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S. Ausim Azizi, MD, PhD


S. Ausim Azizi, MD, PhD


Chairperson, Department of Neurology

Professor, Neurology

Telephone:  215-707-5953

FAX: 215-707-8235

Email: azizia@tuhs.temple.edu


Department of Neurology

Center for Substance Abuse Research


Educational Background:


Undergraduate degree, University of Texas, Austin, TX, 1978


MD, Southwestern Medical School, Dallas, TX, 1990


Internship, Yale University, New Haven Hospital, New Haven, CT, 1991


Residency, Yale University, New Haven Hospital, New Haven, CT, 1994


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clinical Interests:


  • Movement disorders
  • Stroke

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board certification(s):





American Board of Psychiatry and Neurology, 1998

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professional affiliations:

  • Society for Neuroscience
  • American Academy of Neurology
  • International Brain Research Organization
  • American Society for Neurotransplantation and Repair (ASNTR)
  • American Society for Experimental Neurotherapeutics (founding member)
  • Philadelphia Neurological Society
  • American Heart Association

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research interests:


Current research is focused on investigation of cell-based therapies for repair and regeneration of the damaged central nervous system.   We are exploring the signaling pathways of differentiation of adult stem cells into useful neural cells, and the feasibility of neurotransplantation of adult stem cells obtained from bone marrow and other sources for future treatment of Alzheimer's and Parkinson's disease as well as brain trauma and stroke.


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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

23975823. Azizi SA, Krynska B, Derivation of neuronal cells from fetal normal human astrocytes (NHA). Methods Mol Biol 1078:(89-96)2013

23805194. Gordon J, Sariyer IK, De La Fuente-Granada M, Augelli BJ, Otte J, Azizi SA, Amini S, Khalili K, Krynska B, Neural Crest Cells Isolated from the Bone Marrow of Transgenic Mice Express JCV T-Antigen. PLoS One 8:6(e65947)2013

23298784. Azizi SA, "I think therefore I am": new prospects for neural prostheses. Neurosci Lett 538:(1-2)2013 Mar 22

22573347. Imitola J, Pitt K, Peoples JL, Krynska B, Sheikh H, Kesari S, Azizi SA, Multifocal CNS infiltration of chronic lymphocytic leukemia in the form of small-cell solid metastatic lesions. J Neurooncol 109:1(213-5)2012 Aug

21816823. Mukerjee R, Chang JR, Del Valle L, Bagashev A, Gayed MM, Lyde RB, Hawkins BJ, Brailoiu E, Cohen E, Power C, Azizi SA, Gelman BB, Sawaya BE, Deregulation of microRNAs by HIV-1 Vpr protein leads to the development of neurocognitive disorders. J Biol Chem 286:40(34976-85)2011 Oct 7

21352895. Azizi SA, Of sleep, seizures and networks. Neurosci Lett 493:3(61-2)2011 Apr 15

20190567. Del Valle L, Piņa-Oviedo S, Perez-Liz G, Augelli BJ, Azizi SA, Khalili K, Gordon J, Krynska B, Bone marrow-derived mesenchymal stem cells undergo JCV T-antigen mediated transformation and generate tumors with neuroectodermal characteristics. Cancer Biol Ther 9:4(286-94)2010 Feb

19841903. Anandham R, Indira Gandhi P, Kwon SW, Sa TM, Kim YK, Jee HJ, Mixotrophic metabolism in Burkholderia kururiensis subsp. thiooxydans subsp. nov., a facultative chemolithoautotrophic thiosulfate oxidizing bacterium isolated from rhizosphere soil and proposal for classification of the type strain of Burkholderia kururiensis as Burkholderia kururiensis subsp. kururiensis subsp. nov. Arch Microbiol 191:12(885-94)2009 Dec

19393289. Azizi SA, Brain to music to brain! Neurosci Lett 459:1(1-2)2009 Jul 31

19061885. Rieske P, Augelli BJ, Stawski R, Gaughan J, Azizi SA, Krynska B, A population of human brain cells expressing phenotypic markers of more than one lineage can be induced in vitro to differentiate into mesenchymal cells. Exp Cell Res 315:3(462-73)2009 Feb 1

