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Eugen Brailoiu


Eugen Brailoiu, MD


Adjunct Associate Professor, Center for Substance Abuse Research

Telephone: 215-707-2791

Fax: 215-707-6661

Email: eugen.brailoiu@temple.edu



Center for Substance Abuse Research


Educational Background:


MD, University of Medicine and Pharmacy, Iasi, Romania, 1990

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Research Interests:


Confocal of Brain

Calcium mobilizing second messengers and co-players: roles in neuronal functions disregulations.


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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

26232582. Majeed ZR, Ritter K, Robinson J, Blümich SL, Brailoiu E, Cooper RL, New insights into the acute actions from a high dosage of fluoxetine on neuronal and cardiac function: Drosophila, crayfish and rodent models. Comp Biochem Physiol C Toxicol Pharmacol 176-177:(52-61)2015 Jul 29

26077147. Barr JL, Deliu E, Brailoiu GC, Zhao P, Yan G, Abood ME, Unterwald EM, Brailoiu E, Mechanisms of activation of nucleus accumbens neurons by cocaine via sigma-1 receptor-inositol 1,4,5-trisphosphate-transient receptor potential canonical channel pathways. Cell Calcium 58:2(196-207)2015 Aug 1

26038469. Brailoiu E, Deliu E, Sporici RA, Brailoiu GC, Irisin evokes bradycardia by activating cardiac-projecting neurons of nucleus ambiguus. Physiol Rep 3:6()2015 Jun

25972448. Deliu E, Sperow M, Console-Bram L, Carter RL, Tilley DG, Kalamarides DJ, Kirby LG, Brailoiu GC, Brailoiu E, Benamar K, Abood ME, The Lysophosphatidylinositol Receptor GPR55 Modulates Pain Perception in the Periaqueductal Gray. Mol Pharmacol 88:2(265-72)2015 Aug

25416817. Hockey LN, Kilpatrick BS, Eden ER, Lin-Moshier Y, Brailoiu GC, Brailoiu E, Futter CE, Schapira AH, Marchant JS, Patel S, Dysregulation of lysosomal morphology by pathogenic LRRK2 is corrected by TPC2 inhibition. J Cell Sci 128:2(232-8)2015 Jan 15

25406377. Rahman T, Cai X, Brailoiu GC, Abood ME, Brailoiu E, Patel S, Two-pore channels provide insight into the evolution of voltage-gated Ca2+ and Na+ channels. Sci Signal 7:352(ra109)2014 Nov 18

25157141. Lin-Moshier Y, Keebler MV, Hooper R, Boulware MJ, Liu X, Churamani D, Abood ME, Walseth TF, Brailoiu E, Patel S, Marchant JS, The Two-pore channel (TPC) interactome unmasks isoform-specific roles for TPCs in endolysosomal morphology and cell pigmentation. Proc Natl Acad Sci U S A 111:36(13087-92)2014 Sep 9

24809475. Jha A, Brailoiu E, Muallem S, How does NAADP release lysosomal Ca2+? Channels (Austin) 8:3(174-5)2014

24762058. Console-Bram L, Brailoiu E, Brailoiu GC, Sharir H, Abood ME, Activation of GPR18 by cannabinoid compounds: a tale of biased agonism. Br J Pharmacol 171:16(3908-17)2014 Aug

24694382. Brailoiu E, Deliu E, Sporici RA, Benamar K, Brailoiu GC, HIV-1-Tat excites cardiac parasympathetic neurons of nucleus ambiguus and triggers prolonged bradycardia in conscious rats. Am J Physiol Regul Integr Comp Physiol 306:11(R814-22)2014 Jun 1

24401846. Deliu E, Brailoiu GC, Eguchi S, Hoffman NE, Rabinowitz JE, Tilley DG, Madesh M, Koch WJ, Brailoiu E, Direct evidence of intracrine angiotensin II signaling in neurons. Am J Physiol Cell Physiol 306:8(C736-44)2014 Apr 15

