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Martin W. Adler, PhD

Director Emeritus and Senior Advisor, Center for Substance Abuse Research

Laura H. Carnell Professor of Pharmacology
Executive Officer, College on Problems of Drug Dependence

Telephone:  215-707-3242

Fax:  215-707-1904

Email: baldeagl@temple.edu

Center for Substance Abuse Research

Department of Pharmacology

BA, New York University, New York

 

BS, Brooklyn College of Pharmacy, New York

 

MS, Columbia University, New York

 

PhD, Albert Einstein College of Medicine, New York

 

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Dr. Adler's laboratory has shown that the endogenous opioid system (receptors and ligands) is involved in a number of physiological and pathological processes including analgesia, thermoregulation, and brain excitability. These opioid systems produce their biological effects as part of a cascade of events that involve a number of neuropeptides and neurotransmitters. More recently, the interactions of opioids, cytokines and chemokines in the brain have been studied with regard to pain, thermoregulation and immunoregulation. The interactions of opioids with other abused drugs, especially cannabinoids, is a major focus of the laboratory.

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Recent Medically Related Publications, Obtained from PubMed (Click on PubMed ID to view abstract)

22196236. Brailoiu GC, Deliu E, Hooper R, Dun NJ, Undieh AS, Adler MW, Benamar K, Brailoiu E, Agonist-selective effects of opioid receptor ligands on cytosolic calcium concentration in rat striatal neurons. Drug Alcohol Depend 123:1-3(277-81)2012 Jun 1

21826405. Breslow JM, Monroy MA, Daly JM, Meissler JJ, Gaughan J, Adler MW, Eisenstein TK, Morphine, but not trauma, sensitizes to systemic Acinetobacter baumannii infection. J Neuroimmune Pharmacol 6:4(551-65)2011 Dec

21600706. Palma J, Cowan A, Geller EB, Adler MW, Benamar K, Differential antinociceptive effects of buprenorphine and methadone in the presence of HIV-gp120. Drug Alcohol Depend 118:2-3(497-9)2011 Nov 1

21569838. Chen X, Kirby LG, Palma J, Benamar K, Geller EB, Eisenstein TK, Adler MW, The effect of gp120 on morphine's antinociceptive and neurophysiological actions. Brain Behav Immun 25:7(1434-43)2011 Oct

21112161. Benamar K, Palma J, Cowan A, Geller EB, Adler MW, Analgesic efficacy of buprenorphine in the presence of high levels of SDF-1a/CXCL12 in the brain. Drug Alcohol Depend 114:2-3(246-8)2011 Apr 1

20826425. Zhao P, Sharir H, Kapur A, Cowan A, Geller EB, Adler MW, Seltzman HH, Reggio PH, Heynen-Genel S, Sauer M, Chung TD, Bai Y, Chen W, Caron MG, Barak LS, Abood ME, Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and ß-arrestin2 with antinociceptive activity. Mol Pharmacol 78:4(560-8)2010 Oct

20688146. Breslow JM, Feng P, Meissler JJ, Pintar JE, Gaughan J, Adler MW, Eisenstein TK, Potentiating effect of morphine on oral Salmonella enterica serovar Typhimurium infection is µ-opioid receptor-dependent. Microb Pathog 49:6(330-5)2010 Dec

19906780. Benamar K, Addou S, Yondorf M, Geller EB, Eisenstein TK, Adler MW, Intrahypothalamic injection of the HIV-1 envelope glycoprotein induces fever via interaction with the chemokine system. J Pharmacol Exp Ther 332:2(549-53)2010 Feb

19558543. Benamar K, Yondorf M, Geller EB, Eisenstein TK, Adler MW, Physiological evidence for interaction between the HIV-1 co-receptor CXCR4 and the cannabinoid system in the brain. Br J Pharmacol 157:7(1225-31)2009 Aug

