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Mary F. Barbe, PhD


Mary F. Barbe, PhD



Professor, Anatomy and Cell Biology

Telephone: 215-707-6422

Email: mary.barbe@temple.edu



Department of Anatomy and Cell Biology


Educational Background:


BA, Biology, University of North Carolina, Greensboro, NC, 1982


PhD, Anatomy, Bowman Gray School of Medicine, Wake Forest University, Wake Forest, NC, 1987


Postdoctoral Research Fellow, Department of Anatomy and Neurobiology, The Medical College of Pennsylvania, Philadelphia, PA, 1987-1991


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professional affiliations:

  • Somatosensory and Chemosensory Study Section, Center for Scientific Review, regular member
  • Musculoskeletal Research Group, Temple University
  • Society for Neuroscience
  • American Association of the Advancement of Science
  • Society for Neuroscience, Philadelphia Chapter
  • American Society for Bone and Mineral Research
  • American Association of Anatomists
  • Orthopaedic Research Society
  • American Society of Pain

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My focus is on two main areas of research: 1) the effect of repetition and force on musculoskeletal and neural systems, and their interaction in a unique rat model of work-related musculoskeletal disorder (also known as repetitive strain injury), and 2) examining tissue and cellular responses after spinal root/cord injury, or as a consequence of cerebral palsy.


For the past 10 years, I have been involved in neurobiological, cell and molecular biological studies examining the effects of repetition and force on musculoskeletal and neural systems and on sensorimotor function with a research colleague, Dr. Ann Barr (now at Pacific University, Portland, Oregon).  We developed a unique voluntary rat model of Work-Related Musculoskeletal Disorders (also known as repetitive strain injury and overuse injury) with varying levels of repetition and force, and have been working to characterize the short-term effects, and have now expanded to examining the long-term effects, of repetitive and/or forceful tasks on musculoskeletal and nervous system pathophysiology, focusing on injury/inflammation and how these processes induce degenerative tissue changes and sensorimotor dysfunction.  I am currently exploring inflammation-induced catabolic tissue changes versus mechanical overload-induced tissue disruption using pharmaceutical methods to block inflammatory processes.  This work is currently funded by NIOSH and NIAMS.  I am also currently examining means of successful reinnervation of bladder and urethral sphincter targets after spinal root injury in collaboration with Dr. Michael Ruggieri of the Department of Urology, Temple University School of Medicine.  This work is currently funded by NINDS.  Finally, I am funded with Dr. Olivier Coq (University of Marseilles, France) by the Cerebral Palsy Foundation to examine the consequences of immobilization, brain hypoxia, or in combination on the musculoskeletal system and the central nervous system.


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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

26599377. Gold JE, Hallman DM, Hellström F, Björklund M, Crenshaw AG, Djupsjobacka M, Heiden M, Mathiassen SE, Piligian G, Barbe MF, Systematic review of biochemical biomarkers for neck and upper-extremity musculoskeletal disorders. Scand J Work Environ Health :()2015 Nov 24

26524412. Frohbergh ME, Guevara JM, Grelsamer RP, Barbe MF, He X, Simonaro CM, Schuchman EH, Acid ceramidase treatment enhances the outcome of autologous chondrocyte implantation in a rat osteochondral defect model. Osteoarthritis Cartilage :()2015 Oct 30

26517953. Massicotte VS, Frara N, Harris MY, Amin M, Wade CK, Popoff SN, Barbe MF, Prolonged performance of a high repetition low force task induces bone adaptation in young adult rats, but loss in mature rats. Exp Gerontol 72:(204-17)2015 Dec

26452068. Barbe MF, Gomez-Amaya S, Braverman AS, Brown JM, Lamarre NS, Massicotte VS, Lewis JK, Dachert SR, Ruggieri MR Sr, Evidence of vagus nerve sprouting to innervate the urinary bladder and clitoris in a canine model of lower motoneuron lesioned bladder. Neurourol Urodyn :()2015 Oct 9

26245773. Ali S, Cunningham R, Amin M, Popoff SN, Mohamed F, Barbe MF, The extensor carpi ulnaris pseudolesion: evaluation with microCT, histology, and MRI. Skeletal Radiol 44:12(1735-43)2015 Dec