24377350. Sharma VD, Lees J, Hoffman NE, Brailoiu E, Madesh M, Wunder SL, Ilies MA, Modulation of pyridinium cationic lipid-DNA complex properties by pyridinium gemini surfactants and its impact on lipoplex transfection properties. Mol Pharm 11:2(545-59)2014 Feb 3

23878371. Brailoiu GC, Benamar K, Arterburn JB, Gao E, Rabinowitz JE, Koch WJ, Brailoiu E, Aldosterone increases cardiac vagal tone via G protein-coupled oestrogen receptor activation. J Physiol 591:Pt 17(4223-35)2013 Sep 1

23834644. Savarala S, Brailoiu E, Wunder SL, Ilies MA, Tuning the self-assembling of pyridinium cationic lipids for efficient gene delivery into neuronal cells. Biomacromolecules 14:8(2750-64)2013 Aug 12

23814062. Yu J, Deliu E, Zhang XQ, Hoffman NE, Carter RL, Grisanti LA, Brailoiu GC, Madesh M, Cheung JY, Force T, Abood ME, Koch WJ, Tilley DG, Brailoiu E, Differential activation of cultured neonatal cardiomyocytes by plasmalemmal versus intracellular G protein-coupled receptor 55. J Biol Chem 288:31(22481-92)2013 Aug 2

23086942. Deliu E, Brailoiu GC, Mallilankaraman K, Wang H, Madesh M, Undieh AS, Koch WJ, Brailoiu E, Intracellular endothelin type B receptor-driven Ca2+ signal elicits nitric oxide production in endothelial cells. J Biol Chem 287:49(41023-31)2012 Nov 30

22858342. Deliu E, Brailoiu GC, Arterburn JB, Oprea TI, Benamar K, Dun NJ, Brailoiu E, Mechanisms of G protein-coupled estrogen receptor-mediated spinal nociception. J Pain 13:8(742-54)2012 Aug

22774996. Brailoiu GC, Deliu E, Tica AA, Chitravanshi VC, Brailoiu E, Urocortin 3 elevates cytosolic calcium in nucleus ambiguus neurons. J Neurochem 122:6(1129-36)2012 Sep

22196236. Brailoiu GC, Deliu E, Hooper R, Dun NJ, Undieh AS, Adler MW, Benamar K, Brailoiu E, Agonist-selective effects of opioid receptor ligands on cytosolic calcium concentration in rat striatal neurons. Drug Alcohol Depend 123:1-3(277-81)2012 Jun 1

21865584. Tica AA, Dun EC, Tica OS, Gao X, Arterburn JB, Brailoiu GC, Oprea TI, Brailoiu E, G protein-coupled estrogen receptor 1-mediated effects in the rat myometrium. Am J Physiol Cell Physiol 301:5(C1262-9)2011 Nov

21816823. Mukerjee R, Chang JR, Del Valle L, Bagashev A, Gayed MM, Lyde RB, Hawkins BJ, Brailoiu E, Cohen E, Power C, Azizi SA, Gelman BB, Sawaya BE, Deregulation of microRNAs by HIV-1 Vpr protein leads to the development of neurocognitive disorders. J Biol Chem 286:40(34976-85)2011 Oct 7

21719698. Brailoiu GC, Oprea TI, Zhao P, Abood ME, Brailoiu E, Intracellular cannabinoid type 1 (CB1) receptors are activated by anandamide. J Biol Chem 286:33(29166-74)2011 Aug 19

21613610. Deliu E, Tica AA, Motoc D, Brailoiu GC, Brailoiu E, Intracellular angiotensin II activates rat myometrium. Am J Physiol Cell Physiol 301:3(C559-65)2011 Sep

20880839. Brailoiu E, Rahman T, Churamani D, Prole DL, Brailoiu GC, Hooper R, Taylor CW, Patel S, An NAADP-gated two-pore channel targeted to the plasma membrane uncouples triggering from amplifying Ca2+ signals. J Biol Chem 285:49(38511-6)2010 Dec 3

20086172. Ariazi EA, Brailoiu E, Yerrum S, Shupp HA, Slifker MJ, Cunliffe HE, Black MA, Donato AL, Arterburn JB, Oprea TI, Prossnitz ER, Dun NJ, Jordan VC, The G protein-coupled receptor GPR30 inhibits proliferation of estrogen receptor-positive breast cancer cells. Cancer Res 70:3(1184-94)2010 Feb 1