19332079. Zhang M, Adler MW, Abood ME, Ganea D, Jallo J, Tuma RF, CB2 receptor activation attenuates microcirculatory dysfunction during cerebral ischemic/reperfusion injury. Microvasc Res 78:1(86-94)2009 Jun

19255856. Zhang M, Martin BR, Adler MW, Razdan RJ, Kong W, Ganea D, Tuma RF, Modulation of cannabinoid receptor activation as a neuroprotective strategy for EAE and stroke. J Neuroimmune Pharmacol 4:2(249-59)2009 Jun

18727928. Benamar K, Geller EB, Adler MW, A new brain area affected by 3,4-methylenedioxymethamphetamine: A microdialysis-biotelemetry study. Eur J Pharmacol 596:1-3(84-8)2008 Oct 31

18656466. Benamar K, Geller EB, Adler MW, Elevated level of the proinflammatory chemokine, RANTES/CCL5, in the periaqueductal grey causes hyperalgesia in rats. Eur J Pharmacol 592:1-3(93-5)2008 Sep 11

18533278. Finley MJ, Chen X, Bardi G, Davey P, Geller EB, Zhang L, Adler MW, Rogers TJ, Bi-directional heterologous desensitization between the major HIV-1 co-receptor CXCR4 and the kappa-opioid receptor. J Neuroimmunol 197:2(114-23)2008 Jul 15

18304750. Zhang M, Martin BR, Adler MW, Razdan RK, Ganea D, Tuma RF, Modulation of the balance between cannabinoid CB(1) and CB(2) receptor activation during cerebral ischemic/reperfusion injury. Neuroscience 152:3(753-60)2008 Mar 27

18281594. Benamar K, Geller EB, Adler MW, First in vivo evidence for a functional interaction between chemokine and cannabinoid systems in the brain. J Pharmacol Exp Ther 325:2(641-5)2008 May

19248685. Baty DE, Zhang M, Li H, Erb CJ, Adler MW, Ganea D, Loftus CM, Jallo JI, Tuma RF, Cannabinoid CB2 receptor activation attenuates motor and autonomic function deficits in a mouse model of spinal cord injury. Clin Neurosurg 55:(172-7)2008

17898318. Benamar K, Yondorf M, Barreto VT, Geller EB, Adler MW, Deletion of mu-opioid receptor in mice alters the development of acute neuroinflammation. J Pharmacol Exp Ther 323:3(990-4)2007 Dec

17640739. Eisenstein TK, Meissler JJ, Wilson Q, Gaughan JP, Adler MW, Anandamide and Delta9-tetrahydrocannabinol directly inhibit cells of the immune system via CB2 receptors. J Neuroimmunol 189:1-2(17-22)2007 Sep

17459345. Chen X, Geller EB, Rogers TJ, Adler MW, The chemokine CX3CL1/fractalkine interferes with the antinociceptive effect induced by opioid agonists in the periaqueductal grey of rats. Brain Res 1153:(52-7)2007 Jun 11

17245417. Zhang M, Martin BR, Adler MW, Razdan RK, Jallo JI, Tuma RF, Cannabinoid CB(2) receptor activation decreases cerebral infarction in a mouse focal ischemia/reperfusion model. J Cereb Blood Flow Metab 27:7(1387-96)2007 Jul

17194800. Benamar K, Yondorf M, Meissler JJ, Geller EB, Tallarida RJ, Eisenstein TK, Adler MW, A novel role of cannabinoids: implication in the fever induced by bacterial lipopolysaccharide. J Pharmacol Exp Ther 320:3(1127-33)2007 Mar

17173891. Chen X, Geller EB, Adler MW, Nociceptin/orphanin FQ blocks the antinociception induced by mu, kappa and delta opioid agonists on the cold water tail-flick test. Eur J Pharmacol 557:1(32-6)2007 Feb 14

