about | Maps & Directions | contact | admissions | faculty | alumni & development | library | Tech Support Center | dean's office | Policies & Procedures

FAculty directory

Back to alphabetical index

Guenther Boden, MD


Guenther Boden, MD


Laura H. Carnell Professor of Medicine

Telephone:  215-707-8984

FAX: 215-707-5599

Email:  bodengh@tuhs.temple.edu



Department of Medicine, Section of Endocrinology, Diabetes and Metabolism


Educational Background:


MS, Medicine, Heidelberg University, Germany, 1954


MD, University of Munich School of Medicine, Germany, 1959


Dr. Med., Max Planck Institute for Psychiatry, Munich, Germany, 1960


Internship, Cith Hospital, Hamburg, Munich, Germany, 1960-1962; Rochester General Hospital, Rochester, NY, 1967-1970


Fellowship, Biochemistry, University of Tuebigen, Germany, 1963-1965


Fellowship, Joslin Research Lab and Peter Brigham Hospital, Harvard Medical School, Boston, MA, 1965-1967


Return to top



clinical Interests:

  • Diabetes
  • Metabolism

Return to top



research Interests:



Carbohydrate and lipid metabolism

Return to top



board certification(s):



Internal Medicine, 1977

Return to top



professional affiliations:


  • Member, American Diabetes Association
  • Member, Association for Clinical Investigators
  • Diplomat, American Board of Internal Medicine

Return to top



selected publications



Boden G.  Free Fatty Acids in Insulin Secretion in Humans.  Current Diab Reports 5: 167-170, 2005.


Boden G.  Free Acid-Induced Inflammation and Insulin Resistance in Skeletal Muscle and Liver.  Current Diab Reports 6: 177-181, 2006.


Boden G.  Carbohydrates and the Liver.  In: Textbood of Hepatology:  From Basic Science to Clinical Practice.  Section 2: Functions of the Liver.  3rd ed, J.P. Benhamon, ed., Blackwell Publishing, in press.


Boden G.  Obesity, Insulin Resistance/Type 2 Diabetes and Free Fatty Acids.  Expert Review of Endocrinology and Metabolism.  Future Drugs, London, UK, in press.


Rao AK, Vaidyula VR, Boden G.  Diabetes Mellitus and Tissue Factor Pathway in Blood Coagulation, in ress.


Boden G.  Fat Induced Insulin Resistance and Atherosclerosis.  In:  Principles of Molecula Medicine, Humana Press Inc., 2nd ed., Totowa, NJ, in press.


Return to top




Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

26355033. Boden G, Homko C, Barrero CA, Stein TP, Chen X, Cheung P, Fecchio C, Koller S, Merali S, Excessive caloric intake acutely causes oxidative stress, GLUT4 carbonylation, and insulin resistance in healthy men. Sci Transl Med 7:304(304re7)2015 Sep 9

26346575. Fang CY, Boden G, Siu PT, Tseng M, Stressful life events are associated with insulin resistance among Chinese immigrant women in the United States. Prev Med Rep 2:(563-567)2015

25653143. Singh A, Boden G, Rao AK, Tissue factor and Toll-like receptor (TLR)4 in hyperglycaemia-hyperinsulinaemia. Effects in healthy subjects, and type 1 and type 2 diabetes mellitus. Thromb Haemost 113:4(750-8)2015 Apr

25614086. Yuan L, Luo X, Zeng M, Zhang Y, Yang M, Zhang L, Liu R, Boden G, Liu H, Ma ZA, Li L, Yang G, Transcription factor TIP27 regulates glucose homeostasis and insulin sensitivity in a PI3-kinase/Akt-dependent manner in mice. Int J Obes (Lond) 39:6(949-58)2015 Jun

25600163. Homko CJ, Duffy F, Friedenberg FK, Boden G, Parkman HP, Effect of dietary fat and food consistency on gastroparesis symptoms in patients with gastroparesis. Neurogastroenterol Motil 27:4(501-8)2015 Apr

25499349. Li X, Yang M, Wang H, Jia Y, Yan P, Boden G, Yang G, Li L, Overexpression of JAZF1 protected ApoE-deficient mice from atherosclerosis by inhibiting hepatic cholesterol synthesis via CREB-dependent mechanisms. Int J Cardiol 177:1(100-10)2014 Nov 15

25042561. Rao AK, Freishtat RJ, Jalagadugula G, Singh A, Mao G, Wiles A, Cheung P, Boden G, Alterations in insulin-signaling and coagulation pathways in platelets during hyperglycemia-hyperinsulinemia in healthy non-diabetic subject. Thromb Res 134:3(704-10)2014 Sep

24740571. Boden G, Cheung P, Kresge K, Homko C, Powers B, Ferrer L, Insulin resistance is associated with diminished endoplasmic reticulum stress responses in adipose tissue of healthy and diabetic subjects. Diabetes 63:9(2977-83)2014 Sep

