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Roberto Caricchio, MD

 

Roberto Caricchio, MD

 

Associate Professor, Medicine

Associate Professor, Microbiology and Immunology

Telephone:  215-707-0791

FAX: 215-707-3508

Email: roc@temple.edu

 

 

Department of Medicine, Section of Rheumatology

Department of Microbiology and Immunology

Temple Autoimmunity Center

 

Educational Background:

 

Undergraduate degree, A. Landi Liceum, Velletri (Rome) Italy, 1987

 

MD, Catholic University of Sacred Heart, Rome, Italy, 1993

 

Internship, Catholic University of Sacred Heart, Rome, Italy, 1993

 

Residency, Catholic University of Sacred Heart, Rome, Italy, 1996

 

Fellowship, Catholic University of Sacred Heart, Rome, Italy, 1996

 

Research Fellowship, University of North Carolina at Chapel Hill, NC, 1999

 

Residency, Internal Medicine, Temple University Hospital, Philadelphia, PA, 2012

 

Fellowship, Rheumatology, Temple University Hospital, Philadelphia, PA, 2013

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clinical Interests:

 

  • Systemic lupus erythematosus
  • Lupus nephritis

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research Interests:

 

  • Autoimmunity and cell death
  • Lupus nephritis

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board certification(s):

 

Italian Board of Internal Medicine/Rheumatology, 1997

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professional affiliations:

  • Member, Italian Society of Rheumatology, 1995-present
  • Fellow member, American College of Rheumatology, 1997-present
  • Member, American Association of Immunologists, 1997-present
  • Member, Philadelphia Rheumatism Society, 2003-present
  • Member, Immunology Graduate Group (UPENN), 2003-present

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PUBMED PUBLICATIONS :


Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

24845790. Jog NR, Caricchio R, The role of necrotic cell death in the pathogenesis of immune mediated nephropathies. Clin Immunol 153:2(243-253)2014 Aug

23928697. Jog NR, Caricchio R, Differential regulation of cell death programs in males and females by Poly (ADP-Ribose) Polymerase-1 and 17▀ estradiol. Cell Death Dis 4:(e758)2013 Aug 8

23049599. Putterman C, Caricchio R, Davidson A, Perlman H, Systemic lupus erythematosus. Clin Dev Immunol 2012:(437282)2012

22661089. Sriram U, Varghese L, Bennett HL, Jog NR, Shivers DK, Ning Y, Behrens EM, Caricchio R, Gallucci S, Myeloid dendritic cells from B6.NZM Sle1/Sle2/Sle3 lupus-prone mice express an IFN signature that precedes disease onset. J Immunol 189:1(80-91)2012 Jul 1

22127758. Jog NR, Frisoni L, Shi Q, Monestier M, Hernandez S, Craft J, Prak ET, Caricchio R, Caspase-activated DNase is required for maintenance of tolerance to lupus nuclear autoantigens. Arthritis Rheum 64:4(1247-56)2012 Apr

21882343. Garchow BG, Bartulos Encinas O, Leung YT, Tsao PY, Eisenberg RA, Caricchio R, Obad S, Petri A, Kauppinen S, Kiriakidou M, Silencing of microRNA-21 in vivo ameliorates autoimmune splenomegaly in lupus mice. EMBO Mol Med 3:10(605-15)2011 Oct

21076068. Kinjyo I, Gordon SM, Intlekofer AM, Dowdell K, Mooney EC, Caricchio R, Grupp SA, Teachey DT, Rao VK, Lindsten T, Reiner SL, Cutting edge: Lymphoproliferation caused by Fas deficiency is dependent on the transcription factor eomesodermin. J Immunol 185:12(7151-5)2010 Dec 15

19454727. Jog NR, Dinnall JA, Gallucci S, Madaio MP, Caricchio R, Poly(ADP-ribose) polymerase-1 regulates the progression of autoimmune nephritis in males by inducing necrotic cell death and modulating inflammation. J Immunol 182:11(7297-306)2009 Jun 1

18025244. Frisoni L, McPhie L, Kang SA, Monestier M, Madaio M, Satoh M, Caricchio R, Lack of chromatin and nuclear fragmentation in vivo impairs the production of lupus anti-nuclear antibodies. J Immunol 179:11(7959-66)2007 Dec 1

16507174. Colonna L, Dinnall JA, Shivers DK, Frisoni L, Caricchio R, Gallucci S, Abnormal costimulatory phenotype and function of dendritic cells before and after the onset of severe murine lupus. Arthritis Res Ther 8:2(R49)2006

16455965. Denny MF, Chandaroy P, Killen PD, Caricchio R, Lewis EE, Richardson BC, Lee KD, Gavalchin J, Kaplan MJ, Accelerated macrophage apoptosis induces autoantibody formation and organ damage in systemic lupus erythematosus. J Immunol 176:4(2095-104)2006 Feb 15

16177126. Calvani N, Caricchio R, Tucci M, Sobel ES, Silvestris F, Tartaglia P, Richards HB, Induction of apoptosis by the hydrocarbon oil pristane: implications for pristane-induced lupus. J Immunol 175:7(4777-82)2005 Oct 1

16081846. Frisoni L, McPhie L, Colonna L, Sriram U, Monestier M, Gallucci S, Caricchio R, Nuclear autoantigen translocation and autoantibody opsonization lead to increased dendritic cell phagocytosis and presentation of nuclear antigens: a novel pathogenic pathway for autoimmunity? J Immunol 175:4(2692-701)2005 Aug 15