18638414. Witusik M, Piaskowski S, Hulas-Bigoszewska K, Zakrzewska M, Gresner SM, Azizi SA, Krynska B, Liberski PP, Rieske P, Successful elimination of non-neural cells and unachievable elimination of glial cells by means of commonly used cell culture manipulations during differentiation of GFAP and SOX2 positive neural progenitors (NHA) to neuronal cells. BMC Biotechnol 8:(56)2008 Jul 19

18591496. Franco MJ, Vendrame M, Haneef Z, Azizi SA, Teaching NeuroImage: Acute spastic monoplegia secondary to spinal epidural venous engorgement in pregnancy. Neurology 71:1(e1)2008 Jul 1

17996224. Witusik M, Gresner SM, Hulas-Bigoszewska K, Krynska B, Azizi SA, Liberski PP, Brown P, Rieske P, Neuronal and astrocytic cells, obtained after differentiation of human neural GFAP-positive progenitors, present heterogeneous expression of PrPc. Brain Res 1186:(65-73)2007 Dec

17597529. Vendrame M, Azizi SA, Pyramidal and extrapyramidal dysfunction as a sequela of hypoxic injury: case report. BMC Neurol 7:(18)2007 Jun 27

17466455. Azizi SA, Vendrame M, Exercise: a workout for neuroregeneration. Neurosci Lett 418:3(211-2)2007 May 18

17427272. Vendrame M, Azizi SA, The spectrum of neuromyelitis optica: a case of NMO with extensive brain stem involvement. Neurol Res 29:1(32-5)2007 Jan

17241264. Rieske P, Azizi SA, Augelli B, Gaughan J, Krynska B, A population of human brain parenchymal cells express markers of glial, neuronal and early neural cells and differentiate into cells of neuronal and glial lineages. Eur J Neurosci 25:1(31-7)2007 Jan

16351691. Rieske P, Krynska B, Azizi SA, Human fibroblast-derived cell lines have characteristics of embryonic stem cells and cells of neuro-ectodermal origin. Differentiation 73:9-10(474-83)2005 Dec

15896470. Azizi SA, Botulinum toxin: more than meets the naked eye! Neurosci Lett 381:3(205-6)2005 Jun 24

15824360. Luo JJ, Jacobson M, Kamal AK, Azizi SA, Ethmoid abscess with findings simulating Weber syndrome. Neurology 64:7(1266)2005 Apr 12

11509954. Schwarz EJ, Reger RL, Alexander GM, Class R, Azizi SA, Prockop DJ, Rat marrow stromal cells rapidly transduced with a self-inactivating retrovirus synthesize L-DOPA in vitro. Gene Ther 8:16(1214-23)2001 Aug

11117551. Del Valle L, Azizi SA, Krynska B, Enam S, Croul SE, Khalili K, Reactivation of human neurotropic JC virus expressing oncogenic protein in a recurrent glioblastoma multiforme. Ann Neurol 48:6(932-6)2000 Dec

11105688. Prockop DJ, Azizi SA, Phinney DG, Kopen GC, Schwarz EJ, Potential use of marrow stromal cells as therapeutic vectors for diseases of the central nervous system. Prog Brain Res 128:(293-7)2000

10961915. Prockop DJ, Azizi SA, Colter D, Digirolamo C, Kopen G, Phinney DG, Potential use of stem cells from bone marrow to repair the extracellular matrix and the central nervous system. Biochem Soc Trans 28:4(341-5)2000

10543618. Schwarz EJ, Alexander GM, Prockop DJ, Azizi SA, Multipotential marrow stromal cells transduced to produce L-DOPA: engraftment in a rat model of Parkinson disease. Hum Gene Ther 10:15(2539-49)1999 Oct 10

9584957. Azizi SA, Miyamoto C, Principles of treatment of malignant gliomas in adults: an overview. J Neurovirol 4:2(204-16)1998 Apr