17049756. Chen X, Geller EB, Rogers TJ, Adler MW, Rapid heterologous desensitization of antinociceptive activity between mu or delta opioid receptors and chemokine receptors in rats. Drug Alcohol Depend 88:1(36-41)2007 Apr 17

16926415. Feng P, Truant AL, Meissler JJ Jr, Gaughan JP, Adler MW, Eisenstein TK, Morphine withdrawal lowers host defense to enteric bacteria: spontaneous sepsis and increased sensitivity to oral Salmonella enterica serovar Typhimurium infection. Infect Immun 74:9(5221-6)2006 Sep

16594639. Adler MW, Geller EB, Chen X, Rogers TJ, Viewing chemokines as a third major system of communication in the brain. AAPS J 7:4(E865-70)2006 Jan 6

16513108. Feng P, Rahim RT, Cowan A, Liu-Chen LY, Peng X, Gaughan J, Meissler JJ Jr, Adler MW, Eisenstein TK, Effects of mu, kappa or delta opioids administered by pellet or pump on oral Salmonella infection and gastrointestinal transit. Eur J Pharmacol 534:1-3(250-7)2006 Mar 18

16299287. Feng P, Wilson QM, Meissler JJ Jr, Adler MW, Eisenstein TK, Increased sensitivity to Salmonella enterica serovar Typhimurium infection in mice undergoing withdrawal from morphine is associated with suppression of interleukin-12. Infect Immun 73:12(7953-9)2005 Dec

16257420. Chen X, McClatchy DB, Geller EB, Tallarida RJ, Adler MW, The dynamic relationship between mu and kappa opioid receptors in body temperature regulation. Life Sci 78:4(329-33)2005 Dec 12

16204646. Rahim RT, Meissler JJ Jr, Adler MW, Eisenstein TK, Splenic macrophages and B cells mediate immunosuppression following abrupt withdrawal from morphine. J Leukoc Biol 78:6(1185-91)2005 Dec

16204637. Adler MW, Rogers TJ, Are chemokines the third major system in the brain? J Leukoc Biol 78:6(1204-9)2005 Dec

15913793. Feng P, Meissler JJ Jr, Adler MW, Eisenstein TK, Morphine withdrawal sensitizes mice to lipopolysaccharide: elevated TNF-alpha and nitric oxide with decreased IL-12. J Neuroimmunol 164:1-2(57-65)2005 Jul

15700026. Benamar K, McMenamin M, Geller EB, Chung YG, Pintar JE, Adler MW, Unresponsiveness of mu-opioid receptor knockout mice to lipopolysaccharide-induced fever. Br J Pharmacol 144:8(1029-31)2005 Apr

15306234. Benamar K, Rawls SM, Geller EB, Adler MW, Intrahypothalamic injection of deltorphin-II alters body temperature in rats. Brain Res 1019:1-2(22-7)2004 Sep 3

15159137. Rawls SM, Tallarida RJ, Kon DA, Geller EB, Adler MW, GABAA receptors modulate cannabinoid-evoked hypothermia. Pharmacol Biochem Behav 78:1(83-91)2004 May

15124761. Ni X, Geller EB, Eppihimer MJ, Eisenstein TK, Adler MW, Tuma RF, Win 55212-2, a cannabinoid receptor agonist, attenuates leukocyte/endothelial interactions in an experimental autoimmune encephalomyelitis model. Mult Scler 10:2(158-64)2004 Apr

14741440. Rahim RT, Feng P, Meissler JJ, Rogers TJ, Zhang L, Adler MW, Eisenstein TK, Paradoxes of immunosuppression in mouse models of withdrawal. J Neuroimmunol 147:1-2(114-20)2004 Feb