24651811. Boden G, Cheung P, Salehi S, Homko C, Loveland-Jones C, Jayarajan S, Stein TP, Barrero CA, Merali S, Williams KJ, Liu ML, Response to comment on Boden et al. Insulin regulates the unfolded protein response in human adipose tissue. Diabetes 2014;63:912-922. Diabetes 63:4(e2)2014 Apr

24533052. Hu X, Li S, Yang G, Liu H, Boden G, Li L, Efficacy and safety of aldose reductase inhibitor for the treatment of diabetic cardiovascular autonomic neuropathy: systematic review and meta-analysis. PLoS One 9:2(e87096)2014

24286121. Homko CJ, Zamora LC, Boden G, Parkman HP, Bodyweight in patients with idiopathic gastroparesis: roles of symptoms, caloric intake, physical activity, and body metabolism. Neurogastroenterol Motil 26:2(283-9)2014 Feb

24130338. Boden G, Cheung P, Salehi S, Homko C, Loveland-Jones C, Jayarajan S, Stein TP, Williams KJ, Liu ML, Barrero CA, Merali S, Insulin regulates the unfolded protein response in human adipose tissue. Diabetes 63:3(912-22)2014 Mar

23913732. Boden G, Salehi S, Cheung P, Homko C, Song W, Loveland-Jones C, Jayarajan S, Comparison of in vivo effects of insulin on SREBP-1c activation and INSIG-1/2 in rat liver and human and rat adipose tissue. Obesity (Silver Spring) 21:6(1208-14)2013 Jun

23804166. Homko CJ, Zamora LC, Kerper MM, Mozzoli M, Kresge K, Boden G, A Single A1C >= 6.5% Accurately Identifies Type 2 Diabetes/Impaired Glucose Tolerance in African Americans. J Prim Care Community Health 3:4(235-8)2012 Oct 1

23448485. Boden G, Salehi S, Why does obesity increase the risk for cardiovascular disease? Curr Pharm Des 19:32(5678-83)2013

22410811. Singh A, Boden G, Homko C, Gunawardana J, Rao AK, Whole-blood tissue factor procoagulant activity is elevated in type 1 diabetes: effects of hyperglycemia and hyperinsulinemia. Diabetes Care 35:6(1322-7)2012 Jun

22354929. Boden G, Does inhibition of -cell proliferation by free fatty acid in mice explain the progressive failure of insulin secretion in type 2 diabetes? Diabetes 61:3(560-1)2012 Mar

21720421. Makris AP, Borradaile KE, Oliver TL, Cassim NG, Rosenbaum DL, Boden GH, Homko CJ, Foster GD, The individual and combined effects of glycemic index and protein on glycemic response, hunger, and energy intake. Obesity (Silver Spring) 19:12(2365-73)2011 Dec

21475143. Boden G, Song W, Duan X, Cheung P, Kresge K, Barrero C, Merali S, Infusion of glucose and lipids at physiological rates causes acute endoplasmic reticulum stress in rat liver. Obesity (Silver Spring) 19:7(1366-73)2011 Jul

21297467. Boden G, Obesity, insulin resistance and free fatty acids. Curr Opin Endocrinol Diabetes Obes 18:2(139-43)2011 Apr

21266224. Boden G, Merali S, Measurement of the increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals. Methods Enzymol 489:(67-82)2011

21049473. Chen K, Liu ML, Schaffer L, Li M, Boden G, Wu X, Williams KJ, Type 2 diabetes in mice induces hepatic overexpression of sulfatase 2, a novel factor that suppresses uptake of remnant lipoproteins. Hepatology 52:6(1957-67)2010 Dec

20108856. Jimenez C, Santiago M, Sitler M, Boden G, Homko C, Insulin-sensitivity response to a single bout of resistive exercise in type 1 diabetes mellitus. J Sport Rehabil 18:4(564-71)2009 Nov

19897673. Boden G, Silviera M, Smith B, Cheung P, Homko C, Acute tissue injury caused by subcutaneous fat biopsies produces endoplasmic reticulum stress. J Clin Endocrinol Metab 95:1(349-52)2010 Jan

19246600. Boden G, Endoplasmic reticulum stress: another link between obesity and insulin resistance/inflammation? Diabetes 58:3(518-9)2009 Mar

18775356. Boden G, Obesity and free fatty acids. Endocrinol Metab Clin North Am 37:3(635-46, viii-ix)2008 Sep

18664596. Boden G, Song W, Kresge K, Mozzoli M, Cheung P, Effects of hyperinsulinemia on hepatic metalloproteinases and their tissue inhibitors. Am J Physiol Endocrinol Metab 295:3(E692-7)2008 Sep

