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Guenther Boden, MD

Laura H. Carnell Professor of Medicine

Telephone:  215-707-8984

FAX: 215-707-5599

Email:  bodengh@tuhs.temple.edu

Department of Medicine, Section of Endocrinology, Diabetes and Metabolism

MS, Medicine, Heidelberg University, Germany, 1954

 

MD, University of Munich School of Medicine, Germany, 1959

 

Dr. Med., Max Planck Institute for Psychiatry, Munich, Germany, 1960

 

Internship, Cith Hospital, Hamburg, Munich, Germany, 1960-1962; Rochester General Hospital, Rochester, NY, 1967-1970

 

Fellowship, Biochemistry, University of Tuebigen, Germany, 1963-1965

 

Fellowship, Joslin Research Lab and Peter Brigham Hospital, Harvard Medical School, Boston, MA, 1965-1967

 

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• Diabetes
• Metabolism

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Carbohydrate and lipid metabolism

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Internal Medicine, 1977

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• Member, American Diabetes Association
• Member, Association for Clinical Investigators
• Diplomat, American Board of Internal Medicine

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Chapters

Boden G.  Free Fatty Acids in Insulin Secretion in Humans.  Current Diab Reports 5: 167-170, 2005.

Boden G.  Free Acid-Induced Inflammation and Insulin Resistance in Skeletal Muscle and Liver.  Current Diab Reports 6: 177-181, 2006.

Boden G.  Carbohydrates and the Liver.  In: Textbood of Hepatology:  From Basic Science to Clinical Practice.  Section 2: Functions of the Liver.  3rd ed, J.P. Benhamon, ed., Blackwell Publishing, in press.

Boden G.  Obesity, Insulin Resistance/Type 2 Diabetes and Free Fatty Acids.  Expert Review of Endocrinology and Metabolism.  Future Drugs, London, UK, in press.

Rao AK, Vaidyula VR, Boden G.  Diabetes Mellitus and Tissue Factor Pathway in Blood Coagulation, in ress.

Boden G.  Fat Induced Insulin Resistance and Atherosclerosis.  In:  Principles of Molecula Medicine, Humana Press Inc., 2nd ed., Totowa, NJ, in press.

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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

23448485. Boden G, Salehi S, Why Does Obesity Increase the Risk for Cardiovascular Disease? Curr Pharm Des :()2013 Feb 20

22410811. Singh A, Boden G, Homko C, Gunawardana J, Rao AK, Whole-blood tissue factor procoagulant activity is elevated in type 1 diabetes: effects of hyperglycemia and hyperinsulinemia. Diabetes Care 35:6(1322-7)2012 Jun

22354929. Boden G, Does inhibition of ß-cell proliferation by free fatty acid in mice explain the progressive failure of insulin secretion in type 2 diabetes? Diabetes 61:3(560-1)2012 Mar

21720421. Makris AP, Borradaile KE, Oliver TL, Cassim NG, Rosenbaum DL, Boden GH, Homko CJ, Foster GD, The individual and combined effects of glycemic index and protein on glycemic response, hunger, and energy intake. Obesity (Silver Spring) 19:12(2365-73)2011 Dec

21475143. Boden G, Song W, Duan X, Cheung P, Kresge K, Barrero C, Merali S, Infusion of glucose and lipids at physiological rates causes acute endoplasmic reticulum stress in rat liver. Obesity (Silver Spring) 19:7(1366-73)2011 Jul

21297467. Boden G, Obesity, insulin resistance and free fatty acids. Curr Opin Endocrinol Diabetes Obes 18:2(139-43)2011 Apr

21266224. Boden G, Merali S, Measurement of the increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals. Methods Enzymol 489:(67-82)2011

21049473. Chen K, Liu ML, Schaffer L, Li M, Boden G, Wu X, Williams KJ, Type 2 diabetes in mice induces hepatic overexpression of sulfatase 2, a novel factor that suppresses uptake of remnant lipoproteins. Hepatology 52:6(1957-67)2010 Dec

20108856. Jimenez C, Santiago M, Sitler M, Boden G, Homko C, Insulin-sensitivity response to a single bout of resistive exercise in type 1 diabetes mellitus. J Sport Rehabil 18:4(564-71)2009 Nov

