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Joseph Y. Cheung, MD, PhD



Joseph Y. Cheung, MD, PhD, FACP, FAHA, FCPP


Richard Laylord & Dorothy L. Evans Professor & Chair, Medicine
Professor, Center of Translational Medicine

Telephone: 215-707-5069

Fax: 215-707-4756

Email: joseph.cheung@temple.edu


Department of Medicine, Section of Nephrology, Hypertension and Kidney Transplantation

Center for Translational Medicine


Educational Background:


BSc (Hons.), McGill University, Montreal, Canada, 1972


MS, Pennsylvania State University, Hershey, PA, 1974


PhD, Pennsylvania State University, Hershey, PA, 1976


MD, Duke University, Durham, NC, 1978


Internship, Medicine, Duke University Medical Center, Durham, NC, 1978-1979


Residency, Medicine, Duke University Medical Center, Durham, NC, 1979-1980


Fellowship, Nephrology, Massachusetts General Hospital, Boston, MA, 1980-1983

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clinical interests:


  • Acute kidney injury
  • ICU - nephrology

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board certification(s):


  • American Board of Internal Medicine, 1984
  • American Board of Internal Medicine, Nephrology, 1986

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professional affiliations:


Honor memberships by election:

  • American Society of Clinical Investigation
  • Fellow, American Heart Association (Council on Basic Cardiovascular Sciences)
  • Fellow, American College of Physicians
  • Fellow, College of Physicians of Philadelphia

Regular memberships:

  • American Physiological Society
  • Biophysical Society
  • American Society of Nephrology
  • International Society of Nephrology

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research interests:


  • Calcium and heart failure
  • Regulation of sodium-calcium exchanger by phospholemman
  • TRPM2 channels in heart failure
  • Regulation of L-type calcium channels by phospholemman
  • TRPC channels in erythropoiesis

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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

22031698. Chan TO, Zhang J, Rodeck U, Pascal JM, Armen RS, Spring M, Dumitru CD, Myers V, Li X, Cheung JY, Feldman AM, Resistance of Akt kinases to dephosphorylation through ATP-dependent conformational plasticity. Proc Natl Acad Sci U S A 108:46(E1120-7)2011 Nov 15

21890689. Li X, Mikhalkova D, Gao E, Zhang J, Myers V, Zincarelli C, Lei Y, Song J, Koch WJ, Peppel K, Cheung JY, Feldman AM, Chan TO, Myocardial injury after ischemia-reperfusion in mice deficient in Akt2 is associated with increased cardiac macrophage density. Am J Physiol Heart Circ Physiol 301:5(H1932-40)2011 Nov

21884509. Kerkelš R, Boucher M, Zaka R, Gao E, Harris D, Piuhola J, Song J, Serpi R, Woulfe KC, Cheung JY, O'Leary E, Bonventre JV, Force T, Cytosolic phospholipase A(2)a protects against ischemia/reperfusion injury in the heart. Clin Transl Sci 4:4(236-42)2011 Aug

21734189. Zhang XQ, Wang J, Song J, Ji AM, Chan TO, Cheung JY, Residues 248-252 and 300-304 of the cardiac Na+/Ca2+ exchanger are involved in its regulation by phospholemman. Am J Physiol Cell Physiol 301:4(C833-40)2011 Oct

21362533. Feiner EC, Chung P, Jasmin JF, Zhang J, Whitaker-Menezes D, Myers V, Song J, Feldman EW, Funakoshi H, Degeorge BR Jr, Yelamarty RV, Koch WJ, Lisanti MP, McTiernan CF, Cheung JY, Bristow MR, Chan TO, Feldman AM, Left ventricular dysfunction in murine models of heart failure and in failing human heart is associated with a selective decrease in the expression of caveolin-3. J Card Fail 17:3(253-63)2011 Mar

21193587. Wang J, Gao E, Rabinowitz J, Song J, Zhang XQ, Koch WJ, Tucker AL, Chan TO, Feldman AM, Cheung JY, Regulation of in vivo cardiac contractility by phospholemman: role of Na+/Ca2+ exchange. Am J Physiol Heart Circ Physiol 300:3(H859-68)2011 Mar

20718822. Cheung JY, Zhang XQ, Song J, Gao E, Rabinowitz JE, Chan TO, Wang J, Phospholemman: a novel cardiac stress protein. Clin Transl Sci 3:4(189-96)2010 Aug

20008271. Wang J, Gao E, Song J, Zhang XQ, Li J, Koch WJ, Tucker AL, Philipson KD, Chan TO, Feldman AM, Cheung JY, Phospholemman and beta-adrenergic stimulation in the heart. Am J Physiol Heart Circ Physiol 298:3(H807-15)2010 Mar

19525383. Wang J, Chan TO, Zhang XQ, Gao E, Song J, Koch WJ, Feldman AM, Cheung JY, Induced overexpression of Na+/Ca2+ exchanger transgene: altered myocyte contractility, [Ca2+]i transients, SR Ca2+ contents, and action potential duration. Am J Physiol Heart Circ Physiol 297:2(H590-601)2009 Aug

18708446. Song J, Zhang XQ, Wang J, Cheskis E, Chan TO, Feldman AM, Tucker AL, Cheung JY, Regulation of cardiac myocyte contractility by phospholemman: Na+/Ca2+ exchange versus Na+ -K+ -ATPase. Am J Physiol Heart Circ Physiol 295:4(H1615-25)2008 Oct

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