pals1 in retinal progenitor cells models the retinal pathology of Leber Congenital Amaurosis (2012) Hum. Mol. Genet. 21(12) 2663-2676

 

Schneider, D.J., Wu, M., Le, T., Cho, S.-H., Brenner, M.B., Blackburn, M.R., and Agarwal, S.K. Cadherin 11 contributes to pulmonary fibrosis: potential role in TGF-b production and epithelial to mesenchymal transition. (2011) The FASEB Journal 26 (2) 503-512.

 

Kim, S., Lehtinen, M. K., Sessa, A., Zappaterra, M., Cho, S.-H., Gonzalez D., Boggan, B., Austin, C. A., Wijnholds, J., Gambello, M. J., Malicki, J., LaMantia, A. S., Broccoli, V., and Walsh, C. A. The apical complex couples cell fate and cell survival to cerebral cortical development (2010) Neuron 66, 69-84.

 

Trimarchi, J.*, Cho, S.-H.* and Cepko, C.L. Identification of genes expressed preferentially in the developing peripheral margin of the optic cup (2009) Dev. Dyn. 238, 2327-39. * Equally contributed to this work.

 

Jadhav, A. P., Cho, S.-H., and Cepko, C. L. Notch activity permits retinal cells to progress through multiple progenitor states and acquire stem cell properties (2006) Proc Natl Acad Sci 103 (50):18998-19003

Cho, S.-H. and Cepko, C. L. Wnt2b/beta-catenin mediated Wnt signaling determines the peripheral fates of the chick eye (2006) Development 133, (16): 3167-3177

 

Wildner, H., Muller, T., Cho, S.-H., Heppenstall, P., Brohl, D., Lewin, G., Cepko, C., Guillemot, F., and Birchmeier, C.dILA neurons in the dorsal spinal cord are the product of terminal and non-terminal asymmetric progenitor cell divisions, and require Mash1 for their development  (2006) Development 133, (11):2105-2113

 

Blackshaw, S., Harpavat, S., Trimarchi, J., Cai, L., Huang, H., Kuo, W.P., Weber, G., Lee, K., Fraioli, R.E., Cho, S.-H., Yung, R., Asch, E., Ohno-Machado, L., Wong, W.H. and Cepko, C.L. (2004) Genomic analysis of mouse retinal development. PloS Biol 2 (9) E247: 1411-1431.

 

Das, P., Maduzia, L.L., Wang, H., Finelli, A.L., Cho, S.-H., Smith, M.M., and Padgett, R.W. (1998) The Drosophila gene Medea demonstrates the requirement for different classes of Smads in dpp signaling. Development 125, (8):1519-1528

 

Padgett, R.W., Cho, S.-H., and Evangelista, C. (1998) Smads are the central component in transforming growth factor b signaling. Pharmacol. Ther. 78 (1): 47-52

 

Bong, Y.S., Cho, S.-H., Nham, SU and Lee, Y.-I. (1998) Cloning and characterization of cDNAs coding for heavy and light chains of agglutinating monoclonal antibody (HAG12islrh) specific for human red blood cells. Biochem. Biophys. Acta 1380 (2); 156-158

 

Sohn, M.J., Cho, S.-H., Lee, Y.I., (1995) Rapid and simple purification of human-immunodeficiency-virus type-1 epitope P24 and its use in ELISA. Molecules and Cells 5 (4): 388-392 

 

Sohn, M.J., Cho, S.-H., Jang, W., Chong, Y., Nham, S., and Lee, Y.-I. (1993) Rapid and simple purification of human immunodeficiency virus I epitope gp41. J. Virol. Methods 41 (1): 93-100

 

Cho, S.-H., Yoon, J., Chang, J., Ahn, B., Lee, C., and Lee, Y.-I. (1993) Genomic typing of hepatitis C virus from Korean patients: implications of genomic variation in the E2/NS1 region. Biochem. Biophys. Res. Commun. 196 (2):780-788

 

Cho, S.-H., and Kang, C. (1990) DNA sequence-dependent cleavage sites of restriction endonuclease HphI. Mol. Cells 1 (1) 81-86

 

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