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Mark Birkenbach, MD

Associate Professor, Pathology and Laboratory Medicine

Telephone:  215-707-2553

Fax:  215-707-8132

Email: birkenmp@tuhs.temple.edu

Department of Pathology and Laboratory Medicine

Undergraduate degree, AB, Harvard University, Cambridge, MA, 1978

 

MD, Columbia University, New York, NY, 1982

 

Residency, Anatomic Pathology, University of Minnesota, 1982-1985

 

Research Fellowship, University of Chicago, 1985-1987

 

Research Fellowship, Harvard Medical School, 1987-1992

 

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• Transplant medicine
• Renal pathology
• Cardiac pathology

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• Molecular biology of Epstein-Barr virus transformation of B lymphocytes
• Regulation of T cell differentiation by IL-27, IL-35

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Anatomic Pathology, 1987

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International Society for Heart and Lung Transplantation

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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

19549909. Dibra D, Cutrera JJ, Xia X, Birkenbach MP, Li S, Expression of WSX1 in tumors sensitizes IL-27 signaling-independent natural killer cell surveillance. Cancer Res 69:13(5505-13)2009 Jul 1

18941205. Sauer KA, Maxeiner JH, Karwot R, Scholtes P, Lehr HA, Birkenbach M, Blumberg RS, Finotto S, Immunosurveillance of lung melanoma metastasis in EBI-3-deficient mice mediated by CD8+ T cells. J Immunol 181:9(6148-57)2008 Nov 1

18072282. Kinoshita Y, Johnson EM, Gordon RE, Negri-Bell H, Evans MT, Coolbaugh J, Rosario-Peralta Y, Samet J, Slusser E, Birkenbach MP, Daniel DC, Colocalization of MCM8 and MCM7 with proteins involved in distinct aspects of DNA replication. Microsc Res Tech 71:4(288-97)2008 Apr

17506035. Hausding M, Karwot R, Scholtes P, Lehr HA, Wegmann M, Renz H, Galle PR, Birkenbach M, Neurath MF, Blumberg RS, Finotto S, Lung CD11c+ cells from mice deficient in Epstein-Barr virus-induced gene 3 (EBI-3) prevent airway hyper-responsiveness in experimental asthma. Eur J Immunol 37:6(1663-77)2007 Jun

16880260. Wirtz S, Tubbe I, Galle PR, Schild HJ, Birkenbach M, Blumberg RS, Neurath MF, Protection from lethal septic peritonitis by neutralizing the biological function of interleukin 27. J Exp Med 203:8(1875-81)2006 Aug 7

16143360. Ciavarra RP, Taylor L, Greene AR, Yousefieh N, Horeth D, van Rooijen N, Steel C, Gregory B, Birkenbach M, Sekellick M, Impact of macrophage and dendritic cell subset elimination on antiviral immunity, viral clearance and production of type 1 interferon. Virology 342:2(177-89)2005 Nov 25

15756639. Zahn S, Wirtz S, Birkenbach M, Blumberg RS, Neurath MF, von Stebut E, Impaired Th1 responses in mice deficient in Epstein-Barr virus-induced gene 3 and challenged with physiological doses of Leishmania major. Eur J Immunol 35:4(1106-12)2005 Apr

15728491. Wirtz S, Becker C, Fantini MC, Nieuwenhuis EE, Tubbe I, Galle PR, Schild HJ, Birkenbach M, Blumberg RS, Neurath MF, EBV-induced gene 3 transcription is induced by TLR signaling in primary dendritic cells via NF-kappa B activation. J Immunol 174:5(2814-24)2005 Mar 1

15196212. Maaser C, Egan LJ, Birkenbach MP, Eckmann L, Kagnoff MF, Expression of Epstein-Barr virus-induced gene 3 and other interleukin-12-related molecules by human intestinal epithelium. Immunology 112:3(437-45)2004 Jul

12525604. Cavanaugh VJ, Deng Y, Birkenbach MP, Slater JS, Campbell AE, Vigorous innate and virus-specific cytotoxic T-lymphocyte responses to murine cytomegalovirus in the submaxillary salivary gland. J Virol 77:3(1703-17)2003 Feb

12482940. Nieuwenhuis EE, Neurath MF, Corazza N, Iijima H, Trgovcich J, Wirtz S, Glickman J, Bailey D, Yoshida M, Galle PR, Kronenberg M, Birkenbach M, Blumberg RS, Disruption of T helper 2-immune responses in Epstein-Barr virus-induced gene 3-deficient mice. Proc Natl Acad Sci U S A 99:26(16951-6)2002 Dec 24

11854457. Baron BW, Anastasi J, Thirman MJ, Furukawa Y, Fears S, Kim DC, Simone F, Birkenbach M, Montag A, Sadhu A, Zeleznik-Le N, McKeithan TW, The human programmed cell death-2 (PDCD2) gene is a target of BCL6 repression: implications for a role of BCL6 in the down-regulation of apoptosis. Proc Natl Acad Sci U S A 99:5(2860-5)2002 Mar 5

11515847. Omata F, Birkenbach M, Matsuzaki S, Christ AD, Blumberg RS, The expression of IL-12 p40 and its homologue, Epstein-Barr virus-induced gene 3, in inflammatory bowel disease. Inflamm Bowel Dis 7:3(215-20)2001 Aug

10874008. Wang H, Birkenbach M, Hart J, Expression of Jun family members in human colorectal adenocarcinoma. Carcinogenesis 21:7(1313-7)2000 Jul

10064100. Josefsen K, Sørensen LR, Buschard K, Birkenbach M, Glucose induces early growth response gene (Egr-1) expression in pancreatic beta cells. Diabetologia 42:2(195-203)1999 Feb

9751516. Josefsen K, Buschard K, Sørensen LR, Wøllike M, Ekman R, Birkenbach M, Glucose stimulation of pancreatic beta-cell lines induces expression and secretion of dynorphin. Endocrinology 139:10(4329-36)1998 Oct

9679036. Christ AD, Stevens AC, Koeppen H, Walsh S, Omata F, Devergne O, Birkenbach M, Blumberg RS, An interleukin 12-related cytokine is up-regulated in ulcerative colitis but not in Crohn's disease. Gastroenterology 115:2(307-13)1998 Aug

9342359. Devergne O, Birkenbach M, Kieff E, Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin. Proc Natl Acad Sci U S A 94:22(12041-6)1997 Oct 28

8579121. Mosialos G, Birkenbach M, Ayehunie S, Matsumura F, Pinkus GS, Kieff E, Langhoff E, Circulating human dendritic cells differentially express high levels of a 55-kd actin-bundling protein. Am J Pathol 148:2(593-600)1996 Feb

8551575. Devergne O, Hummel M, Koeppen H, Le Beau MM, Nathanson EC, Kieff E, Birkenbach M, A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes. J Virol 70:2(1143-53)1996 Feb

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