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Mary F. Barbe, PhD

Professor, Anatomy and Cell Biology

Telephone: 215-707-6422

Email: mary.barbe@temple.edu

Department of Anatomy and Cell Biology

BA, Biology, University of North Carolina, Greensboro, NC, 1982

 

PhD, Anatomy, Bowman Gray School of Medicine, Wake Forest University, Wake Forest, NC, 1987

 

Postdoctoral Research Fellow, Department of Anatomy and Neurobiology, The Medical College of Pennsylvania, Philadelphia, PA, 1987-1991

 

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• Somatosensory and Chemosensory Study Section, Center for Scientific Review, regular member
• Musculoskeletal Research Group, Temple University
• Society for Neuroscience
• American Association of the Advancement of Science
• Society for Neuroscience, Philadelphia Chapter
• American Society for Bone and Mineral Research
• American Association of Anatomists
• Orthopaedic Research Society
• American Society of Pain

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My focus is on two main areas of research: 1) the effect of repetition and force on musculoskeletal and neural systems, and their interaction in a unique rat model of work-related musculoskeletal disorder (also known as repetitive strain injury), and 2) examining tissue and cellular responses after spinal root/cord injury, or as a consequence of cerebral palsy.

For the past 10 years, I have been involved in neurobiological, cell and molecular biological studies examining the effects of repetition and force on musculoskeletal and neural systems and on sensorimotor function with a research colleague, Dr. Ann Barr (now at Pacific University, Portland, Oregon).  We developed a unique voluntary rat model of Work-Related Musculoskeletal Disorders (also known as repetitive strain injury and overuse injury) with varying levels of repetition and force, and have been working to characterize the short-term effects, and have now expanded to examining the long-term effects, of repetitive and/or forceful tasks on musculoskeletal and nervous system pathophysiology, focusing on injury/inflammation and how these processes induce degenerative tissue changes and sensorimotor dysfunction.  I am currently exploring inflammation-induced catabolic tissue changes versus mechanical overload-induced tissue disruption using pharmaceutical methods to block inflammatory processes.  This work is currently funded by NIOSH and NIAMS.  I am also currently examining means of successful reinnervation of bladder and urethral sphincter targets after spinal root injury in collaboration with Dr. Michael Ruggieri of the Department of Urology, Temple University School of Medicine.  This work is currently funded by NINDS.  Finally, I am funded with Dr. Olivier Coq (University of Marseilles, France) by the Cerebral Palsy Foundation to examine the consequences of immobilization, brain hypoxia, or in combination on the musculoskeletal system and the central nervous system.

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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

23540734. Brown JM, Barbe MF, Albo ME, Ruggieri MR Sr, Anatomical feasibility of performing a nerve transfer from the femoral branch to bilateral pelvic nerves in a cadaver: a potential method to restore bladder function following proximal spinal cord injury. J Neurosurg Spine :()2013 Mar 29

23362053. Lin K, Uzbelger Feldman D, Barbe MF, Transverse cervical nerve: Implications for dental anesthesia. Clin Anat :()2013 Jan 29

23320196. Canu MH, Coq JO, Barbe MF, Dinse HR, Plasticity of adult sensorimotor system. Neural Plast 2012:(768259)2012

23149425. Back SH, Adapala NS, Barbe MF, Carpino NC, Tsygankov AY, Sanjay A, TULA-2, a novel histidine phosphatase, regulates bone remodeling by modulating osteoclast function. Cell Mol Life Sci 70:7(1269-84)2013 Apr

23073844. Lambi AG, Pankratz TL, Mundy C, Gannon M, Barbe MF, Richtsmeier JT, Popoff SN, The skeletal site-specific role of connective tissue growth factor in prenatal osteogenesis. Dev Dyn 241:12(1944-59)2012 Dec

23056540. Kietrys DM, Barr-Gillespie AE, Amin M, Wade CK, Popoff SN, Barbe MF, Aging contributes to inflammation in upper extremity tendons and declines in forelimb agility in a rat model of upper extremity overuse. PLoS One 7:10(e46954)2012