19897673. Boden G, Silviera M, Smith B, Cheung P, Homko C, Acute tissue injury caused by subcutaneous fat biopsies produces endoplasmic reticulum stress. J Clin Endocrinol Metab 95:1(349-52)2010 Jan

19246600. Boden G, Endoplasmic reticulum stress: another link between obesity and insulin resistance/inflammation? Diabetes 58:3(518-9)2009 Mar

18775356. Boden G, Obesity and free fatty acids. Endocrinol Metab Clin North Am 37:3(635-46, viii-ix)2008 Sep

18664596. Boden G, Song W, Kresge K, Mozzoli M, Cheung P, Effects of hyperinsulinemia on hepatic metalloproteinases and their tissue inhibitors. Am J Physiol Endocrinol Metab 295:3(E692-7)2008 Sep

18625123. Boden G, Song WW, Effects of insulin and free fatty acids on matrix metalloproteinases. Curr Diab Rep 8:3(239-42)2008 Jun

18567819. Boden G, Duan X, Homko C, Molina EJ, Song W, Perez O, Cheung P, Merali S, Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals. Diabetes 57:9(2438-44)2008 Sep

18458870. Boden G, Ceramide: a contributor to insulin resistance or an innocent bystander? Diabetologia 51:7(1095-6)2008 Jul

18025411. Boden G, Song W, Pashko L, Kresge K, In vivo effects of insulin and free fatty acids on matrix metalloproteinases in rat aorta. Diabetes 57:2(476-83)2008 Feb

17785358. Boden G, Vaidyula VR, Homko C, Cheung P, Rao AK, Circulating tissue factor procoagulant activity and thrombin generation in patients with type 2 diabetes: effects of insulin and glucose. J Clin Endocrinol Metab 92:11(4352-8)2007 Nov

17547839. Boden G, Rao AK, Effects of hyperglycemia and hyperinsulinemia on the tissue factor pathway of blood coagulation. Curr Diab Rep 7:3(223-7)2007 Jun

17213471. Boden G, Vaidyula V, Homko C, Mozzoli M, Rao AK, Differential effects of somatostatin on circulating tissue factor procoagulant activity and protein. Am J Physiol Endocrinol Metab 292:5(E1333-9)2007 May

17192489. Boden G, Homko C, Mozzoli M, Zhang M, Kresge K, Cheung P, Combined use of rosiglitazone and fenofibrate in patients with type 2 diabetes: prevention of fluid retention. Diabetes 56:1(248-55)2007 Jan

17127486. Vaidyula VR, Boden G, Rao AK, Platelet and monocyte activation by hyperglycemia and hyperinsulinemia in healthy subjects. Platelets 17:8(577-85)2006 Dec

16898568. Boden G, Fatty acid-induced inflammation and insulin resistance in skeletal muscle and liver. Curr Diab Rep 6:3(177-81)2006 Jun

16868831. Gaddipati KV, Simonian HP, Kresge KM, Boden GH, Parkman HP, Abnormal ghrelin and pancreatic polypeptide responses in gastroparesis. Dig Dis Sci 51:8(1339-46)2006 Aug

16503761. Boden G, Zhang M, Recent findings concerning thiazolidinediones in the treatment of diabetes. Expert Opin Investig Drugs 15:3(243-50)2006 Mar

16380494. Vaidyula VR, Rao AK, Mozzoli M, Homko C, Cheung P, Boden G, Effects of hyperglycemia and hyperinsulinemia on circulating tissue factor procoagulant activity and platelet CD40 ligand. Diabetes 55:1(202-8)2006 Jan

16306362. Boden G, She P, Mozzoli M, Cheung P, Gumireddy K, Reddy P, Xiang X, Luo Z, Ruderman N, Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-kappaB pathway in rat liver. Diabetes 54:12(3458-65)2005 Dec

15929861. Boden G, Free fatty acids and insulin secretion in humans. Curr Diab Rep 5:3(167-70)2005 Jun

15916622. Simonian HP, Kresge KM, Boden GH, Parkman HP, Differential effects of sham feeding and meal ingestion on ghrelin and pancreatic polypeptide levels: evidence for vagal efferent stimulation mediating ghrelin release. Neurogastroenterol Motil 17:3(348-54)2005 Jun

