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Mark Birkenbach, MD

Associate Professor, Pathology and Laboratory Medicine

Telephone:  215-707-2553

Fax:  215-707-8132

Email: mark.birkenbach@tuhs.temple.edu

Department of Pathology and Laboratory Medicine

Undergraduate degree, AB, Harvard University, Cambridge, MA, 1978

 

MD, Columbia University, New York, NY, 1982

 

Residency, Anatomic Pathology, University of Minnesota, 1982-1985

 

Research Fellowship, University of Chicago, 1985-1987

 

Research Fellowship, Harvard Medical School, 1987-1992

 

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• Transplant medicine
• Renal pathology
• Cardiac pathology

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• Molecular biology of Epstein-Barr virus transformation of B lymphocytes
• Regulation of T cell differentiation by IL-27, IL-35

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Anatomic Pathology, 1987

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International Society for Heart and Lung Transplantation

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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

23519178. Singh N, Birkenbach M, Caza T, Perl A, Cohen PL, Tuberous sclerosis and fulminant lupus in a young woman. J Clin Rheumatol 19:3(134-7)2013 Apr

20444650. Shao WH, Zhen Y, Rosenbaum J, Eisenberg RA, McGaha TL, Birkenbach M, Cohen PL, A protective role of Mer receptor tyrosine kinase in nephrotoxic serum-induced nephritis. Clin Immunol 136:2(236-44)2010 Aug

21696057. Lee I, Constantinescu S, Gillespie A, Rao S, Silva P, Birkenbach M, Leech S, Karachristos A, Daller JA, Sifontis NM, Targeting alloantibody production with bortezomib: does it make more sense? Clin Transpl :(397-403)2010

19549909. Dibra D, Cutrera JJ, Xia X, Birkenbach MP, Li S, Expression of WSX1 in tumors sensitizes IL-27 signaling-independent natural killer cell surveillance. Cancer Res 69:13(5505-13)2009 Jul 1

20524309. Lee I, Constantinescu S, Gillespie A, Swami A, Birkenbach M, Leech S, Silva P, Karachristos A, Daller JA, Sifontis NM, Bortezomib as therapy for mixed humoral and cellular rejection: should it be first line? Clin Transpl :(425-9)2009

18941205. Sauer KA, Maxeiner JH, Karwot R, Scholtes P, Lehr HA, Birkenbach M, Blumberg RS, Finotto S, Immunosurveillance of lung melanoma metastasis in EBI-3-deficient mice mediated by CD8+ T cells. J Immunol 181:9(6148-57)2008 Nov 1

18072282. Kinoshita Y, Johnson EM, Gordon RE, Negri-Bell H, Evans MT, Coolbaugh J, Rosario-Peralta Y, Samet J, Slusser E, Birkenbach MP, Daniel DC, Colocalization of MCM8 and MCM7 with proteins involved in distinct aspects of DNA replication. Microsc Res Tech 71:4(288-97)2008 Apr

17506035. Hausding M, Karwot R, Scholtes P, Lehr HA, Wegmann M, Renz H, Galle PR, Birkenbach M, Neurath MF, Blumberg RS, Finotto S, Lung CD11c+ cells from mice deficient in Epstein-Barr virus-induced gene 3 (EBI-3) prevent airway hyper-responsiveness in experimental asthma. Eur J Immunol 37:6(1663-77)2007 Jun

16880260. Wirtz S, Tubbe I, Galle PR, Schild HJ, Birkenbach M, Blumberg RS, Neurath MF, Protection from lethal septic peritonitis by neutralizing the biological function of interleukin 27. J Exp Med 203:8(1875-81)2006 Aug 7

16143360. Ciavarra RP, Taylor L, Greene AR, Yousefieh N, Horeth D, van Rooijen N, Steel C, Gregory B, Birkenbach M, Sekellick M, Impact of macrophage and dendritic cell subset elimination on antiviral immunity, viral clearance and production of type 1 interferon. Virology 342:2(177-89)2005 Nov 25

15756639. Zahn S, Wirtz S, Birkenbach M, Blumberg RS, Neurath MF, von Stebut E, Impaired Th1 responses in mice deficient in Epstein-Barr virus-induced gene 3 and challenged with physiological doses of Leishmania major. Eur J Immunol 35:4(1106-12)2005 Apr

15728491. Wirtz S, Becker C, Fantini MC, Nieuwenhuis EE, Tubbe I, Galle PR, Schild HJ, Birkenbach M, Blumberg RS, Neurath MF, EBV-induced gene 3 transcription is induced by TLR signaling in primary dendritic cells via NF-kappa B activation. J Immunol 174:5(2814-24)2005 Mar 1

15196212. Maaser C, Egan LJ, Birkenbach MP, Eckmann L, Kagnoff MF, Expression of Epstein-Barr virus-induced gene 3 and other interleukin-12-related molecules by human intestinal epithelium. Immunology 112:3(437-45)2004 Jul

12525604. Cavanaugh VJ, Deng Y, Birkenbach MP, Slater JS, Campbell AE, Vigorous innate and virus-specific cytotoxic T-lymphocyte responses to murine cytomegalovirus in the submaxillary salivary gland. J Virol 77:3(1703-17)2003 Feb

12482940. Nieuwenhuis EE, Neurath MF, Corazza N, Iijima H, Trgovcich J, Wirtz S, Glickman J, Bailey D, Yoshida M, Galle PR, Kronenberg M, Birkenbach M, Blumberg RS, Disruption of T helper 2-immune responses in Epstein-Barr virus-induced gene 3-deficient mice. Proc Natl Acad Sci U S A 99:26(16951-6)2002 Dec 24