22998376. Vegesna AK, Sloan JA, Singh B, Phillips SJ, Braverman AS, Barbe MF, Ruggieri MR Sr, Miller LS, Characterization of the distal esophagus high-pressure zone with manometry, ultrasound and micro-computed tomography. Neurogastroenterol Motil 25:1(53-60.e6)2013 Jan

22969194. Vegesna AK, Chuang KY, Besetty R, Phillips SJ, Braverman AS, Barbe MF, Ruggieri MR, Miller LS, Circular smooth muscle contributes to esophageal shortening during peristalsis. World J Gastroenterol 18:32(4317-22)2012 Aug 28

22951537. Muth S, Barbe MF, Lauer R, McClure PW, The effects of thoracic spine manipulation in subjects with signs of rotator cuff tendinopathy. J Orthop Sports Phys Ther 42:12(1005-16)2012 Dec

22881037. Brown JM, Barbe MF, Albo ME, Lai HH, Ruggieri MR Sr, Anatomical feasibility of performing intercostal and ilioinguinal nerve to pelvic nerve transfer: a possible technique to restore lower urinary tract innervation. J Neurosurg Spine 17:4(357-62)2012 Oct

22675458. Abdelmagid SM, Barr AE, Rico M, Amin M, Litvin J, Popoff SN, Safadi FF, Barbe MF, Performance of repetitive tasks induces decreased grip strength and increased fibrogenic proteins in skeletal muscle: role of force and inflammation. PLoS One 7:5(e38359)2012

22521835. Delcour M, Russier M, Amin M, Baud O, Paban V, Barbe MF, Coq JO, Impact of prenatal ischemia on behavior, cognitive abilities and neuroanatomy in adult rats with white matter damage. Behav Brain Res 232:1(233-44)2012 Jun 15

22122951. Cattano NM, Driban JB, Balasubramanian E, Barbe MF, Amin M, Sitler MR, Biochemical comparison of osteoarthritic knees with and without effusion. BMC Musculoskelet Disord 12:(273)2011 Nov 28

22087754. Kietrys DM, Barr AE, Barbe MF, Exposure to repetitive tasks induces motor changes related to skill acquisition and inflammation in rats. J Mot Behav 43:6(465-76)2011 Nov

21953679. Ruggieri MR Sr, Braverman AS, Bernal RM, Lamarre NS, Brown JM, Barbe MF, Reinnervation of urethral and anal sphincters with femoral motor nerve to pudendal nerve transfer. Neurourol Urodyn 30:8(1695-704)2011 Nov

21952831. Brennan T, Adapala NS, Barbe MF, Yingling V, Sanjay A, Abrogation of Cbl-PI3K interaction increases bone formation and osteoblast proliferation. Calcif Tissue Int 89:5(396-410)2011 Nov

21807131. Joshi RN, Safadi FF, Barbe MF, Del Carpio-Cano F, Popoff SN, Yingling VR, Different effects on bone strength and cell differentiation in pre pubertal caloric restriction versus hypothalamic suppression. Bone 49:4(810-8)2011 Oct

21761966. Barbe MF, Brown JM, Pontari MA, Dean GE, Braverman AS, Ruggieri MR, Feasibility of a femoral nerve motor branch for transfer to the pudendal nerve for restoring continence: a cadaveric study. J Neurosurg Spine 15:5(526-31)2011 Nov

21615591. Delcour M, Olivier P, Chambon C, Pansiot J, Russier M, Liberge M, Xin D, Gestreau C, Alescio-Lautier B, Gressens P, Verney C, Barbe MF, Baud O, Coq JO, Neuroanatomical, sensorimotor and cognitive deficits in adult rats with white matter injury following prenatal ischemia. Brain Pathol 22:1(1-16)2012 Jan

21464333. Braverman AS, Vegesna AK, Miller LS, Barbe MF, Tiwana M, Hussain K, Ruggieri MR Sr, Pharmacologic specificity of nicotinic receptor-mediated relaxation of muscarinic receptor precontracted human gastric clasp and sling muscle fibers within the gastroesophageal junction. J Pharmacol Exp Ther 338:1(37-46)2011 Jul