14610231. Rawls SM, Tallarida RJ, Gray AM, Geller EB, Adler MW, L-NAME (N omega-nitro-L-arginine methyl ester), a nitric-oxide synthase inhibitor, and WIN 55212-2 [4,5-dihydro-2-methyl-4(4-morpholinylmethyl)-1-(1-naphthalenyl-carbonyl)-6H-pyrrolo[3,2,1ij]quinolin-6-one], a cannabinoid agonist, interact to evoke synergistic hypothermia. J Pharmacol Exp Ther 308:2(780-6)2004 Feb

14597094. Rahim RT, Meissler JJ, Zhang L, Adler MW, Rogers TJ, Eisenstein TK, Withdrawal from morphine in mice suppresses splenic macrophage function, cytokine production, and costimulatory molecules. J Neuroimmunol 144:1-2(16-27)2003 Nov

12954818. Benamar K, Yondorf MZ, Kon D, Geller EB, Adler MW, Role of the nitric-oxide synthase isoforms during morphine-induced hyperthermia in rats. J Pharmacol Exp Ther 307:1(219-22)2003 Oct

12932841. Rawls SM, Adler MW, Gaughan JP, Baron A, Geller EB, Cowan A, NMDA receptors modulate morphine-induced hyperthermia. Brain Res 984:1-2(76-83)2003 Sep 12

12235276. Rawls SM, Cowan A, Tallarida RJ, Geller EB, Adler MW, N-methyl-D-aspartate antagonists and WIN 55212-2 [4,5-dihydro-2-methyl-4(4-morpholinylmethyl)-1-(1-naphthalenyl-carbonyl)-6H-pyrrolo[3,2,1-i,j]quinolin-6-one], a cannabinoid agonist, interact to produce synergistic hypothermia. J Pharmacol Exp Ther 303:1(395-402)2002 Oct

12235273. Benamar K, Geller EB, Adler MW, Role of the nitric oxide pathway in kappa-opioid-induced hypothermia in rats. J Pharmacol Exp Ther 303:1(375-8)2002 Oct

12213522. Rawls SM, Baron DA, Geller EB, Adler MW, Sigma sites mediate DTG-evoked hypothermia in rats. Pharmacol Biochem Behav 73:4(779-86)2002 Nov

12130663. Szabo I, Chen XH, Xin L, Adler MW, Howard OM, Oppenheim JJ, Rogers TJ, Heterologous desensitization of opioid receptors by chemokines inhibits chemotaxis and enhances the perception of pain. Proc Natl Acad Sci U S A 99:16(10276-81)2002 Aug 6

12044979. Rahim RT, Adler MW, Meissler JJ Jr, Cowan A, Rogers TJ, Geller EB, Eisenstein TK, Abrupt or precipitated withdrawal from morphine induces immunosuppression. J Neuroimmunol 127:1-2(88-95)2002 Jun

12023525. Rawls SM, Cabassa J, Geller EB, Adler MW, CB1 receptors in the preoptic anterior hypothalamus regulate WIN 55212-2 [(4,5-dihydro-2-methyl-4(4-morpholinylmethyl)-1-(1-naphthalenyl-carbonyl)-6H-pyrrolo[3,2,1ij]quinolin-6-one]-induced hypothermia. J Pharmacol Exp Ther 301:3(963-8)2002 Jun

12002806. Benamar K, Geller EB, Adler MW, Effect of a mu-opioid receptor-selective antagonist on interleukin-6 fever. Life Sci 70:18(2139-45)2002 Mar 22

11727763. Eisenstein LK, MacFarland AS, Peng X, Hilburger ME, Rahim RT, Meissler LJ Jr, Rogers TJ, Wan AC, Adler MW, Effect of opioids on oral Salmonella infection and immune function. Adv Exp Med Biol 493:(169-76)2001

11606031. Rahim RT, Meissler JJ Jr, Cowan A, Rogers TJ, Geller EB, Gaughan J, Adler MW, Eisenstein TK, Administration of mu-, kappa- or delta2-receptor agonists via osmotic minipumps suppresses murine splenic antibody responses. Int Immunopharmacol 1:11(2001-9)2001 Oct

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