25899717. Frara N, Abdelmagid SM, Sondag GR, Moussa FM, Yingling VR, Owen TA, Popoff SN, Barbe MF, Safadi FF, Transgenic Expression of Osteoactivin/gpnmb Enhances Bone Formation In Vivo and Osteoprogenitor Differentiation Ex Vivo. J Cell Physiol 231:1(72-83)2016 Jan

25739896. Barbe MF, Jain NX, Massicotte VS, Popoff SN, Barr-Gillespie AE, Ergonomic task reduction prevents bone osteopenia in a rat model of upper extremity overuse. Ind Health 53:3(206-21)2015

25714841. Hendesi H, Barbe MF, Safadi FF, Monroy MA, Popoff SN, Integrin mediated adhesion of osteoblasts to connective tissue growth factor (CTGF/CCN2) induces cytoskeleton reorganization and cell differentiation. PLoS One 10:2(e0115325)2015

25666987. Gomez-Amaya SM, Barbe MF, de Groat WC, Brown JM, Tuite GF, Corcos J, Fecho SB, Braverman AS, Ruggieri MR Sr, Neural reconstruction methods of restoring bladder function. Nat Rev Urol 12:2(100-18)2015 Feb

25617052. Fisher PW, Zhao Y, Rico MC, Massicotte VS, Wade CK, Litvin J, Bove GM, Popoff SN, Barbe MF, Increased CCN2, substance P and tissue fibrosis are associated with sensorimotor declines in a rat model of repetitive overuse injury. J Cell Commun Signal 9:1(37-54)2015 Mar

25510309. Abdelmagid SM, Barbe MF, Safadi FF, Role of inflammation in the aging bones. Life Sci 123:(25-34)2015 Feb 15

25444958. Gomez-Amaya SM, Barbe MF, Lamarre NS, Brown JM, Braverman AS, Ruggieri MR Sr, Neuromuscular nicotinic receptors mediate bladder contractions following bladder reinnervation with somatic to autonomic nerve transfer after decentralization by spinal root transection. J Urol 193:6(2138-45)2015 Jun

25310403. Lamarre NS, Braverman AS, Malykhina AP, Barbe MF, Ruggieri MR Sr, Alterations in nerve-evoked bladder contractions in a coronavirus-induced mouse model of multiple sclerosis. PLoS One 9:10(e109314)2014

25279426. Lee S, Barbe MF, Scalia R, Goldfinger LE, Three-dimensional reconstruction of neovasculature in solid tumors and basement membrane matrix using ex vivo X-ray microcomputed tomography. Microcirculation 21:2(159-70)2014 Feb

25199575. Modlesky CM, Whitney DG, Singh H, Barbe MF, Kirby JT, Miller F, Underdevelopment of trabecular bone microarchitecture in the distal femur of nonambulatory children with cerebral palsy becomes more pronounced with distance from the growth plate. Osteoporos Int 26:2(505-12)2015 Feb

25141594. Gold JE, Mohamed FB, Ali S, Barbe MF, Serum and MRI biomarkers in mobile device texting: a pilot study. Hum Factors 56:5(864-72)2014 Aug

25096320. Hoglund LT, Lockard MA, Barbe MF, Hillstrom HJ, Song J, Reinus WR, Barr-Gillespie AE, Physical performance measurement in persons with patellofemoral osteoarthritis: A pilot study. J Back Musculoskelet Rehabil 28:2(335-42)2015

25070655. Thomas SJ, Sarver JJ, Yannascoli SM, Tucker JJ, Kelly JD 4th, Ahima RS, Barbe MF, Soslowsky LJ, Effect of isolated hyperglycemia on native mechanical and biologic shoulder joint properties in a rat model. J Orthop Res 32:11(1464-70)2014 Nov

25066874. Gomez-Amaya SM, Barbe MF, Brown JM, Lamarre NS, Braverman AS, Massicotte VS, Ruggieri MR Sr, Bladder reinnervation using a primarily motor donor nerve (femoral nerve branches) is functionally superior to using a primarily sensory donor nerve (genitofemoral nerve). J Urol 193:3(1042-51)2015 Mar

24994594. Adapala NS, Holland D, Scanlon V, Barbe MF, Langdon WY, Tsygankov AY, Lorenzo JA, Sanjay A, Loss of Cbl-PI3K interaction in mice prevents significant bone loss following ovariectomy. Bone 67:(1-9)2014 Oct