15261337. Cohen PL, Caricchio R, Genetic models for the clearance of apoptotic cells. Rheum Dis Clin North Am 30:3(473-86, viii)2004 Aug

14634086. Caricchio R, McPhie L, Cohen PL, Ultraviolet B radiation-induced cell death: critical role of ultraviolet dose in inflammation and lupus autoantigen redistribution. J Immunol 171:11(5778-86)2003 Dec 1

12093878. Cohen PL, Caricchio R, Abraham V, Camenisch TD, Jennette JC, Roubey RA, Earp HS, Matsushima G, Reap EA, Delayed apoptotic cell clearance and lupus-like autoimmunity in mice lacking the c-mer membrane tyrosine kinase. J Exp Med 196:1(135-40)2002 Jul 1

11973615. Caricchio R, D'Adamio L, Cohen PL, Fas, ceramide and serum withdrawal induce apoptosis via a common pathway in a type II Jurkat cell line. Cell Death Differ 9:5(574-80)2002 May

11346799. Scott RS, McMahon EJ, Pop SM, Reap EA, Caricchio R, Cohen PL, Earp HS, Matsushima GK, Phagocytosis and clearance of apoptotic cells is mediated by MER. Nature 411:6834(207-11)2001 May 10

10612651. Caricchio R, Cohen PL, Spontaneous and induced apoptosis in systemic lupus erythematosus: multiple assays fail to reveal consistent abnormalities. Cell Immunol 198:1(54-60)1999 Nov 25

10497012. Caricchio R, Kovalenko D, Kaufmann WK, Cohen PL, Apoptosis provoked by the oxidative stress inducer menadione (Vitamin K(3)) is mediated by the Fas/Fas ligand system. Clin Immunol 93:1(65-74)1999 Oct

9805181. Zoli A, Altomonte L, Caricchio R, Galossi A, Mirone L, Ruffini MP, Magarˇ M, Serum zinc and copper in active rheumatoid arthritis: correlation with interleukin 1 beta and tumour necrosis factor alpha. Clin Rheumatol 17:5(378-82)1998

9683264. Gangi-Peterson L, Peterson SN, Shapiro LH, Golding A, Caricchio R, Cohen DI, Margulies DH, Cohen PL, bca: an activation-related B-cell gene. Mol Immunol 35:1(55-63)1998 Jan

9647230. Caricchio R, Reap EA, Cohen PL, Fas/Fas ligand interactions are involved in ultraviolet-B-induced human lymphocyte apoptosis. J Immunol 161:1(241-51)1998 Jul 1

9307868. Giacomini PG, Zoli A, Bruno E, Alessandrini M, Caricchio R, Mirone L, Magrini A, Altomonte L, Magaro M, Di Girolamo A, Voluntary oculomotoricity in systemic lupus erythematosus. Clin Exp Rheumatol 15:5(579-80)1997 Sep-Oct

8894371. Zoli A, Altomonte L, Serra A, Santacesaria GC, Caricchio R, Mirone L, Magaro M, Undiagnosed polyarthritis with positive anti-Ro/SSA antibodies following a biliopancreatic bypass for morbid obesity. Clin Rheumatol 15:5(514-5)1996 Sep

8793270. Zoli A, Altomonte L, Caricchio R, Galossi A, Mirone L, Scuderi F, Magaro M, Rheumatoid factor in patients with systemic lupus erythematosus. Clin Rheumatol 15:3(312-3)1996 May

8718655. Magar˛ M, Zoli A, Caricchio R, Angelosante S, Mirone L, Altomonte L, Palazzoni G, [Quantitative ultrasonography in the evaluation of postmenopausal osteoporosis. Comparison with dual energy x-ray absorptiometry]. Ann Ital Med Int 10:4(218-21)1995 Oct-Dec

7554565. Giacomini P, Zoli A, Bruno E, Di Girolamo S, Caricchio R, Altomonte L, Posture in systemic lupus erythematosus. Clin Exp Rheumatol 13:3(357-60)1995 May-Jun

7791157. Zoli A, Zappacosta B, Altomonte L, De Sole P, Caricchio R, Pellegrino M, Mirone L, Giardina B, Magaro M, Platelet lactate dehydrogenase activity in systemic lupus erythematosus: correlation with anticardiolipin antibodies. J Rheumatol 22:4(649-53)1995 Apr

7893573. Magar˛ M, Zoli A, Galossi A, Caricchio R, Mirone L, Scuderi F, Altomonte L, [Antiphospholipid antibodies in systemic lupus erythematosus: study of a caseload of 120 patients]. Ann Ital Med Int 9:4(231-5)1994 Oct-Dec

8081683. Zappacosta B, De Sole P, Fresu R, Caricchio R, Zoli A, Altomonte L, Giardina B, Lactic dehydrogenase activity of platelet subpopulations in a group of patients with systemic lupus erythematosus. Br J Rheumatol 33:9(890-1)1994 Sep

7116032. Lessa I, Almeida FA, Almeida Alves JF, Souza ME, Silva Jesus Mde F, Caricchio R, Prevalence of chronic diseases in a district of Salvador, Bahia, Brazil. Bull Pan Am Health Organ 16:2(138-50)1982

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