20056135. Dun SL, Brailoiu GC, Tica AA, Yang J, Chang JK, Brailoiu E, Dun NJ, Neuronostatin is co-expressed with somatostatin and mobilizes calcium in cultured rat hypothalamic neurons. Neuroscience 166:2(455-63)2010 Mar 17

19940116. Brailoiu E, Hooper R, Cai X, Brailoiu GC, Keebler MV, Dun NJ, Marchant JS, Patel S, An ancestral deuterostome family of two-pore channels mediates nicotinic acid adenine dinucleotide phosphate-dependent calcium release from acidic organelles. J Biol Chem 285:5(2897-901)2010 Jan 29

19620632. Brailoiu E, Churamani D, Cai X, Schrlau MG, Brailoiu GC, Gao X, Hooper R, Boulware MJ, Dun NJ, Marchant JS, Patel S, Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling. J Cell Biol 186:2(201-9)2009 Jul 27

19373968. Brailoiu E, Dun SL, Gao X, Brailoiu GC, Li JG, Luo JJ, Yang J, Chang JK, Liu-Chen LY, Dun NJ, C-peptide of preproinsulin-like peptide 7: localization in the rat brain and activity in vitro. Neuroscience 159:2(492-500)2009 Mar 17

19125412. Dun SL, Brailoiu GC, Gao X, Brailoiu E, Arterburn JB, Prossnitz ER, Oprea TI, Dun NJ, Expression of estrogen receptor GPR30 in the rat spinal cord and in autonomic and sensory ganglia. J Neurosci Res 87:7(1610-9)2009 May 15

19095998. Suzuki H, Kimura K, Shirai H, Eguchi K, Higuchi S, Hinoki A, Ishimaru K, Brailoiu E, Dhanasekaran DN, Stemmle LN, Fields TA, Frank GD, Autieri MV, Eguchi S, Endothelial nitric oxide synthase inhibits G12/13 and rho-kinase activated by the angiotensin II type-1 receptor: implication in vascular migration. Arterioscler Thromb Vasc Biol 29:2(217-24)2009 Feb

19090786. Brailoiu GC, Brailoiu E, Parkesh R, Galione A, Churchill GC, Patel S, Dun NJ, NAADP-mediated channel 'chatter' in neurons of the rat medulla oblongata. Biochem J 419:1(91-7, 2 p following 97)2009 Apr 1

18752653. Gao X, Brailoiu GC, Brailoiu E, Dun SL, Yang J, Chang JK, Dun NJ, Copeptin immunoreactivity and calcium mobilisation in hypothalamic neurones of the rat. J Neuroendocrinol 20:11(1242-51)2008 Nov

18404520. Tuluc F, Bredetean O, Brailoiu E, Meshki J, Garcia A, Dun NJ, Kunapuli SP, The priming effect of extracellular UTP on human neutrophils: Role of calcium released from thapsigargin-sensitive intracellular stores. Purinergic Signal 1:4(359-68)2005 Dec

18375741. Ji R, Lee CM, Gonzales LW, Yang Y, Aksoy MO, Wang P, Brailoiu E, Dun N, Hurford MT, Kelsen SG, Human type II pneumocyte chemotactic responses to CXCR3 activation are mediated by splice variant A. Am J Physiol Lung Cell Mol Physiol 294:6(L1187-96)2008 Jun

18356277. Ohtsu H, Higuchi S, Shirai H, Eguchi K, Suzuki H, Hinoki A, Brailoiu E, Eckhart AD, Frank GD, Eguchi S, Central role of Gq in the hypertrophic signal transduction of angiotensin II in vascular smooth muscle cells. Endocrinology 149:7(3569-75)2008 Jul

18314227. Brailoiu E, Jiang X, Brailoiu GC, Yang J, Chang JK, Wang H, Dun NJ, State-dependent calcium mobilization by urotensin-II in cultured human endothelial cells. Peptides 29:5(721-6)2008 May