24954432. Barbe MF, Adiga R, Gordiienko O, Pleshko N, Selzer ME, Krynska B, Micro-computed tomography assessment of vertebral column defects in retinoic acid-induced rat model of myelomeningocele. Birth Defects Res A Clin Mol Teratol 100:6(453-62)2014 Jun

24779374. Driban JB, Barbe MF, Amin M, Kalariya NS, Zhang M, Lo GH, Tassinari AM, Harper D, Price LL, Eaton CB, Schneider E, McAlindon TE, Validation of quantitative magnetic resonance imaging-based apparent bone volume fraction in peri-articular tibial bone of cadaveric knees. BMC Musculoskelet Disord 15:(143)2014 Apr 29

24730986. Gomez-Amaya SM, Ruggieri MR Sr, Arias Serrato SA, Massicotte VS, Barbe MF, Gross anatomical study of the nerve supply of genitourinary structures in female mongrel hound dogs. Anat Histol Embryol 44:2(118-27)2015 Apr

24583543. Jain NX, Barr-Gillespie AE, Clark BD, Kietrys DM, Wade CK, Litvin J, Popoff SN, Barbe MF, Bone loss from high repetitive high force loading is prevented by ibuprofen treatment. J Musculoskelet Neuronal Interact 14:1(78-94)2014 Mar

24470255. Adapala NS, Barbe MF, Tsygankov AY, Lorenzo JA, Sanjay A, Loss of Cbl-PI3K interaction enhances osteoclast survival due to p21-Ras mediated PI3K activation independent of Cbl-b. J Cell Biochem 115:7(1277-89)2014 Jul

24330081. Miller LS, Vegesna AK, Braverman AS, Barbe MF, Ruggieri MR Sr, Enhanced nicotinic receptor mediated relaxations in gastroesophageal muscle fibers from Barrett's esophagus patients. Neurogastroenterol Motil 26:3(430-9)2014 Mar

24231733. Driban JB, Cattano N, Balasubramanian E, Sitler MR, Amin M, Glutting J, Barbe MF, Saline-assisted aspirations for collecting synovial fluid from noneffused knees: technique and validation. J Sport Rehabil Technical Notes:9()2014 Oct 17

24156755. Barbe MF, Gallagher S, Massicotte VS, Tytell M, Popoff SN, Barr-Gillespie AE, The interaction of force and repetition on musculoskeletal and neural tissue responses and sensorimotor behavior in a rat model of work-related musculoskeletal disorders. BMC Musculoskelet Disord 14:(303)2013 Oct 25

24120859. Palma J, Abood ME, Barbe MF, Benamar K, Functional interaction between HIV-gp120 and opioid system in the preoptic anterior hypothalamus. Drug Alcohol Depend 134:(383-6)2014 Jan 1

24084439. Barbe MF, Gallagher S, Popoff SN, Serum biomarkers as predictors of stage of work-related musculoskeletal disorders. J Am Acad Orthop Surg 21:10(644-6)2013 Oct

24015193. Gao HG, Fisher PW, Lambi AG, Wade CK, Barr-Gillespie AE, Popoff SN, Barbe MF, Increased serum and musculotendinous fibrogenic proteins following persistent low-grade inflammation in a rat model of long-term upper extremity overuse. PLoS One 8:8(e71875)2013

23878206. Hoglund LT, Hillstrom HJ, Barr-Gillespie AE, Lockard MA, Barbe MF, Song J, Frontal plane knee and hip kinematics during sit-to-stand and proximal lower extremity strength in persons with patellofemoral osteoarthritis: a pilot study. J Appl Biomech 30:1(82-94)2014 Feb

23540734. Brown JM, Barbe MF, Albo ME, Ruggieri MR Sr, Anatomical feasibility of performing a nerve transfer from the femoral branch to bilateral pelvic nerves in a cadaver: a potential method to restore bladder function following proximal spinal cord injury. J Neurosurg Spine 18:6(598-605)2013 Jun

23362053. Lin K, Uzbelger Feldman D, Barbe MF, Transverse cervical nerve: implications for dental anesthesia. Clin Anat 26:6(688-92)2013 Sep