15767618. Boden G, Sargrad K, Homko C, Mozzoli M, Stein TP, Effect of a low-carbohydrate diet on appetite, blood glucose levels, and insulin resistance in obese patients with type 2 diabetes. Ann Intern Med 142:6(403-11)2005 Mar 15

15734868. Boden G, Homko C, Mozzoli M, Showe LC, Nichols C, Cheung P, Thiazolidinediones upregulate fatty acid uptake and oxidation in adipose tissue of diabetic patients. Diabetes 54:3(880-5)2005 Mar

15612450. Boden G, Gluconeogenesis and glycogenolysis in health and diabetes. J Investig Med 52:6(375-8)2004 Sep

15333497. Boden G, Laakso M, Lipids and glucose in type 2 diabetes: what is the cause and effect? Diabetes Care 27:9(2253-9)2004 Sep

14624413. Cheung P, Yang G, Boden G, Milrinone, a selective phosphodiesterase 3 inhibitor, stimulates lipolysis, endogenous glucose production, and insulin secretion. Metabolism 52:11(1496-500)2003 Nov

14614173. Boden G, Hoeldtke RD, Nerves, fat, and insulin resistance. N Engl J Med 349:20(1966-7)2003 Nov 13

12962693. Boden G, Carnell LH, Nutritional effects of fat on carbohydrate metabolism. Best Pract Res Clin Endocrinol Metab 17:3(399-410)2003 Sep

12866995. Sivan E, Boden G, Free fatty acids, insulin resistance, and pregnancy. Curr Diab Rep 3:4(319-22)2003 Aug

12832307. Homko C, Deluzio A, Jimenez C, Kolaczynski JW, Boden G, Comparison of insulin aspart and lispro: pharmacokinetic and metabolic effects. Diabetes Care 26:7(2027-31)2003 Jul

12800103. Boden G, Cheung P, Mozzoli M, Fried SK, Effect of thiazolidinediones on glucose and fatty acid metabolism in patients with type 2 diabetes. Metabolism 52:6(753-9)2003 Jun

12784183. Boden G, Effects of free fatty acids (FFA) on glucose metabolism: significance for insulin resistance and type 2 diabetes. Exp Clin Endocrinol Diabetes 111:3(121-4)2003 May

12757160. Gonlachanvit S, Hsu CW, Boden GH, Knight LC, Maurer AH, Fisher RS, Parkman HP, Effect of altering gastric emptying on postprandial plasma glucose concentrations following a physiologic meal in type-II diabetic patients. Dig Dis Sci 48:3(488-97)2003 Mar

12540625. Homko CJ, Cheung P, Boden G, Effects of free fatty acids on glucose uptake and utilization in healthy women. Diabetes 52:2(487-91)2003 Feb

12502503. Boden G, Cheung P, Homko C, Effects of acute insulin excess and deficiency on gluconeogenesis and glycogenolysis in type 1 diabetes. Diabetes 52:1(133-7)2003 Jan

12495777. Boden G, Effects of free fatty acids on gluconeogenesis and glycogenolysis. Life Sci 72:9(977-88)2003 Jan 17

12172479. Boden G, Interaction between free fatty acids and glucose metabolism. Curr Opin Clin Nutr Metab Care 5:5(545-9)2002 Sep

12067837. Boden G, Cheung P, Stein TP, Kresge K, Mozzoli M, FFA cause hepatic insulin resistance by inhibiting insulin suppression of glycogenolysis. Am J Physiol Endocrinol Metab 283:1(E12-9)2002 Jul

12028371. Boden G, Shulman GI, Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and beta-cell dysfunction. Eur J Clin Invest 32 Suppl 3:(14-23)2002 Jun

11727400. Boden G, Pathogenesis of type 2 diabetes. Insulin resistance. Endocrinol Metab Clin North Am 30:4(801-15, v)2001 Dec

11423483. Boden G, Lebed B, Schatz M, Homko C, Lemieux S, Effects of acute changes of plasma free fatty acids on intramyocellular fat content and insulin resistance in healthy subjects. Diabetes 50:7(1612-7)2001 Jul

11289046. Boden G, Chen X, Capulong E, Mozzoli M, Effects of free fatty acids on gluconeogenesis and autoregulation of glucose production in type 2 diabetes. Diabetes 50:4(810-6)2001 Apr

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