9520466. Azizi SA, Stokes D, Augelli BJ, DiGirolamo C, Prockop DJ, Engraftment and migration of human bone marrow stromal cells implanted in the brains of albino rats--similarities to astrocyte grafts. Proc Natl Acad Sci U S A 95:7(3908-13)1998 Mar 31

7586856. Azizi SA, Fayad PB, Fulbright R, Giroux ML, Waxman SG, Clivus and cervical spinal osteomyelitis with epidural abscess presenting with multiple cranial neuropathies. Clin Neurol Neurosurg 97:3(239-44)1995 Aug

8257309. Goldstein JM, Azizi SA, Booss J, Vollmer TL, Human immunodeficiency virus-associated motor axonal polyradiculoneuropathy. Arch Neurol 50:12(1316-9)1993 Dec

2289142. Azizi SA, Woodward DJ, Interactions of visual and auditory mossy fiber inputs in the paraflocculus of the rat: a gating action of multimodal inputs. Brain Res 533:2(255-62)1990 Nov 19

2357542. Waterhouse BD, Azizi SA, Burne RA, Woodward DJ, Modulation of rat cortical area 17 neuronal responses to moving visual stimuli during norepinephrine and serotonin microiontophoresis. Brain Res 514:2(276-92)1990 Apr 30

2723155. Mihailoff GA, Kosinski RJ, Azizi SA, Border BG, Survey of noncortical afferent projections to the basilar pontine nuclei: a retrograde tracing study in the rat. J Comp Neurol 282:4(617-43)1989 Apr 22

3214748. Waterhouse BD, Sessler FM, Cheng JT, Woodward DJ, Azizi SA, Moises HC, New evidence for a gating action of norepinephrine in central neuronal circuits of mammalian brain. Brain Res Bull 21:3(425-32)1988 Sep

3370486. Cheng JT, Sessler FM, Azizi SA, Chapin JK, Waterhouse BD, Electrophysiological actions of norepinephrine in rat lateral hypothalamus. II. An in vitro study of the effects of iontophoretically applied norepinephrine on LH neuronal responses to gamma-aminobutyric acid (GABA). Brain Res 446:1(90-105)1988 Apr 12

2458277. Kosinski RJ, Azizi SA, Mihailoff GA, Convergence of cortico- and cuneopontine projections onto components of the pontocerebellar system in the rat: an anatomical and electrophysiological study. Exp Brain Res 71:3(541-56)1988

2822777. Azizi SA, Woodward DJ, Inferior olivary nuclear complex of the rat: morphology and comments on the principles of organization within the olivocerebellar system. J Comp Neurol 263:4(467-84)1987 Sep 22

2432100. Kosinski RJ, Azizi SA, Border BG, Mihailoff GA, Origin and ultrastructural identification of dorsal column nuclear synaptic terminals in the basilar pontine gray of rats. J Comp Neurol 253:1(92-104)1986 Nov 1

2429739. Border BG, Kosinski RJ, Azizi SA, Mihailoff GA, Certain basilar pontine afferent systems are GABA-ergic: combined HRP and immunocytochemical studies in the rat. Brain Res Bull 17:2(169-79)1986 Aug

4018197. Azizi SA, Burne RA, Woodward DJ, The auditory corticopontocerebellar projection in the rat: inputs to the paraflocculus and midvermis. An anatomical and physiological study. Exp Brain Res 59:1(36-49)1985

6271853. Burne RA, Azizi SA, Mihailoff GA, Woodward DJ, The tectopontine projection the the rat with comments on visual pathways to the basilar pons. J Comp Neurol 202:2(287-307)1981 Oct 20

7229128. Mihailoff GA, Burne RA, Azizi SA, Norell G, Woodward DJ, The pontocerebellar system in the rat: an HRP study. II. Hemispheral components. J Comp Neurol 197:4(559-77)1981 Apr 20

7229127. Azizi SA, Mihailoff GA, Burne RA, Woodward DJ, The pontocerebellar system in the rat: an HRP study. I. Posterior vermis. J Comp Neurol 197:4(543-8)1981 Apr 20

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