23320196. Canu MH, Coq JO, Barbe MF, Dinse HR, Plasticity of adult sensorimotor system. Neural Plast 2012:(768259)2012

23149425. Back SH, Adapala NS, Barbe MF, Carpino NC, Tsygankov AY, Sanjay A, TULA-2, a novel histidine phosphatase, regulates bone remodeling by modulating osteoclast function. Cell Mol Life Sci 70:7(1269-84)2013 Apr

23073844. Lambi AG, Pankratz TL, Mundy C, Gannon M, Barbe MF, Richtsmeier JT, Popoff SN, The skeletal site-specific role of connective tissue growth factor in prenatal osteogenesis. Dev Dyn 241:12(1944-59)2012 Dec

23056540. Kietrys DM, Barr-Gillespie AE, Amin M, Wade CK, Popoff SN, Barbe MF, Aging contributes to inflammation in upper extremity tendons and declines in forelimb agility in a rat model of upper extremity overuse. PLoS One 7:10(e46954)2012

22998376. Vegesna AK, Sloan JA, Singh B, Phillips SJ, Braverman AS, Barbe MF, Ruggieri MR Sr, Miller LS, Characterization of the distal esophagus high-pressure zone with manometry, ultrasound and micro-computed tomography. Neurogastroenterol Motil 25:1(53-60.e6)2013 Jan

22969194. Vegesna AK, Chuang KY, Besetty R, Phillips SJ, Braverman AS, Barbe MF, Ruggieri MR, Miller LS, Circular smooth muscle contributes to esophageal shortening during peristalsis. World J Gastroenterol 18:32(4317-22)2012 Aug 28

22951537. Muth S, Barbe MF, Lauer R, McClure PW, The effects of thoracic spine manipulation in subjects with signs of rotator cuff tendinopathy. J Orthop Sports Phys Ther 42:12(1005-16)2012 Dec

22881037. Brown JM, Barbe MF, Albo ME, Lai HH, Ruggieri MR Sr, Anatomical feasibility of performing intercostal and ilioinguinal nerve to pelvic nerve transfer: a possible technique to restore lower urinary tract innervation. J Neurosurg Spine 17:4(357-62)2012 Oct

22675458. Abdelmagid SM, Barr AE, Rico M, Amin M, Litvin J, Popoff SN, Safadi FF, Barbe MF, Performance of repetitive tasks induces decreased grip strength and increased fibrogenic proteins in skeletal muscle: role of force and inflammation. PLoS One 7:5(e38359)2012

22521835. Delcour M, Russier M, Amin M, Baud O, Paban V, Barbe MF, Coq JO, Impact of prenatal ischemia on behavior, cognitive abilities and neuroanatomy in adult rats with white matter damage. Behav Brain Res 232:1(233-44)2012 Jun 15

22122951. Cattano NM, Driban JB, Balasubramanian E, Barbe MF, Amin M, Sitler MR, Biochemical comparison of osteoarthritic knees with and without effusion. BMC Musculoskelet Disord 12:(273)2011 Nov 28

22087754. Kietrys DM, Barr AE, Barbe MF, Exposure to repetitive tasks induces motor changes related to skill acquisition and inflammation in rats. J Mot Behav 43:6(465-76)2011

21953679. Ruggieri MR Sr, Braverman AS, Bernal RM, Lamarre NS, Brown JM, Barbe MF, Reinnervation of urethral and anal sphincters with femoral motor nerve to pudendal nerve transfer. Neurourol Urodyn 30:8(1695-704)2011 Nov

21952831. Brennan T, Adapala NS, Barbe MF, Yingling V, Sanjay A, Abrogation of Cbl-PI3K interaction increases bone formation and osteoblast proliferation. Calcif Tissue Int 89:5(396-410)2011 Nov

21807131. Joshi RN, Safadi FF, Barbe MF, Del Carpio-Cano F, Popoff SN, Yingling VR, Different effects on bone strength and cell differentiation in pre pubertal caloric restriction versus hypothalamic suppression. Bone 49:4(810-8)2011 Oct

21761966. Barbe MF, Brown JM, Pontari MA, Dean GE, Braverman AS, Ruggieri MR, Feasibility of a femoral nerve motor branch for transfer to the pudendal nerve for restoring continence: a cadaveric study. J Neurosurg Spine 15:5(526-31)2011 Nov

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