18625123. Boden G, Song WW, Effects of insulin and free fatty acids on matrix metalloproteinases. Curr Diab Rep 8:3(239-42)2008 Jun

18567819. Boden G, Duan X, Homko C, Molina EJ, Song W, Perez O, Cheung P, Merali S, Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals. Diabetes 57:9(2438-44)2008 Sep

18458870. Boden G, Ceramide: a contributor to insulin resistance or an innocent bystander? Diabetologia 51:7(1095-6)2008 Jul

18025411. Boden G, Song W, Pashko L, Kresge K, In vivo effects of insulin and free fatty acids on matrix metalloproteinases in rat aorta. Diabetes 57:2(476-83)2008 Feb

17785358. Boden G, Vaidyula VR, Homko C, Cheung P, Rao AK, Circulating tissue factor procoagulant activity and thrombin generation in patients with type 2 diabetes: effects of insulin and glucose. J Clin Endocrinol Metab 92:11(4352-8)2007 Nov

17547839. Boden G, Rao AK, Effects of hyperglycemia and hyperinsulinemia on the tissue factor pathway of blood coagulation. Curr Diab Rep 7:3(223-7)2007 Jun

17213471. Boden G, Vaidyula V, Homko C, Mozzoli M, Rao AK, Differential effects of somatostatin on circulating tissue factor procoagulant activity and protein. Am J Physiol Endocrinol Metab 292:5(E1333-9)2007 May

17192489. Boden G, Homko C, Mozzoli M, Zhang M, Kresge K, Cheung P, Combined use of rosiglitazone and fenofibrate in patients with type 2 diabetes: prevention of fluid retention. Diabetes 56:1(248-55)2007 Jan

17127486. Vaidyula VR, Boden G, Rao AK, Platelet and monocyte activation by hyperglycemia and hyperinsulinemia in healthy subjects. Platelets 17:8(577-85)2006 Dec

16898568. Boden G, Fatty acid-induced inflammation and insulin resistance in skeletal muscle and liver. Curr Diab Rep 6:3(177-81)2006 Jun

16868831. Gaddipati KV, Simonian HP, Kresge KM, Boden GH, Parkman HP, Abnormal ghrelin and pancreatic polypeptide responses in gastroparesis. Dig Dis Sci 51:8(1339-46)2006 Aug

16503761. Boden G, Zhang M, Recent findings concerning thiazolidinediones in the treatment of diabetes. Expert Opin Investig Drugs 15:3(243-50)2006 Mar

16380494. Vaidyula VR, Rao AK, Mozzoli M, Homko C, Cheung P, Boden G, Effects of hyperglycemia and hyperinsulinemia on circulating tissue factor procoagulant activity and platelet CD40 ligand. Diabetes 55:1(202-8)2006 Jan

16306362. Boden G, She P, Mozzoli M, Cheung P, Gumireddy K, Reddy P, Xiang X, Luo Z, Ruderman N, Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-kappaB pathway in rat liver. Diabetes 54:12(3458-65)2005 Dec

15929861. Boden G, Free fatty acids and insulin secretion in humans. Curr Diab Rep 5:3(167-70)2005 Jun

15916622. Simonian HP, Kresge KM, Boden GH, Parkman HP, Differential effects of sham feeding and meal ingestion on ghrelin and pancreatic polypeptide levels: evidence for vagal efferent stimulation mediating ghrelin release. Neurogastroenterol Motil 17:3(348-54)2005 Jun

15767618. Boden G, Sargrad K, Homko C, Mozzoli M, Stein TP, Effect of a low-carbohydrate diet on appetite, blood glucose levels, and insulin resistance in obese patients with type 2 diabetes. Ann Intern Med 142:6(403-11)2005 Mar 15

15734868. Boden G, Homko C, Mozzoli M, Showe LC, Nichols C, Cheung P, Thiazolidinediones upregulate fatty acid uptake and oxidation in adipose tissue of diabetic patients. Diabetes 54:3(880-5)2005 Mar

15612450. Boden G, Gluconeogenesis and glycogenolysis in health and diabetes. J Investig Med 52:6(375-8)2004 Sep

15333497. Boden G, Laakso M, Lipids and glucose in type 2 diabetes: what is the cause and effect? Diabetes Care 27:9(2253-9)2004 Sep

14624413. Cheung P, Yang G, Boden G, Milrinone, a selective phosphodiesterase 3 inhibitor, stimulates lipolysis, endogenous glucose production, and insulin secretion. Metabolism 52:11(1496-500)2003 Nov

14614173. Boden G, Hoeldtke RD, Nerves, fat, and insulin resistance. N Engl J Med 349:20(1966-7)2003 Nov 13

12962693. Boden G, Carnell LH, Nutritional effects of fat on carbohydrate metabolism. Best Pract Res Clin Endocrinol Metab 17:3(399-410)2003 Sep

Return to top