11854457. Baron BW, Anastasi J, Thirman MJ, Furukawa Y, Fears S, Kim DC, Simone F, Birkenbach M, Montag A, Sadhu A, Zeleznik-Le N, McKeithan TW, The human programmed cell death-2 (PDCD2) gene is a target of BCL6 repression: implications for a role of BCL6 in the down-regulation of apoptosis. Proc Natl Acad Sci U S A 99:5(2860-5)2002 Mar 5

11515847. Omata F, Birkenbach M, Matsuzaki S, Christ AD, Blumberg RS, The expression of IL-12 p40 and its homologue, Epstein-Barr virus-induced gene 3, in inflammatory bowel disease. Inflamm Bowel Dis 7:3(215-20)2001 Aug

10874008. Wang H, Birkenbach M, Hart J, Expression of Jun family members in human colorectal adenocarcinoma. Carcinogenesis 21:7(1313-7)2000 Jul

10064100. Josefsen K, Sørensen LR, Buschard K, Birkenbach M, Glucose induces early growth response gene (Egr-1) expression in pancreatic beta cells. Diabetologia 42:2(195-203)1999 Feb

9751516. Josefsen K, Buschard K, Sørensen LR, Wøllike M, Ekman R, Birkenbach M, Glucose stimulation of pancreatic beta-cell lines induces expression and secretion of dynorphin. Endocrinology 139:10(4329-36)1998 Oct

9679036. Christ AD, Stevens AC, Koeppen H, Walsh S, Omata F, Devergne O, Birkenbach M, Blumberg RS, An interleukin 12-related cytokine is up-regulated in ulcerative colitis but not in Crohn's disease. Gastroenterology 115:2(307-13)1998 Aug

9342359. Devergne O, Birkenbach M, Kieff E, Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin. Proc Natl Acad Sci U S A 94:22(12041-6)1997 Oct 28

8579121. Mosialos G, Birkenbach M, Ayehunie S, Matsumura F, Pinkus GS, Kieff E, Langhoff E, Circulating human dendritic cells differentially express high levels of a 55-kd actin-bundling protein. Am J Pathol 148:2(593-600)1996 Feb

8551575. Devergne O, Hummel M, Koeppen H, Le Beau MM, Nathanson EC, Kieff E, Birkenbach M, A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes. J Virol 70:2(1143-53)1996 Feb

7859281. Mosialos G, Birkenbach M, Yalamanchili R, VanArsdale T, Ware C, Kieff E, The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family. Cell 80:3(389-99)1995 Feb 10

7933116. Mosialos G, Yamashiro S, Baughman RW, Matsudaira P, Vara L, Matsumura F, Kieff E, Birkenbach M, Epstein-Barr virus infection induces expression in B lymphocytes of a novel gene encoding an evolutionarily conserved 55-kilodalton actin-bundling protein. J Virol 68:11(7320-8)1994 Nov

8383238. Birkenbach M, Josefsen K, Yalamanchili R, Lenoir G, Kieff E, Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors. J Virol 67:4(2209-20)1993 Apr

1383386. Birkenbach M, Tong X, Bradbury LE, Tedder TF, Kieff E, Characterization of an Epstein-Barr virus receptor on human epithelial cells. J Exp Med 176:5(1405-14)1992 Nov 1

1312681. Li QX, Young LS, Niedobitek G, Dawson CW, Birkenbach M, Wang F, Rickinson AB, Epstein-Barr virus infection and replication in a human epithelial cell system. Nature 356:6367(347-50)1992 Mar 26

1658376. Mannick JB, Cohen JI, Birkenbach M, Marchini A, Kieff E, The Epstein-Barr virus nuclear protein encoded by the leader of the EBNA RNAs is important in B-lymphocyte transformation. J Virol 65:12(6826-37)1991 Dec

1849678. Alfieri C, Birkenbach M, Kieff E, Early events in Epstein-Barr virus infection of human B lymphocytes. Virology 181:2(595-608)1991 Apr

2548016. Birkenbach M, Liebowitz D, Wang F, Sample J, Kieff E, Epstein-Barr virus latent infection membrane protein increases vimentin expression in human B-cell lines. J Virol 63:9(4079-84)1989 Sep

2538015. Hanto DW, Birkenbach M, Frizzera G, Gajl-Peczalska KJ, Simmons RL, Schubach WH, Confirmation of the heterogeneity of posttransplant Epstein-Barr virus-associated B cell proliferations by immunoglobulin gene rearrangement analyses. Transplantation 47:3(458-64)1989 Mar

2820125. Pearson GR, Luka J, Petti L, Sample J, Birkenbach M, Braun D, Kieff E, Identification of an Epstein-Barr virus early gene encoding a second component of the restricted early antigen complex. Virology 160:1(151-61)1987 Sep

3033649. Wang F, Gregory CD, Rowe M, Rickinson AB, Wang D, Birkenbach M, Kikutani H, Kishimoto T, Kieff E, Epstein-Barr virus nuclear antigen 2 specifically induces expression of the B-cell activation antigen CD23. Proc Natl Acad Sci U S A 84:10(3452-6)1987 May

3460083. Sample J, Hummel M, Braun D, Birkenbach M, Kieff E, Nucleotide sequences of mRNAs encoding Epstein-Barr virus nuclear proteins: a probable transcriptional initiation site. Proc Natl Acad Sci U S A 83:14(5096-100)1986 Jul

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