18164555. Brailoiu GC, Brailoiu E, Chang JK, Dun NJ, Excitatory effects of human immunodeficiency virus 1 Tat on cultured rat cerebral cortical neurons. Neuroscience 151:3(701-10)2008 Feb 6

17715404. Jiang X, Yang F, Brailoiu E, Jakubowski H, Dun NJ, Schafer AI, Yang X, Durante W, Wang H, Differential regulation of homocysteine transport in vascular endothelial and smooth muscle cells. Arterioscler Thromb Vasc Biol 27:9(1976-83)2007 Sep

17627999. Brailoiu GC, Dun SL, Brailoiu E, Inan S, Yang J, Chang JK, Dun NJ, Nesfatin-1: distribution and interaction with a G protein-coupled receptor in the rat brain. Endocrinology 148:10(5088-94)2007 Oct

17470522. Brailoiu E, Dun SL, Brailoiu GC, Mizuo K, Sklar LA, Oprea TI, Prossnitz ER, Dun NJ, Distribution and characterization of estrogen receptor G protein-coupled receptor 30 in the rat central nervous system. J Endocrinol 193:2(311-21)2007 May

17465030. Brailoiu GC, Dun SL, Mizuo K, Brailoiu E, Yang J, Chang JK, Dun NJ, Smooth muscle-associated protein 8: distribution and biological activity in the rat brain. J Neurosci Res 85:8(1789-96)2007 Jun

17187876. Dun SL, Brailoiu E, Hsieh WK, Lai CC, Yang J, Chang JK, Dun NJ, Expression and activity of cocaine- and amphetamine-regulated transcript peptide(1-39) in the rat. Regul Pept 140:1-2(47-54)2007 Apr 5

17088418. Dun SL, Brailoiu GC, Brailoiu E, Yang J, Chang JK, Dun NJ, Distribution and biological activity of obestatin in the rat. J Endocrinol 191:2(481-9)2006 Nov

16840716. Ohtsu H, Dempsey PJ, Frank GD, Brailoiu E, Higuchi S, Suzuki H, Nakashima H, Eguchi K, Eguchi S, ADAM17 mediates epidermal growth factor receptor transactivation and vascular smooth muscle cell hypertrophy induced by angiotensin II. Arterioscler Thromb Vasc Biol 26:9(e133-7)2006 Sep

16601133. Dun SL, Brailoiu E, Wang Y, Brailoiu GC, Liu-Chen LY, Yang J, Chang JK, Dun NJ, Insulin-like peptide 5: expression in the mouse brain and mobilization of calcium. Endocrinology 147:7(3243-8)2006 Jul

16595650. Brailoiu E, Churamani D, Pandey V, Brailoiu GC, Tuluc F, Patel S, Dun NJ, Messenger-specific role for nicotinic acid adenine dinucleotide phosphate in neuronal differentiation. J Biol Chem 281:23(15923-8)2006 Jun 9

16595370. Brailoiu E, Brailoiu GC, Mameli G, Dolei A, Sawaya BE, Dun NJ, Acute exposure to ethanol potentiates human immunodeficiency virus type 1 Tat-induced Ca(2+) overload and neuronal death in cultured rat cortical neurons. J Neurovirol 12:1(17-24)2006 Feb

16467404. Shahabuddin S, Ji R, Wang P, Brailoiu E, Dun N, Yang Y, Aksoy MO, Kelsen SG, CXCR3 chemokine receptor-induced chemotaxis in human airway epithelial cells: role of p38 MAPK and PI3K signaling pathways. Am J Physiol Cell Physiol 291:1(C34-9)2006 Jul

15905175. Mifune M, Ohtsu H, Suzuki H, Nakashima H, Brailoiu E, Dun NJ, Frank GD, Inagami T, Higashiyama S, Thomas WG, Eckhart AD, Dempsey PJ, Eguchi S, G protein coupling and second messenger generation are indispensable for metalloprotease-dependent, heparin-binding epidermal growth factor shedding through angiotensin II type-1 receptor. J Biol Chem 280:28(26592-9)2005 Jul 15

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