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Dr. Prem Reddy's group working on cancer therapy Drs. Keith Latham and Zhiming Han working on a nuclear transplantation experiment Drs. Barbara Hoffman, Dan Liebermann, along with graduate student Alisha Mohamed, working on hematopoiesis

fels institute for cancer research & molecular biology

Research Programs

 

 

Molecular Genetics

 

The Molecular Genetics Program investigators elucidate molecular and biochemical processes regulating cell cycle progression, chromatin remodeling, transcription, ubiquitin signaling, and signal transduction.  They also study how these events impinge on cell proliferation, senescence, differentiation, apoptosis and transformation.

 

 

Cell and Developmental Biology

 

Cell and Developmental Biology Program investigators study the genetic, epigenetic, cellular and molecular mechanisms regulating embryonic development, and the molecular, genetic and epidemiological basis of cancer and tumor formation.  Novel mouse model systems are generated using transgene and gene knock-out technologies to study the role of oncogenes and growth suppressor genes in mouse development.  Cloning by somatic  cell nuclear transfer is employed to study gene regulation during normal development.  State-of-the art molecular techniques together with RNA interference technology are also employed to manipulate gene function during development.

 

 

Experimental Therapeutics Program

 

A major goal of experimental therapeutic program is to develop targeted therapies for cancer and other debilitating diseases such as AIDS and to study the mechanism of action of these therapeutic agents.   An important goal of this program is to collaborate with clinical oncologists to conduct Phase Iand Phase II clinical trials of novel therapeutic agents developed as a part of this program. 

 

 

Immunology

 

Immunology program investigators study the regulation of immune system with emphasis on understanding how failure in immune surveillance contributes to cancer and how immunological approaches can be exploited to combat the disease.  In addition, investigators are interested in the possible contribution of certain inflammatory processes to the development of cancer.