21447183. Xin DL, Harris MY, Wade CK, Amin M, Barr AE, Barbe MF, Aging enhances serum cytokine response but not task-induced grip strength declines in a rat model of work-related musculoskeletal disorders. BMC Musculoskelet Disord 12:(63)2011 Mar 29

21403884. Driban JB, Barr AE, Amin M, Sitler MR, Barbe MF, Joint inflammation and early degeneration induced by high-force reaching are attenuated by ibuprofen in an animal model of work-related musculoskeletal disorder. J Biomed Biotechnol 2011:(691412)2011

21382470. Delcour M, Russier M, Xin DL, Massicotte VS, Barbe MF, Coq JO, Mild musculoskeletal and locomotor alterations in adult rats with white matter injury following prenatal ischemia. Int J Dev Neurosci 29:6(593-607)2011 Oct

21332427. Elliott MB, Tuma RF, Amenta PS, Barbe MF, Jallo JI, Acute effects of a selective cannabinoid-2 receptor agonist on neuroinflammation in a model of traumatic brain injury. J Neurotrauma 28:6(973-81)2011 Jun

21254198. Barbe MF, Ruggieri MR Sr, Innervation of parasympathetic postganglionic neurons and bladder detrusor muscle directly after sacral root transection and repair using nerve transfer. Neurourol Urodyn 30:4(599-605)2011 Apr

21116010. Driban JB, Balasubramanian E, Amin M, Sitler MR, Ziskin MC, Barbe MF, The potential of multiple synovial-fluid protein-concentration analyses in the assessment of knee osteoarthritis. J Sport Rehabil 19:4(411-21)2010 Nov

20851882. Adapala NS, Barbe MF, Langdon WY, Nakamura MC, Tsygankov AY, Sanjay A, The loss of Cbl-phosphatidylinositol 3-kinase interaction perturbs RANKL-mediated signaling, inhibiting bone resorption and promoting osteoclast survival. J Biol Chem 285:47(36745-58)2010 Nov 19

20798664. Saine ME, Barbe MF, Agah MR, Yingling VR, Hypothalamic suppression during adolescence varies by bone envelope. Med Sci Sports Exerc 43:4(608-16)2011 Apr

20673790. Elliott MB, Barr AE, Clark BD, Wade CK, Barbe MF, Performance of a repetitive task by aged rats leads to median neuropathy and spinal cord inflammation with associated sensorimotor declines. Neuroscience 170:3(929-41)2010 Oct 27

20506259. Abdelmagid SM, Barbe MF, Hadjiargyrou M, Owen TA, Razmpour R, Rehman S, Popoff SN, Safadi FF, Temporal and spatial expression of osteoactivin during fracture repair. J Cell Biochem 111:2(295-309)2010 Oct 1

20472460. Prosser LA, Lee SC, Barbe MF, VanSant AF, Lauer RT, Trunk and hip muscle activity in early walkers with and without cerebral palsy--a frequency analysis. J Electromyogr Kinesiol 20:5(851-9)2010 Oct

20458732. Rani S, Barbe MF, Barr AE, Litivn J, Role of TNF alpha and PLF in bone remodeling in a rat model of repetitive reaching and grasping. J Cell Physiol 225:1(152-67)2010 Oct

20430948. Prosser LA, Lee SC, VanSant AF, Barbe MF, Lauer RT, Trunk and hip muscle activation patterns are different during walking in young children with and without cerebral palsy. Phys Ther 90:7(986-97)2010 Jul

20392263. Adapala NS, Barbe MF, Langdon WY, Tsygankov AY, Sanjay A, Cbl-phosphatidylinositol 3 kinase interaction differentially regulates macrophage colony-stimulating factor-mediated osteoclast survival and cytoskeletal reorganization. Ann N Y Acad Sci 1192:(376-84)2010 Mar

