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Platelets Sol Sherry, MD Molecular model of PDE3A - click to enlarge

sol sherry thrombosis research center

Educational Programs

 

The organization structure of the Sol Sherry Thrombosis Research Center is an ideal environment for training and professional development for predoctoral and postdoctoral fellows.  We focus on basic training in the fields of biochemistry and physiology of platelets, the biochemistry and molecular biology of coagulation factors, and the physiology and cell biology of vessel wall cells.  Some of our faculty members hold a primary appointment in the Center as well as having secondary appointments in other departments and centers, including the Departments of Medicine, Biochemistry, Physiology, Pharmacology, Microbiology and Immunology, Pathology and Laboratory Medicine, Diagnostic Imaging, Biology, the Fels Institute for Cancer Research and Molecular Biology, and the General Clinical Research Center. This arrangement allows for participation in training in the primary department as well as utilizing the resources and facilities of the Center. Thus, the staff is interwoven by the faculty organizational structure within the School of Medicine.

 

Our Training Program in Thrombosis and Hemostasis is funded by the National Heart, Lung, and Blood Institute of the National Institutes of Health since its inception under the direction of Dr. Sol Sherry.   Center faculty members who participate as trainers have a high level of expertise in research and technical aspects of their investigative areas, such as thrombosis, hemostasis, and vascular biology research. From 1980 until the present, this training grant for pre- and postdoctoral fellows has been place with Dr. Robert W. Colman as its Program Director. Continuation of this institutional training program provides a major mechanism for recruiting young scientists, allowing maximum flexibility and efficiency in attracting quality individuals to the field of thrombosis, hemostasis, and vascular biology research.

 

The physical layout of Temple University’s Health Sciences Center and Temple University Hospital offers a unique training environment for potential investigators in hemostasis and thrombosis. Dr. Colman as Program Director and Dr. Rao as Director of the Sol Sherry Thrombosis Research Center and Chief of the Section of Hematology facilitate interaction between research scientists and clinicians within Temple University.  This advantageous arrangement allows for a wide range of training opportunities in varied facilities throughout the HSC.

 

Four members of the Center are M.D.s in the Department of Medicine have access to the Hospital patient facilities for diagnosis, treatment, and investigative protocols. Former members of the Center who remain in Philadelphia are on our adjunct faculty and visit the Center regularly to collaborate. Strong research alliances exist within the School of Medicine, including the Sections of Oncology, Pathology and Laboratory Medicine, Cardiology, Pulmonary Medicine, Cardiothoracic Surgery, as well as the General Clinical Research Center, just to name a few. 

 

Philadelphia is a major center for thrombosis research.  Collaborations exist between the Sol Sherry Thrombosis Research Center and other prestigious research universities and hospitals in the City , such as the University of Pennsylvania, The Children’s Hospital of Philadelphia, Thomas Jefferson University, and Drexel University.

 

The Center holds a weekly one-hour seminar each Tuesday throughout the academic year. Invited guest speakers present topics related to hemostasis and thrombosis research and are selected among investigators from the Center, other Temple University departments, other Philadelphia institutions, as well as visiting professors to Temple.  Other basic sciences departments at Temple hold a Joint Seminar Series, also offered weekly, with topics related to biochemistry, cell biology, immunology, molecular biology, or physiology.

 

The Thrombosis Seminar Series is a weekly educational session that has been continuously ongoing since 1993.  Our most recent guest speakers and their presentations are as follows: 

 

October 11, 2005.  Pathways of Bradykinin Formation in Plasma.   Kusumam Joseph, Ph.D., Assistant Professor, Department of Medicine, Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC.

 

October 18, 2005.   Patho-Biology of Neutrophil Defensins.  Khalil Bdeir, Ph.D., Assistant Professor, Department of Pathology, University of Pennsylvania, PA.

 

October 25, 2005.  Regulation of Growth and Metabolism by Akt/PKB.   Morris J. Birnbaum, M.D., Ph.D., Professor, Department of Medicine, University of Pennsylvania, Philadelphia, PA.

 

November 1, 2005.   Coagulation Protease Specificity and Function.  Sriram Krishnaswamy Ph.D., Associate Professor of Pediatrics and Pharmacology, Stokes Investigator, The Children’s Hospital of Philadelphia, Philadelphia, PA.

 

November 8, 2005.   Blood Coagulation Microarrays and High Throughput Phenotyping.  Scott L. Diamond, Ph.D., Arthur E. Humphrey Professor of Chemical and Biomolecular Engineering and Bioengineering, Director, Penn Center for Molecular Discovery, University of Pennsylvania, Philadelphia, PA.

 

November 15, 2005.   von Willebrand Factor and ADAMTS13.   J. Evan Sadler M.D., PhD., Professor of Medicine, Howard Hughes Medical Institute, Washington University, St. Louis, MO.

 

November 22, 2005.   Regulators of Endothelial Cell Migration.  Tracee S. Panetti Ph.D., Assistant Professor, Department of Microbiology and Immunology, and Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA.

 

November 29, 2005.   Measurement of Activated Factor XII in Humans.   How XIIa Exists in vivo! David Pritchard, Ph.D., Research Group Leader, Axis Shield Diagnostics, UK, The Technology Park, Dundee, United Kingdom.

 

December 6, 2005.   Hematopoietic Contribution to Vascular Development.   Mark Kahn, M.D., Associate Professor, Director, Cardiovascular Transgenic and Knockout Core Facility, University of Pennsylvania, Philadelphia, PA.

 

December 16, 2005.    Interaction of Angiocidin with the Extracellular Matrix and Its Role in Angiogenesis. George P. Tuszynski, M.D., Professor, Department of Biology, Temple University, Philadelphia, PA.

 

Additional training advantages that the Thrombosis Research Center has long maintained and strongly participates in is the promotion of opportunities for minority students in the field of medicine.  We take part in recruiting students from the highly successful Recruitment Admissions and Retention (RAR) Program, directed by Raul De La Cadena, M.D., a Thrombosis Research Center faculty member. The Recruitment, Admissions and Retention (RAR) Program was initiated in October 1971. Temple University has long-term dedication to the recruitment and retention of students from underrepresented racial/ethnic groups. The current retention and graduation rate for underrepresented minority students at Temple University School of Medicine remains in the high 90 percentile.

 

The Thrombosis Research Center maintains strong participation in the Minority Access to Careers (MARC) Program at Temple University School of Medicine as well.  Its overall mission is to produce a cadre of minority M.D., Ph.D. and M.D./Ph.D. researchers trained in the basic sciences. This is accomplished by enrolling students at the 10th grade level of high school in an organized, recurring program that teaches basic science methods and research in the laboratory of funded investigators at the School of Medicine. Selected participants return on a yearly basis during high school and undergraduate school to engage in a nine-week summer research and clinical medicine preceptorship.  Since July 1, 200, the MARC Program was renewed under the new title “Physician Scientist Training Program”  and seeks to increase the number of minority scientists by providing a training regimen to these “child prodigies” with the ultimate goal of achieving academic development to the level of entering the M.D./Ph.D. dual-degree program or the M.D. track program at Temple, focusing on academic medicine.