20338763. Prosser LA, Lauer RT, VanSant AF, Barbe MF, Lee SC, Variability and symmetry of gait in early walkers with and without bilateral cerebral palsy. Gait Posture 31:4(522-6)2010 Apr

19924499. Driban JB, Sitler MR, Barbe MF, Balasubramanian E, Is osteoarthritis a heterogeneous disease that can be stratified into subsets? Clin Rheumatol 29:2(123-31)2010 Feb

19854058. Lauer RT, Pierce SR, Tucker CA, Barbe MF, Prosser LA, Age and electromyographic frequency alterations during walking in children with cerebral palsy. Gait Posture 31:1(136-9)2010 Jan

19804766. Elliott MB, Jallo JJ, Barbe MF, Tuma RF, Hypertonic saline attenuates tissue loss and astrocyte hypertrophy in a model of traumatic brain injury. Brain Res 1305:(183-91)2009 Dec 11

19743505. Fedorczyk JM, Barr AE, Rani S, Gao HG, Amin M, Amin S, Litvin J, Barbe MF, Exposure-dependent increases in IL-1beta, substance P, CTGF, and tendinosis in flexor digitorum tendons with upper extremity repetitive strain injury. J Orthop Res 28:3(298-307)2010 Mar

19686738. Coq JO, Barr AE, Strata F, Russier M, Kietrys DM, Merzenich MM, Byl NN, Barbe MF, Peripheral and central changes combine to induce motor behavioral deficits in a moderate repetition task. Exp Neurol 220:2(234-45)2009 Dec

19620321. Rani S, Barbe MF, Barr AE, Litvin J, Induction of periostin-like factor and periostin in forearm muscle, tendon, and nerve in an animal model of work-related musculoskeletal disorder. J Histochem Cytochem 57:11(1061-73)2009 Nov

19564053. Bove GM, Weissner W, Barbe MF, Long lasting recruitment of immune cells and altered epi-perineurial thickness in focal nerve inflammation induced by complete Freund's adjuvant. J Neuroimmunol 213:1-2(26-30)2009 Aug 18

19429049. Elliott MB, Barr AE, Barbe MF, Spinal substance P and neurokinin-1 increase with high repetition reaching. Neurosci Lett 454:1(33-7)2009 Apr 17

19295961. Tate AR, McClure P, Kareha S, Irwin D, Barbe MF, A clinical method for identifying scapular dyskinesis, part 2: validity. J Athl Train 44:2(165-73)2009 Mar-Apr

19095091. Rani S, Barbe MF, Barr AE, Litvin J, Periostin-like-factor and Periostin in an animal model of work-related musculoskeletal disorder. Bone 44:3(502-12)2009 Mar

19032977. Elliott MB, Barr AE, Clark BD, Amin M, Amin S, Barbe MF, High force reaching task induces widespread inflammation, increased spinal cord neurochemicals and neuropathic pain. Neuroscience 158:2(922-31)2009 Jan 23

19006175. Zhu S, Barbe MF, Liu C, Hadjiargyrou M, Popoff SN, Rani S, Safadi FF, Litvin J, Periostin-like-factor in osteogenesis. J Cell Physiol 218:3(584-92)2009 Mar

18703677. Pierce SR, Barbe MF, Barr AE, Shewokis PA, Lauer RT, Roles of reflex activity and co-contraction during assessments of spasticity of the knee flexor and knee extensor muscles in children with cerebral palsy and different functional levels. Phys Ther 88:10(1124-34)2008 Oct

18555216. Abdelmagid SM, Barbe MF, Rico MC, Salihoglu S, Arango-Hisijara I, Selim AH, Anderson MG, Owen TA, Popoff SN, Safadi FF, Osteoactivin, an anabolic factor that regulates osteoblast differentiation and function. Exp Cell Res 314:13(2334-51)2008 Aug 1

18511022. Elliott MB, Barr AE, Kietrys DM, Al-Shatti T, Amin M, Barbe MF, Peripheral neuritis and increased spinal cord neurochemicals are induced in a model of repetitive motion injury with low force and repetition exposure. Brain Res 1218:(103-13)2008 Jul 7

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